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1. 发明申请

US20070179565A1 SYSTEM FOR GENERATING A COCHLEAR IMPLANT PROGRAM USING MULTI-ELECTRODE STIMULATION TO ELICIT THE ELECTRICALLY-EVOKED COMPOUND ACTION POTENTIAL 失效
标题翻译：使用多电极刺激来产生电击移植程序以制定电动化复合作用电位的系统
公开(公告)号：US20070179565A1
公开(公告)日：2007-08-02
申请号：US11697605
申请日：2007-04-06
申请人： Edward Overstreet , Leonid Litvak , Michael Faltys
发明人： Edward Overstreet , Leonid Litvak , Michael Faltys
IPC分类号： A61N1/36
CPC分类号： A61N1/37241 , A61N1/0541 , A61N1/36036 , A61N1/37247
摘要： A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.
摘要翻译：多通道人工耳蜗植入系统通过以下方式之一空间扩展靶神经组织中的激发图案：（1）对一小组电极的快速连续刺激，或（2）同时刺激一小组电极。这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为施加的刺激的幅度。从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。

2. 发明申请

US20080021551A1 OPTIMIZING PITCH AND OTHER SPEECH STIMULI ALLOCATION IN A COCHLEAR IMPLANT 有权
标题翻译：优化P CH。。。。。。。。。。。。。。。。。。。。
公开(公告)号：US20080021551A1
公开(公告)日：2008-01-24
申请号：US11830846
申请日：2007-07-31
申请人： Edward Overstreet , Leonid Litvak , William Harrison
发明人： Edward Overstreet , Leonid Litvak , William Harrison
IPC分类号： A61F2/18
CPC分类号： A61N1/36036
摘要： Errors in pitch (frequency) allocation within a cochlear implant are corrected in order to provide a significant and profound improvement in the quality of sound perceived by the cochlear implant user. In one embodiment, the user is stimulated with a reference signal, e.g., the tone “A” (440 Hz) and then the user is stimulated with a probe signal, separated from the reference signal by an octave, e.g., high “A” (880 Hz). The user adjusts the location where the probe signal is applied, using current steering, until the pitch of the probe signal, as perceived by the user, matches the pitch of the reference signal, as perceived by the user. In this manner, the user maps frequencies to stimulation locations in order to tune his or her implant system to his or her unique cochlea.
摘要翻译：修正耳蜗植入物内的间距（频率）分配的误差，以便对由人工耳蜗植入物使用者感知到的声音的质量提供显着和深刻的改善。在一个实施例中，用参考信号（例如，音调“A”（440Hz））刺激用户，然后用探测信号刺激用户，该探测信号与参考信号分开八度，例如高“A” （880Hz）。用户使用当前转向来调整应用探测信号的位置，直到由用户感知到的探测信号的音高与用户感知到的参考信号的音调相匹配。以这种方式，用户将频率映射到刺激位置，以便将他或她的植入系统调整到他或她的独特的耳蜗。

3. 发明申请

US20060287609A1 Methods and systems for automatically identifying whether a neural recording signal includes a neural response signal 有权
标题翻译：用于自动识别神经记录信号是否包括神经反应信号的方法和系统
公开(公告)号：US20060287609A1
公开(公告)日：2006-12-21
申请号：US11142152
申请日：2005-06-01
申请人： Leonid Litvak , Edward Overstreet
发明人： Leonid Litvak , Edward Overstreet
IPC分类号： A61B5/04 , A61B5/05
CPC分类号： A61B5/04001 , A61B5/4041 , A61B5/7217 , A61N1/36036
摘要： Methods of automatically identifying whether a neural recording signal includes a neural response signal include fitting an artifact model to a neural recording signal to produce a fitted artifact model signal, determining a strength-of-response (SOR) metric that describes a distance of the neural recording signal from the fitted artifact model signal, and identifying the neural recording signal as including a neural response signal if the strength-of-response metric is above a pre-determined threshold. Systems for automatically identifying whether a neural recording signal includes a neural response signal include one or more devices configured to fit an artifact model to a neural recording signal to produce a fitted artifact model signal, determine a strength-of-response (SOR) metric that describes a distance of the neural recording signal from the fitted artifact model signal, and automatically identify the neural recording signal as including a neural response signal if said strength-of-response metric is above a pre-determined threshold.
摘要翻译：自动识别神经记录信号是否包括神经反应信号的方法包括将伪像模型拟合到神经记录信号以产生拟合的伪像模型信号，确定描述神经元的距离的响应强度（SOR）度量记录来自拟合假象模型信号的信号，并且如果响应强度度量高于预定阈值，则将神经记录信号识别为包括神经响应信号。用于自动识别神经记录信号是否包括神经反应信号的系统包括被配置为将神经记号模型拟合到神经记录信号以产生拟合假象模型信号的一个或多个装置，确定响应强度（SOR）度量，描述了神经记录信号与拟合假象模型信号的距离，并且如果所述响应强度度量高于预定阈值，则将神经记录信号自动识别为包括神经响应信号。

