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1. 发明申请

US20090275547A1 METAL COMPLEX PHOSPHATIDYL-INOSITOL-3-KINASE INHIBITORS 有权
标题翻译：金属复合磷酸二氢吲哚-3-激酶抑制剂
公开(公告)号：US20090275547A1
公开(公告)日：2009-11-05
申请号：US12112748
申请日：2008-04-30
申请人： Eric Meggers , Peng Xie , Douglas S. Williams , Ronen Marmorstein
发明人： Eric Meggers , Peng Xie , Douglas S. Williams , Ronen Marmorstein
IPC分类号： A61K31/295 , C07F15/00
CPC分类号： C07D498/22 , C07D487/14
摘要： Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.
摘要翻译：提供了抑制人黑素瘤细胞中PI3K脂质激酶和磷酸化AKT的新型有机金属化合物，并且还抑制黑素瘤细胞的迁移。本发明还涉及抑制癌细胞增殖，迁移或两者的方法，包括使癌细胞与公开的有机金属激酶抑制剂接触。还公开了用于治疗激酶受影响的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的所公开的有机金属激酶抑制剂。

2. 发明授权

US08106039B2 Metal complex phosphatidyl-inositol-3-kinase inhibitors 有权
标题翻译：金属络合物磷脂酰肌醇-3-激酶抑制剂
公开(公告)号：US08106039B2
公开(公告)日：2012-01-31
申请号：US12112748
申请日：2008-04-30
申请人： Eric Meggers , Peng Xie , Douglas S. Williams , Ronen Marmorstein
发明人： Eric Meggers , Peng Xie , Douglas S. Williams , Ronen Marmorstein
IPC分类号： A61K31/555 , C07F15/00
CPC分类号： C07D498/22 , C07D487/14
摘要： Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.
摘要翻译：提供了抑制人黑素瘤细胞中PI3K脂质激酶和磷酸化AKT的新型有机金属化合物，并且还抑制黑素瘤细胞的迁移。本发明还涉及抑制癌细胞增殖，迁移或两者的方法，包括使癌细胞与公开的有机金属激酶抑制剂接触。还公开了用于治疗激酶受影响的疾病或病症的方法，包括向有需要的受试者施用治疗有效量的所公开的有机金属激酶抑制剂。

3. 发明授权

US08080660B2 Metal complex glycogen synthase kinase 3 inhibitors 有权
标题翻译：金属络合糖原合成酶激酶3抑制剂
公开(公告)号：US08080660B2
公开(公告)日：2011-12-20
申请号：US11228381
申请日：2005-09-19
申请人： Eric Meggers , Howard Bregman , Douglas S. Williams
发明人： Eric Meggers , Howard Bregman , Douglas S. Williams
IPC分类号： C07F15/00
CPC分类号： C07F17/02 , A61K31/555 , C07F15/0053
摘要： The present inventive subject matter relates to novel metal complex glycogen synthase kinase 3 inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by glycogen synthase kinase 3 activity. Compound II, below, represents an exemplary metal complex glycogen synthase kinase 3 inhibitor according to the present disclosure, wherein variable groups are defined as provided herein:
摘要翻译：本发明的主题涉及新的金属络合物糖原合酶激酶3抑制剂，制备这些化合物的方法，以及使用这些化合物治疗糖原合酶激酶3活性介导的疾病和病症的方法。下文中的化合物II表示根据本公开的示例性金属络合物糖原合酶激酶3抑制剂，其中可变基团如本文所提供的定义：

4. 发明授权

US08656275B2 Matching various combinations of XPATH URIs to the same XML node 失效
标题翻译：将XPATH URI的各种组合匹配到同一个XML节点
公开(公告)号：US08656275B2
公开(公告)日：2014-02-18
申请号：US13406800
申请日：2012-02-28
申请人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
发明人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
IPC分类号： G06F17/00
CPC分类号： G06F17/30917
摘要： Embodiments of the present invention address deficiencies of the art in respect to subscribing and updating nodes within XML documents and provide a novel and non-obvious method, system and computer program product for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs). In one embodiment of the invention, a method for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs) that includes receiving a XPATH expression for a node in an XML document, retrieving the node identified by the XPATH expression, determining if a template exists for the identified node, where the template resides in a database of a document management system, comparing the template expression to the XPATH expression and determining if the expressions match. The method can further include modifying the XPATH expression to account for a dominant attribute required by the template when the XPATH expression does not match the template expression and returning the modified XPATH expression.
摘要翻译：本发明的实施例解决了在XML文档中订阅和更新节点方面的技术缺陷，并提供了一种新颖且非显而易见的方法，系统和计算机程序产品，用于匹配XML路径语言（XPATH）统一资源标识符 URI）。在本发明的一个实施例中，一种用于匹配XML路径语言（XPATH）统一资源标识符（URI）的各种组合的方法，其包括为XML文档中的节点接收XPATH表达式，检索由XPATH表达式标识的节点，确定如果标识的节点存在模板，模板驻留在文档管理系统的数据库中，则将模板表达式与XPATH表达式进行比较，并确定表达式是否匹配。该方法还可以包括修改XPATH表达式，以便在XPATH表达式与模板表达式不匹配并返回修改后的XPATH表达式时，模板所需的显性属性。

