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1. 发明申请

US20050260733A1 Proteases and uses thereof 审中-公开
标题翻译：蛋白酶及其用途
公开(公告)号：US20050260733A1
公开(公告)日：2005-11-24
申请号：US11106623
申请日：2005-04-15
申请人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Michael Agostino , Bethany Freeman , Maya Arai , Carl Flannery , Macy Jin
发明人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Michael Agostino , Bethany Freeman , Maya Arai , Carl Flannery , Macy Jin
IPC分类号： A61K38/48 , C12N9/00 , C12N9/64 , C12Q1/37
CPC分类号： A61K38/4886 , C12N9/6489 , C12Q1/37 , G01N2333/96486 , G01N2400/00 , G01N2500/00
摘要： The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.
摘要翻译：本发明的特征在于使用ADAMTS-8蛋白或其功能衍生物切割聚蛋白聚糖蛋白聚糖或其他蛋白聚糖分子的方法。本发明还涉及用于鉴定能够抑制或增强ADAMTS-8蛋白水解活性的ADAMTS-8调节剂的方法。此外，本发明的特征在于包含ADAMTS-8蛋白质或其衍生物或调节剂的药物组合物。这些药物组合物可用于治疗以蛋白多糖切割或代谢为特征的缺陷或异常的疾病。

2. 发明申请

US20070128616A1 Aggrecanase molecules 审中-公开
标题翻译：聚集蛋白聚糖酶分子
公开(公告)号：US20070128616A1
公开(公告)日：2007-06-07
申请号：US11438609
申请日：2006-05-22
申请人： Christopher Corcoran , Michael Agostino , Edward LaVallie , Carl Flannery , Weilan Zeng , Lisa Collins-Racie , Bethany Freeman
发明人： Christopher Corcoran , Michael Agostino , Edward LaVallie , Carl Flannery , Weilan Zeng , Lisa Collins-Racie , Bethany Freeman
IPC分类号： C12Q1/68 , G01N33/53 , G06F19/00 , C07H21/04 , C12N9/64 , C07K16/40
CPC分类号： C12N9/6421 , A61K2039/505
摘要： Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
摘要翻译：公开了新型聚蛋白聚糖蛋白聚糖蛋白和编码它们的核苷酸序列以及其制备方法。还公开了鉴定和发展聚蛋白聚糖蛋白酶的抑制剂和用于治疗由聚集蛋白聚糖蛋白降解特征的病症的酶的抗体的方法。

3. 发明申请

US20050277175A1 Truncated ADAMTS molecules 审中-公开
标题翻译：截断的ADAMTS分子
公开(公告)号：US20050277175A1
公开(公告)日：2005-12-15
申请号：US11109157
申请日：2005-04-18
申请人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Natalie Twine , Michael Agostino
发明人： Edward LaVallie , Lisa Collins-Racie , Christopher Corcoran , Natalie Twine , Michael Agostino
IPC分类号： C07H21/04 , C12N9/64 , C12P21/06
CPC分类号： C12N9/6489
摘要： The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.
摘要翻译：本发明提供截短的生物活性ADAMTS多肽，特别是那些具有透明质酸酶活性的多肽，更具体地，具有聚集蛋白聚糖蛋白聚糖酶活性的多肽，其表现出比其全长对应物更大的稳定性和均一性和更高的表达产率。本发明还提供编码这种截短的生物活性ADAMTS多肽的核酸分子和用于产生截短的生物活性ADAMTS多肽的方法。此外，本发明提供了鉴定能够调节生物活性ADAMTS多肽，特别是那些抑制聚蛋白聚糖蛋白酶活性的化合物的化合物的方法。

4. 发明申请

US20060177904A1 Secreted proteins and polynucleotides encoding them 失效
公开(公告)号：US20060177904A1
公开(公告)日：2006-08-10
申请号：US11395249
申请日：2006-04-03
申请人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , David Merberg , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
发明人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , David Merberg , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel , Cheryl Evans , Maurice Treacy
IPC分类号： C07H21/04 , C12P21/06 , C12N9/00 , C07K14/47 , C07K16/18
CPC分类号： C07K16/18 , A61K38/00 , C07K14/435 , C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.

5. 发明申请

US20060063227A1 Secreted proteins and polynucleotides encoding them 审中-公开
标题翻译：分泌蛋白质和编码它们的多核苷酸
公开(公告)号：US20060063227A1
公开(公告)日：2006-03-23
申请号：US10745586
申请日：2004-12-14
申请人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Bowman , Vikki Spaulding , Michael Agostino
发明人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Bowman , Vikki Spaulding , Michael Agostino
IPC分类号： C12P21/06
CPC分类号： C07K14/47
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

6. 发明申请

US20050003491A1 Secreted proteins and polynucleotides encoding them 审中-公开
标题翻译：分泌蛋白质和编码它们的多核苷酸
公开(公告)号：US20050003491A1
公开(公告)日：2005-01-06
申请号：US10913553
申请日：2004-08-09
申请人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel
发明人： Kenneth Jacobs , John McCoy , Edward LaVallie , Lisa Collins-Racie , Cheryl Evans , David Merberg , Maurice Treacy , Michael Agostino , Robert Steininger , Vikki Spaulding , Gordon Wong , Hilary Clark , Kim Fechtel
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/475 , C07K14/52 , C07K14/575 , C07K14/705 , C07H21/04 , C07K16/18 , C12N9/00 , C12P21/04
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/52 , C07K14/575 , C07K14/705
摘要： Novel polynucleotides and the proteins encoded thereby are disclosed.
摘要翻译：公开了新的多核苷酸和由此编码的蛋白质。

