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1. 发明授权

US08571653B2 Nerve stimulation techniques 有权
标题翻译：神经刺激技术
公开(公告)号：US08571653B2
公开(公告)日：2013-10-29
申请号：US13022279
申请日：2011-02-07
申请人： Tamir Ben-David , Ehud Cohen , Yossi Gross , Shai Ayal
发明人： Tamir Ben-David , Ehud Cohen , Yossi Gross , Shai Ayal
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/36075 , A61N1/36114
摘要： A method is provided for treating heart failure in a subject in need of such treatment, including applying a stimulating current to parasympathetic nervous tissue of the subject, selected from the group consisting of: a vagus nerve and an epicardial fat pad. The stimulating current is configured to inhibit release of at least one proinflammatory cytokine sufficiently to the treat heart failure of the subject. A level of the at least one proinflammatory cytokine is measured. Optionally, the stimulating current is configured to change a level of Connexin 43 of the subject, and the level of Connexin 43 is also measured. Other embodiments are also described.
摘要翻译：提供了一种用于治疗需要这种治疗的受试者的心力衰竭的方法，包括向受试者的副交感神经组织施加刺激电流，所述副交感神经组织选自：迷走神经和心外膜脂肪垫。刺激电流被配置为抑制至少一种促炎细胞因子释放足以治疗受试者的心力衰竭。测量至少一种促炎细胞因子的水平。可选地，刺激电流被配置为改变受试者的连接蛋白43的水平，并且还测量连接蛋白43的水平。还描述了其它实施例。

2. 发明授权

US08065021B2 Electrode assembly for nerve control 有权
标题翻译：用于神经控制的电极组件
公开(公告)号：US08065021B2
公开(公告)日：2011-11-22
申请号：US11981301
申请日：2007-10-30
申请人： Yossi Gross , Shai Ayal , Ehud Cohen
发明人： Yossi Gross , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/04
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.
摘要翻译：提供用于向神经施加电流的装置。阴极适于放置在神经的阴极纵向位置附近，并将阴极电流施加于神经。初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置现场。

3. 发明授权

US07890185B2 Treatment of disorders by unidirectional nerve stimulation 有权
标题翻译：通过单向神经刺激治疗疾病
公开(公告)号：US07890185B2
公开(公告)日：2011-02-15
申请号：US10722589
申请日：2003-11-25
申请人： Ehud Cohen , Yossi Gross , Shai Ayal
发明人： Ehud Cohen , Yossi Gross , Shai Ayal
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/36114
摘要： Apparatus for treating a condition of a subject is provided. An electrode device is adapted to be coupled to longitudinal nervous tissue of the subject, and a control unit is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.
摘要翻译：提供了用于治疗受试者状况的装置。电极装置适于耦合到受试者的纵向神经组织，并且控制单元适于驱动电极装置向神经组织施加能够诱导在神经组织中传播的动作电位的电流第一个方向，以处理病情。控制单元还适于抑制动作电位在与第一方向相反的第二方向上在神经组织中传播。

4. 发明授权

US08615294B2 Electrode devices for nerve stimulation and cardiac sensing 有权
标题翻译：用于神经刺激和心脏感知的电极装置
公开(公告)号：US08615294B2
公开(公告)日：2013-12-24
申请号：US12228630
申请日：2008-08-13
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Yossi Gross , Nir Schain
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Yossi Gross , Nir Schain
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/4041 , A61B5/6846 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, the apparatus comprising an electrode device, which comprises a housing, which is configured to be placed at least partially around the nerve, so as to define an outer surface of the electrode device and an inner surface that faces the nerve. The electrode device further comprises one or more first electrode contact surfaces, fixed to the inner surface of the housing, and one or more second electrode contact surfaces, fixed to the outer surface of the housing. Other embodiments are also described.
摘要翻译：提供了用于对受试者的神经施用的装置，该装置包括电极装置，该电极装置包括壳体，该壳体构造成至少部分地围绕神经放置，以限定电极装置的外表面，以及面向神经的内表面。电极装置还包括固定到壳体的内表面的一个或多个第一电极接触表面和固定到外壳的外表面的一个或多个第二电极接触表面。还描述了其它实施例。