4. 发明申请

US20060276722A1 Methods and systems for automatically determining a neural response threshold current level 有权
标题翻译：自动确定神经反应阈值电流水平的方法和系统
公开(公告)号：US20060276722A1
公开(公告)日：2006-12-07
申请号：US11141825
申请日：2005-06-01
申请人： Leonid Litvak , Gulam Emadi , Edward Overstreet
发明人： Leonid Litvak , Gulam Emadi , Edward Overstreet
IPC分类号： A61B5/05
CPC分类号： A61B5/04001 , A61B5/7217
摘要： Methods of automatically determining a neural response threshold current level include identifying one or more neural response signals at one or more corresponding stimulation current levels, identifying one or more non-response signals at one or more corresponding stimulation current levels, and analyzing a trend between the neural response signals and the non-response signals. Systems for automatically determining a neural response threshold current level include one or more devices configured to identify one or more neural response signals at one or more corresponding stimulation current levels, identify one or more non-response signals at one or more corresponding stimulation current levels; and analyze a trend between the neural response signals and the non-response signals.
摘要翻译：自动确定神经反应阈值电流水平的方法包括以一个或多个相应的刺激电流水平识别一个或多个神经反应信号，识别一个或多个相应刺激电流水平下的一个或多个非响应信号，以及分析神经反应信号和非响应信号。用于自动确定神经反应阈值电流水平的系统包括被配置为在一个或多个相应的刺激电流水平上识别一个或多个神经反应信号的一个或多个装置，以一个或多个对应的刺激电流水平识别一个或多个非响应信号; 并分析神经反应信号与非应答信号之间的趋势。

5. 发明申请

US20070293785A1 Encoding Fine Time Structure in Presence of Substantial Interaction Across An Electrode Array 失效
标题翻译：编码精细时间结构在电极阵列之间存在显着的相互作用
公开(公告)号：US20070293785A1
公开(公告)日：2007-12-20
申请号：US11845673
申请日：2007-08-27
申请人： Leonid Litvak
发明人： Leonid Litvak
IPC分类号： A61B5/00
CPC分类号： A61N1/36032 , A61N1/36036 , H04R25/50
摘要： Among other things, a stimulation strategy can be customized for a cochlear implant implanted in an individual by testing at least a pair of electrodes selected from an array of electrodes associated with the cochlear implant. Testing the at least a pair of electrodes includes applying a first stimulation to the at least a pair of electrodes using a first pair of pulse trains that are out of phase, and applying a second stimulation to the at least a pair of electrodes using a second pair of pulse trains that are out of phase. A determination is made on whether the at least a pair of electrodes stimulate the same neural population based on a sensitivity of the individual to detect a perceived difference between the two pairs of pulse trains. The one or more electrodes of the array of electrodes are selectively stimulated based on the determination.
摘要翻译：除其他之外，可以通过测试至少一对选自与耳蜗植入物相关联的电极阵列的电极来定制植入在个体中的人工耳蜗植入物的刺激策略。测试所述至少一对电极包括使用不同相的第一对脉冲序列向所述至少一对电极施加第一刺激，并且使用第二刺激对所述至少一对电极施加第二刺激一对不同步的脉冲串。确定至少一对电极是否基于个体的灵敏度来刺激相同的神经群体，以检测两对脉冲串之间的感知差异。基于该确定，选择性地激励电极阵列的一个或多个电极。

