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1. 发明授权

US07919104B2 Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof 有权
标题翻译：肺炎链球菌PsaA抗原的功能表位及其用途
公开(公告)号：US07919104B2
公开(公告)日：2011-04-05
申请号：US11992719
申请日：2005-07-29
申请人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
发明人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
IPC分类号： A61K39/09 , A61K39/02 , A61K39/38 , A61K38/00 , A01N37/18
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. Immunogenic compositions comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier or the peptide of SEQ ID NO:2 and a pharmaceutical carrier are also provided. Methods of using the peptides and antibodies of the invention are provided.
摘要翻译：提供了含有肺炎链球菌PsaA蛋白的功能性表位的P4肽及其相关方法和组合物。提供了具有与P4的构象相同或相似的构象结构的P4肽模拟物（例如，SEQ ID NO：1和SEQ ID NO：2）。提供了特异性结合由公开的肽定义的表位的抗体。 P4特异性抗体是PsaA特异性的，因为P4定义了PsaA特异性表位。还提供了包含SEQ ID NO：1的肽和药物载体或SEQ ID NO：2的肽的药物载体的免疫原性组合物。提供使用本发明的肽和抗体的方法。

2. 发明申请

US20080305123A1 Functional Epitopes of Streptococcus Pneumoniae PsaA Antigen and Uses Thereof 有权
标题翻译：肺炎链球菌PsaA抗原的功能表位及其用途
公开(公告)号：US20080305123A1
公开(公告)日：2008-12-11
申请号：US11992719
申请日：2005-07-29
申请人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
发明人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
IPC分类号： A61K39/09 , C07K14/00 , C12N5/00 , A61P31/04 , C07K16/12 , G01N33/569
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. A peptide that comprises the amino acid sequence defined in SEQ ID NO:1 (an example of the P4 peptide) is provided. Also provided is a peptide comprising the amino acid sequence defined as VPSLFVDSSVDDRPMKTVSQDTNIPIYAQIFTDS (SEQ ID NO:2). P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. For example, the antibody can specifically bind to a peptide comprising the sequence set forth in SEQ ID NO: 1 and having the conformation defined by the peptide consisting of SEQ ID NO: 1. An antibody that specifically binds to a peptide comprising the sequence set forth in SEQ ID NO:2 and having the conformation defined by the peptide consisting of SEQ ID NO:2 is also provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. A vaccine comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier is provided. A vaccine comprising a peptide of SEQ ID NO:2 and a pharmaceutical carrier is also provided. Methods of using the peptides and antibodies of the invention are provided. Diagnostic kits comprising a P4 peptide is also provided.
摘要翻译：提供了含有肺炎链球菌PsaA蛋白的功能性表位的P4肽及其相关方法和组合物。提供了包含SEQ ID NO：1中定义的氨基酸序列（P4肽的实例）的肽。还提供了包含定义为VPSLFVDSSV DDRPMKTVSQDTNIPIYAQIFTDS（SEQ ID NO：2）的氨基酸序列的肽。提供了具有与P4的构象相同或相似的构象结构的P4肽模拟物（例如，SEQ ID NO：1和SEQ ID NO：2）。提供了特异性结合由公开的肽定义的表位的抗体。例如，抗体可以特异性结合包含SEQ ID NO：1所示序列并具有由SEQ ID NO：1组成的肽所定义的构象的肽。特异性结合包含序列集的肽的抗体还提供了具有由SEQ ID NO：2组成的肽定义的构象的SEQ ID NO：2中的SEQ ID NO：2。 P4特异性抗体是PsaA特异性的，因为P4定义了PsaA特异性表位。提供了包含SEQ ID NO：1的肽和药物载体的疫苗。还提供了包含SEQ ID NO：2的肽和药物载体的疫苗。提供使用本发明的肽和抗体的方法。还提供了包含P4肽的诊断试剂盒。

3. 发明授权

US07642068B2 Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor 有权
标题翻译：多价调理吞噬细胞测定选择面板阵列及其用途
公开(公告)号：US07642068B2
公开(公告)日：2010-01-05
申请号：US11910517
申请日：2006-04-21
申请人： Sandra Steiner , Patricia F. Holder , George M. Carlone , GowriSankar Rajam
发明人： Sandra Steiner , Patricia F. Holder , George M. Carlone , GowriSankar Rajam
IPC分类号： C12Q1/18 , C12Q1/00 , G01N33/43 , G01N33/567 , C12Q1/20
CPC分类号： C12Q1/04 , C12Q1/14 , C12Q1/18 , G01N33/52
摘要： This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis.
摘要翻译：本申请公开了一种多价调理吞噬作用试验，其不依赖于细菌菌落的计数以确定调理吞噬作用后的细菌活力。相反，该方法使用代谢比色指示剂来确定是否存在活细菌。还公开了可以用于确定调理吞噬作用后细菌生存力的阵列。

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