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1. 发明申请

US20050260158A1 Human stem cell materials and methods 审中-公开
标题翻译：人类干细胞的材料和方法
公开(公告)号：US20050260158A1
公开(公告)日：2005-11-24
申请号：US10968385
申请日：2004-10-18
申请人： Eliezer Huberman , Yong Zhao
发明人： Eliezer Huberman , Yong Zhao
IPC分类号： A61K35/15 , A61K48/00 , C12N5/071 , C12N5/0786 , C12N5/08
CPC分类号： A61K35/15 , C12N5/0607 , C12N5/0645 , C12N5/0676 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2506/03 , C12N2506/115
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease, including disorders or diseases associated with aberrant function or presence (i.e., level) of pancreatic islet β-cell-like macrophages.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状的方法，包括与胰岛β细胞的异常功能或存在（即水平）相关的疾病或疾病，细胞样巨噬细胞。

2. 发明申请

US20050003534A1 Human stem cell materials and methods 审中-公开
标题翻译：人类干细胞的材料和方法
公开(公告)号：US20050003534A1
公开(公告)日：2005-01-06
申请号：US10854962
申请日：2004-05-26
申请人： Eliezer Huberman , Yong Zhao
发明人： Eliezer Huberman , Yong Zhao
IPC分类号： A61K48/00 , C12N5/02 , C12N5/074 , E02D27/42 , C12N5/08
CPC分类号： C12N5/0607 , C12N2501/22 , C12N2501/2306 , C12N2501/235
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals are provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease including disorders or diseases associated with platelets.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状（包括与血小板相关的疾病或疾病）的方法。

3. 发明申请

US20130129696A1 Human Stem Cell Materials and Methods 审中-公开
标题翻译：人类干细胞材料与方法
公开(公告)号：US20130129696A1
公开(公告)日：2013-05-23
申请号：US13662012
申请日：2012-10-26
申请人： Eliezer Huberman , Yong Zhao
发明人： Eliezer Huberman , Yong Zhao
IPC分类号： C12N5/0781
CPC分类号： C12N5/0635 , A61K35/12 , A61K2035/124 , C12N5/0607 , C12N5/0619 , C12N5/0636 , C12N5/0645 , C12N5/067 , C12N5/069 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/52 , C12N2501/599 , C12N2503/02 , C12N2506/03 , C12N2506/115 , G01N33/5073 , Y02A50/401 , Y02A50/57
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其衍生物的方法。包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状的方法。

4. 发明申请

US20110070644A1 Monocyte-Derived Stem Cells (MDSC) and Methods of Use Thereof 审中-公开
标题翻译：单核细胞衍生干细胞（MDSC）及其使用方法
公开(公告)号：US20110070644A1
公开(公告)日：2011-03-24
申请号：US12954200
申请日：2010-11-24
申请人： Eliezer Huberman , Yong Zhao
发明人： Eliezer Huberman , Yong Zhao
IPC分类号： C12N5/0786 , C12Q1/18 , A61K35/14
CPC分类号： C12N5/0635 , A61K35/12 , A61K2035/124 , C12N5/0607 , C12N5/0619 , C12N5/0636 , C12N5/0645 , C12N5/067 , C12N5/069 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/52 , C12N2501/599 , C12N2503/02 , C12N2506/03 , C12N2506/115 , G01N33/5073 , Y02A50/401 , Y02A50/57
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞来源的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其衍生物的方法。包括治疗疾病或疾病的方法，以及改善与任何此类疾病或疾病相关的症状的方法。

