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1. 发明授权

US4820831A Process for preparing 4,4'-dihydroxydiphenyl sulfone having high purity 失效
标题翻译：制备高纯度的4,4'-二羟基二苯砜的方法
公开(公告)号：US4820831A
公开(公告)日：1989-04-11
申请号：US10095
申请日：1986-12-12
申请人： Eiji Ogata , Koji Ono , Nobuyuki Nate
发明人： Eiji Ogata , Koji Ono , Nobuyuki Nate
IPC分类号： C07C315/00 , B01J31/02 , C07C67/00 , C07C313/00 , C07C317/22 , F15B11/04 , C07C147/10
CPC分类号： C07C317/00
摘要： The process of the present invention is a process for preparing 4,4'-dihydroxydiphenyl sulfone by subjecting phenol, and a sulfonating agent or phenolsulfonic acid to a dehydration reaction in the presence of a solvent, subsequently maintaining the reaction system at a temperature of between 100.degree. to 200.degree. C. and removing the solvent from the reaction system to cause the dehydration reaction to further proceed while allowing 4,4'-dihydroxydiphenyl sulfone to separate out and to subject dissolved 2,4'-dihydroxydiphenyl sulfone formed as a by-product to an isomerization reaction for converting the by-product to 4,4'-dihydroxydiphenyl sulfone, and eventually removing the solvent and the unreacted phenol from the system substantially entirely to complete the isomerization reaction, the process being characterized in that an aromatic sulfonic acid represented by the formula ##STR1## wherein X is a halogen atom, n is 0, 1 or 2, and m is 1 of 2 is caused to be present in the reaction system. 4,4'-Dihydroxydiphenyl sulfone can be produced by the process with a high purity and in a high yield.
摘要翻译： PCT No.PCT / JP86 / 00194 Sec。 371日期：1986年12月12日 102（e）日期1986年12月12日PCT提交1986年4月17日PCT公布。公开号WO86 / 06370 日本1986年11月6日。本发明的方法是通过在溶剂存在下使苯酚和磺化剂或苯酚磺酸进行脱水反应来制备4,4'-二羟基二苯基砜的方法，反应体系在100〜200℃的温度下，从反应体系中除去溶剂，使脱水反应进一步进行，同时使4,4'-二羟基二苯砜分离出来并使溶解的2,4' - 二羟基二苯砜作为副产物形成异构化反应，用于将副产物转化为4,4'-二羟基二苯基砜，并最终从体系中除去溶剂和未反应的苯酚，完全完全异构化反应，该方法其特征在于，由式“IMAGE”表示的芳族磺酸，其中X为卤素原子，n为0,1或2，m为2的m为芳族磺酸存在于反应体系。 4,4'-二羟基二苯砜可以通过高纯度和高收率的方法生产。

2. 发明授权

US4558161A Process for preparing halo-substituted diarylsulfones 失效
标题翻译：卤代二芳基砜的制备方法
公开(公告)号：US4558161A
公开(公告)日：1985-12-10
申请号：US588865
申请日：1984-01-25
申请人： Yukichi Morita , Koji Ono , Eiji Ogata , Osamu Manabe
发明人： Yukichi Morita , Koji Ono , Eiji Ogata , Osamu Manabe
IPC分类号： C07C315/00 , C07C67/00 , C07C313/00 , C07C317/14 , C07C147/06
CPC分类号： C07C317/00
摘要： A process for preparing diarylsulfone, the process comprising reacting chlorosulfonic acid with a mixture of (i) aromatic hydrocarbon represented by the formula ##STR1## wherein one of X and Y is a halogen atom and the other is a halogen atom or a hydrogen atom and (ii) aromatic sulfonic acid represented by the formula ##STR2## wherein X and Y are as defined above.
摘要翻译： PCT No.PCT / JP83 / 00155 Sec。 371日期1984年1月25日 102（e）日期1984年1月25日PCT提交1983年5月20日PCT公布。公开号WO83 / 04251 日本公报1983年12月8日。一种制备二芳基砜的方法，该方法包括使氯磺酸与（ⅰ）式（ⅰ）表示的芳族烃的混合物反应，其中X和Y之一是卤素原子，另一个是卤素原子或氢原子，和（ii）由式“IMAGE”表示的芳族磺酸，其中X和Y如上所定义。

