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1. 发明申请

US20130245757A1 METHOD AND DEVICE FOR IMPROVED SOFT TISSUE SURGERY 审中-公开
标题翻译：改进软组织手术的方法和装置
公开(公告)号：US20130245757A1
公开(公告)日：2013-09-19
申请号：US13601254
申请日：2012-08-31
申请人： Gregory H. Altman , Enrico Mortarino , Raymond E. Olsen
发明人： Gregory H. Altman , Enrico Mortarino , Raymond E. Olsen
IPC分类号： A61F2/12 , D04B1/22
CPC分类号： A61F2/12 , A61L27/3604 , A61L27/3645 , A61L2430/04 , D04B1/22 , D04B21/12 , D10B2211/04 , D10B2509/08
摘要： Methods for determining suitability of an implantable silk scaffold for use in human soft tissue repair by implanting a silk scaffold in a quadruped. The silk scaffold is completely or essentially completely bioresorbed by twelve months after implantation, the silk scaffold (to the extent remaining) with ingrown tissue shows at least about a 60% strength increase by 12 months after implantation, and the thickness of the silk scaffold (to the extent remaining) with ingrown tissue increases by more than 100% by 12 months after implantation.
摘要翻译：通过将丝状支架植入四足体中来确定用于人类软组织修复的可植入丝支架的适用性的方法。丝网支架在植入后十二个月完全或基本上完全生物吸收，植入后12个月时，具有内嵌组织的丝支架（至剩余部分）显示出至少约60％的强度增加，以及丝支架在植入后12个月内，向内生长的组织增加超过100％。

2. 发明申请

US20120185041A1 SILK MEDICAL DEVICE FOR USE IN BREAST AUGMENTATION AND BREAST RECONSTRUCTION 审中-公开
标题翻译：用于乳腺增生和乳腺重建的SILK医疗装置
公开(公告)号：US20120185041A1
公开(公告)日：2012-07-19
申请号：US13306325
申请日：2011-11-29
申请人： Enrico Mortarino , Gregory H. Altman
发明人： Enrico Mortarino , Gregory H. Altman
IPC分类号： A61F2/12
CPC分类号： A61F2/12 , A61F2/0063 , A61F2002/0068 , A61L27/3604 , A61L27/3641 , A61L2430/04 , D04B1/22 , D04B21/12 , D10B2509/08
摘要： A method of using a silk derived medical device in a breast augmentation or in a breast reconstruction cosmetic or surgical procedure such as single-stage or two-stage breast reconstruction or augmentation. The device can be a silk scaffold with a knit pattern that substantially prevents unraveling and preserves the stability of the scaffold especially when cut. An example device can have a knitted mesh which includes at least two yarns laid in a knit direction and engaging each other to define a plurality of node.
摘要翻译：一种使用蚕丝衍生的医疗装置在乳房增大或乳房重建化妆品或外科手术如单级或两级乳房重建或增大中的方法。该装置可以是具有编织图案的丝线支架，其基本上防止破裂并保持支架的稳定性，特别是在切割时。示例性装置可以具有编织网，其包括以编织方向布置的至少两根纱线并且彼此接合以限定多个节点。

3. 发明申请

US20120022646A1 PROSTHETIC DEVICE AND METHOD OF USING IN BREAST AUGMENTATION AND/OR BREAST RECONSTRUCTION 审中-公开
标题翻译：乳腺增生和/或乳房重建中的前体装置和使用方法
公开(公告)号：US20120022646A1
公开(公告)日：2012-01-26
申请号：US13186151
申请日：2011-07-19
申请人： Enrico Mortarino , Gregory H. Altman
发明人： Enrico Mortarino , Gregory H. Altman
IPC分类号： A61F2/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61F2250/0015 , A61F2250/0018 , A61F2250/0019 , A61L27/3604 , A61L27/3641 , A61L2430/04 , D04B1/22 , D04B21/12 , D10B2509/08
摘要： A method of using a biocompatible surgical knitted, silk scaffold device in a breast augmentation or in s breast reconstruction cosmetic or surgical procedure such as single-stage or two-stage breast reconstruction. In an aspect of the invention, the silk scaffold employs a knit pattern that substantially prevents unraveling and preserves the stability of the mesh or scaffold device, especially when the mesh or scaffold device is cut. An example scaffold device employs a knitted mesh including at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. The second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：一种在乳房增大或乳房重建化妆品或外科手术如单阶段或两阶段乳房重建中使用生物相容性手术针织，丝绸支架装置的方法。在本发明的一个方面，丝网支架采用基本上防止开裂并保持网状物或支架装置的稳定性的针织图案，特别是当切割网状物或支架装置时。示例性支架装置使用包括至少两根沿着编织方向布置的纱线的针织网，并且彼此接合以限定多个节点。所述至少两根纱线包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