5. 发明申请

US20080038238A1 Human Stem Cell Materials and Methods 审中-公开
标题翻译：人类干细胞材料与方法
公开(公告)号：US20080038238A1
公开(公告)日：2008-02-14
申请号：US11834416
申请日：2007-08-06
申请人： Eliezer Huberman , Yong Zhao
发明人： Eliezer Huberman , Yong Zhao
IPC分类号： A61K48/00 , A61P43/00 , C12N5/08 , C12N5/10 , C12Q1/02
CPC分类号： C12N5/0635 , A61K35/12 , A61K2035/124 , C12N5/0607 , C12N5/0619 , C12N5/0636 , C12N5/0645 , C12N5/067 , C12N5/069 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/52 , C12N2501/599 , C12N2503/02 , C12N2506/03 , C12N2506/115 , G01N33/5073 , Y02A50/401 , Y02A50/57
摘要： Monocyte derived adult stem cells (MDSCs) isolated from peripheral blood of mammals is provided, along with pharmaceutical compositions containing an MDSC, kits containing a pharmaceutical composition, and methods of preparing, propagating and using MDSCs or differentiated derivatives thereof. The uses of these biological materials include methods of treating disorders or diseases, as well as methods of ameliorating a symptom associated with any such disorder or disease.
摘要翻译：提供从哺乳动物的外周血分离的单核细胞衍生的成体干细胞（MDSC），以及含有MDSC的药物组合物，含有药物组合物的试剂盒，以及制备，增殖和使用MDSC或其差异衍生物的方法。这些生物材料的用途包括治疗疾病或疾病的方法，以及改善与任何此类病症或疾病相关的症状的方法。

6. 发明授权

US06673623B1 Methods and compositions that control lipid production 失效
标题翻译：控制脂质生产的方法和组合物
公开(公告)号：US06673623B1
公开(公告)日：2004-01-06
申请号：US09660107
申请日：2000-09-12
申请人： Eliezer Huberman
发明人： Eliezer Huberman
IPC分类号： G01N3300
CPC分类号： G01N33/502 , G01N33/5008 , Y10S436/805
摘要： The present invention relates generally to the use of lipogenins, proteins, e.g. human extra-cellular matrix protein 1 (ECM-1), human glia-derived nexin I alpha protein (NP-I), human tissue inhibitor of metalloproteinase-2 (TIMP-2) and human histone H2A (H2A) singly or in various combinations to control lipogenesis in a mammal.
摘要翻译：本发明一般涉及脂质成分，蛋白质等的用途。人类细胞外基质蛋白1（ECM-1），人神经胶质来源的nexinIα蛋白（NP-I），金属蛋白酶-2（TIMP-2）和人组蛋白H2A（H2A）的人组织抑制剂单独或各种用于控制哺乳动物脂肪生成的组合。

7. 发明授权

US06826488B1 Crystals, molecular complexes, and methods of developing lead compounds for inhibitors of bacterial IMPDH 失效
标题翻译：晶体，分子复合物，以及开发用于细菌IMPDH抑制剂的铅化合物的方法
公开(公告)号：US06826488B1
公开(公告)日：2004-11-30
申请号：US09533466
申请日：2000-03-23
申请人： Frank R. Collart , Eliezer Huberman , Andrezej Joachimiak , Rongguang Zhang , Edwin M. Westbrook
发明人： Frank R. Collart , Eliezer Huberman , Andrezej Joachimiak , Rongguang Zhang , Edwin M. Westbrook
IPC分类号： G06F1900
CPC分类号： C12N9/0006 , C07K2299/00 , C12Y101/01205
摘要： The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of bacterial IMPDH. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional representation on a computer screen. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen and design compounds, including inhibitory compounds, that bind to IMPDH or homologues thereof. This invention also relates to molecules and molecular complexes that comprise the active site binding pockets of IMPDH or close structural homologues of the active site binding pockets. This invention also relates to compounds and pharmaceutical compositions which are inhibitors of bacterial IMPDH.
摘要翻译：本发明涉及用结构化分子和分子复合物的结构坐标编码的数据存储介质，其包含细菌IMPDH的活性位点结合口袋。这样的数据存储材料能够在计算机屏幕上显示这样的分子和分子复合物或其结构同系物作为图形三维表示。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。此外，本发明涉及使用结构坐标来筛选和设计结合IMPDH或其同系物的化合物（包括抑制性化合物）的方法。本发明还涉及包含IMPDH的活性位点结合袋或活性位点结合口袋的紧密结构同系物的分子和分子复合物。本发明还涉及作为细菌IMPDH抑制剂的化合物和药物组合物。

