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1. 发明申请

US20140201858A1 METHODS FOR SITE-SPECIFIC GENETIC MODIFICATION IN STEM CELLS USING XANTHOMONAS TAL NUCLEASES (XTN) FOR THE CREATION OF MODEL ORGANISMS 审中-公开
标题翻译：使用XANTHOMONAS TAL NUCLEASES（XTN）创建模型有机体的干细胞基因特异性修饰方法
公开(公告)号：US20140201858A1
公开(公告)日：2014-07-17
申请号：US14118544
申请日：2012-05-17
申请人： Eric M. Ostertag , John S. Crawford , J. Keith Joung
发明人： Eric M. Ostertag , John S. Crawford , J. Keith Joung
IPC分类号： C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/00 , A01K2227/105 , A01K2227/108
摘要： The invention relates to organisms and compositions comprising one or more stem cells or one or more embryos, wherein the one or more stem cells or one or more embryos comprise one or more of the following mutations: (i) a deletion mutation; (ii) a knockout mutation; and/or (iii) an addition of a heterologous nucleic acid sequence; wherein the one or more mutations of (i), (ii), and/or (iii) are site-specific mutations caused by a Xanthomonas TAL nuclease (XTN). The invention also relates to method of mutating an embryo, iPS cell, stem cell, or more particularly a spermatogonial stem cell by exposing the nucleic acid sequence contained within such embryos or cell with a Xanthomonas TAL nuclease.
摘要翻译：本发明涉及包含一种或多种干细胞或一种或多种胚胎的生物体和组合物，其中所述一种或多种干细胞或一种或多种胚胎包含一个或多个以下突变：（i）缺失突变; （ii）敲除突变; 和/或（iii）异源核酸序列的添加; 其中（i），（ii）和/或（iii）的一个或多个突变是由黄单胞菌TAL核酸酶（XTN）引起的位点特异性突变。本发明还涉及通过用Xanthomonas TAL核酸酶暴露包含在这样的胚胎或细胞内的核酸序列来突变胚胎，iPS细胞，干细胞或更特别是精原干细胞的方法。

2. 发明授权

US4380239A Intubation of lacrimal ducts 失效
标题翻译：泪管插管
公开(公告)号：US4380239A
公开(公告)日：1983-04-19
申请号：US309527
申请日：1981-10-07
申请人： John S. Crawford , Roy Wainman
发明人： John S. Crawford , Roy Wainman
IPC分类号： A61F9/007 , A61M27/00
CPC分类号： A61F9/00772
摘要： The invention provides a probe set for use particularly in the canaliculus intubation of the lacrimal duct, the probe set comprising: a probe of a light wire which can be readily deflected through an angle of at least 90 degrees to permit the probe to pass from the nasolacrimal duct to the inferior meatus, the probe having an enlarged end portion which is rounded to limit the possibility of damage to tissue when the probe is inserted; and a very flexible tube of minimal rigidity having a first end attached to an end of the probe remote from the end portion and having an outside diameter comparable to that of the end portion so that in use the probe can be inserted and used to draw the tube into the lacrimal duct.
摘要翻译：本发明提供了一种特别用于泪管的泪管插管的探针组，探针组包括：光线的探针，其可以容易地偏转至少90度的角度，以允许探针从鼻泪管到下腔，探针具有扩大的端部，其被圆形以限制当探针插入时对组织的损伤的可能性; 以及具有最小刚性的非常柔性的管，其第一端附接到远离端部的探针的端部，并具有与端部相当的外径，使得在使用中可以将探针插入并用于画出管入泪道。

3. 发明授权

US5323062A System for triac trigger control in combination with a sensing element 失效
标题翻译：与传感元件相结合的三端双向可控硅开关触发控制系统
公开(公告)号：US5323062A
公开(公告)日：1994-06-21
申请号：US803307
申请日：1991-12-02
申请人： John S. Crawford , Malcolm J. Kay , Philip A. Tracy
发明人： John S. Crawford , Malcolm J. Kay , Philip A. Tracy
IPC分类号： H02M1/08 , G05F1/45 , H02M5/257 , H01H35/00
CPC分类号： H02M5/2573 , G05F1/45 , Y10T307/826
摘要： A trigger control circuit of the kind wherein a load is supplied via a triac with current from an AC voltage supply source under the control of a triac control means in combination with a sensing element. In previous circuits the sensing element is energized by a current from a DC source which is derived by rectification and smoothing of the alternating current of an alternating voltage supply source. These circuits have limitations in integrated circuitry. The sensing element herein is energized by an alternating current to produce a sensed alternating current. The triac control means includes an integration element for producing a control signal which represents of the integral of the difference between a value corresponding to the magnitude of the sensed alternating current and a reference value. The triggering or otherwise of the triac is determined by a latch actuated in response to the magnitude of the control signal relative to one or more threshold levels. The trigger control circuit may be used in thermostats or other sensing devices.
摘要翻译：一种触发控制电路，其中在三端双向可控硅开关元件控制装置的控制下，经由三端双向可控硅开关将来自交流电压源的电流与感测元件组合供应。在先前的电路中，感测元件由来自直流电源的电流激励，该直流电源通过交流电源的交流电的整流和平滑得到。这些电路在集成电路中有局限性。这里的感测元件由交流电通电，以产生感测的交流电流。三端双向可控制开关元件控制装置包括用于产生控制信号的积分元件，该控制信号表示与感测的交流电流的大小相对应的值与参考值之间的差的积分。三端双向可控制开关的触发或其他方式由响应于控制信号相对于一个或多个阈值电平的大小而被致动的锁存器来确定。触发控制电路可用于恒温器或其它感测装置。

