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1. 发明申请

US20060136041A1 Slide-and-lock stent 有权
公开(公告)号：US20060136041A1
公开(公告)日：2006-06-22
申请号：US11016269
申请日：2004-12-17
申请人： Eric Schmid , John Nguyen , Steven Howard , Orlando Padilla , Andrew Morris , Robert Eisele , Joseph DiPari , David Matsuura , Philip Simpson , Walter Gillespie , Daniel Moore , Thomas Jackson , Joan Zeltinger , Keith Esser , Donald Brandon
发明人： Eric Schmid , John Nguyen , Steven Howard , Orlando Padilla , Andrew Morris , Robert Eisele , Joseph DiPari , David Matsuura , Philip Simpson , Walter Gillespie , Daniel Moore , Thomas Jackson , Joan Zeltinger , Keith Esser , Donald Brandon
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/92 , A61F2/93 , A61F2210/0076 , A61F2220/005 , A61F2220/0058 , B33Y80/00
摘要： The invention relates to an expandable stent comprising circumferentially adjacent modules. The modules comprise longitudinally adjacent slide-and-lock radial elements which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

2. 发明申请

US20060020324A1 Balloon expandable crush-recoverable stent device 有权
公开(公告)号：US20060020324A1
公开(公告)日：2006-01-26
申请号：US10897235
申请日：2004-07-21
申请人： Eric Schmid , Andrew Morris , John Nguyen , Robert Eisele , Steven Howard , Orlando Padilla , Philip Simpson
发明人： Eric Schmid , Andrew Morris , John Nguyen , Robert Eisele , Steven Howard , Orlando Padilla , Philip Simpson
IPC分类号： A61F2/06
CPC分类号： A61F2/92 , A61F2/01 , A61F2/07 , A61F2/856 , A61F2/958 , A61F2002/075
摘要： An intraluminal, balloon expandable stent for implantation in a body lumen is disclosed. The present invention provides a lumen support stent with an unobstructed through-lumen for use in a blood vessel. A constraining mechanism is provided for securely maintaining the stent in the collapsed condition during delivery. The stent is preferably formed with a series of interconnected slide and lock mechanisms for permitting movement from a collapsed condition to an expanded condition and inhibiting radial recoil from the expanded condition. The stent may be formed from a shape memory alloy for providing crush-recovery after deployment.

3. 发明授权

US09416136B2 Pyrrolopyrimidine compounds and their uses 有权
公开(公告)号：US09416136B2
公开(公告)日：2016-08-16
申请号：US14158358
申请日：2014-01-17
申请人： Gilbert Besong , Christopher Thomas Brain , Clinton A Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu
发明人： Gilbert Besong , Christopher Thomas Brain , Clinton A Brooks , Miles Stuart Congreve , Claudio Dagostin , Guo He , Ying Hou , Steven Howard , Yue Li , Yipin Lu , Paul Mortenson , Troy Smith , Moo Je Sung , Steven Woodhead , Wojciech Wrona , Bharat Lagu
IPC分类号： A61K31/519 , A61P35/04 , C07D487/04 , C07D487/08
CPC分类号： C07D487/04 , A61K31/519 , C07D487/08
摘要： The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

4. 发明授权

US07977477B2 Benzimidazole derivatives and their use as protein kinase inhibitors 失效
标题翻译：苯并咪唑衍生物及其作为蛋白激酶抑制剂的用途
公开(公告)号：US07977477B2
公开(公告)日：2011-07-12
申请号：US10564166
申请日：2004-07-05
申请人： Valerio Berdini , Michael Alistair O'Brien , Maria Grazia Carr , Theresa Rachel Early , Eva Figueroa Navarro , Adrian Liam Gill , Steven Howard , Gary Trewartha , Alison Jo-Anne Woolford , Andrew James Woodhead , Paul Wyatt
发明人： Valerio Berdini , Michael Alistair O'Brien , Maria Grazia Carr , Theresa Rachel Early , Eva Figueroa Navarro , Adrian Liam Gill , Steven Howard , Gary Trewartha , Alison Jo-Anne Woolford , Andrew James Woodhead , Paul Wyatt
IPC分类号： A61K31/5377 , A61K31/4184 , C07D413/14
CPC分类号： A61K31/5377 , A61K31/00 , A61K31/4184 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D513/04
摘要： The invention provides compounds of the formula (I): The compounds have activity against cyclin dependent kinases, glycogen synthase kinase and Auroa kinases and are therefore useful to treat cancer and viral diseases.
摘要翻译：本发明提供式（I）化合物：该化合物具有抗细胞周期蛋白依赖性激酶，糖原合成酶激酶和Auroa激酶的活性，因此可用于治疗癌症和病毒性疾病。

