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1. 发明申请

US20110189141A1 MULTIPLE TARGET T CELL RECEPTOR 审中-公开
标题翻译：多目标细胞受体
公开(公告)号：US20110189141A1
公开(公告)日：2011-08-04
申请号：US12783460
申请日：2010-05-19
申请人： Elisa Kieback , Jehad Charo , Thomas Blankenstein , Wolfgang Uckert , Cynthia Perez
发明人： Elisa Kieback , Jehad Charo , Thomas Blankenstein , Wolfgang Uckert , Cynthia Perez
IPC分类号： A61K35/12 , C07K19/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/63 , C12N5/10 , A61K31/7088 , C12P21/00 , A61K38/17 , A61P35/00 , A61P31/00 , A61P37/06 , A61P37/08 , A61P37/04
CPC分类号： C07K14/7051 , A61K38/00 , C07K2319/33
摘要： The present invention is directed to a functional T cell receptor (TCR) fusion protein (TFP) recognizing and binding to at least one MHC-presented epitope, and containing at least one amino acid sequence recognizing and binding an antigen. The present invention is further directed to an isolated nucleic acid molecule encoding the same, a T cell expressing said TFP, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.
摘要翻译：本发明涉及识别并结合至少一个MHC呈递的表位并且含有至少一个识别和结合抗原的氨基酸序列的功能性T细胞受体（TCR）融合蛋白（TFP）。本发明还涉及编码该分离的核酸分子，表达所述TFP的T细胞和用于治疗涉及表达所述肿瘤相关抗原的恶性细胞的疾病的药物组合物。

2. 发明授权

US09133264B2 Epitope-tag surface expressed proteins and nucleic acids thereof 有权
标题翻译：表位标签表面表达蛋白质及其核酸
公开(公告)号：US09133264B2
公开(公告)日：2015-09-15
申请号：US12373362
申请日：2007-06-22
申请人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
发明人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
IPC分类号： C07K14/47 , C07K14/705 , C07K14/725 , C07K19/00 , C07H21/04 , C12N15/09 , C12N15/63 , C12P21/02 , A61K38/17 , C12N15/62 , C12N15/79 , A61K38/00 , A61K48/00 , A61K35/12 , A61K39/00
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
摘要翻译：本发明涉及一种选择表达功能性融合蛋白的宿主细胞群的方法，所述功能性融合蛋白包含至少一个提供表位的氨基酸序列（表位标签）和在所述宿主的表面上表达的蛋白质的氨基酸序列细胞。优选地，氨基酸序列包含T细胞受体的α或β链。本发明还涉及所述功能性T细胞受体（TCR）α或β链融合蛋白在药物中的用途，特别是在过继转移中。

3. 发明申请

US20100104556A1 EPITOPE-TAG FOR SURFACE-EXPRESSED PROTEINS AND USES THEREOF 有权
标题翻译：用于表面表达蛋白的表皮标记及其用途
公开(公告)号：US20100104556A1
公开(公告)日：2010-04-29
申请号：US12373362
申请日：2007-06-22
申请人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
发明人： Thomas Blankenstein , Wolfgang Uckert , Elisa Kieback , Jehad Charo
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/0783 , C12P21/00 , A61K45/00 , A61P35/00
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
摘要翻译：本发明涉及一种选择表达功能性融合蛋白的宿主细胞群的方法，所述功能性融合蛋白包含至少一个提供表位的氨基酸序列（表位标签）和在所述宿主的表面上表达的蛋白质的氨基酸序列细胞。优选地，氨基酸序列包含T细胞受体的α或β链。本发明还涉及所述功能性T细胞受体（TCR）α或β链融合蛋白在药物中的用途，特别是在过继转移中。