4. 发明授权

US5847367A Circuit arrangement for controlling the temperature of a heating element 失效
标题翻译：用于控制加热元件的温度的电路装置
公开(公告)号：US5847367A
公开(公告)日：1998-12-08
申请号：US873204
申请日：1997-06-11
申请人： Philip T. Hancock , John S. Crawford
发明人： Philip T. Hancock , John S. Crawford
IPC分类号： G05D23/24 , H05B1/02
CPC分类号： H05B1/0266 , G05D23/2401 , Y10T307/773
摘要： The temperature of a heating element (3), which heating element has a temperature dependent resistance, is measured by comparing the current through it with a user adjustable reference value. The AC voltage across a current sensing resistor (7) in series with the heating element (3) is compared in a comparator (9) with a reference AC voltage generated at a tap (6) of a voltage divider (8). The phase of the logic output signal of the comparator (9) indicates a first state in which the heating element (3) is too hot or is not conducting, or a second state in which the heating element (3) is too cold and conducting. A second comparator (16) detects whether or not the heating element (3) is conducting. A logic gate (18) and a latch (17) switch on the current through the heating element (3) in response to timed pulses from a timing circuit (15) and switch off the current through the heating element (3) when the heating element (3) is conducting and too hot.
摘要翻译：通过将通过其加载的电流与用户可调节的参考值进行比较来测量加热元件具有温度依赖性电阻的加热元件（3）的温度。在比较器（9）中与在分压器（8）的抽头（6）处产生的参考交流电压比较与加热元件（3）串联的电流感测电阻器（7）上的交流电压。比较器（9）的逻辑输出信号的相位表示加热元件（3）太热或不导通的第一状态或者加热元件（3）太冷而导通的第二状态。第二比较器（16）检测加热元件（3）是否导通。逻辑门（18）和锁存器（17）响应于来自定时电路（15）的定时脉冲而导通通过加热元件（3）的电流，并且当加热时切断通过加热元件（3）的电流元件（3）导电并且太热。

5. 发明授权

US4521825A Gas ignition circuits 失效
标题翻译：燃气点火电路
公开(公告)号：US4521825A
公开(公告)日：1985-06-04
申请号：US542858
申请日：1983-10-17
申请人： John S. Crawford
发明人： John S. Crawford
IPC分类号： F23Q3/00
CPC分类号： F23Q3/004
摘要： Circuit arrangements for use in the generation of sparks for igniting gas at a gas burner assembly whereby the operation is controlled electrically by means of an electronic control circuit which reacts to the presence or absence of a gas flame. The circuit comprises a charging circuit for a charge storage capacitor, a spark output transformer, an SCR switching device for discharging the charge stored in the capacitor and a non-linear conductive element connected between the anode and the gate of the SCR. Therefore when the anode voltage reaches the required value a trigger signal is applied via said non-linear conductive element to the gate to trigger the discharge of the capacitor by the SCR.
摘要翻译：用于产生用于在气体燃烧器组件处点燃气体的火花的电路装置，由此通过与气体火焰的存在或不存在反应的电子控制电路来电操作操作。电路包括用于电荷存储电容器的充电电路，火花放电变压器，用于放电存储在电容器中的电荷的SCR切换装置和连接在SCR的阳极和栅极之间的非线性导电元件。因此，当阳极电压达到所需值时，通过所述非线性导电元件将触发信号施加到栅极以触发SCR的电容器放电。

6. 发明授权

US4489263A Electronic speed control circuits 失效
标题翻译：电子速度控制电路
公开(公告)号：US4489263A
公开(公告)日：1984-12-18
申请号：US542856
申请日：1983-10-17
申请人： Mark A. Potter , John S. Crawford
发明人： Mark A. Potter , John S. Crawford
IPC分类号： H02P25/10 , H02P5/34
CPC分类号： H02P25/10
摘要： Circuit arrangements to improve the performance of motor speed control circuits using electronic switching on an AC waveform where it is desired to remotely control the electronic switch without either load current or the load waveforms being present at the controlling element. The voltage across the switching device, during the time it is off, is rectified, and used as the charging voltage for the phase firing circuit, with a resistor capacitor timing network determining the firing of the switching device when the capacitor voltage reaches a predetermined value.
摘要翻译：电路布置，以提高电动机速度控制电路的性能，该电路使用交流波形上的电子开关，其中期望远程控制电子开关而不需要负载电流或负载波形存在于控制元件。开关装置的电压在关断期间被整流，并用作相位点火电路的充电电压，当电容器电压达到预定值时，电阻电容器定时网络确定开关装置的点火。

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