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1. 发明授权

US08170661B2 Pacing system controller integrated into indeflator 失效
标题翻译：起搏系统控制器集成到空调器中
公开(公告)号：US08170661B2
公开(公告)日：2012-05-01
申请号：US12496408
申请日：2009-07-01
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler , Michael M. Morris
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler , Michael M. Morris
IPC分类号： A61N1/00
CPC分类号： A61N1/362 , A61M25/10 , A61M25/10181 , A61M25/10185 , A61M25/1025 , A61M2025/105 , A61N1/056 , A61N1/375 , A61N2001/0585
摘要： Systems and methods for temporarily pacing a patient's heart are provided. One system includes a vascular treatment system having a vascular access system and a therapy system. The therapy system includes an indeflator and an elongate medical device and the elongate medical device has an inflatable member and an electrode. The indeflator is adapted to provide pressurized fluid to the inflatable member and electrical signals to the electrode, with its operation manually or automatically controlled. Devices for electrically and fluidly coupling the indeflator and the elongate medical device are also provided.
摘要翻译：提供了临时起搏患者心脏的系统和方法。一个系统包括具有血管通路系统和治疗系统的血管治疗系统。该治疗系统包括一个独立器和一个细长的医疗装置，细长的医疗装置具有一个可充气构件和一个电极。适应器适于将加压流体提供给可膨胀构件，并且电信号到电极，其操作手动或自动控制。还提供了用于电气和流体耦合不平衡装置和细长医疗装置的装置。

2. 发明申请

US20100004706A1 PACING SYSTEM CONTROLLER INTEGRATED INTO INDEFLATOR 失效
标题翻译： PACING系统控制器集成到INDEFLATOR
公开(公告)号：US20100004706A1
公开(公告)日：2010-01-07
申请号：US12496408
申请日：2009-07-01
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler , Michael M. Morris
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler , Michael M. Morris
IPC分类号： A61N1/365 , A61M29/02
CPC分类号： A61N1/362 , A61M25/10 , A61M25/10181 , A61M25/10185 , A61M25/1025 , A61M2025/105 , A61N1/056 , A61N1/375 , A61N2001/0585
摘要： Systems and methods for temporarily pacing a patient's heart are provided. One system includes a vascular treatment system having a vascular access system and a therapy system. The therapy system includes an indeflator and an elongate medical device and the elongate medical device has an inflatable member and an electrode. The indeflator is adapted to provide pressurized fluid to the inflatable member and electrical signals to the electrode, with its operation manually or automatically controlled. Devices for electrically and fluidly coupling the indeflator and the elongate medical device are also provided.
摘要翻译：提供了临时起搏患者心脏的系统和方法。一个系统包括具有血管通路系统和治疗系统的血管治疗系统。该治疗系统包括一个独立器和一个细长的医疗装置，细长的医疗装置具有一个可充气构件和一个电极。适应器适于将加压流体提供给可膨胀构件，并且电信号到电极，其操作手动或自动控制。还提供了用于电气和流体耦合不平衡装置和细长医疗装置的装置。

3. 发明授权

US08340761B2 Myocardial infarction treatment system with electronic repositioning 有权
标题翻译：具有电子重新定位的心肌梗塞治疗系统
公开(公告)号：US08340761B2
公开(公告)日：2012-12-25
申请号：US12793206
申请日：2010-06-03
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
IPC分类号： A61N1/368 , A61N1/372
CPC分类号： A61N1/368 , A61B17/3207 , A61B2017/00557 , A61B2017/00893 , A61N1/056 , A61N1/36578 , A61N2001/0585
摘要： Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
摘要翻译：提供了治疗冠状动脉系统阻塞的方法和装置。冠状动脉系统中的一些阻塞物将血流限制到心脏的一部分，导致局部缺血或梗死。可以通过移位，去除和/或破坏堵塞来治疗这种阻塞，其允许血液再灌注到心脏的梗塞部分。在再灌注之前，期间和/或之后，向心脏提供心脏保护起搏。这些装置具有多个电极，以便提供可以输送心脏保护起搏的多个位置。该装置适于通过电极向心脏输送心脏保护性起搏，导致心脏相对较高水平的不同步。

