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1. 发明授权

US06730657B1 Recombinant proteins from HGF and MSP 失效
标题翻译：来自HGF和MSP的重组蛋白
公开(公告)号：US06730657B1
公开(公告)日：2004-05-04
申请号：US09601040
申请日：2000-09-08
申请人： Enzo Medico , Paolo Michieli , Chiara Colessi , Gianfranco Caselli , Paolo Comoglio
发明人： Enzo Medico , Paolo Michieli , Chiara Colessi , Gianfranco Caselli , Paolo Comoglio
IPC分类号： A61K3800
CPC分类号： C07K14/4753 , A61K38/00 , C07K2319/02
摘要： Recombinant proteins derived by recombination of structural domains obtained from alpha and beta subunits of HGF and/or MSP growth factors. These recombinant proteins contain domains selected from HGF and MSP, and are useful to protect cells, including differentiated cell elements of liver, kidney, and mucosa of the gastorenteral tract, from death (i.e., apoptosis) induced by chemotherapeutics.
摘要翻译：通过从HGF和/或MSP生长因子的α和β亚基获得的结构域的重组产生的重组蛋白质。这些重组蛋白含有选自HGF和MSP的结构域，并且可用于保护细胞，包括胃肠道的肝，肾和粘膜的分化的细胞元件免受化学治疗剂诱导的死亡（即凋亡）。

2. 发明授权

US06551991B1 Recombinant proteins derived from HGF and MSP 失效
标题翻译：来自HGF和MSP的重组蛋白
公开(公告)号：US06551991B1
公开(公告)日：2003-04-22
申请号：US09600991
申请日：2000-09-15
申请人： Enzo Medico , Paolo Michieli , Chiara Collesi , Gianfranco Caselli , Paolo Comoglio
发明人： Enzo Medico , Paolo Michieli , Chiara Collesi , Gianfranco Caselli , Paolo Comoglio
IPC分类号： A61K3800
CPC分类号： C07K14/4753 , A61K38/00 , C07K2319/02 , C12N2799/026
摘要： Recombinant proteins deriving from recombination of structural domains deriving from the &agr; subunits of HGF and/or MSP growth factors. The recombinant proteins of the present invention have biological activity, and protect cells from death (apoptosis) induced by chemotherapeutic drugs. These molecules can conveninently be used to prevent or to treat the toxic side effects of chemotherapeutic agents used in cancer therapy.
摘要翻译：衍生自HGF和/或MSP生长因子的α亚基的结构域的重组的重组蛋白质。本发明的重组蛋白质具有生物活性，保护细胞免受化疗药物诱导的死亡（凋亡）。这些分子可以方便地用于预防或治疗癌症治疗中使用的化学治疗剂的毒副作用。

3. 发明授权

US6030949A Macrophage stimulating protein for the treatment of pathologies of the nervous system 失效
标题翻译：巨噬细胞刺激蛋白用于治疗神经系统病理学
公开(公告)号：US6030949A
公开(公告)日：2000-02-29
申请号：US84233
申请日：1998-05-26
申请人： Paolo Comoglio , Alessandro Vercelli , Francesco Galimi , Gianfranco Caselli , Maria Cristina Stella
发明人： Paolo Comoglio , Alessandro Vercelli , Francesco Galimi , Gianfranco Caselli , Maria Cristina Stella
IPC分类号： A61K38/00 , A61K38/18 , A61K48/00 , A61K38/16
CPC分类号： A61K38/1833 , A61K48/00
摘要： The present invention refers to the use of Macrophage Stimulating Protein (MSP) for the preparation of a medicament for the treatment of pathologies of the central and peripheral nervous system of traumatic, infectious or inflammatory origin.
摘要翻译：本发明涉及巨噬细胞刺激蛋白（MSP）用于制备用于治疗创伤，感染性或炎性起源的中枢和周围神经系统的病理学的药物的用途。

