专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06504858B2 Lasers with low doped gain medium 有权
标题翻译：具有低掺杂增益介质的激光器
公开(公告)号：US06504858B2
公开(公告)日：2003-01-07
申请号：US09745378
申请日：2000-12-20
申请人： Emily Cheng , Dave R Dudley , William L. Nighan, Jr. , James D. Kafka , David E. Spence , David S. Bell
发明人： Emily Cheng , Dave R Dudley , William L. Nighan, Jr. , James D. Kafka , David E. Spence , David S. Bell
IPC分类号： H01S314
CPC分类号： H01S3/09415 , H01S3/07 , H01S3/08072 , H01S3/09408 , H01S3/109 , H01S3/1673
摘要： A high power, diode pumped laser has a Nd:YVO4 gain media. Scaling to higher powers is achieved with the use of a low doped gain media, increasing the length of the gain media as well as increasing the pump volume. Passive cooling is extended to output powers of 10 W or greater.
摘要翻译：大功率二极管泵浦激光器具有Nd：YVO4增益介质。通过使用低掺杂增益介质实现更高功率的扩展，增加了增益介质的长度以及增加了泵的体积。被动冷却延伸到10W或更大的输出功率。

2. 发明授权

US06185235B2 Lasers with low doped gain medium 有权
标题翻译：具有低掺杂增益介质的激光器
公开(公告)号：US06185235B2
公开(公告)日：2001-02-06
申请号：US09199031
申请日：1998-11-24
申请人： Emily Cheng , Dave R. Dudley , William L. Nighan, Jr. , James D. Kafka , David E. Spence , David S. Bell
发明人： Emily Cheng , Dave R. Dudley , William L. Nighan, Jr. , James D. Kafka , David E. Spence , David S. Bell
IPC分类号： H01S314
CPC分类号： H01S3/09415 , H01S3/07 , H01S3/08072 , H01S3/09408 , H01S3/109 , H01S3/1673
摘要： A high power, diode pumped laser has a Nd:YVO4 gain media. Scaling to higher powers is achieved with the use of a low doped gain media, increasing the length of the gain media as well as increasing the pump volume. Passive cooling is extended to output powers of 10 W or greater .
摘要翻译：大功率二极管泵浦激光器具有Nd：YVO4增益介质。通过使用低掺杂增益介质实现更高功率的扩展，增加了增益介质的长度以及增加了泵的体积。被动冷却延伸到10W或更大的输出功率。

3. 发明授权

US5835513A Q-switched laser system providing UV light 失效
标题翻译： Q开关激光系统提供紫外光
公开(公告)号：US5835513A
公开(公告)日：1998-11-10
申请号：US780495
申请日：1997-01-08
申请人： Jan-Willem Pieterse , Alan B. Petersen , Chris Pohalski , Emily Cheng , Randall Lane , William L. Nighan, Jr.
发明人： Jan-Willem Pieterse , Alan B. Petersen , Chris Pohalski , Emily Cheng , Randall Lane , William L. Nighan, Jr.
IPC分类号： G02F1/35 , G02F1/37 , H01S3/109 , H01S3/11 , H01S3/16 , H01S3/10
CPC分类号： G02F1/353 , G02F1/3534 , G02F1/37 , G02F2001/354 , G02F2201/16
摘要： A diode pumped laser includes a high reflector and an output coupler defining a resonator. The resonator includes a gain medium and a Q-switch and produces a fundamental beam. A first non-linear crystal is positioned extra-cavity of the resonator along a path of the fundamental beam. The first non-linear crystal generates a second harmonic beam from the fundamental beam. The first non-linear crystal is critically phased matched. A second non-linear crystal is portioned extra-cavity of the resonator along a path of the fundamental beam and the path of the second harmonic beam. The second non-linear crystal produces a third harmonic beam. The second non-linear crystal is critically phased matched.
摘要翻译：二极管泵浦激光器包括高反射器和限定谐振器的输出耦合器。谐振器包括增益介质和Q开关，并产生基波束。第一非线性晶体沿着基波束的路径被定位在谐振器的外腔。第一非线性晶体从基波束产生二次谐波。第一个非线性晶体被严格分阶段匹配。第二非线性晶体沿着基波束的路径和二次谐波束的路径被分成谐振器的外腔。第二非线性晶体产生三次谐波束。第二个非线性晶体是极其相位匹配的。