6. 发明申请

US20050137650A1 Methods and systems for fitting a cochlear implant to a patient 有权
标题翻译：将耳蜗植入物装配到患者的方法和系统
公开(公告)号：US20050137650A1
公开(公告)日：2005-06-23
申请号：US10989521
申请日：2004-11-16
申请人： Leonid Litvak , Lakshmi Mishra
发明人： Leonid Litvak , Lakshmi Mishra
IPC分类号： A61F11/04 , A61N1/36 , H04R25/00 , A61N1/18
CPC分类号： A61N1/36036 , H04R2225/67
摘要： An exemplary method of fitting a cochlear implant system to a patient includes establishing an implant fitting line having a slope and a position. The implant fitting line represents a relationship between a number of stimulation sites within a cochlea of the patient and a number of corresponding audio frequencies. That is, the implant fitting line defines which locations along the length of the cochlea, when stimulated, are perceived by the patient as specific tones or frequencies. The method further includes presenting a first audio signal having a number of audio frequencies to the patient and applying a stimulus current to one or more stimulation sites corresponding to the number of audio frequencies of the first audio signal. The method further includes adjusting the slope of the fitting line based on a response of the patient to the stimulus current. An exemplary system for fitting a cochlear implant to a patient includes an implantable cochlear stimulator with a number of stimulus channels configured to apply stimulus current to a number of stimulation sites within a cochlea of the patient. The system further includes a speech processor having a number of analysis channels configured to divide an input audio signal into a number of signals having distinct frequencies and mapping circuitry configured to map the number of signals generated by the analysis channels to the stimulus channels according to a mapping scheme. The mapping scheme is adjusted based on a change in a slope of a fitting line, the fitting line representing a relationship between the number of stimulation sites and a number of corresponding audio frequencies.
摘要翻译：将耳蜗植入物系统拟合到患者的示例性方法包括建立具有斜率和位置的植入物嵌合线。植入物拟合线表示患者的耳蜗内的多个刺激部位与多个对应音频之间的关系。也就是说，植入物嵌合线定义当被刺激时沿着耳蜗的长度的哪些位置被患者感知为特定的音调或频率。该方法还包括向患者呈现具有多个音频频率的第一音频信号，并将刺激电流施加到对应于第一音频信号的音频数量的一个或多个刺激位置。该方法还包括基于患者对刺激电流的响应来调节拟合线的斜率。用于将人工耳蜗植入物安装到患者的示例性系统包括具有多个刺激通道的植入式耳蜗刺激器，所述刺激通道被配置为将刺激电流施加到患者耳蜗内的多个刺激部位。该系统还包括语音处理器，其具有多个分析通道，其被配置为将输入音频信号划分成具有不同频率的多个信号，并且映射电路被配置为根据分析通道将分析通道产生的信号数量映射到刺激通道映射方案。基于拟合线的斜率的变化来调整映射方案，拟合线表示刺激位置的数量和对应的音频的数量之间的关系。

7. 发明申请

US20060276719A1 Methods and systems for denoising a neural recording signal 有权
标题翻译：去除神经记录信号的方法和系统
公开(公告)号：US20060276719A1
公开(公告)日：2006-12-07
申请号：US11141824
申请日：2005-06-01
申请人： Leonid Litvak , Abhijit Kulkarni
发明人： Leonid Litvak , Abhijit Kulkarni
IPC分类号： A61B5/04
CPC分类号： A61B5/04001 , A61B5/6849 , A61B5/7217
摘要： Methods of denoising a neural recording signal include correlating a neural recording signal with a number of basis functions to obtain a number of weights and then multiplying the weights with the basis functions to obtain a denoised neural recording signal. The basis functions are derived using principal component analysis. Systems for denoising a neural recording signal include one or more devices configured to correlate a neural recording signal with the basis functions to obtain the weights and then multiply the weights with the basis functions to obtain the denoised neural recording signal.
摘要翻译：去除神经记录信号的方法包括将神经记录信号与多个基函数相关联以获得多个权重，然后将权重与基函数相乘以获得去噪的神经记录信号。使用主成分分析得出基函数。用于去噪神经记录信号的系统包括一个或多个设备，其被配置为将神经记录信号与基本函数相关联以获得权重，然后将权重与基函数相乘以获得去噪的神经记录信号。

