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1. 发明授权

US5776141A Method and apparatus for intraluminal prosthesis delivery 失效
标题翻译：腔内假体递送的方法和装置
公开(公告)号：US5776141A
公开(公告)日：1998-07-07
申请号：US704801
申请日：1996-08-26
申请人： Enrique J. Klein , Aaron V. Kaplan , Mark Clifford , Martin Overbeek-Bloem
发明人： Enrique J. Klein , Aaron V. Kaplan , Mark Clifford , Martin Overbeek-Bloem
IPC分类号： A61M25/00 , A61F2/00 , A61F2/82 , A61F2/958 , A61F11/00
CPC分类号： A61F2/958 , A61F2002/826 , A61F2002/9583 , A61F2250/0098
摘要： A catheter for use in combination with a balloon angioplasty catheter for delivering stents and other intraluminal prostheses comprises a tubular catheter body having a radially expansible portion. The stent is disposed over the radially expansible portion, and structure is provided for retaining the stent on the tubular body prior to deployment. The retaining structure may be active, i.e., requiring the user to retract retaining elements, such as axial members, sheaths, or the like. Alternatively, the retaining structure may be passive, wherein balloon expansion results in release of the prosthesis from the retaining structure. Particular methods for fluoroscopically positioning stents using such delivery catheters, for delivering two or more stents using such delivery catheters, and for overexpanding the ends of the stents for anchoring them in place, are also described.
摘要翻译：用于与用于输送支架和其他管腔内假体的气囊血管成形术导管组合使用的导管包括具有径向可膨胀部分的管状导管体。支架设置在径向可膨胀的部分上，并且提供结构用于在展开之前将支架保持在管状体上。保持结构可以是有效的，即要求用户缩回保持元件，例如轴向元件，护套等。或者，保持结构可以是被动的，其中球囊膨胀导致假体从保持结构的释放。还描述了使用这种输送导管的透视定位支架，用于使用这种输送导管输送两个或更多个支架以及用于过度扩张支架的端部以将其固定在适当位置的特定方法。

2. 发明授权

US5609574A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5609574A
公开(公告)日：1997-03-11
申请号：US241428
申请日：1994-05-11
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在第一实施例中，柔性导管主体具有连接到其远端的膨胀构件与膨胀通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输注排列。在第二实施例中，输注阵列是单独的部件，并且可滑动地容纳在膨胀部件上，膨胀部件可以是球囊扩张导管。在两个实施例中，输注阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

3. 发明授权

US5336178A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5336178A
公开(公告)日：1994-08-09
申请号：US47737
申请日：1993-04-15
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a preferred embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. The infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在优选实施例中，柔性导管主体具有连接到其远端的膨胀构件，其与充气通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输液阵列。输液阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

4. 发明授权

US5840008A Radiation emitting sleeve catheter and methods 失效
标题翻译：辐射套管导管及方法
公开(公告)号：US5840008A
公开(公告)日：1998-11-24
申请号：US555457
申请日：1995-11-13
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M25/00 , A61B17/22 , A61M36/04 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1002 , A61B2017/22068 , A61M2025/1047 , A61N2005/1004 , A61N2005/1005 , A61N2005/1018 , A61N2005/1023 , A61N2005/1025
摘要： The invention provides methods and devices for delivering low level radiation to inhibit neointimal hyperplasia following angioplasty or other intravascular procedures. In an exemplary method, a balloon is inflated within a stenosed region of a blood vessel to produce a treated region. The balloon is then deflated and a radioactive source within a sleeve is aligned over the deflated balloon. The balloon is again inflated at the treated region to engage the sleeve having the radioactive source against the blood vessel within the treated region for from 1 to 40 minutes to deliver a sufficient dosage of radiation to inhibit neointimal hyperplasia.
摘要翻译：本发明提供用于在血管成形术或其他血管内手术之后递送低水平辐射以抑制新内膜增生的方法和装置。在示例性方法中，气球在血管的狭窄区域内充气以产生治疗区域。气球然后放气，套筒内的放射源在放气气球上对准。气囊在处理区域再次膨胀，以将具有放射源的套筒与处理区域内的血管接合1至40分钟以递送足够剂量的辐射以抑制新生内膜增生。