4. 发明申请

US20080201791A1 T Cell Line-Based Packaging Cell Line for the Production of Retroviruses by Enriching of Cd3 Expressing Cells 审中-公开
标题翻译： T细胞系包装细胞系通过丰富Cd3表达细胞生产逆转录病毒
公开(公告)号：US20080201791A1
公开(公告)日：2008-08-21
申请号：US11917842
申请日：2006-06-27
申请人： Wolfgang Uckert , Thomas Blankenstein
发明人： Wolfgang Uckert , Thomas Blankenstein
IPC分类号： A01K67/027 , C12N15/85 , C12N5/10
CPC分类号： C12N7/00 , A01K2217/05 , C07K14/7051 , C12N5/0636 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2810/6054
摘要： The present invention relates to retroviral vector systems, in particular the development of packaging or helper cell lines that are based on T cells and that are suitable for producing T cell receptor retroviruses. Thereby, the present invention relates to T cell line specific retroviral expression vectors, and mammalian T cell line-based helper cell lines. The invention further relates to methods for expressing transgenes and to T cell line specific retroviral vector systems, including biochemical kits, that utilize and/or comprise the T cell line specific retroviral expression vectors and/or mammalian T cell line-based helper cell lines.
摘要翻译：本发明涉及逆转录病毒载体系统，特别涉及基于T细胞并适用于产生T细胞受体逆转录病毒的包装或辅助细胞系的开发。因此，本发明涉及T细胞系特异性逆转录病毒表达载体和哺乳动物T细胞系辅助细胞系。本发明还涉及用于表达转基因和T细胞系特异性逆转录病毒载体系统的方法，包括生物化学试剂盒，其利用和/或包含T细胞系特异性逆转录病毒表达载体和/或哺乳动物T细胞系辅助细胞系。

5. 发明申请

US20110280889A1 HIGH AFFINITY T CELL RECEPTOR AND USE THEREOF 有权
标题翻译：高亲和力细胞受体及其用途
公开(公告)号：US20110280889A1
公开(公告)日：2011-11-17
申请号：US13130665
申请日：2009-11-24
申请人： Dolores Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
发明人： Dolores Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
IPC分类号： A61K38/17 , C12N15/85 , C12N15/861 , C12N15/867 , C12N5/10 , A61P35/00 , C07K7/08 , C07K17/02 , C07K19/00 , C07K14/725 , A61K39/395 , A61K35/14 , C12N5/0783 , C12N15/12
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/1774 , C07K2319/40 , C12N15/85
摘要： The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.
摘要翻译：本发明涉及针对肿瘤相关抗原的高亲和力T细胞受体（TCR），编码其的分离的核酸分子，表达所述TCR的T细胞和用于治疗涉及恶性疾病的药物组合物表达所述肿瘤相关抗原的细胞。

6. 发明申请

US20120128704A1 REPERTOIRE OF ALLO-RESTRICTED PEPTIDE-SPECIFIC T CELL RECEPTOR SEQUENCES AND USE THEREOF 有权
标题翻译： ALLO-限制性肽特异性T细胞受体序列的替代物及其用途
公开(公告)号：US20120128704A1
公开(公告)日：2012-05-24
申请号：US13148653
申请日：2010-02-09
申请人： Dolores J. Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
发明人： Dolores J. Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
IPC分类号： A61K31/7088 , C07K7/08 , C07K7/06 , A61P35/00 , C07K19/00 , A61K35/26 , A61P37/04 , C12N15/12 , C07K14/725
CPC分类号： C07K14/7051 , C07K14/70503
摘要： The present invention is directed to a kit-of-parts or composition containing nucleic acid sequences coding for high-avidity, allo-restricted TCR, wherein the TCR are independently directed against the tyrosinase antigen, the melan-A antigen and the survivin antigen. The invention is further directed to a kit-of-parts or composition containing at least three groups of transgenic lymphocytes transformed with vectors coding for TCR against said antigens. Furthermore, the present invention provides a pharmaceutical composition and its use in the treatment of diseases involving malignant cells expressing said tumor-associated antigens. The invention further relates to a nucleic acid molecule coding for a TCR that recognizes the survivin antigen, a TCR encoded thereby and a T cell expressing said TCR. Further, the invention discloses a vector, a cell and a pharmaceutical composition encoding/containing same and their use in the treatment of diseases involving malignant cells expressing survivin.
摘要翻译：本发明涉及包含编码高亲合力，同种异体限制性TCR的核酸序列的成套工具或组合物，其中TCR独立地针对酪氨酸酶抗原，黑色素A抗原和存活蛋白抗原。本发明还涉及包含至少三组转基因淋巴细胞的试剂盒或组合物，所述转基因淋巴细胞用编码针对所述抗原的TCR的载体转化。此外，本发明提供药物组合物及其在治疗涉及表达所述肿瘤相关抗原的恶性细胞的疾病中的用途。本发明还涉及编码识别存活蛋白抗原的TCR的核酸分子，由此编码的TCR和表达所述TCR的T细胞。此外，本发明公开了一种载体，细胞和编码/含有它们的药物组合物及其在治疗涉及表达存活蛋白的恶性细胞的疾病中的用途。