5. 发明申请

US20100042186A1 Electrode devices for nerve stimulation and cardiac sensing 有权
标题翻译：用于神经刺激和心脏感知的电极装置
公开(公告)号：US20100042186A1
公开(公告)日：2010-02-18
申请号：US12228630
申请日：2008-08-13
申请人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Yossi Gross , Nir Schain
发明人： Tamir Ben-David , Shai Ayal , Ehud Cohen , Yossi Gross , Nir Schain
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/4041 , A61B5/6846 , A61N1/36114
摘要： Apparatus is provided for application to a nerve of a subject, the apparatus comprising an electrode device, which comprises a housing, which is configured to be placed at least partially around the nerve, so as to define an outer surface of the electrode device and an inner surface that faces the nerve. The electrode device further comprises one or more first electrode contact surfaces, fixed to the inner surface of the housing, and one or more second electrode contact surfaces, fixed to the outer surface of the housing. Other embodiments are also described.
摘要翻译：提供了用于对受试者的神经施用的装置，该装置包括电极装置，该电极装置包括壳体，该壳体构造成至少部分地围绕神经放置，以限定电极装置的外表面，以及面向神经的内表面。电极装置还包括固定到壳体的内表面的一个或多个第一电极接触表面和固定到外壳的外表面的一个或多个第二电极接触表面。还描述了其它实施例。

6. 发明申请

US20050038490A1 Electrode assembly for nerve control 有权
标题翻译：用于神经控制的电极组件
公开(公告)号：US20050038490A1
公开(公告)日：2005-02-17
申请号：US10948516
申请日：2004-09-23
申请人： Yossi Gross , Shai Ayal , Ehud Cohen
发明人： Yossi Gross , Shai Ayal , Ehud Cohen
IPC分类号： A61N20060101 , A61N1/05 , A61N1/34 , A61N1/36 , A61N1/362
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.
摘要翻译：提供用于向神经施加电流的装置。阴极适于放置在神经的阴极纵向位置附近，并将阴极电流施加于神经。初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置现场。

7. 发明授权

US07734355B2 Treatment of disorders by unidirectional nerve stimulation 失效
标题翻译：通过单向神经刺激治疗疾病
公开(公告)号：US07734355B2
公开(公告)日：2010-06-08
申请号：US10488334
申请日：2002-01-23
申请人： Ehud Cohen , Yossi Gross , Shai Ayal
发明人： Ehud Cohen , Yossi Gross , Shai Ayal
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61N1/0556 , A61N1/36114
摘要： Apparatus (18) for treating a condition of a subject is provided. An electrode device (100) is adapted to be coupled to longitudinal nervous tissue (40) of the subject, and a control unit (50) is adapted to drive the electrode device to apply to the nervous tissue a current which is capable of inducing action potentials that propagate in the nervous tissue in a first direction, so as to treat the condition. The control unit is further adapted to suppress action potentials from propagating in the nervous tissue in a second direction opposite to the first direction.
摘要翻译：提供了用于治疗受试者状况的装置（18）。电极装置（100）适于联接到受试者的纵向神经组织（40），并且控制单元（50）适于驱动电极装置向神经组织施加能够引起动作的电流在第一方向在神经组织中传播的电位，以便治疗病症。控制单元还适于抑制动作电位在与第一方向相反的第二方向上在神经组织中传播。

