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1. 发明申请

US20060204969A1 Genetic variations (SNPs) adjacent to the AKT1 gene locus, and diagnostic and prognostic uses thereof 审中-公开
标题翻译：与AKT1基因座相邻的遗传变异（SNPs）及其诊断和预后用途
公开(公告)号：US20060204969A1
公开(公告)日：2006-09-14
申请号：US11035377
申请日：2005-01-14
申请人： Eric Hoffman , Joseph Devaney
发明人： Eric Hoffman , Joseph Devaney
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6888 , C12Q2600/124 , C12Q2600/156
摘要： We have identified and isolated a 12 kb region immediately upstream of the AKT1 gene containing eight single nucleotide polymorphic polynucleotides (SNPs) in 4 haplotype regions that show strong association with body composition, Basal Mass Index, and AKT1 expression enhancement in human males. A four-locus haplotype (Haplotype 2) was defined where residues within highly conserved regulatory regions were altered. This haplotype explained up to 26% of population variation in bone cortical volume, 12% of subcutaneous fat volume, and 9% of strength variation, resulting in a body build with large bones, strong muscles, and low subcutaneous fat. Other SNPs detect, presymptomatically, the potential for increased amounts of subcutaneous fat and Type II diabetes. The detection of these SNPs by the techniques described herein forms the foundation for genotype-specific clinical interventions designed to slow the rapid population increases in obesity and Type II diabetes.
摘要翻译：我们已经鉴定并分离了4个单倍型区域中包含八个单核苷酸多态性多核苷酸（SNPs）的AKT1基因上游的12 kb区域，与人体组成，基础质量指数和AKT1表达增强在人类雄性中有很强的相关性。定义了四基因座单倍型（单倍型2），其中高度保守的调控区域内的残基被改变。这种单倍型解释了骨皮层体积，皮下脂肪体积的12％和强度变化的9％的群体变化的26％，导致身体建立与大骨骼，强壮的肌肉和低皮下脂肪。其他SNP检测，在症状前，可能增加皮下脂肪和II型糖尿病。通过本文描述的技术检测这些SNP形成了旨在减缓肥胖和II型糖尿病快速增长的基因型特异性临床干预的基础。

2. 发明申请

US20070111217A1 Quantitative trait locus prognostic for changes in regional adiposity and BMI in Caucasian males 审中-公开
标题翻译：定量性状基因座预测高血压男性局部肥胖和BMI变化
公开(公告)号：US20070111217A1
公开(公告)日：2007-05-17
申请号：US11271918
申请日：2005-11-14
申请人： Julieta Uthurralt , Heather Gordish-Dressman , Eric Hoffman , Joseph Devaney
发明人： Julieta Uthurralt , Heather Gordish-Dressman , Eric Hoffman , Joseph Devaney
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Caucasian males, but not females, presenting with statistically significant increases of L162V allelic SNP of the PPARα gene, relative to that of wild-type homozygotes, have an increased likelihood of increased regional adiposity (subcutaneous fat) and BMI, and are more likely to develop diseases associated with such changes, such as type 2 diabetes and metabolic syndrome.
摘要翻译：与野生型纯合子相比，PPARα基因的L162V等位基因SNP的统计学显着增加的高加索男性而不是雌性具有增加的局部肥胖（皮下脂肪）和BMI增加的可能性，并且更可能发展与这种变化相关的疾病，如2型糖尿病和代谢综合征。

3. 发明授权

US08155403B2 Methods and devices for airway tree labeling and/or matching 有权
标题翻译：用于气道树标签和/或匹配的方法和装置
公开(公告)号：US08155403B2
公开(公告)日：2012-04-10
申请号：US11122974
申请日：2005-05-05
申请人： Juerg Tschirren , Milan Sonka , Joseph Reinhardt , Geoffrey McLennan , Eric Hoffman
发明人： Juerg Tschirren , Milan Sonka , Joseph Reinhardt , Geoffrey McLennan , Eric Hoffman
IPC分类号： G06K9/00
CPC分类号： A61B5/00 , A61B5/0033 , A61B5/08 , G06F19/00 , G06K9/469 , G06K9/6892 , G06K2209/05 , G06K2209/053 , G06K2209/055 , G06T19/00 , G16H50/50
摘要： Devices, such as computer readable media, and methods, such as automated methods, for labeling and/or matching. Some of the devices and methods are particularly useful for anatomical labeling of human airway trees. Some of the devices and methods are particularly useful for matching branch-points of human airway trees from represented in two or more graphs.
摘要翻译：诸如计算机可读介质的设备和用于标签和/或匹配的方法，例如自动化方法。一些装置和方法对人类气道树的解剖标记特别有用。一些装置和方法对于匹配在两个或多个图中表示的人气道树的分支点是特别有用的。