4. 发明授权

US09204953B2 Biocompatible surgical scaffold with varying stretch 有权
标题翻译：生物相容性手术脚手架不同伸展
公开(公告)号：US09204953B2
公开(公告)日：2015-12-08
申请号：US13088833
申请日：2011-04-18
申请人： Enrico Mortarino
发明人： Enrico Mortarino
IPC分类号： A61F2/00 , A61F2/12 , A61L27/36 , D04B1/22 , D04B21/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61F2250/0017 , A61L27/3604 , D04B1/22 , D04B21/12 , D10B2509/08
摘要： A biocompatible surgical scaffold made from a multi-filament silk yarn for soft tissue reconstruction. The scaffold incorporates regions of varying stretch having different physical and mechanical properties that allow contouring to the required soft tissue shape to be replaced or repaired. The porous structure allows tissue in-growth, while the mesh degrades at a rate which allows for a smooth transfer of mechanical properties to the new tissue from the silk scaffold.
摘要翻译：一种用于软组织重建的由多丝丝纱制成的生物相容性手术支架。支架结合具有不同物理和机械性质的不同拉伸区域，其允许轮廓化到要更换或修理的所需软组织形状。多孔结构允许组织生长，而网状物以允许从丝网支架平滑转移机械性能到新组织的速率降解。

5. 发明申请

US20130116785A1 SILK BASED IMPLANTABLE MEDICAL DEVICES AND METHODS FOR DETERMINING SUITABILITY FOR USE IN HUMANS 审中-公开
标题翻译：基于SILK的可植入医疗装置和用于确定人体适用性的方法
公开(公告)号：US20130116785A1
公开(公告)日：2013-05-09
申请号：US13372248
申请日：2012-02-13
申请人： Gregory H. Altman , Enrico Mortarino , Raymond E. Olsen
发明人： Gregory H. Altman , Enrico Mortarino , Raymond E. Olsen
IPC分类号： A61F2/12
CPC分类号： A61L27/56 , A61F2/0063 , A61F2/12 , A61F2002/0068 , A61F2240/008 , A61L27/227 , A61L2430/04 , D04B21/12 , D10B2509/08
摘要： Methods for determining suitability of an implantable silk scaffold for use in human soft tissue repair by implanting a silk scaffold in a quadruped. The silk scaffold is completely or essentially completely bioresorbed by twelve months after implantation, the silk scaffold (to the extent remaining) with ingrown tissue shows at least about a 60% strength increase by 12 months after implantation, and the thickness of the silk scaffold (to the extent remaining) with ingrown tissue increases by more than 100% by 12 months after implantation.
摘要翻译：通过将丝状支架植入四足体中来确定用于人类软组织修复的可植入丝支架的适用性的方法。丝网支架在植入后十二个月完全或基本上完全生物吸收，植入后12个月时，具有内嵌组织的丝支架（至剩余部分）显示出至少约60％的强度增加，以及丝支架在植入后12个月内，向内生长的组织增加超过100％。

6. 发明申请

US20130006279A1 PROSTHETIC DEVICE AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：前置装置及其制造方法
公开(公告)号：US20130006279A1
公开(公告)日：2013-01-03
申请号：US13605631
申请日：2012-09-06
申请人： Enrico Mortarino
发明人： Enrico Mortarino
IPC分类号： A61B17/03
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L27/3604 , A61L31/047 , D04B1/14 , D04B1/22 , D04B7/00 , D04B21/12 , D10B2211/04 , D10B2509/08
摘要： A biocompatible surgical silk mesh prosthetic device employs a knit pattern that substantially prevents unraveling and preserves the stability of the mesh device, especially when the mesh device is cut. An example prosthetic device employs a knitted mesh including at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. the second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：生物相容性手术丝网假体装置采用基本上防止开裂的针织图案，并且保持网格装置的稳定性，特别是当网格装置被切割时。示例性假体装置使用包括至少两根沿针织方向布置的纱线的针织网，并且彼此接合以限定多个节点。所述至少两根纱线包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

7. 发明申请

US20120004723A1 PROSTHETIC DEVICE AND METHOD OF USING IN BREAST AUGMENTATION AND/OR BREAST RECONSTRUCTION 审中-公开
标题翻译：乳腺增生和/或乳房重建中的前体装置和使用方法
公开(公告)号：US20120004723A1
公开(公告)日：2012-01-05
申请号：US13156283
申请日：2011-06-08
申请人： Enrico Mortarino , Gregory H. Altman
发明人： Enrico Mortarino , Gregory H. Altman
IPC分类号： A61F2/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L27/3604 , D04B1/22 , D04B21/12 , D10B2509/08
摘要： A method of using a biocompatible surgical knitted, silk scaffold device in a breast augmentation or in a breast reconstruction cosmetic or surgical procedure such as single-stage or two-stage breast reconstruction. In an aspect of the invention, the silk scaffold employs a knit pattern that substantially prevents unraveling and preserves the stability of the mesh or scaffold device, especially when the mesh or scaffold device is cut. An example scaffold device employs a knitted mesh including at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. The second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：一种在乳房增大或乳房重建化妆品或外科手术如单阶段或两级乳房重建中使用生物相容的外科手术针织，丝绸支架装置的方法。在本发明的一个方面，丝网支架采用基本上防止开裂并保持网状物或支架装置的稳定性的针织图案，特别是当切割网状物或支架装置时。示例性支架装置使用包括至少两根沿着编织方向布置的纱线的针织网，并且彼此接合以限定多个节点。所述至少两根纱线包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

