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1. 发明申请

US20080194598A1 Pyrimidine Carboxylic Acid Derivatives and Use Thereof 审中-公开
标题翻译：嘧啶羧酸衍生物及其用途
公开(公告)号：US20080194598A1
公开(公告)日：2008-08-14
申请号：US11886289
申请日：2006-03-07
申请人： Elisabeth Woltering , Arounarith Tuch , Elke Dittrich-Wengenroth , Axel Kretschmer , Lars Barfacker , Marcus Bauser , Peter Ellinghaus , Klemens Lustig , Elisabeth Pook , Olaf Weber
发明人： Elisabeth Woltering , Arounarith Tuch , Elke Dittrich-Wengenroth , Axel Kretschmer , Lars Barfacker , Marcus Bauser , Peter Ellinghaus , Klemens Lustig , Elisabeth Pook , Olaf Weber
IPC分类号： A61K31/513 , C07D239/34 , C07D239/26 , A61K31/505 , A61P9/10
CPC分类号： C07D239/28 , C07D239/34
摘要： The present application relates to pyrimidinecarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
摘要翻译：本申请涉及嘧啶羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是血脂异常和动脉硬化。

2. 发明申请

US20090215743A1 Tricyclic benzazepine derivatives and their use 审中-公开
标题翻译：三环苯并氮杂衍生物及其用途
公开(公告)号：US20090215743A1
公开(公告)日：2009-08-27
申请号：US10586023
申请日：2004-12-31
申请人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
发明人： Elisabeth Woltering , Michael Härter , Timo Flessner , Mario Jeske , Nils Griebenow , Frank Süssmeier , Hilmar Bischoff , Martin Raabe , Anja Buchmüller , Peter Kolkhof , Peter Ellinghaus , Olaf Weber
IPC分类号： A61K31/5383 , C07D498/04
CPC分类号： C07D498/04
摘要： The present application relates to novel tricyclic benzazepine derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, especially of dyslipidaemias, arteriosclerosis, restenosis and ischaemias.
摘要翻译：本申请涉及新型三环苯并氮杂衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途，优选用于治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化，再狭窄和局部缺血。

3. 发明授权

US08227511B2 Substituted chromanol derivatives and their use 有权
标题翻译：取代的色原醇衍生物及其用途
公开(公告)号：US08227511B2
公开(公告)日：2012-07-24
申请号：US12225211
申请日：2007-03-07
申请人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
发明人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
IPC分类号： A61K31/352 , C07D311/04 , C07D311/96
CPC分类号： C07D311/22 , C07D311/96
摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

4. 发明申请

US20090306197A1 Substituted Chromanol Derivatives and Their Use 有权
标题翻译：取代的Chromanol衍生物及其用途
公开(公告)号：US20090306197A1
公开(公告)日：2009-12-10
申请号：US12225211
申请日：2007-03-07
申请人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
发明人： Carsten Schmeck , Hilmar Bischoff , Volkhart Li , Klemens Lustig , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber
IPC分类号： A61K31/352 , C07D311/04 , C07D311/96 , A61P9/10
CPC分类号： C07D311/22 , C07D311/96
摘要： The present invention relates to substituted chromanol derivatives, to processes for their preparation, to their use on their own or in combination for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本发明涉及取代的苯并二氢吡喃衍生物，其制备方法，其自身用途或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。

5. 发明授权

US08751101B2 Diagnosing a cooling subsystem of an engine system in response to dynamic pressure sensed in the subsystem 失效
标题翻译：根据子系统中感测到的动态压力，诊断发动机系统的冷却子系统
公开(公告)号：US08751101B2
公开(公告)日：2014-06-10
申请号：US13003377
申请日：2009-07-07
申请人： Olaf Weber , Wolfgang Wenzel
发明人： Olaf Weber , Wolfgang Wenzel
IPC分类号： F01P9/06
CPC分类号： G01M15/042 , F01P11/18 , F01P2025/04 , F01P2031/00 , F02B29/0493 , Y02T10/146
摘要： A method of diagnosing a cooling subsystem of an engine system in response a parameter extracted from dynamic hydraulic pressure sensed in the cooling subsystem, and products and systems using same.
摘要翻译：响应于从冷却子系统中感测到的动态液压提取的参数以及使用其的产品和系统来诊断发动机系统的冷却子系统的方法。

6. 发明授权

US08357363B2 Recombinant proteins of parapoxvirus ovis and pharmaceutical compositions therefrom 有权
标题翻译：副作用的重组蛋白及其药物组合物
公开(公告)号：US08357363B2
公开(公告)日：2013-01-22
申请号：US10481112
申请日：2002-06-12
申请人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
发明人： Olaf Weber , Sonja Maria Friederichs , Angela Siegling , Tobias Schlapp , Andrew Allan Mercer , Stephen Bruce Fleming , Hans-Dieter Volk
IPC分类号： A61K39/155 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/53 , A61K2039/572 , C07K14/065 , C07K2319/00 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24222 , C12N2710/24234 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译：本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。