4. 发明授权

US08073210B2 Methods of smoothing segmented regions and related devices 失效
标题翻译：分段区域和相关设备的平滑方法
公开(公告)号：US08073210B2
公开(公告)日：2011-12-06
申请号：US11355321
申请日：2006-02-14
申请人： Joseph Reinhardt , Milan Sonka , Geoffrey McLennan , Eric Hoffman , Soumik Ukil
发明人： Joseph Reinhardt , Milan Sonka , Geoffrey McLennan , Eric Hoffman , Soumik Ukil
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06T5/30 , G06T5/002 , G06T7/12 , G06T7/155 , G06T2207/10081 , G06T2207/20044 , G06T2207/30061
摘要： Automated methods for segmenting and smoothing volumes of interest, such as the mediastinal boundary of a lung. Devices and systems configured to perform the automated methods.
摘要翻译：用于分割和平滑感兴趣体积的自动方法，如肺的纵隔边界。配置为执行自动化方法的设备和系统。

5. 发明授权

US07713517B2 Compositions and methods for enhancing contrast in imaging 有权
标题翻译：用于增强成像对比度的组合和方法
公开(公告)号：US07713517B2
公开(公告)日：2010-05-11
申请号：US10830190
申请日：2004-04-21
申请人： Ananth Annapragada , Ravi V. Bellamkonda , Eric Hoffman , Chandra Vijayalakshmi
发明人： Ananth Annapragada , Ravi V. Bellamkonda , Eric Hoffman , Chandra Vijayalakshmi
IPC分类号： A61K8/00 , A61K9/00 , A61K49/04
CPC分类号： A61K49/0093 , A61K9/1271 , A61K49/0438 , A61K49/0466
摘要： Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast-enhancing agents, and example methods for using the compositions.
摘要翻译：提供了具有在其表面上具有亲水性聚合物并含有相对高浓度的用于计算机断层摄影的对比度增强剂的脂质体的实例组合物。当向受试者施用时，这种脂质体的示例药物组合物通过计算机断层摄影在受试者的血流和其他组织中测量延长的持续时间的增强的对比度。还提供了制备含有高浓度对比度增强剂的脂质体的实例方法，以及使用该组合物的实例方法。

6. 发明授权

US07613335B2 Methods and devices useful for analyzing color medical images 有权
标题翻译：用于分析彩色医学图像的方法和设备
公开(公告)号：US07613335B2
公开(公告)日：2009-11-03
申请号：US10777764
申请日：2004-02-12
申请人： Geoffrey McLennan , Martin Donnelley , Deepa Gopalakrishnan , Eric Hoffman , Joseph Reinhardt , Melissa Suter
发明人： Geoffrey McLennan , Martin Donnelley , Deepa Gopalakrishnan , Eric Hoffman , Joseph Reinhardt , Melissa Suter
IPC分类号： G06K9/00
CPC分类号： G06K9/4652 , G06T7/0012 , G06T7/90 , G06T2200/24 , G06T2207/10016 , G06T2207/30004
摘要： In one embodiment, a method that includes comparing a subject color medical image to normal color medical image data; and identifying abnormal pixels from the subject color medical image. Another embodiment includes a computer readable medium comprising machine readable instructions for implementing one or more steps of that method. Another embodiment includes a device that has a field programmable gate array configured to perform one or more of the steps of that method. Another embodiment includes a device that has an application specific integrated circuit configured to perform one or more of the steps of that method.
摘要翻译：在一个实施例中，一种方法，其包括将主题彩色医学图像与正常彩色医学图像数据进行比较; 以及从所述被摄体彩色医学图像识别异常像素。另一实施例包括计算机可读介质，其包括用于实现该方法的一个或多个步骤的机器可读指令。另一个实施例包括具有被配置为执行该方法的一个或多个步骤的现场可编程门阵列的设备。另一实施例包括具有被配置为执行该方法的一个或多个步骤的专用集成电路的设备。

7. 发明授权

US07180072B2 Method and apparatus for creating a registration network of a scene 失效
标题翻译：用于创建场景的注册网络的方法和装置
公开(公告)号：US07180072B2
公开(公告)日：2007-02-20
申请号：US11065745
申请日：2005-02-25
申请人： Fred M. Persi , Eric Hoffman
发明人： Fred M. Persi , Eric Hoffman
IPC分类号： H01J3/14
CPC分类号： G06T7/33 , G06T2200/04
摘要： An apparatus for creating a registration network of a scene includes a laser scanner for scanning the scene and obtaining data of the scene. The apparatus includes a plurality of targets placed in the scene. The apparatus includes a mechanism for forming a registration network using only the laser scanner data. A method for creating a registration network of the scene.
摘要翻译：用于创建场景的注册网络的装置包括用于扫描场景并获得场景的数据的激光扫描仪。该装置包括放置在场景中的多个目标。该装置包括仅使用激光扫描器数据形成注册网络的机构。一种用于创建场景的注册网络的方法。