5. 发明授权

US08549396B2 Matching various combinations of XPATH URIs to the same XML node 失效
标题翻译：将XPATH URI的各种组合匹配到同一个XML节点
公开(公告)号：US08549396B2
公开(公告)日：2013-10-01
申请号：US12651312
申请日：2009-12-31
申请人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
发明人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
IPC分类号： G06F17/00
CPC分类号： G06F17/30917
摘要： Embodiments of the present invention address deficiencies of the art in respect to subscribing and updating nodes within XML documents and provide a novel and non-obvious method, system and computer program product for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs). In one embodiment of the invention, a method for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs) that includes receiving a XPATH expression for a node in an XML document, retrieving the node identified by the XPATH expression, determining if a template exists for the identified node, where the template resides in a database of a document management system, comparing the template expression to the XPATH expression and determining if the expressions match. The method can further include modifying the XPATH expression to account for a dominant attribute required by the template when the XPATH expression does not match the template expression and returning the modified XPATH expression.
摘要翻译：本发明的实施例解决了在XML文档中订阅和更新节点方面的技术缺陷，并提供了一种新颖且非显而易见的方法，系统和计算机程序产品，用于匹配XML路径语言（XPATH）统一资源标识符 URI）。在本发明的一个实施例中，一种用于匹配XML路径语言（XPATH）统一资源标识符（URI）的各种组合的方法，其包括为XML文档中的节点接收XPATH表达式，检索由XPATH表达式标识的节点，确定如果标识的节点存在模板，模板驻留在文档管理系统的数据库中，则将模板表达式与XPATH表达式进行比较，并确定表达式是否匹配。该方法还可以包括修改XPATH表达式，以便在XPATH表达式与模板表达式不匹配并返回修改后的XPATH表达式时，模板所需的显性属性。

6. 发明申请

US20110161798A1 MATCHING VARIOUS COMBINATIONS OF XPATH URIS TO THE SAME XML NODE 失效
标题翻译：将XPATH URIS的各种组合与相同的XML节点进行匹配
公开(公告)号：US20110161798A1
公开(公告)日：2011-06-30
申请号：US12651312
申请日：2009-12-31
申请人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
发明人： Valerie M. Bennett , Benson K. Chen , Stephen M. Hinton , Douglas S. Williams
IPC分类号： G06F17/00
CPC分类号： G06F17/30917
摘要： Embodiments of the present invention address deficiencies of the art in respect to subscribing and updating nodes within XML documents and provide a novel and non-obvious method, system and computer program product for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs). In one embodiment of the invention, a method for matching various combinations of XML Path Language (XPATH) Uniform Resource Identifiers (URIs) that includes receiving a XPATH expression for a node in an XML document, retrieving the node identified by the XPATH expression, determining if a template exists for the identified node, where the template resides in a database of a document management system, comparing the template expression to the XPATH expression and determining if the expressions match. The method can further include modifying the XPATH expression to account for a dominant attribute required by the template when the XPATH expression does not match the template expression and returning the modified XPATH expression.
摘要翻译：本发明的实施例解决了在XML文档中订阅和更新节点方面的技术缺陷，并提供了一种新颖且非显而易见的方法，系统和计算机程序产品，用于匹配XML路径语言（XPATH）统一资源标识符 URI）。在本发明的一个实施例中，一种用于匹配XML路径语言（XPATH）统一资源标识符（URI）的各种组合的方法，其包括为XML文档中的节点接收XPATH表达式，检索由XPATH表达式标识的节点，确定如果标识的节点存在模板，模板驻留在文档管理系统的数据库中，则将模板表达式与XPATH表达式进行比较，并确定表达式是否匹配。该方法还可以包括修改XPATH表达式，以便在XPATH表达式与模板表达式不匹配并返回修改后的XPATH表达式时，模板所需的显性属性。

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