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1. 发明授权

US08445589B2 Lung volume reduction therapy using crosslinked non-natural polymers 有权
公开(公告)号：US08445589B2
公开(公告)日：2013-05-21
申请号：US13493409
申请日：2012-06-11
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： C08F8/00
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.

2. 发明申请

US20120245627A1 Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers 有权
标题翻译：使用交联非天然聚合物的肺减容治疗
公开(公告)号：US20120245627A1
公开(公告)日：2012-09-27
申请号：US13493409
申请日：2012-06-11
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： A61L24/04 , A61B17/03
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
摘要翻译：本发明的一个方面涉及包含非天然聚合物的水凝胶，所述非天然聚合物包含多个侧链亲核基团和包含至少两个侧链亲电子基团的交联剂。本发明的另一方面涉及包含非天然聚合物的水凝胶，其包含多个侧链亲电基团和包含至少两个亲核基团的交联剂。本发明的另一方面涉及一种用于减少患者体内肺容量的方法，包括施用如本文所述的水凝胶组合物的步骤。此外，本发明的水凝胶可用于实现胸膜固定术，密封胸膜瘘，密封肺中的空气泄漏，实现止血，组织密封（例如血管，内脏）或其任何组合。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

3. 发明授权

US08198365B2 Lung volume reduction therapy using crosslinked non-natural polymers 有权
标题翻译：使用交联非天然聚合物的肺体积减少治疗
公开(公告)号：US08198365B2
公开(公告)日：2012-06-12
申请号：US12117367
申请日：2008-05-08
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： C08F8/00
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
摘要翻译：本发明的一个方面涉及包含非天然聚合物的水凝胶，所述非天然聚合物包含多个侧链亲核基团和包含至少两个侧链亲电子基团的交联剂。本发明的另一方面涉及包含非天然聚合物的水凝胶，其包含多个侧链亲电基团和包含至少两个亲核基团的交联剂。本发明的另一方面涉及一种用于减少患者体内肺容量的方法，包括施用如本文所述的水凝胶组合物的步骤。此外，本发明的水凝胶可用于实现胸膜固定术，密封胸膜瘘，密封肺中的空气泄漏，实现止血，组织密封（例如血管，内脏）或其任何组合。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

4. 发明申请

US20080281352A1 Lung Volume Reduction Therapy Using Crosslinked Non-Natural Polymers 有权
标题翻译：使用交联非天然聚合物的肺减容治疗
公开(公告)号：US20080281352A1
公开(公告)日：2008-11-13
申请号：US12117367
申请日：2008-05-08
申请人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , James A. Krom , Alexander Schwarz , Larry W. Tsai
IPC分类号： A61B17/03 , C08G65/00 , A61K9/00
CPC分类号： A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要： One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
摘要翻译：本发明的一个方面涉及包含非天然聚合物的水凝胶，所述非天然聚合物包含多个侧链亲核基团和包含至少两个侧链亲电子基团的交联剂。本发明的另一方面涉及包含非天然聚合物的水凝胶，其包含多个侧链亲电基团和包含至少两个亲核基团的交联剂。本发明的另一方面涉及一种用于减少患者体内肺容量的方法，包括施用如本文所述的水凝胶组合物的步骤。此外，本发明的水凝胶可用于实现胸膜固定术，密封胸膜瘘，密封肺中的空气泄漏，实现止血，组织密封（例如血管，内脏）或其任何组合。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

5. 发明申请

US20100040538A1 Polymer Systems for Lung Volume Reduction Therapy 有权
标题翻译：用于肺减容治疗的聚合物体系
公开(公告)号：US20100040538A1
公开(公告)日：2010-02-18
申请号：US12443021
申请日：2007-09-26
申请人： Edward P. Ingenito , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , Alexander Schwarz , Larry W. Tsai
IPC分类号： A61K9/10 , A61K31/74 , A61K31/78 , A61K51/00 , A61P11/00
CPC分类号： A61K31/736 , A61K9/007 , A61K9/06 , A61K31/74
摘要： One aspect of the invention relates to a hydrogel comprising a polymer comprising a plurality of pendent hydroxyl groups, a crosslinker, and a sclerosing agent. Another aspect of the invention relates to a method for reducing lung volume in a patient comprising the steps of advancing into a region of a patient's lung via said patient's trachea a multi-lumen catheter lumen through a bronchoscope; and co-administering, through the multi-lumen catheter, a first mixture comprising a first amount of a polymer containing a plurality of pendent hydroxyl groups; a second mixture comprising a second amount of a crosslinker; and a third mixture comprising a third amount of a sclerosing agent; thereby forming a hydrogel in said region. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema of the lung.
摘要翻译：本发明的一个方面涉及包含含有多个侧链羟基的聚合物，交联剂和硬化剂的水凝胶。本发明的另一方面涉及一种用于减轻患者肺容积的方法，包括以下步骤：通过所述病人的气管进入通过支气管镜的多腔导管内腔的患者肺部区域; 并且通过所述多腔导管共同施用包含第一量含有多个侧链羟基的聚合物的第一混合物; 第二混合物，其包含第二量的交联剂; 和包含第三量的硬化剂的第三混合物; 从而在所述区域中形成水凝胶。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

