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1. 发明申请

US20080047026A1 Method For Isolating A Self-Renewing, Multipotent, Slow-Cycling Cell 有权
标题翻译：分离自我更新，多能，慢循环细胞的方法
公开(公告)号：US20080047026A1
公开(公告)日：2008-02-21
申请号：US10580511
申请日：2004-11-12
申请人： Elaine Fuchs , Tudorita Tumbar , Cedrick Blanpain , William E. Lowry
发明人： Elaine Fuchs , Tudorita Tumbar , Cedrick Blanpain , William E. Lowry
IPC分类号： C12N5/06 , A01K67/027 , C12Q1/68
CPC分类号： C12N5/063 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C07K14/4702 , C12N15/8509 , C12N2500/14 , C12N2501/115 , C12N2501/155 , C12N2501/585 , C12N2501/599 , C12N2502/1323
摘要： The present invention relates to methods for isolating infrequently-dividing, slow-cycling cells, a feature which is typical of stem cells in their niche. The methods of the present invention are advantageously used as classical stem cells can be isolated. Further provided are methods for generating clonal populations and inhibiting the differentiation of these cells. In addition markers for distinguishing these cells from progenitor cells are also disclosed.
摘要翻译：本发明涉及用于分离不常见的慢循环细胞的方法，其特征是干细胞在其利基中的典型特征。本发明的方法有利地用作可以分离的经典干细胞。还提供了产生克隆群体并抑制这些细胞分化的方法。此外，还公开了用于区分这些细胞与祖细胞的标志物。

2. 发明授权

US07829336B2 Method for isolating a self-renewing, multipotent, slow-cycling cell 有权
标题翻译：分离自我更新，多潜能，慢循环细胞的方法
公开(公告)号：US07829336B2
公开(公告)日：2010-11-09
申请号：US10580511
申请日：2004-11-12
申请人： Elaine Fuchs , Tudorita Tumbar , Cedrick Blanpain , William E. Lowry
发明人： Elaine Fuchs , Tudorita Tumbar , Cedrick Blanpain , William E. Lowry
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/063 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C07K14/4702 , C12N15/8509 , C12N2500/14 , C12N2501/115 , C12N2501/155 , C12N2501/585 , C12N2501/599 , C12N2502/1323
摘要： The present invention relates to methods for isolating infrequently-dividing, slow-cycling cells, a feature which is typical of stem cells in their niche. The methods of the present invention are advantageously used as classical stem cells can be isolated. Further provided are methods for generating clonal populations and inhibiting the differentiation of these cells. In addition markers for distinguishing these cells from progenitor cells are also disclosed.
摘要翻译：本发明涉及用于分离不常见的慢循环细胞的方法，其特征是干细胞在其利基中的典型特征。本发明的方法有利地用作可以分离的经典干细胞。还提供了产生克隆群体并抑制这些细胞分化的方法。此外，还公开了用于区分这些细胞与祖细胞的标志物。

3. 发明申请

US20100285589A1 GENERATION OF PLURIPOTENT CELLS FROM FIBROBLASTS 有权
标题翻译：来自FIBROBLASTS的PLUIPOTENT细胞的产生
公开(公告)号：US20100285589A1
公开(公告)日：2010-11-11
申请号：US12743776
申请日：2008-11-19
申请人： William E. Lowry , Kathrin Plath
发明人： William E. Lowry , Kathrin Plath
IPC分类号： C12N15/867 , C12N5/10
CPC分类号： C12N5/0696 , C07K14/4702 , C12N5/0619 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2501/50 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/45 , C12N2510/00 , C12N2799/027
摘要： Provided are methods and compositions useful for producing and propagating stem cells from fibroblasts.
摘要翻译：提供了用于从成纤维细胞产生和繁殖干细胞的方法和组合物。

