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1. 发明申请

US20100016907A1 REPLACEMENT OR SUPPLEMENTATION OF A NUCLEUS PULPOSUS USING A HYDROGEL 有权
标题翻译：使用HYDROGEL替代或补充核桃浆
公开(公告)号：US20100016907A1
公开(公告)日：2010-01-21
申请号：US12568577
申请日：2009-09-28
申请人： Edward Vresilovic , Michael F. Keane , Alasair J.T. Clemow , Nigel G. Smith
发明人： Edward Vresilovic , Michael F. Keane , Alasair J.T. Clemow , Nigel G. Smith
IPC分类号： A61B17/58
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

2. 发明授权

US08118874B2 Replacement or supplementation of a nucleus pulposus using a hydrogel 有权
标题翻译：使用水凝胶替代或补充髓核
公开(公告)号：US08118874B2
公开(公告)日：2012-02-21
申请号：US12568577
申请日：2009-09-28
申请人： Edward Vresilovic , Michael F. Keane , Alastair J. T. Clemow , Nigel G. Smith
发明人： Edward Vresilovic , Michael F. Keane , Alastair J. T. Clemow , Nigel G. Smith
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/3468 , A61B17/3472 , A61F2/4611 , A61F2002/3008 , A61F2002/30242 , A61F2002/444 , A61F2002/4495 , A61F2002/4627 , A61F2230/0071 , A61F2250/0098 , A61L27/00 , A61L27/52
摘要： A nucleus pulposus of an intervertebral disc is supplemented or replaced by an elongated, physiologically fully hydrated hydrogel prosthesis inserted into the central region of an intervertebral disc, where it can fold upon itself to form a prosthesis body within the central region of the annulus fibrosus. The hydrogel prosthesis may have expanded portions that assist in preventing expulsion of the prosthesis through the insertion aperture. An instrument for inserting the prosthesis has a cutter for severing the elongated prosthesis within the central region of the intervertebral disc after a sufficient amount has been implanted.
摘要翻译：椎间盘的髓核由插入到椎间盘的中心区域中的细长的，生理上完全水合的水凝胶假体补充或代替，其中它可以折叠在其上以在纤维环的中心区域内形成假体。水凝胶假体可以具有有助于防止假体通过插入孔排出的扩张部分。用于插入假体的器具具有切割器，用于在已经植入足够数量之后切断椎间盘中心区域内的细长假体。

3. 发明申请

US20080312744A1 SUPPLEMENTATION OR REPLACEMENT OF A NUCLEUS PULPOSUS OF AN INTERVERTEBRAL DISC 有权
标题翻译：补充或替代椎间盘突出的核素
公开(公告)号：US20080312744A1
公开(公告)日：2008-12-18
申请号：US12163407
申请日：2008-06-27
申请人： Edward Vresilovic , Michael F. Keane , Thomas P. Schaer
发明人： Edward Vresilovic , Michael F. Keane , Thomas P. Schaer
IPC分类号： A61F2/44 , A61B19/00 , A61B17/00
CPC分类号： A61F2/442 , A61B17/86 , A61F2/28 , A61F2/4611 , A61F2002/2839 , A61F2002/30224 , A61F2002/30242 , A61F2002/444 , A61F2002/4445 , A61F2002/4627 , A61F2002/4631 , A61F2230/0069 , A61F2230/0071
摘要： A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.
摘要翻译：位于纤维环内的椎间盘的中心核心区域的退化的髓核被补充或替换，其中通过包括以下步骤的方法将生物相容性材料的量引入中心核心区域的方法包括以下步骤：1）通过与所述椎间盘相邻的椎体从椎体的外表面延伸到纤维环的中心纤芯区域; 2）通过通道将一定量的生物相容性物质引入到纤维环的中心纤芯区域; 3）通过通道将生物相容性材料加压至足以减轻由退化的髓核引起的症状的术后压力; 和4）密封通道同时保持足够的术后压力。在密封通道之后，椎骨成形术可以可选地在椎骨中进行。

