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1. 发明授权

US4513008A Virucidal compositions and therapy 失效
标题翻译：病毒组成和治疗
公开(公告)号：US4513008A
公开(公告)日：1985-04-23
申请号：US404199
申请日：1982-07-30
申请人： Emanuel Revici , Bob E. Sherwood , Herman P. Benecke , John M. Rice , Richard W. Geisler
发明人： Emanuel Revici , Bob E. Sherwood , Herman P. Benecke , John M. Rice , Richard W. Geisler
IPC分类号： A61K31/045 , A61K31/11 , A61K31/20
CPC分类号： A61K31/20 , A61K31/045 , A61K31/11
摘要： A method of inactivating enveloped virus comprises contacting said virus with a virucidally effective amount of a C.sub.20-24 linear polyunsaturated acid, aldehyde or primary alcohol having 5-7 double bonds, a pharmaceutically acceptable salt of said acid, or a mixture thereof. Topical administration of the virucide is preferred and is effective in treating lesions associated with herpes infections. Pharmaceutical compositions for use in the present method are provided.
摘要翻译：灭活包膜病毒的方法包括使所述病毒与病毒有效量的具有5-7个双键的C20-24线性多不饱和酸，醛或伯醇，所述酸的药学上可接受的盐或其混合物接触。病毒杀虫剂的局部施用是优选的，并且在治疗与疱疹感染相关的病变中是有效的。提供了用于本方法的药物组合物。

2. 发明授权

US4440781A Oxyoctadecanoates as psychotropic agents 失效
标题翻译：十八烷酸作为精神药物
公开(公告)号：US4440781A
公开(公告)日：1984-04-03
申请号：US387636
申请日：1982-06-11
申请人： Herman P. Benecke , Bob E. Sherwood
发明人： Herman P. Benecke , Bob E. Sherwood
IPC分类号： A61K31/34 , C07D307/12 , C07D307/28 , C07D307/32
CPC分类号： A61K31/34 , Y10S514/811 , Y10S514/813
摘要： A method for producing a psychotropic response, especially for alleviating the symptoms of alcohol withdrawal, comprises administering to a human or animal subject in need thereof a psychotropically effective non-toxic amount of an oxyoctadecanoate. A composition for use in the present method is provided.
摘要翻译：用于产生精神药物反应的方法，特别是用于缓解酒精戒断的症状的方法包括向有需要的人或动物受试者施用精神有效的无毒量的十八烷酸酯。提供了用于本方法的组合物。

3. 发明授权

US4427694A Sesamin as a psychotropic agent 失效
标题翻译：芝麻素作为精神药物
公开(公告)号：US4427694A
公开(公告)日：1984-01-24
申请号：US387638
申请日：1982-06-11
申请人： Herman P. Benecke , Bob E. Sherwood
发明人： Herman P. Benecke , Bob E. Sherwood
IPC分类号： C07D493/04 , A61K31/36
CPC分类号： C07D493/04 , Y10S514/811 , Y10S514/813
摘要： A method for producing a psychotropic response, especially for alleviating the symptoms of alcohol withdrawal, comprises administering to a human or animal subject in need thereof a psychotropically effective non-toxic amount of sesamin. A composition for use in the present method is provided.
摘要翻译：用于产生精神药物反应的方法，特别是用于减轻戒酒症状的方法包括向有需要的人或动物受试者施用精神有效的无毒量的芝麻素。提供了用于本方法的组合物。

4. 发明授权

US06391337B2 Directly compressible high load acetaminophen formulations 失效
标题翻译：直接可压缩的高负荷对乙酰氨基酚制剂
公开(公告)号：US06391337B2
公开(公告)日：2002-05-21
申请号：US09798755
申请日：2001-03-02
申请人： Edward A. Hunter , Bob E. Sherwood , Joseph A. Zeleznik
发明人： Edward A. Hunter , Bob E. Sherwood , Joseph A. Zeleznik
IPC分类号： A61K920
CPC分类号： A61K9/2095 , A61K9/2009 , A61K9/2054 , A61K31/167
摘要： Direct compressed solid pharmaceutical dosage forms containing: a) from about 40 to about 95% by weight acetaminophen; b) from about 1 to about 60% by weight of a direct compression vehicle comprising microcrystalline cellulose; and c) from about 0.01 to about 4.0% by weight of a pharmaceutically-acceptable lubricant are disclosed. The acetaminophen and direct compression vehicle are combined under high shear conditions which are sufficient to transform acetaminophen and direct compression vehicle into a homogenous granulate without degradation. In preferred aspects of the invention, the lubricant is also combined with the acetaminophen and direct compression vehicle under high shear conditions. Methods of preparing the directly compressed solid pharmaceutical dosage forms and methods of treatment with the dosage forms are also disclosed. The methods are particularly well suited for preparing directly compressed dosage forms containing high load (i.e., up to 80% or greater) amounts of acetaminophen based on the weight of the total tablet.
摘要翻译：直接压缩固体药物剂型，其包含：a）约40至约95重量％的对乙酰氨基酚; b）约1至约60重量％的包含微晶纤维素的直接压片; 和c）约0.01至约4.0重量％的药学上可接受的润滑剂。对乙酰氨基酚和直接压缩载体在高剪切条件下组合，足以将对乙酰氨基酚和直接压缩载体转化成均匀的颗粒而不降解。在本发明的优选方面，润滑剂还在高剪切条件下与对乙酰氨基酚和直接压缩载体组合。还公开了制备直接压片的固体药物剂型的方法和剂型的治疗方法。该方法特别适用于制备基于总片剂重量的含有高负荷量（即高达80％或更多）量的对乙酰氨基酚的直接压缩剂型。

