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1. 发明授权

US07968089B2 Proteoglycan degrading mutants for the treatment of CNS 有权
标题翻译：蛋白多糖降解突变体用于治疗CNS
公开(公告)号：US07968089B2
公开(公告)日：2011-06-28
申请号：US12167573
申请日：2008-07-03
申请人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
发明人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Rohini D'Souza
IPC分类号： A61K38/51 , C12N15/60 , C12N9/88
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
摘要翻译：本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。

2. 发明申请

US20090041728A1 Proteoglycan Degrading Mutants for the Treatment of CNS 有权
标题翻译：蛋白多糖降解突变体用于治疗CNS
公开(公告)号：US20090041728A1
公开(公告)日：2009-02-12
申请号：US12167573
申请日：2008-07-03
申请人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
发明人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
IPC分类号： A61K35/74 , A61K38/16 , A61P25/00
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
摘要翻译：本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。

3. 发明授权

US07429375B2 Proteoglycan degrading mutants for the treatment of CNS 有权
标题翻译：蛋白多糖降解突变体用于治疗CNS
公开(公告)号：US07429375B2
公开(公告)日：2008-09-30
申请号：US10848561
申请日：2004-05-17
申请人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
发明人： Elliott A. Gruskin , Rohini D'Souza , Gargi Roy , Anthony O. Caggiano
IPC分类号： C12N9/88 , A61K38/51
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system (“CNS”) injury or disease.
摘要翻译：本公开涉及软骨素酶蛋白的制备和缺失突变体及其在促进治疗组合物扩散到组织中的方法及其在中枢神经系统（“CNS”）损伤或疾病之后神经功能恢复的用途。

4. 发明授权

US08906363B2 Fusion proteins for the treatment of CNS 有权
标题翻译：用于治疗CNS的融合蛋白
公开(公告)号：US08906363B2
公开(公告)日：2014-12-09
申请号：US10848564
申请日：2004-05-17
申请人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
发明人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
IPC分类号： A61K38/51 , C12N9/26 , C07K19/00 , C12N9/88 , A61K38/00
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
摘要翻译：本公开涉及能够用于治疗脊髓损伤和中枢神经系统（CNS）的相关病症的组合物，特别是包括蛋白多糖降解分子和能够阻断和/或超过神经元活性的组合物的组合物生长抑制分子，以及融合蛋白，其包括蛋白聚糖降解结构域和能够阻断和或超过神经元生长抑制分子活性的结构域。

5. 发明申请

US20090028829A1 Fusion proteins for the treatment of CNS 有权
标题翻译：用于治疗CNS的融合蛋白
公开(公告)号：US20090028829A1
公开(公告)日：2009-01-29
申请号：US10848564
申请日：2004-05-17
申请人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
发明人： Elliott A. Gruskin , Anthony O. Caggiano , Gargi Roy , Jennifer Iaci , Michael P. Zimber
IPC分类号： A61K35/12 , A61K38/47 , A61K38/02 , A61P25/00
CPC分类号： C12N9/88 , A61K35/30 , A61K38/00 , A61K38/51 , A61K45/06 , C07K14/005 , C07K19/00 , C07K2319/00 , C07K2319/03 , C07K2319/10 , C12N9/2408 , C12Y302/01035 , C12Y302/01036 , C12Y402/02001 , C12Y402/02004 , C12Y402/02005
摘要： This disclosure relates to compositions capable of use in the treatment of spinal cord injuries and related disorders of the central nervous system (CNS), and in particular, compositions including proteoglycan degrading molecules and compositions capable of blocking and/or over coming the activity of neuronal growth inhibitory molecules, as well as fusion proteins which includes a proteoglycan degrading domain and a domain capable of blocking and or over coming the activity of neuronal growth inhibitory molecules.
摘要翻译：本公开涉及能够用于治疗脊髓损伤和中枢神经系统（CNS）的相关病症的组合物，特别是包括蛋白多糖降解分子和能够阻断和/或超过神经元活性的组合物的组合物生长抑制分子，以及融合蛋白，其包括蛋白聚糖降解结构域和能够阻断和或超过神经元生长抑制分子活性的结构域。

6. 发明授权

US08226941B2 Methods of purifying chondroitinase and stable formulations thereof 有权
标题翻译：软骨素酶的纯化方法及其稳定配方
公开(公告)号：US08226941B2
公开(公告)日：2012-07-24
申请号：US11568831
申请日：2005-05-18
申请人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
发明人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
IPC分类号： A61K38/46 , A61K38/47 , C12N9/24 , C07H21/04
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/02004
摘要： An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.
摘要翻译：本发明的一个方面涉及软骨素酶的稳定制剂和软骨素酶的纯化方法。纯化软骨素酶的方法包括从细胞中提取酶的步骤，使用阳离子交换层析从粗细胞提取物中分离软骨素酶，通过凝胶过滤色谱法除去杂质，以及通过阴离子交换膜除去内毒素以产生纯化的软骨素酶。

