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1. 发明授权

US5835620A Boundary mapping system and method 失效
标题翻译：边界映射系统及方法
公开(公告)号：US5835620A
公开(公告)日：1998-11-10
申请号：US576988
申请日：1995-12-19
申请人： Eran Kaplan , Opher Shapira , Yuval Harary , Daniel Hachnochi , Richard S. F. Scott
发明人： Eran Kaplan , Opher Shapira , Yuval Harary , Daniel Hachnochi , Richard S. F. Scott
IPC分类号： G02B21/36 , G06K9/00 , G06K9/32 , G06T1/00 , G06T5/00
CPC分类号： G06T7/0081 , G06K9/00127 , G06K9/32 , G06T7/0012 , G06T7/0022 , G06T7/0091 , G06T2207/10056 , G06T2207/10152 , G06T2207/20132 , G06T2207/30024
摘要： A method of mapping areas of a slide includes the steps of selectively illuminating the slide from a first light source oriented generally obliquely to the surface of the slide, obtaining a first image of the slide illuminated by the first light source, selectively illuminated the slide from a second light source providing generally scattered light, obtaining an image of said second image illuminated by the second light source, and generating a map of areas of significance based on the first and second images.
摘要翻译：映射幻灯片区域的方法包括以下步骤：从大致倾斜于幻灯片表面的第一光源选择性地照亮幻灯片，获得由第一光源照亮的幻灯片的第一图像，从第一光源选择性地照亮幻灯片通常提供散射光的第二光源，获得由第二光源照射的所述第二图像的图像，以及基于第一和第二图像生成有意义的区域的图。

2. 发明授权

US07141773B2 Image focusing in fluorescent imaging 有权
标题翻译：图像聚焦在荧光成像
公开(公告)号：US07141773B2
公开(公告)日：2006-11-28
申请号：US10485116
申请日：2002-08-06
申请人： Eran Kaplan , Avner Freiberger
发明人： Eran Kaplan , Avner Freiberger
IPC分类号： H01J27/00
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/244 , G02B21/245 , G02B21/367
摘要： An imaging apparatus with an autofocus mechanism for obtaining focused images. The apparatus comprises: an objective lens, a focus controller for altering a distance between the objective lens and a sample, an object finder for finding objects of interest within the sample, for example cells, and a light intensity measurement unit which measures light intensity levels of the thus identified objects of interest. The focus control alters the sample-objective distance to maximize the light intensity levels being measured, thereby to arrive at a focus position. Objects of interest may be identified by filtering out large objects and optionally by masking out background regions. The apparatus is useful for microscopy and particularly for fluorescent imaging in which light levels are low and noise is often high.
摘要翻译：一种具有用于获得聚焦图像的自动对焦机构的成像装置。该装置包括：物镜，用于改变物镜与样本之间的距离的聚焦控制器，用于在样本内发现感兴趣对象的对象取景器，例如单元，以及测量光强度水平的光强度测量单元的感兴趣的对象。聚焦控制改变了采样 - 目标距离，以最大化所测量的光强度水平，从而达到聚焦位置。可以通过滤出大对象并且可选地通过掩蔽背景区域来识别感兴趣对象。该装置对于显微镜是有用的，特别是对于光水平低且噪声通常较高的荧光成像。

3. 发明授权

US5629766A Global MTF measurement system 失效
标题翻译：全球MTF测量系统
公开(公告)号：US5629766A
公开(公告)日：1997-05-13
申请号：US523871
申请日：1995-09-06
申请人： Eran Kaplan
发明人： Eran Kaplan
IPC分类号： G01M11/02
CPC分类号： G01M11/0292
摘要： The MTF for an optical or electronic device(s) is evaluated over a substantial portion of an image signal. As a result, a composite MTF representing a more global evaluation is achieved. Furthermore, the MTF for all or part of a system can be evaluated in situ.
摘要翻译：用于光学或电子设备的MTF在图像信号的大部分上进行评估。因此，实现了代表更全球评估的复合MTF。此外，可以对现场的所有或部分系统的MTF进行评估。

4. 发明授权

US07050087B2 Data acquisition and display system and method 有权
公开(公告)号：US07050087B2
公开(公告)日：2006-05-23
申请号：US09729787
申请日：2000-12-06
申请人： Yuval Harari , Eran Kaplan
发明人： Yuval Harari , Eran Kaplan
IPC分类号： H04N7/18
CPC分类号： G02B21/0004
摘要： A data acquisition and display system comprises: a data acquisition device, such as a camera, microscope, telescope, thermal imager, medical scanning device, radar etc, operable to acquire data in scans over a field of interest using each of at least a first and a second data acquisition method. A field data storage device stores the field data together with corresponding field location data that describes a location within the field of interest. A field data display device such as a screen is operable to display simultaneously data from matched locations in the field of interest acquired respectively by the different data acquisition methods. The data, generally image data, may be superimposed or displayed side by side as desired. Preferably, one of the images being displayed is live whilst the other is recalled from the field data storage device.

5. 发明申请

US20050056767A1 Image focusing in fluorescent imaging 有权
标题翻译：图像聚焦在荧光成像
公开(公告)号：US20050056767A1
公开(公告)日：2005-03-17
申请号：US10485116
申请日：2004-02-05
申请人： Eran Kaplan , Avner Freiberger
发明人： Eran Kaplan , Avner Freiberger
IPC分类号： G02B7/28 , G01N21/64 , G02B7/36 , G02B21/16 , G02B21/24 , G02B21/36 , H04N5/232 , H01L27/00
CPC分类号： G01N21/6458 , G02B21/16 , G02B21/244 , G02B21/245 , G02B21/367
摘要： An imaging apparatus with an autofocus mechanism for obtaining focused images. The apparatus comprises: an objective lens, a focus controller for altering a distance between the objective lens and a sample, an object finder for finding objects of interest within the sample, for example cells, and a light intensity measurement unit which measures light intensity levels of the thus identified objects of interest. The focus control alters the sample-objective distance to maximize the light intensity levels being measured, thereby to arrive at a focus position. Objects of interest may be identified by filtering out large objects and optionally by masking out background regions. The apparatus is useful for microscopy and particularly for fluorescent imaging in which light levels are low and noise is often high.

6. 发明申请

US20050026297A1 Kits and methods for preparing gell samples optmimized for dual staining 审中-公开
标题翻译：用于制备凝胶样品的试剂盒和方法优化为双染色
公开(公告)号：US20050026297A1
公开(公告)日：2005-02-03
申请号：US10493319
申请日：2004-05-05
申请人： Michal Daniely , Malka Reichart , Eran Kaplan , Yulia Zilberstein
发明人： Michal Daniely , Malka Reichart , Eran Kaplan , Yulia Zilberstein
IPC分类号： G01N1/30 , G01N33/50 , G01N33/00
CPC分类号： G01N1/30 , G01N33/5094 , Y10T436/15
摘要： A method of preparing nucleated peripheral blood or bone marrow cells optimized for at least dual mode imaging. The method including: (a) isolating nucleated cells from a peripheral blood or a bone marrow sample; and (b) resuspending the nucleated cells in the presence of a morphology preserver including at least 1% serum, and recovering a cell fraction thereby preparing the nucleated peripheral blood or bone marrow cells optimized for at least dual mode imaging.

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