5. 发明申请

US20080031374A1 BROADCAST TRANSMISSION WITH SPATIAL SPREADING IN A MULTI-ANTENNA COMMUNICATION SYSTEM 有权
公开(公告)号：US20080031374A1
公开(公告)日：2008-02-07
申请号：US11870386
申请日：2007-10-10
申请人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
发明人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
IPC分类号： H04L1/02
CPC分类号： H04L25/03866 , H04B7/043 , H04B7/0615 , H04B7/0669 , H04B7/0678 , H04B7/068 , H04B7/12 , H04L5/0007 , H04L25/0204 , H04L25/0224 , H04W52/42
摘要： An access point in a multi-antenna system broadcasts data using spatial spreading to randomize an “effective” channel observed by each user terminal for each block of data symbols broadcast by the access point. At the access point, data is coded, interleaved, and modulated to obtain ND data symbol blocks to be broadcast in NM transmission spans, where ND≧1 and NM>1. The ND data symbol blocks are partitioned into NM data symbol subblocks, one subblock for each transmission span. A steering matrix is selected (e.g., in a deterministic or pseudo-random manner from among a set of L steering matrices) for each subblock. Each data symbol subblock is spatially processed with the steering matrix selected for that subblock to obtain transmit symbols, which are further processed and broadcast via NT transmit antennas and in one transmission span to user terminals within a broadcast coverage area.

6. 发明申请

US20070211814A1 DATA TRANSMISSION WITH SPATIAL SPREADING IN A MIMO COMMUNICATION SYSTEM 有权
标题翻译：数据传输与MIMO通信系统中的空间传播
公开(公告)号：US20070211814A1
公开(公告)日：2007-09-13
申请号：US11683736
申请日：2007-03-08
申请人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
发明人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
IPC分类号： H04L1/02
CPC分类号： H04B7/0417 , H04B7/0626 , H04B7/0678 , H04L1/0002 , H04L1/0003 , H04L1/0009 , H04L5/0023 , H04L25/0224
摘要： For data transmission with spatial spreading, a transmitting entity (1) encodes and modulates each data packet to obtain a corresponding data symbol block, (2) multiplexes data symbol blocks onto NS data symbol streams for transmission on NS transmission channels of a MIMO channel, (3) spatially spreads the NS data symbol streams with steering matrices, and (4) spatially processes NS spread symbol streams for full-CSI transmission on NS eigenmodes or partial-CSI transmission on NS spatial channels of the MIMO channel. A receiving entity (1) obtains NR received symbol streams via NR receive antennas, (2) performs receiver spatial processing for full-CSI or partial-CSI transmission to obtain NS detected symbol streams, (3) spatially despreads the NS detected symbol streams with the same steering matrices used by the transmitting entity to obtain NS recovered symbol streams, and (4) demodulates and decodes each recovered symbol block to obtain a corresponding decoded data packet.
摘要翻译：对于具有空间扩展的数据传输，发送实体（1）对每个数据分组进行编码和调制，以获得相应的数据符号块，（2）将数据符号块复用到N个S / S数据符号流上以便传输（3）用导向矩阵空间扩展N S S个数据符号流，并且（4）空间地处理N S S个数据符号流， / SUB>扩展符号流，用于N信道本征模式上的全CSI传输或MIMO信道的N SUB空间信道上的部分CSI传输。接收实体（1）通过N个N个接收天线获得接收到的N N个符号流，（2）执行用于全CSI或部分CSI传输的接收机空间处理，以获得（3）使用发送实体使用的相同导向矩阵空间地解扩N N S S个检测到的符号流，以获得N N个S＆lt; S＆lt; S＆lt; （4）对每个恢复的符号块进行解调和解码以获得对应的解码数据分组。