7. 发明授权

US07566000B2 Method and system for providing a flexible product purchase account for members of a healthcare organization 有权
标题翻译：为医疗机构成员提供灵活的产品采购帐户的方法和系统
公开(公告)号：US07566000B2
公开(公告)日：2009-07-28
申请号：US11060158
申请日：2005-02-17
申请人： Michael Agostino , Scott A. McArthur , Doug Egan
发明人： Michael Agostino , Scott A. McArthur , Doug Egan
IPC分类号： G06K7/10
CPC分类号： G06Q30/02 , G06Q20/40
摘要： A method and system for facilitating a redemption of benefits for a customer with the use of a benefit card is provided that includes associating an identification code with the customer, the identification code being stored on the benefit card, accessing an account record associated with the identification code, and determining if an item presented for purchase by the customer is eligible for a benefit discount. Also included is calculating an appropriate discount for the item if it is determined that the item was eligible for a benefit discount.
摘要翻译：提供一种方法和系统，用于促进使用利益卡为客户兑换利益，其包括将识别码与客户相关联，识别码存储在利益卡上，访问与识别相关联的帐户记录代码，以及确定由客户呈现供购买的物品是否符合获利优惠。还包括如果确定该项目有资格获得优惠折扣，则计算该项目的适当折扣。

8. 发明授权

US4290162A Light-weight floor-standing drain cleaner 失效
标题翻译：轻便落地式排水清洁剂
公开(公告)号：US4290162A
公开(公告)日：1981-09-22
申请号：US139985
申请日：1980-04-14
申请人： Michael Agostino
发明人： Michael Agostino
IPC分类号： E03F9/00 , B08B9/02
CPC分类号： E03F9/005
摘要： Employing a relatively short cable in a drum with a closely spaced inner portion, an effective floor-standing drain cleaner is provided which is portable, usable in most simple situations, is light in weight and drivable by a removable electric hand drill.
摘要翻译：在具有紧密间隔的内部部分的鼓中使用相对较短的电缆，提供有效的落地式排水清洁器，其是便携式的，可在大多数简单的情况下使用，重量轻并且可通过可拆卸的电动手钻驱动。

9. 发明授权

US4841580A Buoyant and non-buoyant valve 失效
标题翻译：浮力和非浮力阀
公开(公告)号：US4841580A
公开(公告)日：1989-06-27
申请号：US132319
申请日：1987-12-14
申请人： Michael Agostino
发明人： Michael Agostino
IPC分类号： E03D1/14
CPC分类号： E03D1/142
摘要： A flush valve for use in a flush tank for control by the operator of the amount used in flushing, the valve including an elongate body having a solid generally hemispherical protuberance extending outwardly on one side and a hollow frusto-conical cup member extending outwardly from the other side. A tab and opening therethrough on the forward portion of the body for connection to the valve operating system allows the valve to be alternatively turned with the cup member facing upward and being non-buoyant or having the cup member facing downwardly whereby air trapped therein renders the valve buoyant for substantially a full flush. Spaced arm members extend laterally from the rearward portion of the valve body and have one or more openings pivotally mounting the valve to the normal overflow tube to position the valve with respect to the water outlet in either selected position.
摘要翻译：一种用于冲洗水箱的冲洗阀，用于操作者用于冲洗的量控制，该阀包括一个细长体，该细长体具有在一侧向外延伸的实心大致半球状的突起，以及从该侧向外延伸的中空的截头圆锥形杯构件另一边。在主体的前部与阀操作系统连接的突片和开口允许阀可选地转动，其中杯构件面向上并且是非浮力的或者使杯体面向下，从而使空气被捕获在其中阀浮力基本上完全冲洗。间隔的臂构件从阀体的后部横向延伸并且具有一个或多个开口可枢转地将阀安装到正常溢流管，以将阀相对于出水口定位在任一选定位置。

10. 发明授权

US4829605A Dual flush valve assembly 失效
标题翻译：双冲程阀总成
公开(公告)号：US4829605A
公开(公告)日：1989-05-16
申请号：US30369
申请日：1987-03-26
申请人： Michael Agostino
发明人： Michael Agostino
IPC分类号： E03D1/14
CPC分类号： E03D1/142
摘要： A dual flush valve assembly for a toilet tank including an overflow pipe, a pair of spaced inlets communicating with the pipe, a pair of flap valves selectively closing the inlets, a pair of spaced handles connected to respective valve operating rods controlling the flap valves, a fitting disposed in an opening in a front of a tank mounting the handles thereto in substantially the same vertical plane one above the other, and two spaced pairs of shoulders extending outwardly from the fitting with the handles being movable between a respective spaced pair of shoulders to limit the movement thereof. The flap valves have a wedge shaped body and are reversible for increased life thereof. The pipe and pair of inlets are removably mounted to a drain extending within the tank from the toilet basin without removal of the drain pipe. The overflow pipe may be aligned with the drain pipe with the inlets being offset therefrom, or one drain pipe and full flush inlet may be offset with the partial flush inlet being aligned with the drain pipe.
摘要翻译：一种用于马桶水箱的双冲洗阀组件，包括溢流管，与管连通的一对间隔开的入口，一对选择性地关闭入口的活门阀，连接到控制活瓣阀的相应阀操作杆的一对隔开的手柄，一个配置在一个开口中，一个安装手柄的开口中的一个开口，该手柄在大体上相同的垂直平面上相互垂直放置，并且两个间隔开的一对肩部从配件向外伸出，手柄可在相应间隔开的肩部之间移动以限制其运动。瓣阀具有楔形体，并且是可逆的以增加其寿命。管道和一对入口可移除地安装到从马桶盆内延伸到罐内的排水口，而不需排除排水管。溢流管可以与排水管对准，其中入口从其排出，或者一个排水管和全冲洗入口可以偏移，而部分冲洗入口与排水管对齐。

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