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1. 发明授权

US08008020B2 Biomarkers for peripheral artery disease 有权
标题翻译：外周动脉疾病的生物标志物
公开(公告)号：US08008020B2
公开(公告)日：2011-08-30
申请号：US11597667
申请日：2005-05-26
申请人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujun Zhang
发明人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujun Zhang
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.
摘要翻译：本发明提供了血浆中的浓度与患有血浆样品的患者中存在或不存在PAD有关的生物标志物。本发明还提供用于区分长跛行者的PAD患者和不是PAD患者的生物标志物。此外，本发明提供了用于鉴定另外的生物标志物的方法，用于检测患者中生物标志物的方法，以及用于鉴定与生物标志物相互作用并可用于预防或治疗患者中PAD的药剂（包括药剂）的方法。

2. 发明申请

US20110313681A1 BIOMARKERS FOR PERIPHERAL ARTERY DISEASE 审中-公开
标题翻译：外周动脉疾病的生物标志物
公开(公告)号：US20110313681A1
公开(公告)日：2011-12-22
申请号：US13218012
申请日：2011-08-25
申请人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujan Zhang
发明人： Eric T. Fung , John P. Cooke , Xiao-Ying Meng , Tai-Tung Yip , Fujan Zhang
IPC分类号： G06F19/00 , C07K14/435 , C07K16/18 , C07K14/76
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition, the invention provides methods for identifying additional biomarkers, methods for detecting the biomarkers in patients, and methods for identifying agents, including pharmaceutical agents, which interact with the biomarkers and are useful for preventing or treating PAD in patients.
摘要翻译：本发明提供了血浆中的浓度与患有血浆样品的患者中存在或不存在PAD有关的生物标志物。本发明还提供用于区分长跛行者的PAD患者和不是PAD患者的生物标志物。此外，本发明提供了用于鉴定另外的生物标志物的方法，用于检测患者中生物标志物的方法，以及用于鉴定与生物标志物相互作用并可用于预防或治疗患者中PAD的药剂（包括药剂）的方法。

3. 发明申请

US20080274481A1 Methods for diagnosing ovarian cancer 审中-公开
标题翻译：诊断卵巢癌的方法
公开(公告)号：US20080274481A1
公开(公告)日：2008-11-06
申请号：US12079588
申请日：2008-03-27
申请人： Eric T. Fung , Tai-Tung Yip , Vladimir Podust , Mats Brannstrom , Karin Sundfeldt , Bjorg Kristjansdottir
发明人： Eric T. Fung , Tai-Tung Yip , Vladimir Podust , Mats Brannstrom , Karin Sundfeldt , Bjorg Kristjansdottir
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , C07K1/1077 , G01N33/6848
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.
摘要翻译：本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌，低恶性潜能的卵巢癌，良性卵巢疾病或其他恶性病症。生物标志物可以通过SELDI质谱，免疫分析法或其他手段检测。

4. 发明申请

US20100047847A1 Methods for diagnosing ovarian cancer 有权
标题翻译：诊断卵巢癌的方法
公开(公告)号：US20100047847A1
公开(公告)日：2010-02-25
申请号：US12584832
申请日：2009-09-11
申请人： Eric T. Fung , Tai-Tung Yip , Vladimir Podust , Mats Brannstrom , Karin Sundfeldt , Bjorg Kristjansdottir
发明人： Eric T. Fung , Tai-Tung Yip , Vladimir Podust , Mats Brannstrom , Karin Sundfeldt , Bjorg Kristjansdottir
IPC分类号： C12Q1/02 , G01N33/00
CPC分类号： G01N33/57449 , C07K1/1077 , G01N33/6848
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.
摘要翻译：本发明提供了可用于评估患者卵巢癌状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌，低恶性潜能的卵巢癌，良性卵巢疾病或其他恶性病症。生物标志物可以通过SELDI质谱，免疫分析法或其他手段检测。