7. 发明申请

US20060067421A1 Spatial spreading with space-time and space-frequency transmit diversity schemes for a wireless communication system 有权
标题翻译：用于无线通信系统的空时和空频发射分集方案的空间扩展
公开(公告)号：US20060067421A1
公开(公告)日：2006-03-30
申请号：US11217818
申请日：2005-09-01
申请人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
发明人： Jay Walton , John Ketchum , Mark Wallace , Steven Howard
IPC分类号： H04L1/02
CPC分类号： H04L1/0668 , H04B7/0615 , H04B7/0617 , H04B7/0667 , H04B7/0678 , H04B7/068 , H04B7/0689 , H04B7/0697 , H04B7/12 , H04J13/004 , H04L1/0041 , H04L1/0606 , H04L1/0625 , H04L1/0637 , H04L5/0023 , H04L27/2626
摘要： Techniques for transmitting data using a combination of transmit diversity schemes are described. These transmit diversity schemes include spatial spreading, continuous beamforming, cyclic delay diversity, space-time transmit diversity (STTD), space-frequency transmit diversity (SFTD), and orthogonal transmit diversity (OTD). A transmitting entity processes one or more (ND) data symbol streams based on a transmit diversity scheme (e.g., STTD, SFTD, or OTD) to generate multiple (NC) coded symbol streams. Each data symbol stream may be sent as a single coded symbol stream or as multiple (e.g., two) coded symbol streams using STTD, SFTD, or OTD. The transmitting entity may perform spatial spreading on the NC coded symbol streams with different matrices to generate multiple (NT) transmit symbol streams for transmission from NT antennas. Additionally or alternatively, the transmitting entity may perform continuous beamforming on the NT transmit symbol streams in either the time domain or the frequency domain.
摘要翻译：描述了使用发射分集方案的组合来发送数据的技术。这些发射分集方案包括空间扩展，连续波束成形，循环延迟分集，时空发射分集（STTD），空频发射分集（SFTD）和正交发射分集（OTD）。发射实体基于发射分集方案（例如，STTD，SFTD或OTD）处理一个或多个（N N D D）个数据符号流，以产生多个（N SUB））编码符号流。每个数据符号流可以作为单个编码符号流或使用STTD，SFTD或OTD作为多个（例如，两个）编码符号流发送。发送实体可以在具有不同矩阵的N C C个编码符号流上执行空间扩展，以产生用于从N T T发送的多个（N T T T T）个发送符号流， / SUB>天线。附加地或替代地，发送实体可以在时域或频域中的N T个发送符号流上执行连续波束成形。

8. 发明申请

US20060013250A1 Unified MIMO transmission and reception 有权
标题翻译：统一的MIMO传输和接收
公开(公告)号：US20060013250A1
公开(公告)日：2006-01-19
申请号：US10892732
申请日：2004-07-15
申请人： Steven Howard , Jay Walton , Mark Wallace
发明人： Steven Howard , Jay Walton , Mark Wallace
IPC分类号： H04Q7/24
CPC分类号： H04B7/0413 , H04B7/0417 , H04B7/0421 , H04B7/0617 , H04L1/0026
摘要： A “unified” MIMO system that supports multiple operating modes for efficient data transmission is described. Each operating mode is associated with different spatial processing at a transmitting entity. For example, four operating modes may be defined for (1) full-CSI or partial-CSI transmission and (2) with or without steering transmit diversity (STD). An appropriate operating mode may be selected for use based on various factors (e.g., availability of a good channel estimate). With steering transmit diversity, data is spatially spread and transmitted on multiple spatial channels, and a single rate may then be used for all spatial channels used for data transmission. A receiving entity may utilize a minimum mean square error (MMSE) technique for all operating modes. The receiving entity may derive a spatial filter matrix and perform receiver spatial processing in the same manner for all operating modes, albeit with different effective channel response matrices.
摘要翻译：描述了支持多种操作模式以实现有效数据传输的“统一”MIMO系统。每个操作模式与发送实体处的不同空间处理相关联。例如，可以为（1）全CSI或部分CSI传输定义四种操作模式，以及（2）具有或不具有导向发射分集（STD）的操作模式。可以基于各种因素（例如，良好信道估计的可用性）来选择适当的操作模式来使用。利用转向发射分集，数据在空间上扩展并在多个空间信道上传输，然后可以将单个速率用于用于数据传输的所有空间信道。接收实体可以针对所有操作模式使用最小均方误差（MMSE）技术。接收实体可以导出空间滤波器矩阵并且以相同的方式对所有操作模式执行接收机空间处理，尽管具有不同的有效信道响应矩阵。

