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1. 发明授权

US5679783A DNA encoding a tissue differentiation affecting factor 失效
标题翻译：编码组织分化影响因子的DNA
公开(公告)号：US5679783A
公开(公告)日：1997-10-21
申请号：US343760
申请日：1994-11-22
申请人： Edward M. De Robertis , Yoshiki Sasai
发明人： Edward M. De Robertis , Yoshiki Sasai
IPC分类号： A61K38/00 , C07K14/475 , C12N15/12 , C07K14/46
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： A functional polypeptide designated "chordin" is described that is capable of inducing dorsal (and neural tissue) development in vertebrates, and which appears to be a secreted protein. There are substantial regions of conservation with Xenopus chordin with mouse chordin, and the human gene should also be similar in those regions. A full length Xenopus cDNA for chordin is illustrated by FIGS. 1A-1F, and contains a reading frame encoding a 941 residue, 105 kDa precursor protein.
摘要翻译：描述了能够在脊椎动物中诱导背部（和神经组织）发育，并且其似乎是分泌蛋白质的称为“chordin”的功能性多肽。有非常大的保护区域与爪蟾chordin与小鼠chordin，人类基因也应该是相似的那些地区。用于chordin的全长非洲爪蟾cDNA被图示。 1A-1F，并且包含编码941残基，105kDa前体蛋白的阅读框。

2. 发明授权

US6133232A Endoderm, cardiac and neural inducing factors 失效
标题翻译：内胚层，心脏和神经诱导因子
公开(公告)号：US6133232A
公开(公告)日：2000-10-17
申请号：US878474
申请日：1997-06-18
申请人： Edward M. De Robertis , Tewis Bouwmeester
发明人： Edward M. De Robertis , Tewis Bouwmeester
IPC分类号： C12N15/09 , A61K38/00 , C07K14/475 , C07K19/00 , A61K38/18 , C07K14/46
CPC分类号： C07K14/475 , A61K38/00
摘要： Two novel proteins have been designated "cerberus" and "frzb-1," respectively. Cerberus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is designated "PAPC" which promotes the formation of dorsal mesoderm and somites in the embryo.
摘要翻译：两种新型蛋白质分别被称为“cerberus”和“frzb-1”。 Cerberus在非洲爪蟾胚胎的胚胎发生期间被表达为分泌肽，并且在头部组织器区域中具体表达。这种新分子具有内胚层，心脏和神经组织诱导活性，应该证明在需要这些和其他组织的再生，分化或修复的治疗，诊断和临床应用中是有用的。 Frzb-1是通过与细胞外空间中的Wnt生长因子结合而起作用的Wnt家族的生长因子的可溶性拮抗剂。第三种新型蛋白质被命名为“PAPC”，其促进胚胎中背部中胚层和体细胞的形成。

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