7. 发明授权

US07959914B2 Methods of reducing extravasation of inflammatory cells 有权
标题翻译：减少炎症细胞外渗的方法
公开(公告)号：US07959914B2
公开(公告)日：2011-06-14
申请号：US10847636
申请日：2004-05-17
申请人： Elliott A. Gruskin , Jack L. Tseng , Anthony O. Caggiano
发明人： Elliott A. Gruskin , Jack L. Tseng , Anthony O. Caggiano
IPC分类号： A61K38/43 , A61K38/51
CPC分类号： A61K38/51 , A61K38/47
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
摘要翻译：提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。

8. 发明申请

US20080311642A1 Methods of Purifying Chondroitinase and Stable Formulations Thereof 有权
标题翻译：纯化软骨素酶及其稳定配方的方法
公开(公告)号：US20080311642A1
公开(公告)日：2008-12-18
申请号：US11568831
申请日：2005-05-18
申请人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
发明人： Anthony O. Caggiano , Elliott A. Gruskin , Yelena G. Sheptovitsky , Sarah Kasperbauer
IPC分类号： C12N9/24
CPC分类号： C12N9/88 , A61K38/00 , C12Y402/02004
摘要： An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography, and removing endotoxin through an anion-exchange membrane to produce a purified chondroitinase.
摘要翻译：本发明的一个方面涉及软骨素酶的稳定制剂和软骨素酶的纯化方法。纯化软骨素酶的方法包括从细胞中提取酶的步骤，使用阳离子交换层析从粗细胞提取物中分离软骨素酶，通过凝胶过滤色谱法除去杂质，以及通过阴离子交换膜除去内毒素以产生纯化的软骨素酶。

9. 发明授权

US08679481B2 Methods of reducing extravasation of inflammatory cells 有权
标题翻译：减少炎症细胞外渗的方法
公开(公告)号：US08679481B2
公开(公告)日：2014-03-25
申请号：US13103347
申请日：2011-05-09
申请人： Elliott A. Gruskin , Jack L. Tseng , Anthony O. Caggiano
发明人： Elliott A. Gruskin , Jack L. Tseng , Anthony O. Caggiano
IPC分类号： A61K38/43 , A61K38/51
CPC分类号： A61K38/51 , A61K38/47
摘要： A method for modifying access of cells to extravascular spaces and regions comprising administering to a patient an enzyme that cleaves chondroitin sulfate proteoglycans is provided. It has been found that administration of an enzyme that cleaves chondroitin sulfate proteoglycans to a patient disrupts extravasation of cells from the blood stream into tissue. The present invention provides methods of reducing penetration of cells associated with inflammation into tissue of a patient. Several methods are also provided for the regulation and suppression of inflammation comprising administering enzymes that digest chondroitin sulfates. Also provided are methods of treating and preventing inflammation associated with infection, injury and disease.
摘要翻译：提供了一种用于修饰细胞进入血管外空间和区域的方法，包括向患者施用切割硫酸软骨素蛋白聚糖的酶。已经发现，向患者施用将硫酸软骨素蛋白聚糖切割的酶破坏细胞从血液进入组织的外渗。本发明提供了减少与炎症相关的细胞穿透到患者组织中的方法。还提供了几种用于调节和抑制炎症的方法，其包括施用消化硫酸软骨素的酶。还提供了治疗和预防与感染，损伤和疾病相关的炎症的方法。

10. 发明授权

US07485295B2 Compositions and methods of using chondroitinase ABCI mutants 有权
标题翻译：使用软骨素酶ABCI突变体的组成和方法
公开(公告)号：US07485295B2
公开(公告)日：2009-02-03
申请号：US11527318
申请日：2006-09-26
申请人： Anthony O. Caggiano , Jennifer Iaci , Andrea Vecchione , Elizabeth Markensohn
发明人： Anthony O. Caggiano , Jennifer Iaci , Andrea Vecchione , Elizabeth Markensohn
IPC分类号： A61K38/47 , A61K38/46 , C12N9/24 , C07H21/04
CPC分类号： C12N9/88 , A61K38/00 , A61K38/51 , C12Y402/02004
摘要： One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
摘要翻译：本发明的一个方面涉及软骨素酶ABCI的突变体。这种软骨素酶ABCI突变体表现出改变的软骨素裂解酶活性或增加的抗应激因子灭活活性，包括暴露于紫外光或热。还提供了使用软骨素酶ABCI突变酶的方法。

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