4. 发明授权

US08501811B2 TASPASE1 inhibitors and their uses 失效
标题翻译： TASPASE1抑制剂及其用途
公开(公告)号：US08501811B2
公开(公告)日：2013-08-06
申请号：US13162992
申请日：2011-06-17
申请人： James Hsieh , Emily Cheng
发明人： James Hsieh , Emily Cheng
IPC分类号： A61K31/175 , A61K31/519 , A61K31/41 , A61K31/415
CPC分类号： C07C335/40 , C07C327/42 , C07C2602/42 , C07D231/14 , C07D257/04 , C07D277/48 , C07D333/62 , C07D413/12 , C07D487/04
摘要： Provided herein are small molecule inhibitors of Taspase1 and methods of using the small molecule inhibitors of Taspase1 to treat neoplasm in subjects in need thereof.
摘要翻译：本文提供了Taspase1的小分子抑制剂和使用Taspase1的小分子抑制剂治疗有需要的受试者的肿瘤的方法。

5. 发明申请

US20060068482A1 Taspase1 and methods of use 审中-公开
标题翻译： Taspase1和使用方法
公开(公告)号：US20060068482A1
公开(公告)日：2006-03-30
申请号：US10974127
申请日：2004-10-26
申请人： James Hsieh , Stanley Korsmeyer , Susan Korsmeyer , Emily Cheng
发明人： James Hsieh , Stanley Korsmeyer , Susan Korsmeyer , Emily Cheng
IPC分类号： C12N9/64 , C07H21/04 , C12P21/06
CPC分类号： C12N9/6478
摘要： A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the MLL protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
摘要翻译：描述了一种新型蛋白酶Taspase1。 Taspase1参与MLL蛋白的切割，这是适当的HOX基因调控所必需的。提供使用Taspase1的诊断方法，以及Taspase1的抑制剂。还描述了使用Taspase1抑制剂的方法。例如，Taspase1的抑制剂可用于治疗受试者中的癌症，例如白血病。

6. 发明授权

US5907570A Diode pumped laser using gain mediums with strong thermal focussing 失效
标题翻译：二极管泵浦激光使用具有强烈热聚焦的增益介质
公开(公告)号：US5907570A
公开(公告)日：1999-05-25
申请号：US955768
申请日：1997-10-22
申请人： William L. Nighan , Mark S. Keirstead , Emily Cheng
发明人： William L. Nighan , Mark S. Keirstead , Emily Cheng
IPC分类号： H01S3/08 , H01S3/042 , H01S3/094 , H01S3/0941 , H01S3/16
CPC分类号： H01S3/09415 , H01S3/042 , H01S3/08045 , H01S3/0805 , H01S3/08072 , H01S3/1611 , H01S3/1673
摘要： A diode pumped laser includes a resonator mirror and an output coupler, defining a laser resonator with a resonator optical axis. A strong thermal lens gain medium with a TEM.sub.00 mode diameter is mounted in the resonator along the resonator optical axis. The dopant level of the gain medium is in the range of 0.01 to less than 0.5 percent. A diode pump source supplies a pump beam to the gain medium in the laser resonator, and produces an output beam with a diameter larger than the TEM.sub.00 mode diameter to reduce thermal birefringence. A power source supplies power to the diode pump source. A polarizing element can be positioned in the resonator, along with a aperture stop The laser operates well over a large range of pump powers. Its slope efficiency in the TEM.sub.00 mode is greater than 40%, with an overall efficiency greater than 25%. One of the gain mediums used is Nd:YVO.sub.4. This material exhibits high gain and a short upper state lifetime. These properties make it attractive in designing a Q-switched laser, or one that is insensitive to optical feedback. Another material is Nd:YAG. The technique of optimizing the pump beam spot size is found to minimize loss due to thermal birefringence.
摘要翻译：二极管泵浦激光器包括谐振器镜和输出耦合器，其限定具有谐振器光轴的激光谐振器。谐振器中沿着谐振器光轴安装了具有TEM00模式直径的强热透镜增益介质。增益介质的掺杂剂水平在0.01至小于0.5％的范围内。二极管泵浦源将激光束提供给激光谐振器中的增益介质，并产生直径大于TEM00模式直径的输出光束，以减少热双折射。电源为二极管泵浦源供电。偏振元件可以与孔径光阑一起定位在谐振器中。激光器在大范围的泵浦功率下运行良好。其TEM00模式的斜率效率大于40％，总效率大于25％。使用的增益介质之一是Nd：YVO4。该材料具有较高的增益和较短的上限寿命。这些性质使得在设计Q开关激光器或对光学反馈不敏感的激光器方面具有吸引力。另一种材料是Nd：YAG。发现优化泵浦光斑尺寸的技术可以使由于热双折射引起的损耗最小化。