8. 发明申请

US20080033507A1 SYSTEMS FOR FITTING A COCHLEAR IMPLANT TO A PATIENT 有权
标题翻译：用于将COCHLEAR植入物置于患者身上的系统
公开(公告)号：US20080033507A1
公开(公告)日：2008-02-07
申请号：US11841501
申请日：2007-08-20
申请人： Leonid Litvak , Lakshmi Mishra
发明人： Leonid Litvak , Lakshmi Mishra
IPC分类号： A61F11/00
CPC分类号： A61N1/36036 , H04R2225/67
摘要： Systems for fitting an implantable cochlear stimulator to a patient include an interface unit configured to display a graphical representation of an implant fitting line as part of a graphical user interface. The implant fitting line has a slope and a horizontal position and represents a mapping relationship between a plurality of audio frequencies and a plurality of stimulation sites within a cochlea of the patient. The interface unit is further configured to facilitate adjustment of the slope and/or horizontal position of the fitting line.
摘要翻译：用于将可植入人工耳蜗刺激器装配到患者的系统包括被配置为作为图形用户界面的一部分显示植入物嵌合线的图形表示的界面单元。植入物嵌合线具有斜率和水平位置，并且表示多个音频频率与患者的耳蜗内的多个刺激部位之间的映射关系。接口单元还被配置为便于调整装配线的斜率和/或水平位置。

9. 发明申请

US20060106446A1 Inner hair cell stimulation model for the use by an intra-cochlear implant 失效
公开(公告)号：US20060106446A1
公开(公告)日：2006-05-18
申请号：US10992390
申请日：2004-11-17
申请人： Gene Fridman , Leonid Litvak
发明人： Gene Fridman , Leonid Litvak
IPC分类号： H04R25/00
CPC分类号： A61N1/36032 , A61N1/36036
摘要： The stimulation provided in the electrically stimulated cochlea is modulated in accordance with the amplitude of a received acoustic signal and the onset of a sound in a received acoustic signal to provide increased sound perception. An onset time that corresponds to the onset of a sound is detected in an acoustic signal associated with a frequency band. A forcing voltage and a transmitting factor are determined, wherein the forcing voltage and the transmitting factor are associated with the frequency band at the detected onset time. The acoustic signal is modulated as a function of the forcing voltage and the transmitting factor to generate an output signal. The generated output signal can be used to stimulate the cochlea. The modulation strategy can be used in conjunction with sound processing strategies that employ frequency modulation, amplitude modulation, or a combination of frequency and amplitude modulation.

10. 发明申请

US20060100672A1 Method and system of matching information from cochlear implants in two ears 审中-公开
标题翻译：双耳耳蜗植入物匹配信息的方法和系统
公开(公告)号：US20060100672A1
公开(公告)日：2006-05-11
申请号：US10982371
申请日：2004-11-05
申请人： Leonid Litvak
发明人： Leonid Litvak
IPC分类号： A61N1/08
CPC分类号： A61N1/36036 , A61N1/0541 , A61N1/37235
摘要： Disclosed are systems and methods for matching pitch information between bilateral cochlear implants in order to maximize a patient's listening experience. The system permits an electrode array of a first cochlear implant to be pitch matched to an electrode array of a second cochlear implant system by utilizing virtual electrodes, which enable cochlear stimulation at a location in between physical electrodes on the electrode array. At least one electrode of the first electrode array is mapped to a virtual electrode of the second electrode array.
摘要翻译：公开了用于匹配双侧耳蜗植入物之间的间距信息以便最大化患者的听觉体验的系统和方法。该系统允许通过利用虚拟电极使第一耳蜗植入物的电极阵列与第二耳蜗植入物系统的电极阵列进行间距匹配，这使得能够在电极阵列上的物理电极之间的位置进行耳蜗刺激。第一电极阵列的至少一个电极被映射到第二电极阵列的虚拟电极。

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