8. 发明申请

US20110224703A1 PROSTHETIC DEVICE HAVING DIAGONAL YARNS AND METHOD OF MANUFACTURING THE SAME 有权
标题翻译：具有对角纱的前置装置及其制造方法
公开(公告)号：US20110224703A1
公开(公告)日：2011-09-15
申请号：US13093651
申请日：2011-04-25
申请人： Enrico Mortarino
发明人： Enrico Mortarino
IPC分类号： A61B17/03 , D04B21/00 , D04B7/30 , D04B7/04
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L27/3604 , D04B1/22 , D04B21/08 , D04B21/12 , D10B2509/08
摘要： A knitted scaffold comprising at least two silk yarns in a knit direction and a yarn member diagonal to the knit direction to thereby provide a knitted fabric or mesh for surgical use that can retain its shape and/or resist collapse when opposing forces are applied at an angle from the knit direction. The knitted scaffold may include at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns can include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. The second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：一种编织支架，其包括至少两根编织方向的丝线和与编织方向对角的纱线构件，从而提供用于外科用途的针织物或网状物，其可以在相对的力施加在角度从编织方向。针织支架可以包括至少两根以编织方向铺设的纱线并且彼此接合以限定多个节点。所述至少两根纱线可以包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

9. 发明授权

US09326840B2 Prosthetic device and method of manufacturing the same 有权
标题翻译：假体装置及其制造方法
公开(公告)号：US09326840B2
公开(公告)日：2016-05-03
申请号：US13088706
申请日：2011-04-18
申请人： Enrico Mortarino
发明人： Enrico Mortarino
IPC分类号： A61F2/00 , A61F2/12 , A61L27/36 , D04B1/22 , D04B21/08 , D04B21/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L27/3604 , D04B1/14 , D04B1/22 , D04B21/08 , D04B21/12 , D10B2509/08
摘要： A biocompatible surgical silk mesh prosthetic device employs a knit pattern that substantially prevents unraveling and preserves the stability of the mesh device, especially when the mesh device is cut. An example prosthetic device employs a knitted mesh including at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. the second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：生物相容性手术丝网假体装置采用基本上防止开裂的针织图案，并且保持网格装置的稳定性，特别是当网格装置被切割时。示例性假体装置使用包括至少两根沿针织方向布置的纱线的针织网，并且彼此接合以限定多个节点。所述至少两根纱线包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

10. 发明授权

US09204954B2 Knitted scaffold with diagonal yarn 有权
标题翻译：带对角纱的针织脚手架
公开(公告)号：US09204954B2
公开(公告)日：2015-12-08
申请号：US13093651
申请日：2011-04-25
申请人： Enrico Mortarino
发明人： Enrico Mortarino
IPC分类号： A61F2/00 , A61F2/12 , A61L27/36 , D04B1/22 , D04B21/08 , D04B21/12
CPC分类号： A61F2/0063 , A61F2/12 , A61F2002/0068 , A61L27/3604 , D04B1/22 , D04B21/08 , D04B21/12 , D10B2509/08
摘要： A knitted scaffold comprising at least two silk yarns in a knit direction and a yarn member diagonal to the knit direction to thereby provide a knitted fabric or mesh for surgical use that can retain its shape and/or resist collapse when opposing forces are applied at an angle from the knit direction. The knitted scaffold may include at least two yarns laid in a knit direction and engaging each other to define a plurality of nodes. The at least two yarns can include a first yarn and a second yarn extending between and forming loops about two nodes. The second yarn has a higher tension at the two nodes than the first yarn. The second yarn substantially prevents the first yarn from moving at the two nodes and substantially prevents the knitted mesh from unraveling at the nodes.
摘要翻译：一种编织支架，其包括至少两根编织方向的丝线和与编织方向对角的纱线构件，从而提供用于外科用途的针织物或网状物，其可以在相对的力施加在角度从编织方向。针织支架可以包括至少两根以编织方向铺设的纱线并且彼此接合以限定多个节点。所述至少两根纱线可以包括第一纱线和在两个节点之间延伸并形成环的第二纱线。第二根纱线在两个节点处的张力比第一根纱线高。第二纱线基本上防止第一纱线在两个节点处移动，并且基本上防止针织网在节点处解开。

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