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1. 发明授权

US5323010A Time resolved optical array detectors and CCD cameras for frequency domain fluorometry and/or phosphorimetry 失效
标题翻译：用于频域荧光测定和/或荧光测定的时间分辨光学阵列检测器和CCD照相机
公开(公告)号：US5323010A
公开(公告)日：1994-06-21
申请号：US983829
申请日：1992-12-01
申请人： Enrico Gratton , Martin VandeVen , Beniamino Barbieri
发明人： Enrico Gratton , Martin VandeVen , Beniamino Barbieri
IPC分类号： G01J3/44 , G01N21/64
CPC分类号： G01N21/6408 , G01J3/4406 , G01N2021/1772 , G01N2021/1789
摘要： An apparatus for cross-correlation frequency domain fluorometry-phosphorimetry comprises a source of electromatic radiation and means for amplitude modulating the radiation at the first frequency. The amplitude modulated radiation is directed at a sample, while an optical array detector measures the resulting luminescence of the sample. A signal is provided coherent with the amplitude modulated electromagnetic radiation signals, at a second frequency which is different from the first frequency. The apparatus has the capability for shutting off and turning on the coherent signal at the second frequency in a cycle which is at a third frequency that is different from the difference between the first and second frequencies. This produces a resultant signal at a frequency derived from the difference and the third frequency. The resultant signal, when turned on, modulates the gain of the detecting means or multiplies its output, depending upon the nature of the detecting means. The amount of luminescence measured by the optical array detector is read when the coherent signal is off in its cycle of the third frequency. A signal from the reader described above is then detected at a frequency of the resultant signal to determine phase shift and modulation changes of the luminescence.
摘要翻译：用于互相关频域荧光测定法的装置包括电离辐射源和用于以第一频率幅度调制辐射的装置。幅度调制辐射指向样本，而光学阵列检测器测量样品的所得发光。在与第一频率不同的第二频率处提供与调幅电磁辐射信号相干的信号。该装置具有在与第一和第二频率之间的差异不同的周期中以第二频率关闭和接通相干信号的能力。这产生一个从差值和第三个频率得到的频率的合成信号。所得到的信号在导通时根据检测装置的性质调制检测装置的增益或乘法器的输出。当相干信号在其第三频率的周期中关闭时，读取由光学阵列检测器测量的发光量。然后在所得信号的频率处检测来自上述读取器的信号，以确定发光的相移和调制变化。

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