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1. 发明申请

US20050019389A1 Enteric formulations of proanthocyanidin polymer antidiarrheal compositions 有权
标题翻译：原花色素聚合物抗腹泻组合物的肠溶制剂
公开(公告)号：US20050019389A1
公开(公告)日：2005-01-27
申请号：US10919969
申请日：2004-08-17
申请人： Edward Rozhon , Atul Khandwala , Akram Sabouni , Gul Balwani , Jody Chan , David Sesin
发明人： Edward Rozhon , Atul Khandwala , Akram Sabouni , Gul Balwani , Jody Chan , David Sesin
IPC分类号： C07D311/62 , A61K9/10 , A61K9/28 , A61K9/32 , A61K9/50 , A61K9/54 , A61K9/58 , A61K31/352 , A61K31/353 , A61K31/765 , A61K36/18 , A61K47/32 , A61P1/12 , A61P31/04 , A61K35/78 , A61K31/7048 , A61K9/48
CPC分类号： A61K31/353 , A61K9/2846 , A61K9/5078 , A61K31/765 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/481 , Y10S514/867
摘要： Pharmaceutical compositions containing a proanthocyanidin polymer composition which are useful for the treatment and prevention of secretory diarrhea are provided. The invention specifically relates to pharmaceutical formulations of a proanthocyanidin polymer composition which has been isolated from a Croton spp. or a Calophyllum spp. In particular, the invention relates to a formulation of a proanthocyanidin polymer composition which protects the composition from the effects of stomach acid after oral administration, particularly to those formulations which are enteric coated. The invention also relates to methods of producing a directly compressible proanthocyanidin polymer composition, as well as compositions containing the directly compressible proanthocyanidin polymer composition.
摘要翻译：提供了含有用于治疗和预防分泌性腹泻的原花色素聚合物组合物的药物组合物。本发明具体涉及从巴豆属中分离的原花色素聚合物组合物的药物制剂。或Calophyllum spp。特别地，本发明涉及一种原始花色素聚合物组合物的制剂，其在口服给药后保护组合物免受胃酸的作用，特别是那些肠溶衣制剂。本发明还涉及制备直接可压缩的原花青素聚合物组合物的方法，以及含有直接可压制的原花色素聚合物组合物的组合物。

2. 发明授权

US5362737A Methods of treating aphthous ulcers and other mucocutaneous disorders with amlexanox 失效
标题翻译：使用amlexanox治疗口疮性溃疡和其他粘膜皮肤病的方法
公开(公告)号：US5362737A
公开(公告)日：1994-11-08
申请号：US6670
申请日：1993-01-19
申请人： Kakubhai R. Vora , Atul Khandwala , Charles G. Smith
发明人： Kakubhai R. Vora , Atul Khandwala , Charles G. Smith
IPC分类号： A61K8/49 , A61K31/44 , A61Q11/00 , A01N43/40 , A61K7/22
CPC分类号： A61K31/44 , A61K8/49 , A61Q11/00 , Y10S514/901 , Y10S514/902 , Y10S514/928
摘要： A method of treating aphthous ulcers and other mucocutaneous disorders is disclosed. The method comprises contacting the mucocutaneous disorder with a composition in the form of a paste, solution, gel, quick-disintegrating tablet, mouthwash, ointment, cream, powder, adhesive patch, aerosolized spray, lozenge, troche, dentifrice, or dental floss that contains an effective amount of an active compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl, phenyl, carboxyl, hydroxyl, alkoxy, carboxyalkyl (i.e. esters), cyano, acylamino, or amino group which may be unsubstituted or substituted by up to two alkyl groups; m is 0, 1 or 2 and R.sub.2 is alkyl, alkenyl, alkoxy, halgoen, nitro, hydroxy, carboxyl, butadienylene (--CH.dbd.CH--CH.dbd.CH--) which forms a benzene ring with any adjacent carbon atoms, cyano, carboxyalkyl, trifluoromethyl, or amino group which may be unsubstituted or substituted by at least one alkyl; and R.sub.3 is carboxyl, cyano, arylalkoxycarbonyl, alkoxycarbonyl, or carboxamide which may be unsubstituted or substituted by at least one alkyl, and the salts thereof.
摘要翻译：公开了一种治疗口腔溃疡和其他粘膜皮肤病的方法。该方法包括使粘膜皮肤疾病与糊剂，溶液，凝胶，快速崩解片剂，漱口剂，软膏剂，霜剂，粉剂，粘贴剂，雾化喷雾剂，锭剂，锭剂，洁牙剂或牙线形式的组合物接触，含有有效量的下式的活性化合物：其中R 1是氢，烷基，苯基，羧基，羟基，烷氧基，羧基烷基（即酯），氰基，酰氨基或氨基，其可以是未取代的或被最多两个烷基; m是0,1或2，R2是与任何相邻碳原子形成苯环的烷基，烯基，烷氧基，卤代，硝基，羟基，羧基，亚丁二烯基（-CH = CH-CH = CH-），氰基，，三氟甲基或氨基，其可以是未取代的或被至少一个烷基取代; 并且R 3是羧基，氰基，芳基烷氧基羰基，烷氧基羰基或甲酰胺，其可以是未取代的或被至少一个烷基取代，及其盐。

