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1. 发明授权

US07727395B2 Method and apparatus for processing organic waste 有权
标题翻译：处理有机废物的方法和装置
公开(公告)号：US07727395B2
公开(公告)日：2010-06-01
申请号：US12178292
申请日：2008-07-23
申请人： Eric E. Fitch , David M. O'Keefe , David C. Palmer
发明人： Eric E. Fitch , David M. O'Keefe , David C. Palmer
IPC分类号： C02F3/28 , C05F5/00 , C05F11/00
CPC分类号： C02F3/28 , C02F3/2806 , C02F3/2846 , C02F11/125 , C02F2103/32 , C02F2303/10 , Y02E50/343 , Y02W10/12 , Y02W10/30 , Y02W30/47
摘要： A method for processing brewery waste that includes receiving spent grain, low strength wastewater and high strength wastewater. The spent grain, low strength wastewater and high strength wastewater is processed with a plug flow anaerobic digester to produce a first output. A portion of the first output is processed with an upflow anaerobic sludge blanket digester to produce a second output. A portion of the second output is processed with a fixed-film anaerobic digester to produce a third output.
摘要翻译：一种处理啤酒废物的方法，包括接收废粮，低强度废水和高强度废水。废浆，低强度废水和高强度废水用活塞式厌氧消化器处理，产生第一输出。第一输出的一部分用上流厌氧污泥床消化器处理以产生第二输出。用固定膜厌氧消化器处理第二输出的一部分以产生第三输出。

2. 发明申请

US20100018917A1 METHODS AND APPARATUS FOR PROCESSING ORGANIC WASTE 有权
标题翻译：用于处理有机废物的方法和装置
公开(公告)号：US20100018917A1
公开(公告)日：2010-01-28
申请号：US12178292
申请日：2008-07-23
申请人： Eric E. Fitch , David M. O'Keefe , David C. Palmer
发明人： Eric E. Fitch , David M. O'Keefe , David C. Palmer
IPC分类号： C02F3/28 , C02F11/04
CPC分类号： C02F3/28 , C02F3/2806 , C02F3/2846 , C02F11/125 , C02F2103/32 , C02F2303/10 , Y02E50/343 , Y02W10/12 , Y02W10/30 , Y02W30/47
摘要： A method for processing brewery waste that includes receiving spent grain, low strength wastewater and high strength wastewater. The spent grain, low strength wastewater and high strength wastewater is processed with a plug flow anaerobic digester to produce a first output. A portion of the first output is processed with an upflow anaerobic sludge blanket digester to produce a second output. A portion of the second output is processed with a fixed-film anaerobic digester to produce a third output.
摘要翻译：一种处理啤酒废物的方法，包括接收废粮，低强度废水和高强度废水。废浆，低强度废水和高强度废水用活塞式厌氧消化器处理，产生第一输出。第一输出的一部分用上流厌氧污泥床消化器处理以产生第二输出。用固定膜厌氧消化器处理第二输出的一部分以产生第三输出。

3. 发明申请

US20120283433A1 NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES 审中-公开
标题翻译：制备环丙基酰胺衍生物的新方法
公开(公告)号：US20120283433A1
公开(公告)日：2012-11-08
申请号：US13542821
申请日：2012-07-06
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10
CPC分类号： C07D295/192
摘要： The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其用于治疗由组胺受体介导的病症和病症。

4. 发明申请

US20120029191A1 NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES 审中-公开
公开(公告)号：US20120029191A1
公开(公告)日：2012-02-02
申请号：US13270924
申请日：2011-10-11
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10
CPC分类号： C07D295/192
摘要： The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

5. 发明授权

US08063206B2 Processes for the preparation of cyclopropyl-amide derivatives 有权
标题翻译：制备环丙基 - 酰胺衍生物的方法
公开(公告)号：US08063206B2
公开(公告)日：2011-11-22
申请号：US12840134
申请日：2010-07-20
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10
CPC分类号： C07D295/192
摘要： The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其用于治疗由组胺受体介导的病症和病症。

6. 发明申请

US20100286391A1 NOVEL PROCESSES FOR THE PREPARATION OF CYCLOPROPYL-AMIDE DERIVATIVES 有权
标题翻译：制备环丙基酰胺衍生物的新方法
公开(公告)号：US20100286391A1
公开(公告)日：2010-11-11
申请号：US12840134
申请日：2010-07-20
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10 , C07D401/10
CPC分类号： C07D295/192
摘要： The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其用于治疗由组胺受体介导的病症和病症。