6. 发明授权

US08361484B2 Polymer systems for lung volume reduction therapy 有权
标题翻译：用于肺容积减少治疗的聚合物体系
公开(公告)号：US08361484B2
公开(公告)日：2013-01-29
申请号：US12443021
申请日：2007-09-27
申请人： Edward P. Ingenito , Alexander Schwarz , Larry W. Tsai
发明人： Edward P. Ingenito , Alexander Schwarz , Larry W. Tsai
IPC分类号： A61K9/00
CPC分类号： A61K31/736 , A61K9/007 , A61K9/06 , A61K31/74
摘要： One aspect of the invention relates to a hydrogel comprising a polymer comprising a plurality of pendent hydroxyl groups, a crosslinker, and a sclerosing agent. Another aspect of the invention relates to a method for reducing lung volume in a patient comprising the steps of advancing into a region of a patient's lung via said patient's trachea a multi-lumen catheter lumen through a bronchoscope; and co-administering, through the multi-lumen catheter, a first mixture comprising a first amount of a polymer containing a plurality of pendent hydroxyl groups; a second mixture comprising a second amount of a crosslinker; and a third mixture comprising a third amount of a sclerosing agent; thereby forming a hydrogel in said region. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema of the lung.
摘要翻译：本发明的一个方面涉及包含含有多个侧链羟基的聚合物，交联剂和硬化剂的水凝胶。本发明的另一方面涉及一种用于减轻患者肺容积的方法，包括以下步骤：通过所述病人的气管，通过支气管镜进入多腔导管腔，进入患者肺部区域; 并且通过所述多腔导管共同施用包含第一量含有多个侧链羟基的聚合物的第一混合物; 第二混合物，其包含第二量的交联剂; 和包含第三量的硬化剂的第三混合物; 从而在所述区域中形成水凝胶。在某些实施方案中，本文所述的组合物和方法旨在用于治疗患有肺气肿的患者。

7. 发明申请

US20080261884A1 Lung Volume Reduction Therapy Using Crosslinked Biopolymers 有权
标题翻译：使用交联生物聚合物的肺减容治疗
公开(公告)号：US20080261884A1
公开(公告)日：2008-10-23
申请号：US12062189
申请日：2008-04-03
申请人： Larry W. Tsai , Edward P. Ingenito
发明人： Larry W. Tsai , Edward P. Ingenito
IPC分类号： A61K38/38 , A61P11/00
CPC分类号： A61L24/108 , A61K38/38 , A61K45/06 , A61L2430/00 , A61K2300/00
摘要： One aspect of the present invention relates to bronchoscopic lung volume reduction using solutions of biopolymers that can be polymerized in situ with a crosslinker and a polymeric additive which accelerates the cross-linking reaction. In certain embodiments, the biopolymer solutions can be in the form of a foam or gel. The biopolymer compositions disclosed herein may also be used for indications other than lung volume reduction, such as sealing fistulas or performing emergency tamponade of vessels.
摘要翻译：本发明的一个方面涉及使用可以与加速交联反应的交联剂和聚合物添加剂原位聚合的生物聚合物的支气管镜肺体积减少。在某些实施方案中，生物聚合物溶液可以是泡沫或凝胶的形式。本文公开的生物聚合物组合物还可以用于肺容积减小以外的适应症，例如密封瘘或执行血管的紧急填塞。

8. 发明授权

US08911750B2 Lung volume reduction therapy using crosslinked biopolymers 有权
标题翻译：使用交联生物聚合物的肺体积减少治疗
公开(公告)号：US08911750B2
公开(公告)日：2014-12-16
申请号：US12062189
申请日：2008-04-03
申请人： Larry W. Tsai , Edward P. Ingenito
发明人： Larry W. Tsai , Edward P. Ingenito
IPC分类号： A61K9/00
CPC分类号： A61L24/108 , A61K38/38 , A61K45/06 , A61L2430/00 , A61K2300/00
摘要： One aspect of the present invention relates to bronchoscopic lung volume reduction using solutions of biopolymers that can be polymerized in situ with a crosslinker and a polymeric additive which accelerates the cross-linking reaction. In certain embodiments, the biopolymer solutions can be in the form of a foam or gel. The biopolymer compositions disclosed herein may also be used for indications other than lung volume reduction, such as sealing fistulas or performing emergency tamponade of vessels.
摘要翻译：本发明的一个方面涉及使用可以与加速交联反应的交联剂和聚合物添加剂原位聚合的生物聚合物的支气管镜肺体积减少。在某些实施方案中，生物聚合物溶液可以是泡沫或凝胶的形式。本文公开的生物聚合物组合物还可以用于肺容积减小以外的适应症，例如密封瘘或执行血管的紧急填塞。

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