4. 发明申请

US20110040344A1 MYOCARDIAL INFARCTION TREATMENT SYSTEM WITH ELECTRONIC REPOSITIONING 有权
标题翻译：具有电子记录功能的MYOCARDIAL INFARCTION治疗系统
公开(公告)号：US20110040344A1
公开(公告)日：2011-02-17
申请号：US12793206
申请日：2010-06-03
申请人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
发明人： Eric A. Mokelke , Allan C. Shuros , James A. Esler
IPC分类号： A61B17/22 , A61N1/36
CPC分类号： A61N1/368 , A61B17/3207 , A61B2017/00557 , A61B2017/00893 , A61N1/056 , A61N1/36578 , A61N2001/0585
摘要： Methods and devices for treating a blockage in the coronary arterial system are provided. Some blockages in the coronary arterial system restrict the blood flow to a portion of the heart, causing ischemia or infarction. Such blockages may be treated by displacing, removing and/or breaking up the blockage, which allows blood to reperfuse into the infarcted portion of the heart. Before, during, and/or after the reperfusion, cardioprotective pacing is provided to the heart. The devices have multiple electrodes in order to provide multiple locations at which the cardioprotective pacing may be delivered. The devices are adapted to deliver cardioprotective pacing to the heart via the electrode that results in a relatively high level of dyssynchrony of the heart.
摘要翻译：提供了治疗冠状动脉系统阻塞的方法和装置。冠状动脉系统中的一些阻塞物将血流限制到心脏的一部分，导致局部缺血或梗死。可以通过移位，去除和/或破坏堵塞来治疗这种阻塞，其允许血液再灌注到心脏的梗死部分。在再灌注之前，期间和/或之后，向心脏提供心脏保护起搏。这些装置具有多个电极，以便提供可以输送心脏保护起搏的多个位置。该装置适于通过电极向心脏输送心脏保护性起搏，导致心脏相对较高水平的不同步。

5. 发明申请

US20100249860A1 EXTERNAL CARDIAC STIMULATION PATCH 审中-公开
标题翻译：外部心脏刺激贴
公开(公告)号：US20100249860A1
公开(公告)日：2010-09-30
申请号：US12720246
申请日：2010-03-09
申请人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
发明人： Allan C. Shuros , Eric A. Mokelke , James A. Esler
IPC分类号： A61N1/365 , A61N1/39
CPC分类号： A61N1/3625 , A61N1/3627 , A61N1/37247 , A61N1/3925 , A61N1/3968 , A61N1/3993
摘要： An external cardiac stimulation patch integrates a transcutaneous cardiac stimulation device and body-surface electrodes with a skin patch. The skin patch is to be attached onto a patient to provide for electrical contacts between the body-surface electrodes and a patient. The transcutaneous cardiac stimulation device delivers pacing pulses to the heart of the patient through pacing electrodes selected from the body-surface electrodes.
摘要翻译：外部心脏刺激贴片将经皮心脏刺激装置和体表电极与皮肤贴片集成。将皮肤贴片贴在患者身上，以提供身体表面电极与患者之间的电接触。经皮心脏刺激装置通过选自身体表面电极的起搏电极将起搏脉冲提供给患者的心脏。

6. 发明授权

US08812104B2 Method and apparatus for automated control of pacing post-conditioning 有权
标题翻译：起搏后调节自动控制的方法和装置
公开(公告)号：US08812104B2
公开(公告)日：2014-08-19
申请号：US12877622
申请日：2010-09-08
申请人： Eric A. Mokelke , James A. Esler
发明人： Eric A. Mokelke , James A. Esler
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36 , A61N1/056 , A61N1/3621 , A61N1/3625 , A61N1/3627 , A61N1/3702 , A61N1/371 , A61N1/372 , G06F19/00 , G06F19/324 , G16H40/63 , G16H50/20
摘要： Pacing post-conditioning (PPC) therapy is applied to a patient to minimize ischemic injury associated with MI and/or reperfusion injury associated with a post-MI revascularization procedure. In various embodiments, a PPC therapy is delivered by executing a pacing protocol with pacing parameters determined and dynamically adjusted based on patient-specific factors to ensure efficacy and safety of the patient.
摘要翻译：起搏后期治疗（PPC）治疗应用于患者以最小化与MI和/或再灌注损伤相关的与MI后血运重建术相关的缺血性损伤。在各种实施例中，通过执行起搏协议来执行PPC治疗，其中基于患者特异性因素确定并动态调整起搏参数，以确保患者的功效和安全性。