7. 发明申请

US20120015990A1 TASPASE1 INHIBITORS AND THEIR USES 失效
标题翻译： TASPASE1抑制剂及其用途
公开(公告)号：US20120015990A1
公开(公告)日：2012-01-19
申请号：US13162992
申请日：2011-06-17
申请人： James Hsieh , Emily Cheng
发明人： James Hsieh , Emily Cheng
IPC分类号： A61K31/4245 , C07D277/38 , A61K31/381 , A61K31/426 , C07D231/10 , A61P35/00 , C07D257/04 , A61K31/41 , C07C337/06 , A61K31/175 , C07D271/12 , C07D333/62 , A61K31/415
CPC分类号： C07C335/40 , C07C327/42 , C07C2602/42 , C07D231/14 , C07D257/04 , C07D277/48 , C07D333/62 , C07D413/12 , C07D487/04
摘要： Provided herein are small molecule inhibitors of Taspase1 and methods of using the small molecule inhibitors of Taspase1 to treat neoplasm in subjects in need thereof.
摘要翻译：本文提供了Taspase1的小分子抑制剂和使用Taspase1的小分子抑制剂治疗有需要的受试者的肿瘤的方法。

8. 发明申请

US20050085420A1 Method of modulating apoptosis and compositions thereof 审中-公开
标题翻译：调节凋亡的方法及其组合物
公开(公告)号：US20050085420A1
公开(公告)日：2005-04-21
申请号：US10897485
申请日：2004-07-22
申请人： Stanley Korsmeyer , Emily Cheng
发明人： Stanley Korsmeyer , Emily Cheng
IPC分类号： A61K38/17 , C12Q20060101
CPC分类号： A61K38/17
摘要： Disclosed herein are methods for modulating apoptosis. Methods are provided for inhibiting or preventing apoptosis by promoting formation of a complex of BAK and Voltage-Dependent Anion Channel 2 (VDAC2). The invention also provides methods of promoting or inducing apoptosis by disrupting or inhibiting formation of a VDAC2/BAK complex. Also disclosed are methods of screening for compounds that promote or disrupt the VDAC2/BAK complex.
摘要翻译：本文公开了调节凋亡的方法。提供了通过促进形成BAK和电压依赖性阴离子通道2（VDAC2）的复合物来抑制或预防凋亡的方法。本发明还提供通过破坏或抑制VDAC2 / BAK复合物的形成来促进或诱导凋亡的方法。还公开了筛选促进或破坏VDAC2 / BAK复合物的化合物的方法。

9. 发明授权

US06287298B1 Diode pumped, multi axial mode intracavity doubled laser 失效
标题翻译：二极管泵浦，多轴模式腔内双激光
公开(公告)号：US06287298B1
公开(公告)日：2001-09-11
申请号：US09070478
申请日：1998-04-30
申请人： William L. Nighan , John Cole , Emily Cheng
发明人： William L. Nighan , John Cole , Emily Cheng
IPC分类号： A61F9008
CPC分类号： G02F1/37 , G02F2001/3542 , H01S3/081 , H01S3/094053 , H01S3/0941 , H01S3/09415 , H01S3/109 , H01S3/13 , H01S3/1611 , H01S3/1643 , H01S3/1653 , H01S3/1673
摘要： A diode pumped, multi axial mode, intracavity doubled laser has at least two resonator mirrors that define a resonator cavity. A Nd:YVO4 laser crystal and a LBO doubling crystal are positioned in the resonator cavity. A diode pump source supplies a pump beam to the laser crystal and produces a laser crystal beam with at least three axial modes that are incident on the doubling crystal. A frequency doubled output beam is generated with an output power of at least 1 watt.
摘要翻译：二极管泵浦，多轴模式，腔内倍增激光器具有限定谐振腔的至少两个谐振器反射镜。 Nd：YVO4激光晶体和LBO倍晶体位于谐振腔中。二极管泵浦源将激光束提供给激光晶体，并产生具有至少三个轴向模式的激光晶体光束，入射到倍晶上。产生输出功率至少为1瓦的倍频输出光束。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式