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1. 发明授权

US08738106B2 Device, system and method for in vivo analysis 有权
标题翻译：装置，系统和体内分析方法
公开(公告)号：US08738106B2
公开(公告)日：2014-05-27
申请号：US11831857
申请日：2007-07-31
申请人： Elisha Rabinowitz , Emil-Israel Katz
发明人： Elisha Rabinowitz , Emil-Israel Katz
IPC分类号： A61B5/1455
CPC分类号： A61K49/0093 , A61B1/041 , A61B5/073 , A61K49/0002 , A61K49/0084
摘要： A device for in vivo analysis includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo; and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample. The in-vivo imaging device, typically an autonomous capsule, may have a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.
摘要翻译：用于体内分析的装置包括：反应室，用于存储能够与体内收集的样品反应的检测试剂; 和任选的标记物质室，以存储能够结合至少部分由检测试剂和样品反应产生的化合物的标记物质。体内成像装置（通常是自主胶囊）可以具有壳体，壳体包括窗口; 位于所述壳体内以照射通过所述窗户的体腔的照明源; 成像器从窗体接收从体腔反射的光; 以及将图像数据传送到接收系统的发射机。窗口涂有含有标记物的脂质体，使得成像仪可以获取包括标记的图像。

2. 发明申请

US20080146896A1 DEVICE, SYSTEM AND METHOD FOR IN VIVO ANALYSIS 有权
标题翻译：用于体检分析的装置，系统和方法
公开(公告)号：US20080146896A1
公开(公告)日：2008-06-19
申请号：US11831857
申请日：2007-07-31
申请人： Elisha Rabinowitz , Emil-Israel Katz
发明人： Elisha Rabinowitz , Emil-Israel Katz
IPC分类号： A61B5/00 , A61B1/06
CPC分类号： A61K49/0093 , A61B1/041 , A61B5/073 , A61K49/0002 , A61K49/0084
摘要： A device for in vivo analysis includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo; and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample. The in-vivo imaging device, typically an autonomous capsule, may have a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.
摘要翻译：用于体内分析的装置包括：反应室，用于存储能够与体内收集的样品反应的检测试剂; 和任选的标记物质室，以存储能够结合至少部分由检测试剂和样品反应产生的化合物的标记物质。体内成像装置（通常是自主胶囊）可以具有壳体，壳体包括窗口; 位于所述壳体内以照射通过所述窗户的体腔的照明源; 成像器从窗体接收从体腔反射的光; 以及将图像数据传送到接收系统的发射机。窗口涂有含有标记物的脂质体，使得成像仪可以获取包括标记的图像。

3. 发明申请

US20090318766A1 DEVICE, SYSTEM AND METHOD FOR IN-VIVO ANALYSIS 有权
标题翻译：用于体内分析的装置，系统和方法
公开(公告)号：US20090318766A1
公开(公告)日：2009-12-24
申请号：US12294656
申请日：2007-04-10
申请人： Elisha Rabinovitz , Emil-Israel Katz
发明人： Elisha Rabinovitz , Emil-Israel Katz
IPC分类号： A61B1/06
CPC分类号： A61B5/0084 , A61B1/00016 , A61B1/00029 , A61B1/041 , A61B1/043 , A61B5/0071 , A61B5/073
摘要： An in-vivo imaging device, typically an autonomous capsule, having a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.
摘要翻译：具有壳体的体内成像装置，通常为自主胶囊，所述壳体包括窗口; 位于所述壳体内以照射通过所述窗户的体腔的照明源; 成像器从窗体接收从体腔反射的光; 以及将图像数据传送到接收系统的发射机。窗口涂有含有标记物的脂质体，使得成像仪可以获取包括标记的图像。

4. 发明授权

US08663093B2 Device, system and method for in-vivo analysis 有权
标题翻译：用于体内分析的装置，系统和方法
公开(公告)号：US08663093B2
公开(公告)日：2014-03-04
申请号：US12294656
申请日：2007-04-10
申请人： Elisha Rabinovitz , Emil-Israel Katz
发明人： Elisha Rabinovitz , Emil-Israel Katz
IPC分类号： A61B1/00 , A61B1/04 , A61B1/06 , A61B5/00
CPC分类号： A61B5/0084 , A61B1/00016 , A61B1/00029 , A61B1/041 , A61B1/043 , A61B5/0071 , A61B5/073
摘要： An in-vivo imaging device, typically an autonomous capsule, having a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.
摘要翻译：具有壳体的体内成像装置，通常为自主胶囊，所述壳体包括窗口; 位于所述壳体内以照射通过所述窗户的体腔的照明源; 成像器从窗体接收从体腔反射的光; 以及将图像数据传送到接收系统的发射机。窗口涂有含有标记物的脂质体，使得成像仪可以获取包括标记的图像。

5. 发明申请

US20110092768A1 DEVICE, SYSTEM AND METHOD FOR IN-VIVO ANALYSIS 审中-公开
标题翻译：用于体内分析的装置，系统和方法
公开(公告)号：US20110092768A1
公开(公告)日：2011-04-21
申请号：US12740764
申请日：2008-11-02
申请人： Noam Emanuel , Emil-Israel Katz , Elena Khazanov , Abraham Rubinstein , Yechezkel Barenholz , Abdel Kareem Azab
发明人： Noam Emanuel , Emil-Israel Katz , Elena Khazanov , Abraham Rubinstein , Yechezkel Barenholz , Abdel Kareem Azab
IPC分类号： A61B1/04 , B05D1/36 , B05D5/00
CPC分类号： A61B1/041
摘要： A device for in-vivo detection comprises a housing having an optical window and enclosing an imager that is configured to image the optical window. An external surface of the optical window has trypsin immobilized thereon, and may also be coated with a steric barrier protection, which may be polyethylene glycol (PEG). A trypsin-Alpha-1-antitrypsin complex formed on the window may have an affinity to a binding agent, which is tagged by a tag selected from a group consisting of a colorant, a fluorescent moiety, and a radioactive moiety.
摘要翻译：用于体内检测的装置包括具有光学窗口并且包围被配置成对光学窗口成像的成像器的壳体。光学窗口的外表面具有固定在其上的胰蛋白酶，并且还可以涂覆有空间屏障保护，其可以是聚乙二醇（PEG）。形成在窗户上的胰蛋白酶-β-1-抗胰蛋白酶复合物可以对结合剂具有亲和性，所述结合剂由选自着色剂，荧光部分和放射性部分的标签标记。

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