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1. 发明申请

US20090137785A1 RAB9 PROTEIN CRYSTAL STRUCTURES AND METHODS FOR IDENTIFYING RAB9 MODULATORS 审中-公开
标题翻译： RAB9蛋白晶体结构和识别RAB9调节剂的方法
公开(公告)号：US20090137785A1
公开(公告)日：2009-05-28
申请号：US11933636
申请日：2007-11-01
申请人： Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
发明人： Edward J. Meehan , Liqing Chen , Enrico L. DiGiammarino , Thomas W. Hodge
IPC分类号： C07K14/00
CPC分类号： C12N9/16 , C07K2299/00 , G01N2500/04
摘要： The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.
摘要翻译：本发明涉及与GDP或GTP类似物鸟苷5' - （β，γ-亚氨基）三磷酸（GppNHp）复合的结晶Rab9，Rab9-GDP和Rab9-GppNHp复合物中Rab9的三维坐标和结构，并将其用于药物设计。特别地，本发明涉及用于生产足够质量的Rab9晶体的方法，以在其GTP结合（开/主动）和GDP-结合（关/非活性）两者中获得Rab9的三维结构确定为高分辨率）构象。本发明还涉及用Rab9-GDP和Rab9-GppNHp复合物中的Rab9的三维坐标编码的计算机可读介质，其中使用图形显示软件程序，三维坐标创建可以在能够将电子文件表示为三维图像的计算机。

2. 发明申请

US20060073582A1 Rab9 protein crystal structures and methods for identifying Rab9 modulators 审中-公开
标题翻译： Rab9蛋白晶体结构和鉴定Rab9调节剂的方法
公开(公告)号：US20060073582A1
公开(公告)日：2006-04-06
申请号：US11154203
申请日：2005-06-16
申请人： Edward Meehan , Liqing Chen , Enrico DiGiammarino , Thomas Hodge
发明人： Edward Meehan , Liqing Chen , Enrico DiGiammarino , Thomas Hodge
IPC分类号： G01N33/48 , C12N9/12 , G06F19/00
CPC分类号： C12N9/16 , C07K2299/00 , G01N2500/04
摘要： The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.
摘要翻译：本发明涉及与GDP或GTP类似物鸟苷5' - （β，γ-亚氨基）三磷酸（GppNHp）复合的结晶Rab9，Rab9-GDP和Rab9-GppNHp复合物中Rab9的三维坐标和结构，并将其用于药物设计。特别地，本发明涉及用于生产足够质量的Rab9晶体的方法，以在其GTP结合（开/主动）和GDP-结合（关/非活性）两者中获得Rab9的三维结构确定为高分辨率）构象。本发明还涉及用Rab9-GDP和Rab9-GppNHp复合物中的Rab9的三维坐标编码的计算机可读介质，其中使用图形显示软件程序，三维坐标创建可以在能够将电子文件表示为三维图像的计算机。

3. 外观设计

USD1023741S1 Gift box with window 有权
公开(公告)号：USD1023741S1
公开(公告)日：2024-04-23
申请号：US29842297
申请日：2022-06-12
申请人： Liqing Chen
设计人： Liqing Chen
摘要： FIG. 1 is a perspective view of a gift box with window showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left view thereof;
FIG. 5 is a right view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof;
FIG. 8 is a perspective view thereof, showing in an exploded position;
FIG. 9 is a perspective view of the outer box portion, shown separately to show aspects of the design that are not visibly when combined;
FIG. 10 is a perspective view of the inner box portion in an unfolded position; and,
FIG. 11 is a top view thereof.

4. 外观设计

USD1030474S1 Drawer folding gift box 有权
公开(公告)号：USD1030474S1
公开(公告)日：2024-06-11
申请号：US29842294
申请日：2022-06-12
申请人： Liqing Chen
设计人： Liqing Chen
摘要： FIG. 1 is a front, right and top perspective view of a drawer folding gift box showing my new design;
FIG. 2 is a front view thereof;
FIG. 3 is a rear view thereof;
FIG. 4 is a left view thereof;
FIG. 5 is a right view thereof;
FIG. 6 is a top view thereof;
FIG. 7 is a bottom view thereof;
FIG. 8 is a front perspective view thereof, shown in an open configuration;
FIG. 9 is a top plan view of the inner box, shown in an unassembled configuration;
FIG. 10 is top perspective view thereof;
FIG. 11 is a top perspective view of the outer box, shown in an unassembled configuration;
FIG. 12 is an exploded perspective view of the outer and inner boxes, each shown in a partially assembled configuration; and,
FIG. 13 is an exploded perspective view of the outer and inner boxes, each shown assembled and positioned for use.

5. 外观设计

USD961375S1 Combined folding gift box with lid 有权
公开(公告)号：USD961375S1
公开(公告)日：2022-08-23
申请号：US29785030
申请日：2021-05-24
申请人： Liqing Chen
设计人： Liqing Chen

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