5. 发明申请

US20120220491A1 RETENTATE CHROMATOGRAPHY AND PROTEIN CHIP ARRAYS WITH APPLICATIONS IN BIOLOGY AND MEDICINE 有权
标题翻译：再生色素和蛋白质芯片阵列与生物医学应用
公开(公告)号：US20120220491A1
公开(公告)日：2012-08-30
申请号：US13211522
申请日：2011-08-17
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： C40B30/10
CPC分类号： C40B30/04 , B01D15/1878 , B01D15/305 , B01D15/3809 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3253 , B01J20/3265 , B01J20/3274 , B01J20/3289 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2220/54 , C12Q1/00 , C40B40/10 , G01N30/00 , G01N30/02 , G01N30/461 , G01N30/463 , G01N30/466 , G01N30/48 , G01N30/482 , G01N30/90 , G01N30/95 , G01N33/531 , G01N33/538 , G01N33/543 , G01N33/54306 , G01N33/54353 , G01N33/54373 , G01N33/54393 , G01N33/566 , G01N33/6803 , G01N33/6845 , G01N33/6851 , G01N2030/008 , G01N2030/009 , Y02A90/26 , Y10S422/906 , Y10S435/803 , Y10S435/81 , Y10S435/814 , Y10S435/815 , Y10S435/97 , Y10S435/973 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10S436/811 , Y10S436/813 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/2525 , Y10T436/25375 , Y10T436/255 , B01D15/363 , B01D15/322 , B01D15/327 , B01D15/3804 , B01D15/362 , B01D15/38 , B01D15/26
摘要： Analytes in a sample are resolved by retentate chromatography in a procedure involving adsorbing the analytes on a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
摘要翻译：样品中的分析物通过在多个不同选择性条件下将底物上分析物吸附的方法中的滞留层析法解析，并通过解吸光谱法检测保留在底物上的分析物。这些方法在生物学和医学中是有用的，包括临床诊断和药物发现。

6. 发明授权

US08173433B2 Platelet biomarkers for cancer 失效
标题翻译：癌症血小板生物标志物
公开(公告)号：US08173433B2
公开(公告)日：2012-05-08
申请号：US11658377
申请日：2005-04-22
申请人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
发明人： Judah M. Folkman , Giannoula Klement , Tai-Tung Yip , William E. Rich , Vladimir N. Podust
IPC分类号： G01N33/48 , A61K35/14
CPC分类号： G01N33/6872 , G01N33/57484 , G01N2333/49 , G01N2333/503 , G01N2333/515 , G01N2800/24 , G01N2800/368
摘要： The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.
摘要翻译：本发明涉及免疫学和生物化学领域。特别地，本发明描述了用于早期检测具有全身血管生成活性相关变化，特别是癌症，炎性病症，感染以及与怀孕和流产有关的事件的临床病症的方法，装置和试剂盒。

7. 发明授权

US08014952B2 Serum biomarkers in lung cancer 失效
公开(公告)号：US08014952B2
公开(公告)日：2011-09-06
申请号：US10539291
申请日：2003-12-16
申请人： Timothy Tak Chun Yip , Chi Shing Cho , Siu Kie Au , Tai-Tung Yip , Christine Yip , Victor Yip
发明人： Timothy Tak Chun Yip , Chi Shing Cho , Siu Kie Au , Tai-Tung Yip , Christine Yip , Victor Yip
IPC分类号： G01N33/48
CPC分类号： G01N33/6851 , G01N33/57423 , G06F19/18
摘要： Certain biomarkers and biomarker combinations are useful in a qualifying lung cancer status in a subject. A diagnostic methodology employing these biomarkers and combinations can detect whether a subject has lung cancer. MARKER IDMWFRACTION IM-12011A IM-22030A IM-32069A IM-42128A IM-52146A IM-62186A IM-72232A IM-82277A IM-92295A IM-102318A IM-112411A IM-122434A IM-132467A IM-142482A IM-152498A IM-162565A IM-172574A IM-182586A IM-192605A IM-202722A IM-212746A IM-222788A IM-232855A IM-242871A IM-252984A IM-263030A IM-273144A IM-283243A IM-293273A IM-303290A IM-313369A IM-323445A IM-333483A IM-343676A IM-353779A IM-363793A IM-373893A IM-383960A IM-393972A IM-403984A IM-414068A IM-424178A IM-434287A IM-444297A IM-454309A IM-464484A IM-474649A IM-484798A IM-495104A IM-505918A IM-516122A IM-526192A IM-536452A IM-546660A IM-557768A IM-568145A IM-578954A IM-589312A IM-599449A IM-6010272A IM-6111683A IM-6213376A IM-6314698A IM-6415190A IM-6466758A IM-6515951A IM-6615172A IM-6715925A IM-6823436A IM-6939794A IM-7044166A IM-7148890A IM-7254028A IM-7360170A IM-7574372A IM-7675545A IM-7777543A IM-7879507A IM-7988854A IM-80101831A IM-81104301A IM-82125160A IM-83132978A IM-84149099A IM-852016B IM-862029B IM-872144B IM-882130B IM-892168B IM-902164B IM-912200B IM-922284B IM-932299B IM-942314B IM-952414B IM-962428B IM-972451B IM-982468B IM-992483B IM-1002565B IM-1012583B IM-1022597B IM-1032697B IM-1042715B IM-1052740B IM-1062752B IM-1072767B IM-1082885B IM-1092882B IM-1102967B IM-1112977B IM-1122994B IM-1133031B IM-1143048B IM-1153148B IM-1163166B IM-1173283B IM-1183308B IM-1193332B IM-1203432B IM-1213450B IM-1223561B IM-1233615B IM-1243714B IM-1253730B IM-1263834B IM-1273899B IM-1283969B IM-1293986B IM-1303997B IM-1314013B IM-1324181B IM-1334297B IM-1344311B IM-1354465B IM-1364484B IM-1374579B IM-1384608B IM-1394669B IM-1404747B IM-1414862B IM-1424891B IM-1435033B IM-1445077B