5. 发明授权

US5713860A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5713860A
公开(公告)日：1998-02-03
申请号：US464153
申请日：1995-06-05
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在第一实施例中，柔性导管主体具有连接到其远端的膨胀构件与膨胀通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输注排列。在第二实施例中，输注阵列是单独的部件，并且可滑动地容纳在膨胀部件上，膨胀部件可以是球囊扩张导管。在两个实施例中，输注阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

6. 发明授权

US5599306A Method and apparatus for providing external perfusion lumens on balloon catheters 失效
标题翻译：用于在气囊导管上提供外部灌注腔的方法和装置
公开(公告)号：US5599306A
公开(公告)日：1997-02-04
申请号：US536555
申请日：1995-09-29
申请人： Enrique J. Klein , Jordan Bajor , Paul Alba , Aaron V. Kaplan
发明人： Enrique J. Klein , Jordan Bajor , Paul Alba , Aaron V. Kaplan
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0025 , A61M2025/0063 , A61M2025/0183 , A61M2025/1004 , A61M2025/1072 , A61M2025/1079 , A61M2025/1081 , A61M2025/1095 , A61M25/0023 , A61M25/1002
摘要： A catheter sleeve includes a radially expansible distal region having a plurality of axial blood perfusion lumens or channels formed thereon. The catheter sleeve may be introduced over a conventional angioplasty balloon catheter with the expansible region lying over the balloon. When the balloon of the angioplasty catheter is expanded, the perfusion lumens will provide a flow path for blood around the expanded balloon. Optionally, the catheter sleeve may further include drug infusion lumens over the radially expansible region. In this way, drugs can be delivered over prolonged periods while the underlying angioplasty balloon is inflated and blood flows through the lumens or channels to perfuse the distal myocardium.
摘要翻译：导管套管包括具有多个轴向血液灌注腔或形成在其上的通道的可径向扩张的远端区域。可以将导管套管引入常规的血管成形术球囊导管，其中可膨胀区域位于气囊上。当血管成形术导管的气囊膨胀时，灌注内腔将为扩张的气囊周围的血液提供流路。任选地，导管套筒还可包括在径向可膨胀区域上的药物输注腔。以这种方式，药物可以在长时间内递送，而下面的血管成形术球囊被充气并且血液流过腔或通道以灌注远端心肌。

7. 发明授权

US5855563A Method and apparatus for sequentially performing multiple intraluminal procedures 失效
标题翻译：顺序执行多个腔内手术的方法和装置
公开(公告)号：US5855563A
公开(公告)日：1999-01-05
申请号：US666778
申请日：1996-06-19
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： Sleeve catheters having an interactive device near their distal ends are provided for introduction while disposed over conventional interventional and imaging catheters. Exemplary interactive devices on the sleeve catheters include ultrasonic imaging arrays, drug delivery lumens, and the like. The sleeve catheters are most commonly used with angioplasty catheters, stent placement catheters, atherectomy catheters, and the like.
摘要翻译：在其远端附近具有交互式装置的套管设置用于引入，同时设置在常规介入和成像导管之上。套管导管上的示例性交互设备包括超声波成像阵列，药物输送腔等。套管导管最常用于血管成形术导管，支架置入导管，粥样斑块切除术导管等。