4. 发明授权

US5594105A Peptide inhibitors of mitogenesis and motogenesis 失效
标题翻译：有丝分裂和机制的肽抑制剂
公开(公告)号：US5594105A
公开(公告)日：1997-01-14
申请号：US266514
申请日：1994-06-27
申请人： Paolo Comoglio , Carola Ponzetto
发明人： Paolo Comoglio , Carola Ponzetto
IPC分类号： C12N15/09 , A61K38/00 , A61K38/03 , A61K38/10 , A61K38/45 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/71 , C12N9/12 , C12P21/02 , C12R1/91 , C07K7/00
CPC分类号： C12N9/12 , C07K14/71 , A61K38/00
摘要： The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility. The peptides of the invention may be chemically synthesized from single amino acids and/or preformed peptides of two or more amino acid residues.The peptides of the invention find an useful application in the treatment of a neoplastic disease.
摘要翻译：细胞生物学领域中的发明涉及能够与细胞内信号转导体相互作用的新型肽，从而干扰导致细胞增殖和运动的信号转导途径。本发明的肽可以由单个氨基酸和/或两个或更多个氨基酸残基的预制肽化学合成。本发明的肽在治疗肿瘤性疾病中发现有用的应用。

5. 发明授权

US5968501A Hepatocyte growth factor--induced proliferation and differentiation of erythroid cells 失效
标题翻译：肝细胞生长因子诱导的红细胞增殖和分化
公开(公告)号：US5968501A
公开(公告)日：1999-10-19
申请号：US836896
申请日：1997-05-22
申请人： Paolo Comoglio
发明人： Paolo Comoglio
IPC分类号： C12N15/09 , A61K38/00 , A61K38/18 , A61P1/16 , A61P7/00 , C07K14/475 , C07K14/52 , C12N5/06 , C12P21/02 , C12R1/91
CPC分类号： C07K14/4753 , A61K38/1833 , C12N2799/026
摘要： Hepatocyte growth factor stimulates proliferation and differentiation of hematopoietic cells, most preferably burst-forming unit-erythroid cells. The hepatocyte growth factor may be obtained from cells transformed with human gene sequences coding therefor. Pharmaceutical compositions useful to induce the proliferation and differentiation of hematopoietic cells may contain hepatocyte growth factor as an active principle in admixture with a suitable carrier. The pharmaceutical compositions may additionally contain stem cell factor as an active principle.
摘要翻译： PCT No.PCT / EP95 / 04589 Sec。 371日期：1997年5月22日 102（e）日期1997年5月22日PCT提交1995年11月22日PCT公布。出版物WO96 / 15802 日期1996年5月30日血细胞生长因子刺激造血细胞的增殖和分化，最优选的是形成爆发的单位红细胞。肝细胞生长因子可以从用其编码的人基因序列转化的细胞获得。用于诱导造血细胞增殖和分化的药物组合物可以含有作为与合适载体混合的活性成分的肝细胞生长因子。药物组合物可另外含有作为活性成分的干细胞因子。

6. 发明授权

US5912183A Peptide inhibitors of mitogenesis and motogenesis 失效
标题翻译：有丝分裂和机制的肽抑制剂
公开(公告)号：US5912183A
公开(公告)日：1999-06-15
申请号：US654604
申请日：1996-05-29
申请人： Paolo Comoglio , Carola Ponzetto
发明人： Paolo Comoglio , Carola Ponzetto
IPC分类号： C12N15/09 , A61K38/00 , A61K38/03 , A61K38/10 , A61K38/45 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/71 , C12N9/12 , C12P21/02 , C12R1/91 , C07K7/00
CPC分类号： C12N9/12 , C07K14/71 , A61K38/00
摘要： The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility.The peptides of the invention may be chemically synthesized from single amino acids and/or preformed peptides of two or more amino acid residues.The peptides of the invention find an useful application in the treatment of a neoplastic disease.
摘要翻译：细胞生物学领域中的发明涉及能够与细胞内信号转导体相互作用的新型肽，从而干扰导致细胞增殖和运动的信号转导途径。本发明的肽可以由单个氨基酸和/或两个或更多个氨基酸残基的预制肽化学合成。本发明的肽在治疗肿瘤性疾病中发现有用的应用。