5. 发明授权

US5665414A Cellulosic materials for incorporation into food products and methods of making same 失效
标题翻译：用于掺入食品的纤维素材料及其制造方法
公开(公告)号：US5665414A
公开(公告)日：1997-09-09
申请号：US419633
申请日：1995-04-06
申请人： Bob E. Sherwood , Jouko Johannes Virtanen
发明人： Bob E. Sherwood , Jouko Johannes Virtanen
IPC分类号： A23C19/086 , A23L5/41 , A23L29/262 , A61K9/20 , A23C19/09 , A23L1/0534
CPC分类号： A23C19/086 , A23L29/262 , A23L5/41 , A61K9/2054 , Y10S426/804
摘要： New cellulosic materials derive from pulps having an ISO brightness of from 80 to about 90 are disclosed. The celluloses substantially match the color of the food products admixed therewith to provide food products such as sauces, emulsions, frozen desserts, reduced fat products and the like with substantially uniform color. The invention also includes substantially non-agglomerating particulate cheese products such as grated or shredded cheeses in admixture with cellulose derived from a pulp having the ISO qualities described above. The cellulose is present in an amount which is sufficient to substantially prevent agglomeration of the particulate cheese product yet is sensorially undetected. Other aspects of the invention include methods of preparing the liquid, semi-solid or frozen food products containing the selected cellulose as well as methods of preparing the substantially non-agglomerating cheese product.
摘要翻译：公开了具有80至约90的ISO亮度的纸浆的新型纤维素材料。纤维素基本上与混合的食品的颜色相匹配，以提供基本均匀的颜色的食品，例如调味汁，乳液，冷冻甜点，减脂产品等。本发明还包括基本上非附聚的颗粒状干酪产品，例如磨碎或切碎的奶酪，与来自具有上述ISO质量的纸浆的纤维素混合。纤维素的存在量足以基本上防止颗粒状干酪产品的附聚，但在传感上未被检测到。本发明的其它方面包括制备含有所选择的纤维素的液体，半固体或冷冻食品的方法以及制备基本上非凝聚性干酪产品的方法。

6. 发明授权

US06858231B2 Pharmaceutical excipient having improved compressibility 失效
公开(公告)号：US06858231B2
公开(公告)日：2005-02-22
申请号：US10338361
申请日：2003-01-08
申请人： Bob E. Sherwood , John H. Staniforth , Edward A. Hunter
发明人： Bob E. Sherwood , John H. Staniforth , Edward A. Hunter
IPC分类号： A61K9/20 , A61K9/26 , A61K47/02 , A61K47/04 , A61K47/38 , A61K9/14
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2036 , A61K9/205 , Y10S977/727 , Y10S977/773 , Y10S977/775 , Y10S977/801 , Y10S977/89 , Y10S977/896 , Y10S977/904 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

7. 发明授权

US06521261B2 Pharmaceutical excipient having improved compressibility 失效
公开(公告)号：US06521261B2
公开(公告)日：2003-02-18
申请号：US09981319
申请日：2001-10-16
申请人： Bob E. Sherwood , John H. Staniforth , Edward A. Hunter
发明人： Bob E. Sherwood , John H. Staniforth , Edward A. Hunter
IPC分类号： A61K914
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2036 , A61K9/205 , Y10S977/727 , Y10S977/773 , Y10S977/775 , Y10S977/801 , Y10S977/89 , Y10S977/896 , Y10S977/904 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.