3. 发明授权

US4162270A Process for producing 4,4'-dihydroxydiphenylsulfone of high purity 失效
标题翻译：生产高纯度的4,4'-二羟基二苯基砜的方法
公开(公告)号：US4162270A
公开(公告)日：1979-07-24
申请号：US896611
申请日：1978-04-14
申请人： Eiji Ogata , Koji Ono , Shoji Nakagaki
发明人： Eiji Ogata , Koji Ono , Shoji Nakagaki
IPC分类号： C07C315/00 , C07C317/22 , C07C147/10
CPC分类号： C07C315/00
摘要： In a process for producing 4,4'-dihydroxydiphenylsulfone by reacting phenol with sulfuric acid in the presence of a solvent, an improvement which comprises using at least a member selected from the group consisting of chlorobenzene, dichlorobenzene, trichlorobenzene, chlorotoluene, diethylbenzene, xylene, decalin, tetralin and tetrachloroethane as the solvent and removing said solvent progressively and finally substantially completely from the mixture while maintaining the reaction mixture at a temperature of about 160.degree. to about 200.degree. C. to effect precipitation of 4,4'-dihydroxydiphenylsulfone and isomerization of 2,4'-dihydroxydiphenylsulfone to 4,4'-dihydroxydiphenylsulfone.
摘要翻译：在溶剂存在下，通过苯酚与硫酸反应生产4,4'-二羟基二苯砜的方法，包括使用至少一种选自氯苯，二氯苯，三氯苯，氯甲苯，二乙苯，二甲苯，十氢化萘，四氢化萘和四氯乙烷作为溶剂，并逐渐地并最终基本上完全从混合物中除去所述溶剂，同时将反应混合物保持在约160℃至约200℃的温度，以实现4,4'-二羟基二苯砜和 2,4'-二羟基二苯砜异构化为4,4'-二羟基二苯砜。

4. 发明授权

US5097074A Process for purifying 4,4'-dihydroxydiphenylsulfone 失效
标题翻译：纯化4,4'-二羟基二苯基砜的方法
公开(公告)号：US5097074A
公开(公告)日：1992-03-17
申请号：US362411
申请日：1989-04-10
申请人： Eiji Ogata , Koji Ono
发明人： Eiji Ogata , Koji Ono
IPC分类号： C07C315/06 , C07C317/22 , C07C317/24
CPC分类号： C07C315/06
摘要： The invention provides a process for purifying crude 4,4'-dihydroxydiphenylsulfone characterized by dissolving the crude 4,4'-dihydroxydiphenylsulfone in an aqueous solution of a basic substance, precipitating a mono-salt of 4,4'-dihydroxydiphenylsulfone from the resulting solution by salting out, separating the salt off and subsequently treating the salt with an acid, and also porovides a process for preparing a mono-salt of 4,4'-dihydroxydiphenylsulfone characterized by dissolving crude 4,4'-dihydroxydiphenylsulfone in an aqueous solution of a basic substance, precipitating a mono-salt of 4,4'-dihydroxydiphenylsulfone from the resulting solution by salting out, and separating the salt off.
摘要翻译： PCT No.PCT / JP88 / 00813 Sec。 371日期：1989年4月10日 102（e）日期1989年4月10日PCT提交1988年8月17日PCT公布。出版物WO89 / 01469 日本特开1989年2月23日。本发明提供一种纯化粗制4,4'-二羟基二苯砜的方法，其特征在于将粗制4,4'-二羟基二苯砜溶于碱性物质的水溶液中，沉淀出4,4'-二羟基二苯砜的单盐通过盐析从所得溶液中分离出脱盐并随后用酸处理盐，并且还可以制备4,4'-二羟基二苯基砜单盐的方法，其特征在于将粗4,4'-二羟基二苯砜 - 二羟基二苯砜在碱性物质的水溶液中，通过盐析从所得溶液中沉淀出4,4'-二羟基二苯砜的单盐，并将盐分离。

