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1. 发明授权

US07338758B2 Compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
标题翻译：用于鉴定，评估，预防和治疗人类癌症的组合物和方法
公开(公告)号：US07338758B2
公开(公告)日：2008-03-04
申请号：US10071510
申请日：2002-02-08
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
摘要翻译：本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。本发明还涉及治疗靶标的鉴定。本发明具有许多“灵敏度标记”。这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。本发明还具有许多“电阻标记”。这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

2. 发明授权

US07871775B2 Compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
公开(公告)号：US07871775B2
公开(公告)日：2011-01-18
申请号：US12002783
申请日：2007-12-17
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, Jr. , Gordon B. Mills
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, Jr. , Gordon B. Mills
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.

3. 发明授权

US08080368B2 Compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
标题翻译：用于鉴定，评估，预防和治疗人类癌症的组合物和方法
公开(公告)号：US08080368B2
公开(公告)日：2011-12-20
申请号：US12956500
申请日：2010-11-30
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, Jr. , Gordon B. Mills
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, Jr. , Gordon B. Mills
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
摘要翻译：本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。本发明还涉及治疗靶标的鉴定。本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药剂治疗敏感并且在细胞中不表达（或以相当低的水平表达）耐药性。本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达）对该药物的治疗敏感。本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

4. 发明申请

US20120141604A1 NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS 审中-公开
标题翻译：人类癌症鉴定，评估，预防和治疗的新组合物和方法
公开(公告)号：US20120141604A1
公开(公告)日：2012-06-07
申请号：US13289230
申请日：2011-11-04
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, JR. , Gordon B. Mills
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown , Robert C. Bast, JR. , Gordon B. Mills
IPC分类号： C40B30/04 , A61K33/24 , A61P35/00 , A61K31/337
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
摘要翻译：本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。本发明还涉及治疗靶标的鉴定。本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药物治疗敏感并且在细胞中未表达（或以相当低的水平表达）耐药性。本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达）对该药物的治疗敏感。本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

5. 发明申请

US20110104306A1 NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS 失效
标题翻译：人类癌症鉴定，评估，预防和治疗的新组合物和方法
公开(公告)号：US20110104306A1
公开(公告)日：2011-05-05
申请号：US12956500
申请日：2010-11-30
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
IPC分类号： A61K33/24 , C12Q1/02 , C12Q1/68 , A61P35/00 , A61K31/337
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
摘要翻译：本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。本发明还涉及治疗靶标的鉴定。本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药物治疗敏感并且在细胞中未表达（或以相当低的水平表达）耐药性。本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达）对该药物的治疗敏感。本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

6. 发明申请

US20080286780A1 Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
标题翻译：用于鉴定，评估，预防和治疗人类癌症的新型组合物和方法
公开(公告)号：US20080286780A1
公开(公告)日：2008-11-20
申请号：US12002783
申请日：2007-12-17
申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
发明人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/574
CPC分类号： G01N33/6893 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57496 , G01N2500/00 , G01N2800/52
摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
摘要翻译：本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。本发明还涉及治疗靶标的鉴定。本发明具有许多“灵敏度标记”。这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。本发明还具有许多“电阻标记”。这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

7. 外观设计

USD399587S Indirect light fixture 失效
公开(公告)号：USD399587S
公开(公告)日：1998-10-13
申请号：US65099
申请日：1997-01-21
申请人： Frederick A. Compton , Jeffrey L. Brown
设计人： Frederick A. Compton , Jeffrey L. Brown

8. 外观设计

USD397479S Indirect light fixture 失效
公开(公告)号：USD397479S
公开(公告)日：1998-08-25
申请号：US65098
申请日：1997-01-21
申请人： Frederick A. Compton , Jeffrey L. Brown
设计人： Frederick A. Compton , Jeffrey L. Brown

9. 外观设计

USD281014S Angulated venipuncture needle 失效
公开(公告)号：USD281014S
公开(公告)日：1985-10-15
申请号：US462858
申请日：1983-01-31
申请人： Jeffrey L. Brown
设计人： Jeffrey L. Brown

10. 发明授权

US5865528A Indirect light fixture 失效
标题翻译：间接灯具
公开(公告)号：US5865528A
公开(公告)日：1999-02-02
申请号：US816358
申请日：1997-03-13
申请人： Frederick A. Compton , Jeffrey L. Brown
发明人： Frederick A. Compton , Jeffrey L. Brown
IPC分类号： F21S8/00 , F21S8/06 , F21V5/02 , F21V7/00 , F21V11/14 , F21V13/04 , F21V15/01 , F21V23/02 , F21K00/00
CPC分类号： F21V13/04 , F21S8/033 , F21S8/06 , F21V5/02 , F21V7/0008 , F21V7/0016 , F21V11/14 , F21V15/013 , F21V23/02 , F21V7/0025 , F21W2131/402 , F21Y2103/00 , F21Y2113/00
摘要： The present invention comprises a light fixture including a housing, a light source, means to secure a light source to the housing, a lens and a reflector. The reflector and lens are positioned so as to direct light from the light source onto an unlit side of the housing.The light fixture is normally suspended from the ceiling or attached to a wall. A greater portion of the light from the light source is reflected off the ceiling or wall, whereas a smaller portion of the light from the light source is reflected off the reflector and onto the housing. After the smaller portion is reflected off the housing, the smaller portion and the larger portion are traveling in generally the same direction, thereby reducing the contrast between the housing and the ceiling or wall.The present fixture housing is very shallow, preferably less than about 3" deep. It includes one or more side rails, with each side rail being utilized to reflect the light from the light source onto the housing with a first reflector and to alter other diffuse lighting characteristics with a lens, perforated metal, or a second reflector.
摘要翻译：本发明包括一种灯具，其包括壳体，光源，用于将光源固定到壳体的装置，透镜和反射器。反射器和透镜被定位成将来自光源的光引导到壳体的未照射侧。灯具通常悬挂在天花板上或附着在墙壁上。来自光源的较大部分的光从天花板或壁反射，而来自光源的较小部分的光从反射器反射到壳体上。在较小部分从壳体反射之后，较小部分和较大部分沿大致相同的方向行进，从而减小了壳体与天花板或墙壁之间的对比度。本装置外壳非常浅，优选小于3“深。它包括一个或多个侧轨，每个侧轨用于将来自光源的光用第一反射器反射到壳体上，并且用透镜，穿孔金属或第二反射器改变其它漫射照明特性。

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