7. 发明申请

US20110071584A1 METHOD AND APPARATUS FOR AUTOMATED CONTROL OF PACING POST-CONDITIONING 有权
标题翻译：用于自动控制后处理的方法和装置
公开(公告)号：US20110071584A1
公开(公告)日：2011-03-24
申请号：US12877622
申请日：2010-09-08
申请人： Eric A. Mokelke , James A. Esler
发明人： Eric A. Mokelke , James A. Esler
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/36 , A61N1/056 , A61N1/3621 , A61N1/3625 , A61N1/3627 , A61N1/3702 , A61N1/371 , A61N1/372 , G06F19/00 , G06F19/324 , G16H40/63 , G16H50/20
摘要： Pacing post-conditioning (PPC) therapy is applied to a patient to minimize ischemic injury associated with MI and/or reperfusion injury associated with a post-MI revascularization procedure. In various embodiments, a PPC therapy is delivered by executing a pacing protocol with pacing parameters determined and dynamically adjusted based on patient-specific factors to ensure efficacy and safety of the patient.
摘要翻译：起搏后期治疗（PPC）治疗应用于患者以最小化与MI和/或再灌注损伤相关的与MI后血运重建术相关的缺血性损伤。在各种实施例中，通过执行起搏协议来执行PPC治疗，其中基于患者特异性因素确定并动态调整起搏参数，以确保患者的功效和安全性。

8. 发明申请

US20100298900A1 CARDIAC PACEMAKER WITH TABLE-BASED PACING MODE IMPLEMENTATION 审中-公开
标题翻译：具有基于表的PACING模式实现的CARDIAC PACEMAKER
公开(公告)号：US20100298900A1
公开(公告)日：2010-11-25
申请号：US12848894
申请日：2010-08-02
申请人： David W. Yost , Doug M. Birkholz , James A. Esler
发明人： David W. Yost , Doug M. Birkholz , James A. Esler
IPC分类号： A61N1/362
CPC分类号： A61N1/362
摘要： A device and method for implementing a bradycardia pacing mode are disclosed which is mostly hardware-based but still allows the flexibility for making major changes in brady behavior normally found only in firmware-based implementations. The brady behavior of the device is encapsulated by a table in an area of RAM referred to as brady RAM, and the brady behavior can be changed by re-loading the brady RAM with a different table.
摘要翻译：公开了一种用于实现心动过缓起搏模式的装置和方法，其基本上是基于硬件的，但是仍然允许在通常仅在基于固件的实现中通常发现的轻度行为的主要变化的灵活性。设备的缓冲行为由RAM中称为brady RAM的RAM中的表封装，并且可以通过用不同的表重新加载brady RAM来改变brady行为。

9. 发明授权

US06240313B1 Cardiac rhythm management system with prevention of double counting of events 有权
公开(公告)号：US06240313B1
公开(公告)日：2001-05-29
申请号：US09294725
申请日：1999-04-19
申请人： James A. Esler
发明人： James A. Esler
IPC分类号： A61B50468
CPC分类号： A61N1/3627 , A61N1/368
摘要： A cardiac rhythm management system recognizes patterns of interval durations, distinguishing between events in different heart chambers even though signals associated with those different heart chambers are processed using a commonly shared sensing circuit. A therapy delivery algorithm ignores intervals between cardiac events occurring in different heart chambers when determining a cardiac rate upon which the delivery of therapy is based. This reduces the risk of inappropriate delivery of therapy to the patient. Delayed conduction left ventricular beats are not erroneously recognized as a subsequent right ventricular beat, preventing such short intervals from inappropriately triggering a defibrillation countershock. The system detects cardiac events, obtains a current interval between a current cardiac event and a previous cardiac event, and classifies the current interval into at least first and second categories, based on a duration of the current interval. The system determines timing of delivery of output energy based on whether a previous interval is in the first category and the current interval is in the second category. The system then stores the current interval as the previous interval.

10. 发明授权

US08682435B2 Cardiac rhythm management system with prevention of double counting of events 有权
标题翻译：心脏节律管理系统，预防事件重复计数
公开(公告)号：US08682435B2
公开(公告)日：2014-03-25
申请号：US12152100
申请日：2008-05-12
申请人： James A. Esler
发明人： James A. Esler
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/368
摘要： A cardiac rhythm management system recognizes patterns of interval durations, distinguishing between events in different heart chambers even though signals associated with those different heart chambers are processed using a commonly shared sensing circuit. A therapy delivery algorithm ignores intervals between cardiac events occurring in different heart chambers when determining a cardiac rate upon which the delivery of therapy is based. This reduces the risk of inappropriate delivery of therapy to the patient. Delayed conduction left ventricular beats are not erroneously recognized as a subsequent right ventricular beat, preventing such short intervals from inappropriately triggering a defibrillation countershock.
摘要翻译：心律管理系统识别间隔持续时间的模式，区分不同心室中的事件，即使使用共同感测电路来处理与那些不同心室相关联的信号。治疗传递算法在确定治疗递送所基于的心率时，忽略在不同心室中发生的心脏事件之间的间隔。这降低了向患者不当地递送治疗的风险。延迟传导的左心室搏动不会被错误地识别为随后的右心室搏动，从而防止这种短时间间隔不适当地触发除颤反射。

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