5. 发明申请

US20080227312A1 Multilayer wiring substrate 有权
标题翻译：多层布线基板
公开(公告)号：US20080227312A1
公开(公告)日：2008-09-18
申请号：US12076014
申请日：2008-03-12
申请人： Eiji Ogata , Kazunori Omori , Koichi Namimatsu , Kazunari Fukagawa
发明人： Eiji Ogata , Kazunori Omori , Koichi Namimatsu , Kazunari Fukagawa
IPC分类号： H01R12/06
CPC分类号： H05K3/4046 , H05K3/3447 , H05K2201/0133 , H05K2201/09645 , H05K2201/1059
摘要： A first wiring pattern formed on a first layer of a multilayer wiring substrate, a second wiring pattern formed on a layer different from the first layer on which the first wiring pattern is formed, a penetration hole penetrating the front surface and the back surface of the substrate, and a penetration hole penetrating a front surface and a back surface of the substrate; and a fitting connector having a conductor part on a side surface inscribed in the penetration hole and fitting into the penetration hole are provided. The first wiring pattern and the second wiring pattern are exposed from the internal surface of the penetration hole, and the fitting connector connects a first end part of the conductor part and a second end part with an exposed part of the first wiring pattern and an exposed part of the second wiring pattern, respectively.
摘要翻译：形成在多层布线基板的第一层上的第一布线图案，形成在与形成有第一布线图案的第一层不同的层上的第二布线图案，穿透第一布线图案的前表面和后表面的穿透孔基板和穿透基板的前表面和后表面的穿透孔; 以及配合连接器，其具有位于贯通孔内侧的嵌合于贯通孔的侧面的导体部。第一布线图案和第二布线图案从穿孔的内表面露出，并且嵌合连接器将导体部的第一端部和第二端部与第一布线图案的露出部分连接，分别是第二布线图案的一部分。

6. 发明授权

US06635253B2 Composition for enhancing immunological effects 失效
标题翻译：用于增强免疫学效果的组合物
公开(公告)号：US06635253B2
公开(公告)日：2003-10-21
申请号：US09794161
申请日：2001-02-28
申请人： Shinobu Ito , Eiji Ogata
发明人： Shinobu Ito , Eiji Ogata
IPC分类号： A61K3938
CPC分类号： A61K47/24 , A61K9/0019 , A61K31/375 , A61K31/665 , A61K39/39 , A61K45/06 , A61K47/22 , A61K2039/55511
摘要： An object of the present invention is to provide a composition for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens, containing a stable activity-type provitamin; a method for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens by administering the composition; and a method of employing the composition. A composition for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens, contains L-ascorbic acid-2-phosphate and/or &agr;-tocopheryl phosphate as a stable activity antioxidant provitamin.
摘要翻译：本发明的目的是提供一种用于增强含有稳定的活性型前病毒的病毒，细菌和/或感染性疾病病原体的疫苗的免疫效果的组合物; 通过施用组合物来增强疫苗对病毒，细菌和/或感染性疾病病原体的免疫效果的方法; 和采用该组合物的方法。用于增强疫苗对病毒，细菌和/或感染性疾病病原体的免疫效果的组合物含有L-抗坏血酸-2-磷酸和/或α-生育酚磷酸酯作为稳定活性的抗氧化剂前维生素。

7. 发明授权

US06437002B1 Agent for preventing and treating skin diseases 失效
标题翻译：预防和治疗皮肤病的药剂
公开(公告)号：US06437002B1
公开(公告)日：2002-08-20
申请号：US09418317
申请日：1999-10-14
申请人： Shinobu Ito , Eiji Ogata , Hiroshi Ikeno
发明人： Shinobu Ito , Eiji Ogata , Hiroshi Ikeno
IPC分类号： A61K3100
CPC分类号： C07F9/65515 , A61K8/11 , A61K8/14 , A61K8/676 , A61K9/127 , A61K31/7048 , A61K2800/412 , A61K2800/522 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07D307/62
摘要： The present invention relates to an agent for preventing and treating skin diseases comprising as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity; wherein R1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R2 to R4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.
摘要翻译：本发明涉及一种用于预防和治疗皮肤疾病的药剂，其包含作为活性成分的作为下式（1）表示的化合物的抗坏血酸衍生物或其盐，本身不具有抗氧化活性，能够在体内转化成具有抗氧化活性的化合物;其中R1表示能够通过醚或酯键与抗坏血酸骨架的2-位上的碳键合并在体内可转化为羟基的基团，R 2〜R 4可以相同或不同，表示羟基或由其衍生的基团。