8. 发明授权

US07413909B2 Method and apparatus for desorption and ionization of analytes 失效
标题翻译：分析物的解吸和电离的方法和装置
公开(公告)号：US07413909B2
公开(公告)日：2008-08-19
申请号：US10882608
申请日：2004-06-30
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N33/537
CPC分类号： H01J49/164 , G01N33/68 , G01N33/6851 , H01J49/0418 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
摘要翻译：本发明一般涉及用于解析和离子化分析物的方法和装置，用于通过诸如质谱法或生物传感器等方法的后续科学分析。更具体地，本发明涉及质谱领域，特别涉及用于分析大分子如蛋白质或生物分子的基质辅助激光解吸/电离，飞行时间质谱的类型。最具体地，本发明涉及样品探针几何形状，样品探针组合物和样品探针表面化学物质，其能够使分析物（包括完整的大分子）从探针表面直接选择性捕获和解吸到气体（蒸气）相中而没有添加化学基质。

9. 发明授权

US07071003B2 Surface-enhanced laser desorption/Ionization for desorption and detection of analytes 失效
标题翻译：表面增强激光解吸/电离解吸和分析物检测
公开(公告)号：US07071003B2
公开(公告)日：2006-07-04
申请号：US09123253
申请日：1998-07-27
申请人： T. William Hutchens , Tai-Tung Yip
发明人： T. William Hutchens , Tai-Tung Yip
IPC分类号： G01N21/75
CPC分类号： H01J49/0418 , G01N1/405 , G01N33/6851 , Y10T436/24 , Y10T436/25 , Y10T436/255
摘要： This invention is directed to probes that are removably insertable into mass spectrometers. The probes have sample presenting surfaces, at least, that contain non-metallic materials. The probes are useful in methods of desorbing analytes from the probe surface. The invention also is directed to detection systems that include the probes and methods of detecting analytes using the system.
摘要翻译：本发明涉及可拆卸地插入质谱仪中的探针。探针具有至少包含非金属材料的样品呈现表面。探针可用于从探针表面解吸分析物的方法。本发明还涉及包括探针和使用该系统检测分析物的方法的检测系统。

10. 发明申请

US20050181398A1 Specific detection of host response protein clusters 审中-公开
标题翻译：特异性检测宿主反应蛋白簇
公开(公告)号：US20050181398A1
公开(公告)日：2005-08-18
申请号：US11031302
申请日：2005-01-07
申请人： Eric Fung , Rebecca Caffrey , Tai-Tung Yip
发明人： Eric Fung , Rebecca Caffrey , Tai-Tung Yip
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/68 , G06F19/00
CPC分类号： G01N33/6842 , G01N33/5091 , G01N33/6803 , G16B40/00
摘要： Methods of specifically detecting host response protein clusters and of correlating patterns of expression of these clusters with various clinical parameters are provided.
摘要翻译：提供了特异性检测宿主反应蛋白簇的方法以及将这些簇的表达模式与各种临床参数相关联的方法。

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