4. 发明授权

US07670085B2 In situ immobilization of subsurface contamination 失效
标题翻译：地下污染的原位固定
公开(公告)号：US07670085B2
公开(公告)日：2010-03-02
申请号：US11606404
申请日：2006-11-28
申请人： Wesley L. Bratton , Joseph W Maresca, Jr. , William E. Lowry , Dawn Samara Kaback
发明人： Wesley L. Bratton , Joseph W Maresca, Jr. , William E. Lowry , Dawn Samara Kaback
IPC分类号： B09B1/00
CPC分类号： B09C1/005
摘要： Vertical migration of a plume of subsurface contamination in the vadose zone to the groundwater is prevented by forming and maintaining one or more desiccation layers in the vadose zone in or above a layer of contamination. Horizontal barrier layers are produced by injecting dry air at a specific elevation in one borehole and removing the air at another borehole. These horizontal layers act as an impermeable barrier to the vertical migration of dissolved contaminants.
摘要翻译：通过在污染层中或上方的渗流区中形成并保持一个或多个干燥层，可以防止渗流区中的下层污染物向地下水的垂直迁移。通过在一个井眼中注入特定高度的干燥空气并且在另一个井眼处去除空气来产生水平阻挡层。这些水平层作为溶解污染物的垂直迁移的不渗透屏障。

5. 发明申请

US20190350909A1 COMPOSITIONS AND METHODS FOR MODULATING HAIR GROWTH 审中-公开
公开(公告)号：US20190350909A1
公开(公告)日：2019-11-21
申请号：US16415822
申请日：2019-05-17
申请人： William E. Lowry , Matilde Miranda
发明人： William E. Lowry , Matilde Miranda
IPC分类号： A61K31/436 , A61K8/49 , A61K9/00 , A61P17/14 , A61Q7/00
摘要： The present disclosure relates to pharmaceutical compositions and methods for inhibiting Pde, promoting hair growth, and treating hair growth disorders, such as baldness or alopecia.

6. 发明授权

US09005966B2 Generation of pluripotent cells from fibroblasts 有权
标题翻译：从成纤维细胞产生多能细胞
公开(公告)号：US09005966B2
公开(公告)日：2015-04-14
申请号：US12743776
申请日：2008-11-19
申请人： William E. Lowry , Kathrin Plath
发明人： William E. Lowry , Kathrin Plath
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , C12N15/00 , C12N5/074 , C12N5/0793 , C07K14/47
CPC分类号： C12N5/0696 , C07K14/4702 , C12N5/0619 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2501/50 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/45 , C12N2510/00 , C12N2799/027
摘要： Provided are methods and compositions useful for producing and propagating stem cells from fibroblasts.
摘要翻译：提供了用于从成纤维细胞产生和繁殖干细胞的方法和组合物。

7. 发明授权

US6098448A In situ measurement apparatus and method of measuring soil permeability and fluid flow 失效
标题翻译：测量土壤渗透率和流体流量的现场测量仪器和方法
公开(公告)号：US6098448A
公开(公告)日：2000-08-08
申请号：US061078
申请日：1998-04-15
申请人： William E. Lowry , Neva Gray Mason , Daniel Merewether
发明人： William E. Lowry , Neva Gray Mason , Daniel Merewether
IPC分类号： G01N15/08
CPC分类号： G01N15/08 , G01N15/0826
摘要： An apparatus and method for discrete soil gas and saturated liquid permeability measurements with direct push emplacement systems (such as a cone penetrometer rod). A modified direct push emplacement system having at least one injection port and at least two measurement ports is first engaged to penetrate the soil to a predetermined depth. Gas or liquid is then injected into the soil at a predetermined location on the penetrometer rod. Next, a pressure response is recorded from each measurement port, which is at a known distance from the injection port (on the same penetrometer rod). This differential pressure response data allows calculation of the soil permeability directly by using a one-dimensional, spherical, steady state, porous flow model to measure the effective permeability of the soil, without substantial disturbance of the surrounding soil. The present invention minimizes false indications of reduced permeability as a result of soil compaction during the penetrometer emplacement.
摘要翻译：一种用于离散土壤气体和饱和液体渗透性测量的设备和方法，具有直接推入位置系统（例如锥形穿透仪棒）。首先接合具有至少一个注射口和至少两个测量口的改进的直接推入装置，以将土壤穿透到预定的深度。然后将气体或液体在穿透仪棒上的预定位置注入土壤中。接下来，从距离注入口（在相同的测量棒上）已知距离的每个测量端口记录压力响应。这种压差响应数据可以直接使用一维球形稳态多孔流模型来计算土壤渗透率，以测量土壤的有效渗透率，而不会对周围土壤产生实质的干扰。本发明使渗透仪在渗透计量过程中由于土壤压实而导致的渗透性降低的错误迹象最小化。