7. 发明申请

US20120330575A1 ESTIMATING ENGINE SYSTEM PARAMETERS BASED ON ENGINE CYLINDER PRESSURE 审中-公开
标题翻译：基于发动机气缸压力估算发动机系统参数
公开(公告)号：US20120330575A1
公开(公告)日：2012-12-27
申请号：US12442158
申请日：2007-10-05
申请人： Olaf Weber , John Shutty , Wolfgang Wenzel
发明人： Olaf Weber , John Shutty , Wolfgang Wenzel
IPC分类号： G01M15/08 , G06F19/00
CPC分类号： F02D41/22 , F01N3/0821 , F02B37/18 , F02B37/24 , F02D35/023 , F02D41/0007 , F02D2041/288 , F02D2200/025 , F02D2200/0408 , F02D2200/0416 , Y02T10/144 , Y02T10/40
摘要： A method includes sensing pressure within an engine cylinder, and estimating at least one other engine system parameter based on the sensed pressure. Another method includes designing an engine system, which includes one or more engine cylinder pressure sensors and one or more other engine system sensors. According to this method, the engine system is operated, and engine cylinder pressure is sensed using the engine cylinder pressure sensors, which are in communication with an engine cylinder of an engine of the engine system. Also, other engine system parameters are sensed to obtain at least one other engine system parameter using the other engine system sensors. The engine cylinder pressure is correlated to the at least one other engine system parameter, and engine cylinder pressure is used to replace or augment the at least one other engine system parameter that correlates to the engine cylinder pressure.
摘要翻译：一种方法包括感测发动机气缸内的压力，以及基于感测到的压力来估计至少一个其它发动机系统参数。另一种方法包括设计包括一个或多个发动机气缸压力传感器和一个或多个其它发动机系统传感器的发动机系统。根据该方法，发动机系统被操作，并且使用与发动机系统的发动机的发动机气缸连通的发动机气缸压力传感器感测发动机气缸压力。此外，感测其它发动机系统参数以使用其它发动机系统传感器获得至少一个其它发动机系统参数。发动机气缸压力与至少一个其它发动机系统参数相关联，并且发动机气缸压力用于替换或增加与发动机气缸压力相关的至少一个其它发动机系统参数。

8. 发明申请

US20110125361A1 DIAGNOSING A COOLING SUBSYSTEM OF AN ENGINE SYSTEM IN RESPONSE TO DYNAMIC PRESSURE SENSED IN THE SUBSYSTEM 失效
标题翻译：诊断发动机系统的冷却子系统对动力传感器在子系统中的响应
公开(公告)号：US20110125361A1
公开(公告)日：2011-05-26
申请号：US13003377
申请日：2009-07-07
申请人： Olaf Weber , Wolfgang Wenzel
发明人： Olaf Weber , Wolfgang Wenzel
IPC分类号： F01P9/00 , F01P3/20 , F02M25/07
CPC分类号： G01M15/042 , F01P11/18 , F01P2025/04 , F01P2031/00 , F02B29/0493 , Y02T10/146
摘要： A method of diagnosing a cooling subsystem of an engine system in response a parameter extracted from dynamic hydraulic pressure sensed in the cooling subsystem, and products and systems using same.
摘要翻译：响应于从冷却子系统中感测到的动态液压提取的参数以及使用其的产品和系统来诊断发动机系统的冷却子系统的方法。

9. 发明授权

US07897159B2 Parapoxviruses in combination with classical cytotoxic chemotherapeutic agents as biochemotherapy for the treatment of cancer 有权
标题翻译： Parapoxviruses与经典细胞毒性化学治疗剂结合用作治疗癌症的生物化学疗法
公开(公告)号：US07897159B2
公开(公告)日：2011-03-01
申请号：US12123360
申请日：2008-05-19
申请人： Olaf Weber
发明人： Olaf Weber
IPC分类号： A61K39/275
CPC分类号： A61K45/06 , A61K35/768 , C12N2710/24232 , A61K35/76 , A61K2300/00
摘要： The invention relates to a method for the production of a pharmaceutical composition for treating cancer by combining Parapoxvirus ovis with at least one anticancer agent. The invention furthermore relates to a method for treating a patient afflicted with cancer comprising the administration of Parapoxvirus ovis in combination with at least one anticancer agent.
摘要翻译：本发明涉及一种生产用于治疗癌症的药物组合物的方法，该药物组合物通过将副痘病毒与至少一种抗癌剂相结合。本发明还涉及治疗患有癌症的患者的方法，包括与至少一种抗癌剂组合施用副痘病毒ovis。

10. 发明申请

US20100300088A1 METHOD OF CONTROLLING A TURBOCHARGER 审中-公开
标题翻译：控制涡轮增压器的方法
公开(公告)号：US20100300088A1
公开(公告)日：2010-12-02
申请号：US12599316
申请日：2008-05-13
申请人： Volker Joergl , Olaf Weber
发明人： Volker Joergl , Olaf Weber
IPC分类号： F02D23/00
CPC分类号： F02B37/24 , F01P2060/02 , F02B37/164 , F02B39/16 , F02M26/05 , F02M26/06 , Y02T10/144
摘要： Another embodiment of the invention includes a method of controlling a turbocharger to achieve at least one of: produce air in excess of that required to operate a combustion engine at a specific power demand; control the flow of gas through the turbine; or control the turbine speed independent of boost pressure required to avoid specific speeds.
摘要翻译：本发明的另一实施例包括一种控制涡轮增压器以实现以下至少之一的方法：产生超过在特定功率需求下操作内燃机所需的空气的空气; 控制通过涡轮机的气体流量; 或者独立于避免特定速度所需的增压压力来控制涡轮速度。

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