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1. 发明申请

US20130090309A1 AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS 有权
标题翻译：含氨基吡啶类的吡咯啉类激酶（SYK）抑制剂
公开(公告)号：US20130090309A1
公开(公告)日：2013-04-11
申请号：US13704484
申请日：2012-04-30
申请人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
发明人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
IPC分类号： A61K31/444 , A61K31/496 , A61K45/06 , A61K31/675 , C07F5/02 , A61K31/69 , C07D417/14 , C07F9/6558
CPC分类号： A61K31/444 , A61K31/496 , A61K31/675 , A61K31/69 , A61K45/06 , C07D277/04 , C07D417/14 , C07F5/025 , C07F9/65583
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译：本发明提供某些含有氨基 - 吡啶的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。

2. 发明授权

US08796310B2 Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors 有权
标题翻译：含氨基吡啶的脾脏酪氨酸激酶（SYK）抑制剂
公开(公告)号：US08796310B2
公开(公告)日：2014-08-05
申请号：US13704484
申请日：2012-04-30
申请人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
发明人： Eric Thomas Romeo , Michelle R. Machacek , Benjamin Wesley Trotter , Thomas Allen Miller , Brian Michael Andresen , Neville John Anthony , Brandon M. Taoka , Yuan Liu
IPC分类号： A61K31/444 , C07D277/04
CPC分类号： A61K31/444 , A61K31/496 , A61K31/675 , A61K31/69 , A61K45/06 , C07D277/04 , C07D417/14 , C07F5/025 , C07F9/65583
摘要： The invention provides certain amino-pyridine-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and n are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译：本发明提供某些含有氨基 - 吡啶的式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和n如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。

3. 发明申请

US20160060255A1 THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS 有权
标题翻译：噻唑替代氨基酸作为分离型酪氨酸激酶抑制剂
公开(公告)号：US20160060255A1
公开(公告)日：2016-03-03
申请号：US14786464
申请日：2014-04-22
申请人： Neville J. ANTHONY , Brain M. ANDERSEN , Alan B. NORTHRUP , Kaleen K. CHILDERS , Anthony FRIO , Thomas A. MILLER , Yuan LIU , Michelle R. MACHACEK , Hyun Chong WOO , Kerrie B. SPENCER , John Michael ELLIS , Micheal D. ALTMAN , Eric T. ROMEO , Daniel GUAY , Jonathan GRIMM , Marie-Eve LEBRUN , Joel S. ROBICHAUD , Liping WANG , Byron DUBOIS , Qiaolin DENG , MERICK SHARP & DOHNE CORP. , MERCK CANADA INC.
发明人： Neville J. Anthony , Brian M. Andresen , Alan B. Northrup , Kaleen K. Childers , Anthony Donofrio , Thomas A. Miller , Yuan Liu , Michelle R. Machacek , Hyun Chong Woo , Kerrie B. Spencer , John Michael Ellis , Michael D. Altman , Eric T. Romeo , Daniel Guay , Jonathan Grimm , Marie-Eve Lebrun , Joel S. Robichaud , Liping Wang , Byron DuBois , Qiaolin Deng
IPC分类号： C07D417/14 , A61K31/53 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/497
CPC分类号： C07D417/14 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , C07D417/12
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译：本发明提供式（I）的某些噻唑取代的氨基杂芳基化合物或其药学上可接受的盐，其中X 1，X 2，X 3，X 4，Y 1，Y 2，Y 3，Y 4和R 4如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。

4. 发明授权

US11304969B2 Treatments of prostate cancer 有权
公开(公告)号：US11304969B2
公开(公告)日：2022-04-19
申请号：US16751696
申请日：2020-01-24
申请人： Yuk-Ching Tse-Dinh , Yuan Liu , Irina Agoulnik
发明人： Yuk-Ching Tse-Dinh , Yuan Liu , Irina Agoulnik
IPC分类号： A61K31/7048 , A61P35/00 , A61K45/06 , A61K31/546 , A61K31/4365 , A61K31/593
摘要： The present invention provides compounds, compositions and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol β and LIG I.

