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    • 2. 发明授权
    • Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
    • 用于鉴定调节过早翻译终止和无义mRNA衰变的小分子的方法
    • US07291461B2
    • 2007-11-06
    • US10519243
    • 2003-06-23
    • Ellen WelchJin Zhuo
    • Ellen WelchJin Zhuo
    • C12Q1/68C07H21/02C07H21/04
    • C12Q1/6897
    • The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that modulate the post-transcriptional expression of any gene with a premature translation stop codon. The invention particularly relates to using any gene encoding a premature stop codon to identify compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay. A compound that modulates premature translation termination and/or nonsense-mediated mRNA decay of a target gene is identified using standard methods known in the art to measure changes in translation or mRNA stability of the gene product or mRNA of the gene with the premature stop codon. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
    • 本发明涉及通过筛选和鉴定调节具有过早翻译终止密码子的任何基因的转录后表达的化合物来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物的方法。 本发明特别涉及使用编码过早终止密码子的任何基因来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物。 使用本领域已知的标准方法鉴定调节前体转录终止和/或无义介导的mRNA基因的衰老的化合物,以测量基因产物或基因mRNA的mRNA稳定性的变化,所述基因产物或mRNA的早期终止密码子 。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单,灵敏的测定。
    • 3. 发明申请
    • Methods for identifying small molecules that modulate premature translation termination and nonsense mrna decay
    • 用于鉴定调节过早翻译终止和废话mrna衰变的小分子的方法
    • US20050233327A1
    • 2005-10-20
    • US10519243
    • 2003-06-23
    • Ellen WelchJin Zhuo
    • Ellen WelchJin Zhuo
    • C12Q1/68
    • C12Q1/6897
    • The present invention relates to methods for identifying compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay by screening and identifying compounds that modulate the post-transcriptional expression of any gene with a premature translation stop codon. The invention particularly relates to using any gene encoding a premature stop codon to identify compounds that modulate premature translation termination and/or nonsense-mediated mRNA decay. A compound that modulates premature translation termination and/or nonsense-mediated mRNA decay of a target gene is identified using standard methods known in the art to measure changes in translation or mRNA stability of the gene product or mRNA of the gene with the premature stop codon. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
    • 本发明涉及通过筛选和鉴定调节具有过早翻译终止密码子的任何基因的转录后表达的化合物来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物的方法。 本发明特别涉及使用编码过早终止密码子的任何基因来鉴定调节过早翻译终止和/或无义介导的mRNA衰变的化合物。 使用本领域已知的标准方法鉴定调节前体转录终止和/或无义介导的mRNA基因的衰老的化合物,以测量基因产物或基因mRNA的mRNA稳定性的变化,所述基因产物或mRNA的早期终止密码子 。 本发明的方法提供了用于识别药物引线的化合物文库的高通量筛选的简单,灵敏的测定。