8. 发明授权

US5279565A Intravascular treatment apparatus and method 失效
标题翻译：血管内治疗装置及方法
公开(公告)号：US5279565A
公开(公告)日：1994-01-18
申请号：US12704
申请日：1993-02-03
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M25/007 , A61M29/02 , A61B2017/22084 , A61M2025/0057 , A61M2025/0096 , A61M2025/1095
摘要： An intravascular treatment apparatus provides means for infusing a treatment site with an agent and means for positioning the delivery interface against the treatment site which operate independently of one another. In a preferred embodiment, the apparatus includes a flexible body having a deflectable support frame at its distal end. A plurality of platforms, each comprising a plenum and a delivery interface, is coupled to the support frame. The platforms may be deployed radially from the body by deflecting the support frame using an actuator shaft extending through a passage in the body. The platforms are connected to a supply passage through the body. In this way, the apparatus may be positioned within a body lumen, usually an artery, with the platforms near a treatment site. By actuating the actuator shaft, the platforms are deployed against the treatment site. Independently of the platform deployment, a therapeutic agent may be supplied to the platforms and expelled through the delivery interface and into the treatment site to impregnate the treatment site.
摘要翻译：血管内治疗装置提供用于向治疗部位注入药剂的装置和用于将输送界面定位在相互独立操作的治疗部位上的装置。在优选实施例中，该装置包括柔性主体，其在其远端具有可偏转的支撑框架。多个平台，每个平台包括一个增压室和一个输送界面，它连接到支撑框架上。平台可以通过使用延伸穿过身体中的通道的致动器轴使支撑框架偏转而从身体径向展开。平台连接到穿过身体的供应通道。以这种方式，该装置可以位于体腔内，通常是动脉，其中平台靠近治疗部位。通过致动致动器轴，平台相对于处理部位展开。独立于平台部署，治疗剂可以供应到平台并通过输送界面排出并进入治疗部位以浸渍治疗部位。

9. 发明授权

US5658248A Double-blind infusion device and method 失效
标题翻译：双盲输液装置及方法
公开(公告)号：US5658248A
公开(公告)日：1997-08-19
申请号：US511567
申请日：1995-08-04
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M5/14 , A61M5/00 , A61M5/168 , A61M39/00 , A61M1/00
CPC分类号： A61M5/00
摘要： Type-A (operational) and type-B (non-operational) syringes (2A, 2B), used for double-blind clinical tests, are constructed so the type-B syringe mimics the operation of the type-A syringe while avoiding the delivery of anything into the patient. Each syringe includes an injector (4), a fluid connector (12) coupling the exit port (10) of the injector to a discharge port (14) to which a catheter or needle cannula is connected, a valve (18) positioned along the fluid connector, and a dumping reservoir (24) mounted to the valve. The type-A valve fluidly couples the exit port to the discharge port in both purging and infusion positions. The type-B valve couples the exit port to the discharge port in the purging position, but couples the exit port to the dumping reservoir in the infusion position. The infusate is directed through the catheter and into the patient when in the infusion position with the type-A valve but is directed into the dumping reservoir with the type-B valve.
摘要翻译：构建用于双盲临床试验的A型（可操作）和B型（非操作型）注射器（2A，2B），因此B型注射器模拟A型注射器的操作，同时避免将任何东西交付给患者。每个注射器包括注射器（4），将注射器的出口（10）连接到导管或针插管所连接的排出口（14）的流体连接器（12），沿着流体连接器和安装到阀的倾倒储存器（24）。 A型阀在清洗和排液位置都将出口流体地连接到排出口。 B型阀将出口连接到排气位置的排出口，但将输出端口连接到倾倒储存器的输液位置。当使用A型阀的输液位置时，输注物通过导管引导进入患者，但是用B型阀引导到倾倒储存器中。

10. 发明授权

US5571086A Method and apparatus for sequentially performing multiple intraluminal procedures 失效
公开(公告)号：US5571086A
公开(公告)日：1996-11-05
申请号：US222143
申请日：1994-04-01
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： Sleeve catheters having an interactive device near their distal ends are provided for introduction while disposed over conventional interventional and imaging catheters. Exemplary interactive devices on the sleeve catheters include ultrasonic imaging arrays, drug delivery lumens, and the like. The sleeve catheters are most commonly used with angioplasty catheters, stent placement catheters, atherectomy catheters, and the like.

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