5. 发明授权

US10564359B2 Optical interconnect apparatus 有权
公开(公告)号：US10564359B2
公开(公告)日：2020-02-18
申请号：US15732563
申请日：2018-01-04
申请人： Jinghui Li , Yuan Liu , Haiquan Zhang , Xiaodong Huang
发明人： Jinghui Li , Yuan Liu , Haiquan Zhang , Xiaodong Huang
IPC分类号： G02B6/293 , H04J14/02 , G02B6/42 , G02B6/38
摘要： Embodiment of present invention provide an optical interconnect apparatus. The apparatus includes an optical signal path; a first set of pigtail fibers attached to a first end of the optical signal path via a first wavelength-division-multiplexing (WDM) filter; and a second set of pigtail fibers attached to a second end of the optical signal path via a second WDM filter. Embodiment of present invention further provide an interconnected optical system that includes a first optical transport terminal having a first set of optical signal ports and a second optical transport terminal having a second set of optical signal ports, with the two sets of optical signal ports being interconnected by the optical interconnect apparatus.

6. 发明授权

US08874167B2 Method and system for multi-standby operation for a multi-SIM multi-standby communication device 有权
标题翻译：一种用于多SIM多待机通信设备的多待机操作方法和系统
公开(公告)号：US08874167B2
公开(公告)日：2014-10-28
申请号：US12816782
申请日：2010-06-16
申请人： Xiaoxin Qiu , Yuan Liu , Yaxin Cao , Zhijun Gong , Yongqian Wang , Stephen Richards
发明人： Xiaoxin Qiu , Yuan Liu , Yaxin Cao , Zhijun Gong , Yongqian Wang , Stephen Richards
IPC分类号： H04B1/38 , H04W48/18 , H04W88/06
CPC分类号： H04W48/18 , H04W8/183 , H04W88/06
摘要： A communication device comprises a single radio resource unit that is shared by a plurality of virtual modems (VMs), each uniquely associated with a single one of a plurality of SIM cards. Traffic related to the SIM cards are concurrently handled utilizing corresponding VMs. Available radio resource in the single radio resource unit are shared by the VMs based on corresponding VM states, namely, an active state, an idle state and a suspended state. VMs in an idle state concurrently monitor paging events and concurrently perform idle mode procedures such as location updating. VMs not related to an intended traffic are suspended. A VM related to the intended traffic is transitioned from an idle state to an active state to enable the communication for the intended traffic. Once the communication is complete, the suspended VMs are resumed to continue idle mode activities.
摘要翻译：通信设备包括由多个虚拟调制解调器（VM）共享的单个无线电资源单元，每个单独的无线电资源单元唯一地与多个SIM卡中的单个的SIM卡相关联。使用相应的虚拟机同时处理与SIM卡有关的流量。单个无线电资源单元中的可用无线电资源由VM根据相应的VM状态，即活动状态，空闲状态和挂起状态共享。处于空闲状态的虚拟机同时监视寻呼事件并同时执行空闲模式过程，如位置更新。与预期流量无关的虚拟机将被暂停。与预期流量相关的虚拟机从空闲状态转换到活动状态，以实现预期流量的通信。通信完成后，恢复暂停的虚拟机以继续空闲模式活动。

7. 发明授权

US08859776B2 Substituted piperidines that increase p53 activity and the uses thereof 有权
标题翻译：增加p53活性的替代哌啶及其用途
公开(公告)号：US08859776B2
公开(公告)日：2014-10-14
申请号：US13501685
申请日：2010-10-05
申请人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
发明人： Stephane L. Bogen , Yao Ma , Yaolin Wang , Brian Robert Lahue , Latha G. Nair , Manami Shizuka , Matthew Ernst Voss , Margarita Kirova-Snover , Weidong Pan , Yuan Tian , Bheemashankar A. Kulkarni , Craig R. Gibeau , Yuan Liu , Giovanna Scapin , Diane Rindgen , Ronald J. Doll , Timothy J. Guzi , Danny J. Hicklin , Amin Nomeir , Gerald W. Shipps, Jr. , Malcolm MacCoss
IPC分类号： C07D401/00 , A01N43/40 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D409/14
摘要： The present invention provides a compound of Formula 1 as described herein or a pharmaceutically acceptable salt, solvate or ester thereof. The compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
摘要翻译：本发明提供本文所述的式1的化合物或其药学上可接受的盐，溶剂合物或酯。该化合物可用作HDM2蛋白的抑制剂。还公开了包含上述化合物的药物组合物和使用其治疗癌症的方法。