7. 发明授权

US06235876B1 Liquid phase process for the preparation of GNRH peptides 有权
标题翻译：用于制备GNRH肽的液相方法
公开(公告)号：US06235876B1
公开(公告)日：2001-05-22
申请号：US09350231
申请日：1999-07-08
申请人： David C. Palmer , Ahmed Abdel-Magid , Urs P. Eggmann , Bruce Harris , Kirk L. Sorgi
发明人： David C. Palmer , Ahmed Abdel-Magid , Urs P. Eggmann , Bruce Harris , Kirk L. Sorgi
IPC分类号： C07K704
CPC分类号： C07K5/0815 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K7/23 , Y02P20/55
摘要： A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1-(A)D-Phe-AA3-AA4-(R2-AA5-AA6-AA7-AA8-Pro-AA10-NH2 Formula 1 which comprises: (a) reacting a peptide of the formula: T-(R2)AA5-AA6-X where T is (P2) AA4 orP2 and X is AA7-OH or is —OH, with a peptide of the formula: X′-AA8-Pro-AA10-NH2 or acid-addition salt form thereof, where X′ is AA7 when X is absent and X′ is absent when X is AA7-OH; in a liquid reaction medium in the presence of a peptide coupling reagent and a strong organic amine base to obtain a product of the formula: T-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2 (b) removing the P2 protecting group at the N-terminus, and (c) reacting the product of step (b) or an acid addition salt thereof, with a peptide of the formula: G-AA1-(R1)D-Phe-AA3-T′ or acid-addition salt form thereof, where T′ is AA4-OH when T is absent and is absent when T is P2-AA4, in a liquid reaction medium to obtain a GnRH peptide of the formula: G-AA1-(A)D-Phe-AA3-AA4-(R2)AA5-AA6-AA7-AA8-Pro-AA10-NH2.
摘要翻译：用于制备下式的GnRH肽类似物的液相方法：其包括：（a）使下式的肽与其中T是（P2）AA4或P2，X是AA7-OH或-OH的肽反应，式：或其酸加成盐形式，其中当X不存在时X'为AA 7，X为AA 7 -OH时X'不存在; 在液体反应介质中，在肽偶联剂和强有机胺碱存在下，得到下式的产物：（b）在N末端除去P2保护基，和（c）使步骤（b）或其酸加成盐与下式的肽或其酸加成盐形式，当T不存在时T'为AA4-OH，当T为P2-AA4时不存在，在液体反应中培养基以获得下式的GnRH肽：

8. 发明授权

US07728129B2 Processes for the preparation of piperazinyl and diazapanyl benzamide derivatives 有权
标题翻译：制备哌嗪基和二氮杂苯甲酰基苯甲酰胺衍生物的方法
公开(公告)号：US07728129B2
公开(公告)日：2010-06-01
申请号：US11553158
申请日：2006-10-26
申请人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人： Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号： C07D413/10
CPC分类号： C07D295/192 , C07D207/06 , C07D211/14 , C07D295/182 , C07D413/04
摘要： The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides of formula (I), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译：本发明涉及制备本说明书中定义的式（I）的取代的哌嗪基和二氮杂环庚烷基苯甲酰胺的新方法，其可用于治疗由组胺受体介导的病症和病症。

9. 发明申请

US20100029942A1 Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives 审中-公开
标题翻译：苯并咪唑-2-基嘧啶衍生物的制备方法
公开(公告)号：US20100029942A1
公开(公告)日：2010-02-04
申请号：US12459224
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
发明人： Sergio Cesco-Cancian , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Tong Xiao , Diego Broggini , Susanne Lochner
IPC分类号： C07D401/14
CPC分类号： C07D403/04
摘要： The present invention is directed to benzoimidazol-2-yl pyrimidine derivatives useful as histamine H4 receptor modulators and processes for the preparation of such compounds.
摘要翻译：本发明涉及可用作组胺H 4受体调节剂的苯并咪唑-2-基嘧啶衍生物及其制备方法。

10. 发明申请

US20100004450A1 Process for the preparation of substituted pyrimidine derivatives 有权
标题翻译：制备取代嘧啶衍生物的方法
公开(公告)号：US20100004450A1
公开(公告)日：2010-01-07
申请号：US12459229
申请日：2009-06-29
申请人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人： Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号： C07D401/12 , C07D211/22 , C07D211/26
CPC分类号： C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要： The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译：本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法，以及H4调节剂合成中的中间体。

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