8. 发明授权

US5585115A Pharmaceutical excipient having improved compressability 失效
标题翻译：具有改善的压缩性的药物赋形剂
公开(公告)号：US5585115A
公开(公告)日：1996-12-17
申请号：US370576
申请日：1995-01-09
申请人： Bob E. Sherwood , Edward A. Hunter , John H. Staniforth
发明人： Bob E. Sherwood , Edward A. Hunter , John H. Staniforth
IPC分类号： A61K9/20 , A61K9/26 , A61K47/02 , A61K47/04 , A61K47/38 , A61K9/14
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2036 , A61K9/205 , Y10S977/727 , Y10S977/773 , Y10S977/775 , Y10S977/801 , Y10S977/89 , Y10S977/896 , Y10S977/904 , Y10S977/906 , Y10S977/915 , Y10T428/2982
摘要： A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
摘要翻译：公开了具有改进的压缩性的微晶纤维素基赋形剂，无论是用于直接压片，干法制粒还是湿法制粒。赋形剂是微晶纤维素颗粒的聚集物和约0.1％至约20％的微晶纤维素重量的二氧化硅颗粒，其中微晶纤维素和二氧化硅彼此紧密结合。新型赋形剂中使用的二氧化硅具有约1纳米至约100微米的粒度。最优选地，二氧化硅是胶体二氧化硅的等级。

9. 发明授权

US06936277B2 Pharmaceutical excipient having improved compressibility 失效
标题翻译：药物赋形剂具有改善的压缩性
公开(公告)号：US06936277B2
公开(公告)日：2005-08-30
申请号：US10145563
申请日：2002-05-14
申请人： John N. Staniforth , Edward A. Hunter , Bob E. Sherwood
发明人： John N. Staniforth , Edward A. Hunter , Bob E. Sherwood
IPC分类号： A61K9/20 , A61K9/14 , A61K9/50
CPC分类号： A61K9/2031 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2036 , A61K9/205 , A61K9/2054 , A61K9/2095
摘要： A method of preparing an excipient composition includes forming an aqueous slurry containing a mixture of microcrystalline cellulose in the form of a wet cake and a surfactant, said surfactant being present in an amount from about 0.1% to about 0.5% by weight of the wet-cake microcrystalline cellulose; and drying said slurry to obtain an excipient comprising a plurality of agglomerated particles of microcrystalline cellulose in intimate association with said surfactant. The excipient may be mixed with a therapeutically active agent to form a dosage form. The surfactant provides a hydrophobic boundary at cellulose surfaces, and improves absorptivity of the therapeutically active agent.
摘要翻译：制备赋形剂组合物的方法包括形成含有湿滤饼形式的微晶纤维素和表面活性剂的混合物的水性浆料，所述表面活性剂的存在量为湿润片剂重量的约0.1％至约0.5％蛋糕微晶纤维素; 并干燥所述浆料以获得包含多个与所述表面活性剂紧密结合的微晶纤维素附聚颗粒的赋形剂。赋形剂可以与治疗活性剂混合以形成剂型。表面活性剂在纤维素表面提供疏水性边界，并提高治疗活性剂的吸收性。

10. 发明授权

US06746693B2 Pharmaceutical excipient having improved compressibility 有权
标题翻译：药物赋形剂具有改善的压缩性
公开(公告)号：US06746693B2
公开(公告)日：2004-06-08
申请号：US10266518
申请日：2002-10-08
申请人： John N. Staniforth , Bob E. Sherwood , Edward A. Hunter
发明人： John N. Staniforth , Bob E. Sherwood , Edward A. Hunter
IPC分类号： A61K914
CPC分类号： A61K9/2013 , A61K9/2009 , A61K9/2018 , A61K9/2036 , A61K9/205 , A61K9/2054 , Y10S977/906
摘要： A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide. An extra low moisture excipient is provided which exhibits improved compressibility as compared to conventional microcrystalline cellulose, while providing a moisture content of of from about 0.5 to 2.5% LOD, preferably between about 0.5 and about 1.8%, more preferably between 0.8 and 1.5%, and most preferably between about 0.8 and about 1.2%.
摘要翻译：公开了具有改进的压缩性的微晶纤维素基赋形剂，无论是用于直接压片，干法制粒还是湿法制粒。赋形剂是微晶纤维素颗粒的聚集物和约0.1％至约20％的微晶纤维素重量的二氧化硅颗粒，其中微晶纤维素和二氧化硅彼此紧密结合。在新型赋形剂中使用的二氧化硅具有1纳米至约100微米的粒度。最优选地，二氧化硅是胶体二氧化硅的等级。提供了与常规微晶纤维素相比显示出改善的可压缩性的特别低的水分赋形剂，同时提供约0.5至2.5％LOD，优选约0.5至约1.8％，更优选0.8至1.5％的水分含量，最优选在约0.8至约1.2％之间。

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