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1. 发明申请

US20120196320A1 Optical Projection Tomography Microscopy (OPTM) for Large Specimen Sizes 有权
标题翻译：光学投影断层扫描（OPTM）用于大样本尺寸
公开(公告)号：US20120196320A1
公开(公告)日：2012-08-02
申请号：US13091088
申请日：2011-04-20
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall , Duane W. Storti
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall , Duane W. Storti
IPC分类号： G01N1/30 , H04N13/02 , G01N1/31 , H04N7/18
CPC分类号： G01N1/30
摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
摘要翻译：声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。计算机捕获图像并生成3D合成图像。还要求的是用于制备用于光学显微镜的样品的系统和方法。一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

2. 发明授权

US08867803B2 Optical projection tomography microscopy (OPTM) for large specimen sizes 有权
标题翻译：光学投影断层显微镜（OPTM）用于大样本尺寸
公开(公告)号：US08867803B2
公开(公告)日：2014-10-21
申请号：US13091088
申请日：2011-04-20
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
IPC分类号： G06K9/00
CPC分类号： G01N1/30
摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
摘要翻译：声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。计算机捕获图像并生成3D合成图像。还要求的是用于制备用于光学显微镜的样品的系统和方法。一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

3. 发明授权

US10557778B2 Optical projection tomography microscopy (OPTM) for large specimen sizes 有权
公开(公告)号：US10557778B2
公开(公告)日：2020-02-11
申请号：US14453938
申请日：2014-08-07
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
IPC分类号： G01N1/30
摘要： An imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images is disclosed. One embodiment includes a light source and an imaging system having an adjustable focal position, which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also disclosed is a system and method for preparing a specimen for optical microscopy. One embodiment includes fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

4. 发明申请

US20140342395A1 OPTICAL PROJECTION TOMOGRAPHY MICROSCOPY (OPTM) FOR LARGE SPECIMEN SIZES 审中-公开
标题翻译：光学投影显微镜（OPTM）用于大样本尺寸
公开(公告)号：US20140342395A1
公开(公告)日：2014-11-20
申请号：US14453938
申请日：2014-08-07
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
IPC分类号： G01N1/30
CPC分类号： G01N1/30
摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
摘要翻译：声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。计算机捕获图像并生成3D合成图像。还要求的是用于制备用于光学显微镜的样品的系统和方法。一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。

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