7. 发明授权

US06245742B1 Peptide antagonists of cellular mitogenesis and motogenesis and their therapeutic use 失效
标题翻译：细胞有丝分裂和机制的肽拮抗剂及其治疗用途
公开(公告)号：US06245742B1
公开(公告)日：2001-06-12
申请号：US08930616
申请日：1997-10-15
申请人： Carlo Battistini , Patrizia Giordano , Sabrina De Rosa , Fabio Corradi , Paolo Comoglio , Alberto Bardelli
发明人： Carlo Battistini , Patrizia Giordano , Sabrina De Rosa , Fabio Corradi , Paolo Comoglio , Alberto Bardelli
IPC分类号： A61K3800
CPC分类号： C07K5/0827 , C07K5/0202 , C07K5/1016 , C07K5/1027 , C07K14/71
摘要： The present invention relates to peptides and peptidomimetic compounds and pharmaceutical compositions containing them as useful pharmacological agents in the control or treatment of proliferative diseases such as cancer, against tumor growing and/or tumoral metastasis, and psoriasis and in the control or treatment of inflammatory, allergic, autoimmune, viral, and cardiovascular diseases. These new compounds have the unique property to inhibit the recognition of several phosphotyrosine containing motifs within all the cellular receptors and cytosolic transducers by a wide spectrum of SH2 domains contained in cytosolic transducers and other effector proteins laying along different pathways of the signal transduction process and with a particularly high affinity for the SH2 domain of the adaptor transducer Grb2, a key element along the pathway to mitogenesis and motogenesis, this last activity leading to invasiveness and to metastasis. The invention also relates to methods for production of the compounds and methods of treatment employing the compounds.
摘要翻译：本发明涉及肽和拟肽化合物和药物组合物，其含有它们作为控制或治疗增殖性疾病如癌症，抗肿瘤生长和/或肿瘤转移以及牛皮癣以及控制或治疗炎症，过敏性，自身免疫性，病毒性和心血管疾病。这些新化合物具有独特的性质，可以通过广泛的SH2结构域抑制所有细胞受体和细胞溶质转导体中识别的含有多种含磷酸酪氨酸基序，这些SH2结构域包含在信号转导过程不同途径的细胞溶质转导和其他效应蛋白中，对于适应器传感器Grb2的SH2结构域特别高的亲和力，Grb2是沿着有丝分裂和发育的途径的关键因素，这是导致侵袭和转移的最后一个活动。本发明还涉及化合物的制备方法和使用该化合物的处理方法。

8. 发明授权

US5571509A Truncated forms of the hepatocyte growth factor (HGF) receptor 失效
标题翻译：截短形式的肝细胞生长因子（HGF）受体
公开(公告)号：US5571509A
公开(公告)日：1996-11-05
申请号：US879384
申请日：1992-05-07
申请人： Paolo Comoglio , Tiziana Crepaldi , Maria Prat
发明人： Paolo Comoglio , Tiziana Crepaldi , Maria Prat
IPC分类号： A61K38/00 , C07K14/00 , C07K14/705 , C07K14/71 , C07K14/82 , C07K16/32 , C07K19/00 , C12N5/06 , C12N9/12 , C12N15/12 , C12P21/02 , C12R1/91 , C12N9/10 , A61K38/45
CPC分类号： C07K14/82 , C07K16/32 , A61K38/00
摘要： A protein, which is useful as an antagonist of hepatocyte growth factor, is composed of two disulphide-linked chains of 50 kDa and 75 or 85 kDa respectively, the 5 kDa chain being the .alpha.-chain of the tyrosine kinase encoded by the MET protooncogene and the 75 or 85 kDa chain being a C-terminal truncated form of the .beta.-chain of the said tyrosine kinase.
摘要翻译：可用作肝细胞生长因子拮抗剂的蛋白质分别由50kDa和75或85kDa的两个二硫键连接的链组成，5kDa链是由MET原癌基因编码的酪氨酸激酶的α-链并且75或85kDa链是所述酪氨酸激酶的β-链的C-末端截短形式。

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