4. 发明授权

US08147553B2 Supplementation or replacement of a nucleus pulposus of an intervertebral disc 有权
标题翻译：补充或更换椎间盘髓核
公开(公告)号：US08147553B2
公开(公告)日：2012-04-03
申请号：US12163407
申请日：2008-06-27
申请人： Edward Vresilovic , Michael F. Keane , Thomas P. Schaer
发明人： Edward Vresilovic , Michael F. Keane , Thomas P. Schaer
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61B17/86 , A61F2/28 , A61F2/4611 , A61F2002/2839 , A61F2002/30224 , A61F2002/30242 , A61F2002/444 , A61F2002/4445 , A61F2002/4627 , A61F2002/4631 , A61F2230/0069 , A61F2230/0071
摘要： A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.
摘要翻译：位于纤维环内的椎间盘的中心核心区域的退化的髓核被补充或替换，其中通过包括以下步骤的方法将生物相容性材料的量引入中心核心区域的方法包括以下步骤：1）通过与所述椎间盘相邻的椎体从椎体的外表面延伸到纤维环的中心纤芯区域; 2）通过通道将一定量的生物相容性物质引入到纤维环的中心纤芯区域; 3）通过通道将生物相容性材料加压至足以减轻由退化的髓核引起的症状的术后压力; 和4）密封通道同时保持足够的术后压力。在密封通道之后，椎骨成形术可以可选地在椎骨中进行。

5. 发明授权

US09078953B2 Crosslinked hydrogels 有权
标题翻译：交联水凝胶
公开(公告)号：US09078953B2
公开(公告)日：2015-07-14
申请号：US12747411
申请日：2008-12-16
申请人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
发明人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
IPC分类号： A61K31/79 , A61K31/785 , A61P43/00 , A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

6. 发明授权

US08287595B2 Hydrogel balloon prosthesis for nucleus pulposus 有权
标题翻译：水髓球囊假体为髓核
公开(公告)号：US08287595B2
公开(公告)日：2012-10-16
申请号：US11510747
申请日：2006-08-25
申请人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
发明人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
IPC分类号： A61F2/44
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译：用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性水凝胶。优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

7. 发明申请

US20110153022A1 BALLOON-ASSISTED ANNULUS REPAIR 审中-公开
标题翻译：气球辅助神经修复
公开(公告)号：US20110153022A1
公开(公告)日：2011-06-23
申请号：US12994340
申请日：2009-05-29
申请人： Wamis Singhatat , Nigel G. Smith , Garland W. Fussell , Michael F. Keane , Anthony M. Lowman
发明人： Wamis Singhatat , Nigel G. Smith , Garland W. Fussell , Michael F. Keane , Anthony M. Lowman
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30014 , A61F2002/3008 , A61F2002/30179 , A61F2002/30461 , A61F2002/30576 , A61F2002/30583 , A61F2002/30878 , A61F2002/4435
摘要： The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defect. After the inflatable device has been properly positioned, a filler material (11) is injected into the inflatable device to expand the device to a second expanded state. In the second expanded state, the inflatable annulus repair device seals the annulus defect, secures its position within the annulus defect to thereby limit or prevent migration, and applies a compression force to a captured portion of the annulus adjacent to the defect. The inflatable device is preferably filled with a liquid that solidifies into an elastic material within the device.
摘要翻译：本发明涉及一种用于密封位于椎间盘空间的环状纤维化中的环带缺损的可充气环带修复装置（10）。在使用中，充气装置以第一未膨胀状态优选通过插管（100）引入到环空缺陷中。在充气装置被适当地定位之后，将填充材料（11）注入到充气装置中以使装置膨胀到第二膨胀状态。在第二膨胀状态下，可充气环带修复装置密封环空缺陷，确保其在环空缺陷内的位置，从而限制或防止迁移，并将压缩力施加到与缺陷相邻的环的捕获部分。充气装置优选地填充有在装置内固化成弹性材料的液体。

8. 发明申请

US20100047437A1 HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS 审中-公开
标题翻译：氢化球藻对核仁的影响
公开(公告)号：US20100047437A1
公开(公告)日：2010-02-25
申请号：US12608565
申请日：2009-10-29
申请人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
发明人： Edward Vresilovic , Michele S. Marcolongo , Anthony M. Lowman , Alastair J. T. Clemow , Michael F. Keane
IPC分类号： A61L33/04
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译：用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性水凝胶。优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

9. 发明授权

US08703157B2 Phase transitioning hydrogels 有权
标题翻译：相转移水凝胶
公开(公告)号：US08703157B2
公开(公告)日：2014-04-22
申请号：US12994336
申请日：2009-05-27
申请人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
发明人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
IPC分类号： A61K9/00
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly(vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly(vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译：一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量水凝胶组合物。水凝胶组合物还可以包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

10. 发明申请

US20100272672A1 CROSSLINKED HYDROGELS 有权
标题翻译：交联水晶
公开(公告)号：US20100272672A1
公开(公告)日：2010-10-28
申请号：US12747411
申请日：2008-12-16
申请人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
发明人： Kristin B. Kita , Nigel G. Smith , Anthony M. Lowman , Garland W. Fussell , Michael F. Keane
IPC分类号： A61K31/79 , A61K31/785 , A61P43/00
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

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