9. 发明授权

US06972297B2 2-Hydroxy-mutilin carbamate derivatives for antibacterial use 失效
标题翻译：用于抗菌的2-羟基 - 氨基甲酸酯衍生物
公开(公告)号：US06972297B2
公开(公告)日：2005-12-06
申请号：US10240908
申请日：2001-03-29
申请人： Gerald Brooks , Eric Hunt , Steven Howard
发明人： Gerald Brooks , Eric Hunt , Steven Howard
IPC分类号： C07D237/24 , A61K31/426 , A61K31/44 , A61K31/4409 , A61K31/495 , A61K31/4985 , A61K31/50 , A61K31/505 , A61K31/519 , A61P31/04 , C07D213/81 , C07D213/82 , C07D233/61 , C07D239/42 , C07D241/26 , C07D277/20 , C07D277/56 , C07D417/04 , C07D471/04 , C07D487/04 , C07D211/98 , C07D211/94 , C07D237/20
CPC分类号： C07D417/04 , C07D213/81 , C07D239/42 , C07D277/56 , C07D487/04
摘要： 2-(S)-hydroxymutilin carbamate derivatives of formula (I), in which R1 is a 5- or 6-membered optionally substituted heteroaryl group; and R2 is vinyl or ethyl, are useful in the treatment of bacterial infections
摘要翻译：式（I）的2-（S） - 羟基糊精氨基甲酸酯衍生物，其中R 1是5或6元任选取代的杂芳基; 和R 2是乙烯基或乙基，可用于治疗细菌感染

10. 发明申请

US20050195733A1 Transmit diversity and spatial spreading for an OFDM-based multi-antenna communication system 有权
标题翻译：基于OFDM的多天线通信系统的发射分集和空间扩展
公开(公告)号：US20050195733A1
公开(公告)日：2005-09-08
申请号：US10794918
申请日：2004-03-05
申请人： J. Walton , John Ketchum , Mark Wallace , Steven Howard , Sanjiv Nanda
发明人： J. Walton , John Ketchum , Mark Wallace , Steven Howard , Sanjiv Nanda
IPC分类号： H04J99/00 , H04B7/04 , H04B7/06 , H04L27/26 , H04J11/00
CPC分类号： H04B7/0615 , H04B7/0413 , H04L27/2602
摘要： A multi-antenna transmitting entity transmits data to a single- or multi-antenna receiving entity using (1) a steered mode to direct the data transmission toward the receiving entity or (2) a pseudo-random transmit steering (PRTS) mode to randomize the effective channels observed by the data transmission across the subbands. The PRTS mode may be used to achieve transmit diversity or spatial spreading. For transmit diversity, the transmitting entity uses different pseudo-random steering vectors across the subbands but the same steering vector across a packet for each subband. The receiving entity does not need to have knowledge of the pseudo-random steering vectors or perform any special processing. For spatial spreading, the transmitting entity uses different pseudo-random steering vectors across the subbands and different steering vectors across the packet for each subband. Only the transmitting and receiving entities know the steering vectors used for data transmission.
摘要翻译：多天线发射实体使用（1）向接收实体指导数据传输的导向模式或（2）伪随机发射转向（PRTS）模式来将数据发送到单天线或多天线接收实体，以随机化通过子带上的数据传输观察到的有效信道。 PRTS模式可以用于实现发射分集或空间扩展。对于发射分集，发射实体在子带上使用不同的伪随机导引向量，但是在每个子带的分组上使用相同的导向向量。接收实体不需要具有伪随机导引向量的知识或执行任何特殊处理。对于空间扩展，发射实体在子带上使用不同的伪随机导引向量，并且跨每个子带的分组使用不同的导向矢量。只有发送和接收实体知道用于数据传输的导向向量。

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