8. 发明申请

US20080132964A1 Selective nerve fiber stimulation for treating heart conditions 审中-公开
公开(公告)号：US20080132964A1
公开(公告)日：2008-06-05
申请号：US11981369
申请日：2007-10-30
申请人： Ehud Cohen , Shai Ayal , Tamir Ben-David , Omry Ben-Ezra , Yossi Gross
发明人： Ehud Cohen , Shai Ayal , Tamir Ben-David , Omry Ben-Ezra , Yossi Gross
IPC分类号： A61N1/36 , A61N1/39 , A61N1/365
CPC分类号： A61B5/412 , A61B5/024 , A61B5/4029 , A61B5/4041 , A61B5/7217 , A61N1/0551 , A61N1/0556 , A61N1/36114 , A61N1/3621 , A61N1/3627
摘要： Apparatus is provided that includes an electrode device, adapted to be coupled to a vagus nerve of a subject, and a control unit, adapted to drive the electrode device to apply to the vagus nerve a current that reduces heart rate variability of the subject. Also provided is a method comprising applying to a vagus nerve of a subject a current that reduces heart rate variability of the subject.

9. 发明申请

US20080109045A1 SELECTIVE NERVE FIBER STIMULATION FOR TREATING CONDITIONS 审中-公开
标题翻译：选择性神经纤维刺激治疗条件
公开(公告)号：US20080109045A1
公开(公告)日：2008-05-08
申请号：US11932579
申请日：2007-10-31
申请人： Yossi Gross , Shai Ayal , Ehud Cohen
发明人： Yossi Gross , Shai Ayal , Ehud Cohen
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus for treating a heart condition of a subject is provided, including an electrode device, which is adapted to be coupled to a vagus nerve of the subject. A control unit is adapted to drive the electrode device to apply to the vagus nerve a stimulating current, which is capable of inducing action potentials in a therapeutic direction in a first set and a second set of nerve fibers of the vagus nerve. The control unit is also adapted to drive the electrode device to apply to the vagus nerve an inhibiting current, which is capable of inhibiting the induced action potentials traveling in the therapeutic direction in the second set of nerve fibers, the nerve fibers in the second set having generally larger diameters than the nerve fibers in the first set.
摘要翻译：提供了用于治疗受试者的心脏病状的装置，包括适于联接到受试者的迷走神经的电极装置。控制单元适于驱动电极装置向迷走神经施加刺激电流，其能够诱导迷走神经的第一组和第二组神经纤维中的治疗方向的动作电位。控制单元还适于驱动电极装置向迷走神经施加抑制电流，该抑制电流能够抑制在第二组神经纤维中的治疗方向上的诱导作用电位，第二组神经纤维其直径大于第一组中的神经纤维。

10. 发明授权

US06907295B2 Electrode assembly for nerve control 失效
标题翻译：用于神经控制的电极组件
公开(公告)号：US06907295B2
公开(公告)日：2005-06-14
申请号：US10205474
申请日：2002-07-24
申请人： Yossi Gross , Shai Ayal , Ehud Cohen
发明人： Yossi Gross , Shai Ayal , Ehud Cohen
IPC分类号： A61N20060101 , A61N1/05 , A61N1/34 , A61N1/36 , A61N1/362 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36007 , A61N1/36071 , A61N1/36114
摘要： Apparatus is provided for applying current to a nerve. A cathode is adapted to be placed in a vicinity of a cathodic longitudinal site of the nerve and to apply, a cathodic current to the nerve. A primary inhibiting anode is adapted to be placed in a vicinity of a primary anodal longitudinal site of the nerve and to apply a primary anodal current to the nerve. A secondary inhibiting anode is adapted to be placed in a vicinity of a secondary anodal longitudinal site of the nerve and to apply a secondary anodal current to the nerve, the secondary anodal longitudinal site being closer to the primary anodal longitudinal site than to the cathodic longitudinal site.
摘要翻译：提供用于向神经施加电流的装置。阴极适于放置在神经的阴极纵向位置附近并施加阴极电流至神经。初级抑制阳极适于放置在神经的主要阳极纵向位置附近，并向神经施加初级阳极电流。辅助抑制阳极适于放置在神经的次级阳极纵向位置附近，并将次要阳极电流施加到神经，次级阳极纵向位置比阴极纵向更靠近初级阳极纵向位置现场。

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