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1. 发明授权

US08628922B2 Screening method for cell aging 有权
标题翻译：细胞衰老筛选方法
公开(公告)号：US08628922B2
公开(公告)日：2014-01-14
申请号：US13382629
申请日：2010-07-08
申请人： Elizabeth Jane Mellor , Michael Youdell , Anitha Nair , Alexandre Akoulitchev
发明人： Elizabeth Jane Mellor , Michael Youdell , Anitha Nair , Alexandre Akoulitchev
IPC分类号： C12Q1/68
CPC分类号： G01N33/5008 , G01N33/6872 , G01N2440/10 , G01N2800/00
摘要： The present invention relates to a method for increasing the chronological lifespan of a cell comprising disrupting the function of at least one of the SAGA1 SLIK and/or SALSA complexes in said cell.
摘要翻译：本发明涉及一种用于增加细胞的时间寿命的方法，包括破坏所述细胞中至少一种SAGA1 SLIK和/或SALSA复合物的功能。

2. 发明申请

US20120270213A1 SCREENING METHOD FOR CELL AGING 有权
标题翻译：细胞衰老筛选方法
公开(公告)号：US20120270213A1
公开(公告)日：2012-10-25
申请号：US13382629
申请日：2010-07-08
申请人： Elizabeth Jane Mellor , Michael Youdell , Anitha Nair , Alexandre Akoulitchev
发明人： Elizabeth Jane Mellor , Michael Youdell , Anitha Nair , Alexandre Akoulitchev
IPC分类号： C12Q1/68 , C07D498/16 , G01N21/76 , C12N5/071 , G01N21/64
CPC分类号： G01N33/5008 , G01N33/6872 , G01N2440/10 , G01N2800/00
摘要： The present invention relates to a method for increasing the chronological lifespan of a cell comprising disrupting the function of at least one of the SAGA1 SLIK and/or SALSA complexes in said cell.
摘要翻译：本发明涉及一种用于增加细胞的时间寿命的方法，包括破坏所述细胞中至少一种SAGA1 SLIK和/或SALSA复合物的功能。

3. 发明申请

US20120136046A1 METHOD OF TREATING AGE RELATED DISORDERS 审中-公开
标题翻译：治疗老年相关疾病的方法
公开(公告)号：US20120136046A1
公开(公告)日：2012-05-31
申请号：US13382648
申请日：2010-07-08
申请人： Elizabeth Jane Mellor , Michael Youdell , Jonathan Ayling , Alexandre Akoulitchev
发明人： Elizabeth Jane Mellor , Michael Youdell , Jonathan Ayling , Alexandre Akoulitchev
IPC分类号： A61K31/436 , A61P29/00 , A61P9/00 , A61P3/10 , A61P25/24 , C12N5/071 , A61P21/00 , A61P19/08 , C12N5/02 , A61K31/7088 , C12N1/18 , C07D498/18 , A61P25/28 , A61P3/04
CPC分类号： A61K38/13 , A61K31/436
摘要： The present invention relates to the use of fujimycin for the treatment of a disorder related to the chronological and/or replicative life-span of a cell, and to methods for increasing the replicative life span of a cell, said method comprising disrupting the function of a polynucleotide or gene encoding a polypeptide comprising SEQ ID No: 1, 3 or 5.
摘要翻译：本发明涉及富马霉素用于治疗与细胞的时间顺序和/或复制寿命相关的病症的用途，以及用于增加细胞的复制寿命的方法，所述方法包括破坏细胞的功能编码包含SEQ ID No：1,3或5的多肽的多核苷酸或基因。

4. 发明申请

US20110098342A1 METHODS OF DETECTING LONG RANGE CHROMOSOMAL INTERACTIONS 审中-公开
标题翻译：检测长距离色素相互作用的方法
公开(公告)号：US20110098342A1
公开(公告)日：2011-04-28
申请号：US12995261
申请日：2009-06-02
申请人： Aroul Selvam Ramadass , Alexandre Akoulitchev , Elizabeth Jane Mellor
发明人： Aroul Selvam Ramadass , Alexandre Akoulitchev , Elizabeth Jane Mellor
IPC分类号： A61K31/7105 , C12Q1/68 , C07H21/02 , A61P43/00
CPC分类号： C12Q1/6806 , C12Q2537/164 , C12Q2525/207
摘要： The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of: —(i) in vitro crosslinking of said long range chromosomal interactions present at the at least one chromosomal locus; (ii) isolating the cross linked DNA from said chromosomal locus; (iii) subjecting said cross linked DNA to restriction digestion with an enzyme that cuts at least once within the at least one chromosomal locus; (iv) ligating said cross linked cleaved DNA ends to form DNA loops; (v) identifying the presence of said DNA loops; wherein the presence of DNA loops indicates the presence of a specific long range chromosomal interaction.
摘要翻译：本发明涉及一种监测表观遗传变化的方法，包括监测至少一个染色体基因座处的条件性长程染色体相互作用的变化，其中长距离相互作用的光谱与特定生理条件相关联，所述方法包括以下步骤： - （ i）在至少一个染色体基因座处存在的所述长程染色体相互作用的体外交联; （ii）从所述染色体基因座分离交联的DNA; （iii）使所述交联的DNA用在至少一个染色体基因座内至少切割一次的酶进行限制性消化; （iv）连接所述交联的切割的DNA末端以形成DNA环; （v）鉴定所述DNA环的存在; 其中DNA环的存在表明存在特异性的长程染色体相互作用。

5. 发明授权

US09777327B2 DNA conformation (loop structures) in normal and abnormal gene expression 有权
公开(公告)号：US09777327B2
公开(公告)日：2017-10-03
申请号：US12279133
申请日：2007-02-19
申请人： Alexandre Akoulitchev , Aroul Selvam Ramadass , Leonid Leonidovich Nikitenko
发明人： Alexandre Akoulitchev , Aroul Selvam Ramadass , Leonid Leonidovich Nikitenko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Q2525/301 , C12Q2523/101
摘要： Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression.

6. 发明申请

US20090186352A1 DNA Conformation 有权
标题翻译： DNA构象
公开(公告)号：US20090186352A1
公开(公告)日：2009-07-23
申请号：US12279133
申请日：2007-02-19
申请人： Alexandre Akoulitchev , Aroul Selvam Ramadass , Leonid Leonidovich Nikitenko
发明人： Alexandre Akoulitchev , Aroul Selvam Ramadass , Leonid Leonidovich Nikitenko
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , C12Q2525/301 , C12Q2523/101
摘要： Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual has abnormal gene expression.
摘要翻译：在个体中检测或诊断异常基因表达的方法，包括在来自个体的样品中确定存在或不存在其中两个分离的基因区域已经紧密接近的染色体结构，从而检测或诊断是否个体具有异常的基因表达。

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