8. 发明申请

US20060254834A1 Method and apparatus for moving a bed 审中-公开
标题翻译：移动床的方法和装置
公开(公告)号：US20060254834A1
公开(公告)日：2006-11-16
申请号：US11127689
申请日：2005-05-11
申请人： Alfred Dassler , Eric Hoffman , Scott Smiley
发明人： Alfred Dassler , Eric Hoffman , Scott Smiley
IPC分类号： B62M7/14
CPC分类号： A61G7/08
摘要： A bed moving device includes a two part frame with the lower section having a motor and at least one driving wheel. The upper section rotates independent of the lower section and includes at least one suction device for attachment to a headboard or footboard of a bed and a set of controllers for directing the speed and direction of the motor and for directing a direction of the bed. The motor supplies the driving force to move the device and bed.
摘要翻译：床移动装置包括两部分框架，其下部具有马达和至少一个驱动轮。上部部分独立于下部部分旋转并且包括用于附接到床的床头板或脚踏板和用于引导电动机的速度和方向并且用于引导床的方向的一组控制器的至少一个抽吸装置。电机提供驱动力来移动设备和床。

9. 发明授权

US09198921B2 Non-hormonal steroid modulators of NF-κB for treatment of disease 有权
标题翻译： NF-κB的非激素类固醇调节剂用于治疗疾病
公开(公告)号：US09198921B2
公开(公告)日：2015-12-01
申请号：US13639650
申请日：2011-04-05
申请人： John M. McCall , Eric Hoffman , Kanneboyina Nagaraju
发明人： John M. McCall , Eric Hoffman , Kanneboyina Nagaraju
IPC分类号： A61K31/56 , C07J5/00 , A61K31/573 , A61K31/575 , A61K45/06 , C07J7/00 , C07J13/00 , C07J21/00 , C07J51/00
CPC分类号： C07J9/005 , A61K31/573 , A61K31/575 , A61K45/06 , C07J5/003 , C07J5/0038 , C07J5/0053 , C07J5/0069 , C07J5/0076 , C07J7/008 , C07J9/00 , C07J13/005 , C07J21/00 , C07J51/00 , Y02A50/479
摘要： The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors of NF-κB for the treatment or prevention of muscular wasting disease, including muscular dystrophy.
摘要翻译：本发明涉及可用作治疗神经肌肉疾病如肌营养不良的化合物和方法，以及作为NF-κB抑制剂用于治疗或预防肌肉萎缩性疾病，包括肌营养不良症的化合物和方法。

10. 发明授权

US08428692B2 Systems and methods for bioluminescent computed tomographic reconstruction 有权
标题翻译：生物发光计算机断层扫描重建的系统和方法
公开(公告)号：US08428692B2
公开(公告)日：2013-04-23
申请号：US13304063
申请日：2011-11-23
申请人： Ge Wang , Eric Hoffman , Geoffrey McLennan
发明人： Ge Wang , Eric Hoffman , Geoffrey McLennan
IPC分类号： A61B5/05
CPC分类号： A61B5/0035 , A61B5/0071 , A61B5/0073 , A61B5/0077 , A61B5/055 , A61B6/032 , A61B6/4014 , A61B6/4266 , A61B6/4417 , A61B6/466 , A61B6/508 , A61B6/5247 , G01R33/4808 , G06T11/005
摘要： An image of an object is synergistically reconstructed using two or multiple imaging modalities. A first reconstructed image, showing structural information of the object is produced using a first imaging modality. The first reconstructed image is segmented, and known optical properties of the object are then mapped to the first reconstructed image. Optical signal emissions from the object are detected and registered with the first reconstructed image. A second reconstructed image volume is then produced using a second imaging modality, based on the mapped optical properties after registration between the first image and the data from the second modality. The second reconstructed image depicts some optical property, such as a bioluminescent source distribution, or optical properties, such as, attenuation and scattering properties, of the object.
摘要翻译：使用两个或多个成像模态协同重建对象的图像。使用第一成像模态产生显示对象的结构信息的第一重建图像。第一重建图像被分割，然后将对象的已知光学属性映射到第一重构图像。检测来自物体的光信号发射并将其与第一重构图像一起登记。然后，基于第一图像和来自第二模态的数据之间的配准之后的映射光学性质，使用第二成像模态产生第二重建图像体积。第二重建图像描绘了物体的一些光学性质，例如生物发光源分布或光学性质，例如衰减和散射性质。

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