7. 发明授权

US09409969B2 Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof 有权
标题翻译：同种异体限制性肽特异性T细胞受体序列的汇编及其用途
公开(公告)号：US09409969B2
公开(公告)日：2016-08-09
申请号：US13148653
申请日：2010-02-09
申请人： Dolores J. Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
发明人： Dolores J. Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
IPC分类号： C07H21/04 , C07K14/705
CPC分类号： C07K14/7051 , C07K14/70503
摘要： The present invention is directed to a kit-of-parts or composition containing nucleic acid sequences coding for high-avidity, allo-restricted TCR, wherein the TCR are independently directed against the tyrosinase antigen, the melan-A antigen and the survivin antigen. The invention is further directed to a kit-of-parts or composition containing at least three groups of transgenic lymphocytes transformed with vectors coding for TCR against said antigens. Furthermore, the present invention provides a pharmaceutical composition and its use in the treatment of diseases involving malignant cells expressing said tumor-associated antigens. The invention further relates to a nucleic acid molecule coding for a TCR that recognizes the survivin antigen, a TCR encoded thereby and a T cell expressing said TCR. Further, the invention discloses a vector, a cell and a pharmaceutical composition encoding/containing same and their use in the treatment of diseases involving malignant cells expressing survivin.
摘要翻译：本发明涉及包含编码高亲合力，同种异体限制性TCR的核酸序列的成套工具或组合物，其中TCR独立地针对酪氨酸酶抗原，黑色素A抗原和存活蛋白抗原。本发明还涉及包含至少三组转基因淋巴细胞的试剂盒或组合物，所述转基因淋巴细胞用编码针对所述抗原的TCR的载体转化。此外，本发明提供药物组合物及其在治疗涉及表达所述肿瘤相关抗原的恶性细胞的疾病中的用途。本发明还涉及编码识别存活蛋白抗原的TCR的核酸分子，由此编码的TCR和表达所述TCR的T细胞。此外，本发明公开了一种载体，细胞和编码/含有它们的药物组合物及其在治疗涉及表达存活蛋白的恶性细胞的疾病中的用途。

8. 发明授权

US08697854B2 High affinity T cell receptor and use thereof 有权
标题翻译：高亲和力T细胞受体及其用途
公开(公告)号：US08697854B2
公开(公告)日：2014-04-15
申请号：US13130665
申请日：2009-11-24
申请人： Dolores Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
发明人： Dolores Schendel , Susanne Wilde , Bernhard Frankenberger , Wolfgang Uckert
IPC分类号： C07K14/725 , C12N15/12
CPC分类号： C07K14/7051 , A61K35/17 , A61K38/1774 , C07K2319/40 , C12N15/85
摘要： The present invention is directed to a high affinity T cell receptor (TCR) against a tumor-associated antigen, an isolated nucleic acid molecule encoding same, a T cell expressing said TCR, and a pharmaceutical composition for use in the treatment of diseases involving malignant cells expressing said tumor-associated antigen.
摘要翻译：本发明涉及针对肿瘤相关抗原的高亲和力T细胞受体（TCR），编码其的分离的核酸分子，表达所述TCR的T细胞和用于治疗涉及恶性疾病的药物组合物表达所述肿瘤相关抗原的细胞。

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