8. 发明授权

US06420419B1 L-ascorbic acid 2-phosphate zinc salt and process for manufacturing the same 失效
标题翻译： L-抗坏血酸2-磷酸锌盐及其制造方法
公开(公告)号：US06420419B1
公开(公告)日：2002-07-16
申请号：US09095895
申请日：1998-06-11
申请人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
发明人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
IPC分类号： A61K31341
CPC分类号： A61K31/665 , C07D307/62
摘要： L-Ascorbic acid 2-phosphate zinc salt and a salt hydrate thereof having excellent solubility and exhibiting good stability even under weakly acidic conditions. Also disclosed is a process of manufacturing L-ascorbic acid 2-phosphate zinc salt by displacing a cation of a salt of an L-ascorbic acid 2-phosphate other than a zinc salt with a zinc cation. Further disclosed is a composition containing L-ascorbic acid 2-phosphate zinc salt or a salt hydrate thereof as an active ingredient.
摘要翻译： L-抗坏血酸2-磷酸锌盐及其盐水合物，即使在弱酸性条件下也具有优异的溶解性和良好的稳定性。还公开了通过用锌阳离子置换除了锌盐之外的L-抗坏血酸2-磷酸盐的阳离子来制造L-抗坏血酸2-磷酸锌盐的方法。进一步公开了含有L-抗坏血酸2-磷酸锌盐或其盐水合物作为活性成分的组合物。

9. 发明授权

US6046181A Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic 有权
标题翻译：高纯度生育磷酸酯，其生产方法，分析方法和化妆品
公开(公告)号：US6046181A
公开(公告)日：2000-04-04
申请号：US342228
申请日：1999-06-29
申请人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
发明人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
IPC分类号： A61K8/02 , A61K8/67 , A61Q1/02 , A61Q1/04 , A61Q5/02 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C07F9/655 , G01N30/02 , G01N30/88 , G01N33/82 , A61K7/035 , A61K7/00 , A61K7/02 , A61K7/021 , A61K7/027
CPC分类号： G01N33/82 , A61K8/0212 , A61K8/678 , A61Q19/00 , C07F9/65522 , A61Q1/02 , A61Q1/04 , A61Q11/00 , A61Q19/10 , A61Q5/02 , A61Q7/00 , G01N2030/884 , G01N30/02 , Y10S514/846
摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.
摘要翻译：本文公开了高纯度的生育磷酸酯和/或其盐（生育磷酸酯），其中P，P'-二生育酚低磷酸盐和/或其盐（P，P'-二生育基二磷酸酯）的含量不高于超过3％重量; 一种生产高纯度生育磷酸酯和/或其盐的方法，其包括使生育酚与三卤氧磷反应，然后用酸或碱性水溶液处理，从而形成生育磷酸酯（i），其中P，含有作为副产物形成的P'-二生育基二磷酸酯（ⅱ），在酸性条件下水解P，P'-二生育基二磷酸酯（ⅱ），任选地在碱性条件下使水解产物中性或碱性。以及分析生育磷酸酯的方法，包括使用填充有与其键合的聚甲基丙烯酸酯的凝胶的高效液相色谱柱分析含有成分（i）和（ii）的样品的长链烷基。高纯度的生育磷酸酯中没有或仅有非常少量的P，P'-二生育基二磷酸酯，因此高纯度的生育磷酸酯表现出抗氧化和促进血液循环的作用，具有优异的水溶性，是粉末状的，它非常容易，没有皮肤刺激和过敏原，并确保皮肤安全。因此，高纯度的生育磷酸酯可用作化妆品成分。组分（i）和（ii）的量可以通过上述方法以高精度简单地测量。

10. 发明授权

US6022867A Method of administering vitamin E to animals and compositions containing tocopheryl phosphates and salts thereof for animals 失效
标题翻译：向动物施用维生素E的方法以及含有生育磷酸酯及其盐的动物的组合物
公开(公告)号：US6022867A
公开(公告)日：2000-02-08
申请号：US980371
申请日：1997-11-28
申请人： Shinobu Ito , Eiji Ogata
发明人： Shinobu Ito , Eiji Ogata
IPC分类号： A23K1/16 , A23L1/32 , A61K31/665 , G01N33/82 , A61K31/355
CPC分类号： A61K31/665 , A23K20/174 , A23L15/00 , G01N33/82
摘要： A vitamin E source composition for administration to animals, which comprises a tocopheryl phosphate, a salt thereof or a composition containing a tocopheryl phosphate or a salt thereof. Also, disclosed is a method of supplying vitamin E to animals which comprises administering to animals the above vitamin E source composition. The tocopheryl phosphoric acid and a salt thereof can be formed into a composition and also can contain an antioxidant or the like.
摘要翻译：一种用于给予动物的维生素E源组合物，其包含生育磷酸酯，其盐或含有生育磷酸酯或其盐的组合物。此外，还公开了向动物提供维生素E的方法，其包括向动物施用上述维生素E源组合物。生育磷酸及其盐可以形成为组合物，也可以含有抗氧化剂等。

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