8. 发明授权

US08692861B2 Telepresence system, telepresence method, and video collection device 有权
公开(公告)号：US08692861B2
公开(公告)日：2014-04-08
申请号：US12888769
申请日：2010-09-23
申请人： Yuan Liu , Jing Wang , Guangyao Zhao
发明人： Yuan Liu , Jing Wang , Guangyao Zhao
IPC分类号： H04N7/14
CPC分类号： H04N5/23238 , H04N7/144 , H04N7/15 , H04N21/42203 , H04N21/439 , H04N21/4788
摘要： A telepresence system, a telepresence method, and a video collection device are disclosed. The telepresence system includes a video collection device, a video display device, an audio collection device, an audio player, and an audio and video communication device. The audio and video communication device transmits videos collected by the video collection device on a local end and audios collected by the audio collection device on the local end to a remote end through a network; the video display device and the audio player on the remote end play the images and audios respectively; and the video collection device is a panoramic camera. The technical solution under the present invention overcomes the poor effect of panoramic presence in the existing telepresence system, and improves the telepresence system in terms of depth presence, seamless display and eye contact.

9. 发明授权

US08526946B2 Periodic registration updates for multiple SIM user equipment 失效
标题翻译：定期更新多个SIM卡用户设备
公开(公告)号：US08526946B2
公开(公告)日：2013-09-03
申请号：US13545515
申请日：2012-07-10
申请人： Giridhar Pattaswamy , Navin K. Karra , Abhishek Pandit , Stephen J Richards , Yuan Liu , Yaxin Cao , Jun Lin
发明人： Giridhar Pattaswamy , Navin K. Karra , Abhishek Pandit , Stephen J Richards , Yuan Liu , Yaxin Cao , Jun Lin
IPC分类号： H04W4/00
CPC分类号： H04W8/183 , H04W48/18 , H04W60/02 , H04W76/15 , H04W88/06 , Y02D70/10
摘要： Systems and methods are presented to support operation of a multiple subscriber identity module (SIM) device. A first SIM may perform a data transfer or voice call. During the first SIM's data transfer or voice call, transition times are identified to transition communication resources to a second SIM for use in performing a registration update communication with a network controller that supports the second SIM. The registration update communication may include a periodic location update, a periodic routing update, or a periodic tracking update. The multiple SIM device may identify the transition time by obtaining periodic registration timing information from the network controller, configuring a periodic registration timer based on the periodic registration timing information, and setting the transition time as an expiration time of the periodic registration timer.
摘要翻译：呈现系统和方法以支持多用户识别模块（SIM）设备的操作。第一SIM卡可以执行数据传输或语音呼叫。在第一SIM数据传输或语音呼叫期间，识别转换时间以将通信资源转换到第二SIM卡，用于与支持第二SIM卡的网络控制器执行注册更新通信。注册更新通信可以包括周期性位置更新，周期性路由更新或周期性跟踪更新。多SIM设备可以通过从网络控制器获得周期性的注册定时信息来识别转换时间，基于周期性注册定时信息配置周期性注册定时器，并将转换时间设置为周期性注册定时器的到期时间。

10. 发明授权

US08446459B2 Video communication method, device, and system 有权
标题翻译：视频通信方式，设备和系统
公开(公告)号：US08446459B2
公开(公告)日：2013-05-21
申请号：US12971392
申请日：2010-12-17
申请人： Ping Fang , Chen Liu , Yuan Liu
发明人： Ping Fang , Chen Liu , Yuan Liu
IPC分类号： H04N13/00
CPC分类号： H04N7/15 , G06T7/11 , G06T7/194 , G06T2207/10028 , H04N13/156 , H04N13/271 , H04N13/286 , H04N19/597
摘要： A video communication method, device, and system are provided, which relate to the filed of video communications, so as to solve problems that currently scenes of two parties of communication need special arrangement to improve sense of reality and scene contents cannot be displayed in a 3D video mode. Therefore, scenes of two parties of communication do not need special arrangement to improve the sense of reality of users, and the scene contents can be displayed in a 3D video mode. The video communication method, device, and system are applicable to video communication such as common video chat, video telephony, and video conference.
摘要翻译：提供了涉及视频通信领域的视频通信方法，装置和系统，以解决目前两方通信的当前场景需要特殊布置以提高现实感和场景内容的问题不能在 3D视频模式。因此，通信双方的场景不需要特殊的安排来提高用户的现实感，场景内容可以以3D视频模式显示。视频通信方法，设备和系统适用于通用视频聊天，视频电话和视频会议等视频通信。

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