8. 发明授权

US6035701A Method and system to locate leaks in subsurface containment structures using tracer gases 失效
标题翻译：使用示踪气体定位地下围护结构泄漏的方法和系统
公开(公告)号：US6035701A
公开(公告)日：2000-03-14
申请号：US60952
申请日：1998-04-15
申请人： William E. Lowry , Sandra Dalvit Dunn , Robert Walsh , Daniel Merewether , Desario V. Rao
发明人： William E. Lowry , Sandra Dalvit Dunn , Robert Walsh , Daniel Merewether , Desario V. Rao
IPC分类号： B09B1/00 , B09C1/00 , E02D1/00 , E02D31/00 , E21B47/10 , G01M3/20 , G01M3/22 , E02D3/00 , G01N33/22
CPC分类号： B09C1/00 , B09B1/00 , E02D1/00 , E21B47/1015 , G01M3/20 , E02D2600/10 , E02D31/00 , Y02W30/35
摘要： The present invention integrates an inverse modeling technique and a field measurement system. The system uses inexpensive and non-hazardous gaseous tracers injected inside the contained volume of a barrier to quantify the location and size of any leaks in the barrier. The vapor sampling point installation, which allows the collection of soil gas samples from multiple points around the barrier installation, can be accomplished with conventional drilling or direct push techniques. The system uses a field-proven soil gas analyzer, incorporated in a sampling system capable of monitoring many sample points with relatively high time resolution. A rigorous inverse modeling technology is integrated with the data system for real time analysis.
摘要翻译：本发明集成了逆建模技术和现场测量系统。该系统使用注入屏障容纳体积内的便宜且无危险的气体示踪剂来量化屏障中任何泄漏的位置和大小。采用传统的钻井或直接推压技术，可以实现从隔离装置周围多个点收集土壤气体样品的蒸气取样点装置。该系统采用经现场验证的土壤气体分析仪，并纳入采样系统，能够以较高的时间分辨率监测多个采样点。将严格的反向建模技术与数据系统集成进行实时分析。

9. 发明授权

US5686674A System for characterizing surfaces of pipes, ducts or similar structures 失效
标题翻译：用于表征管道，管道或类似结构的表面的系统
公开(公告)号：US5686674A
公开(公告)日：1997-11-11
申请号：US514592
申请日：1995-08-14
申请人： William E. Lowry , Sandra Dalvit Dunn , Charles D. Cremer , Eric J. Cramer
发明人： William E. Lowry , Sandra Dalvit Dunn , Charles D. Cremer , Eric J. Cramer
IPC分类号： E21B23/08 , F16L55/48
CPC分类号： F16L55/48 , E21B23/08
摘要： A system for characterizing contamination or integrity information from within a pipe, including a flexible tubular membrane which is extendable within the pipe and inflatable to a diameter effective to urge the tubular membrane against the rigid wall. The tubular membrane has a first end and a second end, and is initially rolled up and connected to a reel inside of a deployment system. A tether connects the deployment system to a characterization tool retained within the tubular membrane, which is attached adjacent to the second end of the tubular membrane. When the system is engaged, pressurized fluid enters the tubular membrane causing the membrane to invert and distend into and through the pipe's interior. Simultaneously, the attached characterization tool is towed adjacent to and in parallel with the path of the tubular membrane's second end, is protected from contamination by the surrounding tubular membrane, and is capable of repetitive testing for several forms of information, such as structural integrity of the pipe's interior or radioactive contamination. As the tool traverses the pipe's interior, this information is transmitted to a data acquisition system. When the system is disengaged, the deployment system, the tether and the characterization tool are used to retrieve the system in reverse order. A vent is provided for equalizing pressure beneath the tubular membrane while retracting the membrane.
摘要翻译：用于从管内表征污染或完整性信息的系统，包括柔性管状膜，其可在管内延伸并且可膨胀至直径以有效地将管状膜推向刚性壁。管状膜具有第一端和第二端，并且初始地卷起并连接到展开系统内部的卷筒。系绳将部署系统连接到保持在管状膜内的表征工具，其连接在管状膜的第二端附近。当系统接合时，加压流体进入管状膜，导致膜反转并膨胀并穿过管道的内部。同时，附着的表征工具在管状膜的第二端的路径附近被拖曳并且与管状膜的第二端的路径平行地被保护，免受周围管状膜的污染，并且能够重复测试几种形式的信息，例如结构完整性管道内部或放射性污染。当工具穿过管道内部时，该信息被传送到数据采集系统。当系统脱离时，部署系统，系绳和表征工具用于以相反的顺序检索系统。提供排气口用于在收缩膜的同时使管状膜下方的压力均衡。

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