3. 发明授权

US5409690A Treatment of multidrug resistant diseases in cancer cell by potentiating with masoprocol 失效
标题翻译：通过用马索波罗增强治疗癌细胞中的多药耐药性疾病
公开(公告)号：US5409690A
公开(公告)日：1995-04-25
申请号：US81663
申请日：1993-06-23
申请人： Stephen Howell , Atul Khandwala , Om P. Sachdev , Charles G. Smith
发明人： Stephen Howell , Atul Khandwala , Om P. Sachdev , Charles G. Smith
IPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/22 , A61K31/475 , A61K33/24 , A61K48/00 , A61K31/045 , A61K31/70
CPC分类号： A61K31/70 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/22 , A61K31/475 , A61K33/24
摘要： Disclosed are: a method for reversing multidrug resistance in a mammal; and a composition to reverse multidrug resistance comprising: ##STR1## wherein R.sub.1 and R.sub.2 are independently H, lower alkyl or lower acyl;R.sub.3, R.sub.4 and R.sub.5 are independently H or lower alkyl;R.sub.7, R.sub.8 and R.sub.9 are independently H, hydroxy, lower alkoxy or lower acyloxy; andR.sub.10, R.sub.11, R.sub.12 and R.sub.13 are independently H or lower alkyl, in a pharmaceutically acceptable vehicle.
摘要翻译：公开了一种逆转哺乳动物多药耐药性的方法，和反向多药耐药性的组合物，其包含：其中R 1和R 2独立地为H，低级烷基或低级酰基; R3，R4和R5独立地为H或低级烷基; R 7，R 8和R 9独立地为H，羟基，低级烷氧基或低级酰氧基; R 10，R 11，R 12和R 13独立地为H或低级烷基。

4. 发明授权

US5541232A Treatment of multidrug resistant diseases 失效
标题翻译：治疗多药耐药性疾病
公开(公告)号：US5541232A
公开(公告)日：1996-07-30
申请号：US264740
申请日：1994-06-23
申请人： Stephen Howell , Atul Khandwala , Om P. Sachdey , Charles G. Smith
发明人： Stephen Howell , Atul Khandwala , Om P. Sachdey , Charles G. Smith
IPC分类号： A61K31/05 , A61K31/085 , A61K31/09 , A61K31/22 , A61K31/475 , A61K33/24 , A61K31/045
CPC分类号： A61K31/70 , A61K31/05 , A61K31/085 , A61K31/09 , A61K31/22 , A61K31/475 , A61K33/24
摘要： A method and composition for treating multidrug resistance in a mammal, in which the composition includes NDGA or an analog of NDGA in accordance with the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are independently H, lower alkyl or lower acyl;R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are independently H or lower alkyl;R.sub.7, R.sub.8 and R.sub.9 are independently H, hydroxy, lower alkoxy or lower acyloxy; andR.sub.10, R.sub.11, R.sub.12 and R.sub.13 are independently H or lower alkyl, in a pharmaceutically acceptable vehicle.The method is particularly suitable for administering an antineoplastic agent, and the composition includes the combination of NDGA, or an analog with such an antineoplastic agent.
摘要翻译：一种用于治疗哺乳动物多药耐药性的方法和组合物，其中该组合物包含NDGA或根据下式的NDGA类似物：其中R1和R2独立地为H，低级烷基或低级酰基; R3，R4，R5和R6独立地为H或低级烷基; R 7，R 8和R 9独立地为H，羟基，低级烷氧基或低级酰氧基; R 10，R 11，R 12和R 13独立地为H或低级烷基。该方法特别适用于施用抗肿瘤剂，组合物包括NDGA或类似物与这种抗肿瘤剂的组合。

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