8. 发明授权

US5665583A Methods and materials relating to IMPDH and GMP production 失效
标题翻译：与IMPDH和GMP生产有关的方法和材料
公开(公告)号：US5665583A
公开(公告)日：1997-09-09
申请号：US232302
申请日：1988-08-12
申请人： Frank R. Collart , Eliezer Huberman
发明人： Frank R. Collart , Eliezer Huberman
IPC分类号： A61K48/00 , C07K16/40 , C12N1/21 , C12N9/04 , C12N15/53 , C12P19/32 , C12N15/52 , C12N15/63 , C12N15/85
CPC分类号： C12N9/0006 , C07K16/40 , C12P19/32 , C12Y101/01205 , A61K48/00
摘要： Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase ("IMPDH"). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.
摘要翻译：公开了编码具有肌苷5'-单磷酸脱氢酶（“IMPDH”）的生物学性质的真核蛋白质的纯化和分离的DNA序列。说明性地，哺乳动物（例如，人）IMPDH编码DNA序列可用于宿主细胞的转化或转染，用于大规模重组产生由细胞内的IMPDH催化合成产生的酶活性表达产物和/或产物（例如，GMP）。包含IMPDH编码DNA序列的载体可用于基因扩增过程。本发明提供的重组蛋白质和合成肽可用作免疫学试剂和用于定量检测IMPDH的抗体（包括多克隆和单克隆抗体）的制备。

9. 发明授权

US07183106B1 Bacterial inosine 5′-monophosphate dehydrogenase (“IMPDH”) DNA as a dominant selectable marker in mammals and other eukaryotes 有权
标题翻译：细菌肌苷5'-单磷酸脱氢酶（“IMPDH”）DNA作为哺乳动物和其他真核生物中的主要选择标记
公开(公告)号：US07183106B1
公开(公告)日：2007-02-27
申请号：US10856409
申请日：2004-05-28
申请人： Eliezer Huberman , Mekhine J. Baccam
发明人： Eliezer Huberman , Mekhine J. Baccam
IPC分类号： C12N15/00
CPC分类号： C12N9/0006
摘要： The present invention relates to a nucleic acid sequence and its corresponding protein sequence useful as a dominant selectable marker in eukaryotes. More specifically the invention relates to a nucleic acid encoding a bacterial IMPDH gene that has been engineered into a eukaryotic expression vectors, thereby permitting bacterial IMPDH expression in mammalian cells. Bacterial IMPDH expression confers resistance to MPA which can be used as dominant selectable marker in eukaryotes including mammals. The invention also relates to expression vectors and cells that express the bacterial IMPDH gene as well as gene therapies and protein synthesis.
摘要翻译：本发明涉及可用作真核生物中显性选择标记的核酸序列及其相应的蛋白质序列。更具体地，本发明涉及编码细菌IMPDH基因的核酸，其已经被工程化成真核表达载体，从而允许在哺乳动物细胞中表达细菌IMPDH。细菌IMPDH表达赋予对MPA的抗性，其可以用作包括哺乳动物在内的真核生物的显性选择标记。本发明还涉及表达细菌IMPDH基因以及基因治疗和蛋白质合成的表达载体和细胞。

10. 发明授权

US06479628B1 Methods and materials relating to IMPDH and GMP production 失效
标题翻译：与IMPDH和GMP生产有关的方法和材料
公开(公告)号：US06479628B1
公开(公告)日：2002-11-12
申请号：US09712372
申请日：2000-11-13
申请人： Frank R. Collart , Eliezer Huberman
发明人： Frank R. Collart , Eliezer Huberman
IPC分类号： A61K3800
CPC分类号： C12N9/0006 , A61K48/00 , C07K16/40 , C12P19/32 , C12Y101/01205
摘要： Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5′-monophosphate dehydrogenase (“IMPDH”). Illustratively, mammalian (e.g., human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g., GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitative detection of IMPDH.
摘要翻译：公开了编码具有肌苷5'-单磷酸脱氢酶（“IMPDH”）的生物学性质的真核蛋白质的纯化和分离的DNA序列。说明性地，哺乳动物（例如，人）IMPDH编码DNA序列可用于宿主细胞的转化或转染，用于大规模重组产生由细胞内的IMPDH催化合成产生的酶活性表达产物和/或产物（例如，GMP）。包含IMPDH编码DNA序列的载体可用于基因扩增过程。本发明提供的重组蛋白质和合成肽可用作免疫学试剂和用于定量检测IMPDH的抗体（包括多克隆和单克隆抗体）的制备。

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