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1. 发明授权

US4695658A Aryl carboxylate process 失效
标题翻译：芳基羧酸酯工艺
公开(公告)号：US4695658A
公开(公告)日：1987-09-22
申请号：US589257
申请日：1984-03-12
申请人： Edward C. Taylor , Alan H. Katz , Randy A. Bull , Lance R. Byers , Richard A. Brown
发明人： Edward C. Taylor , Alan H. Katz , Randy A. Bull , Lance R. Byers , Richard A. Brown
IPC分类号： C07C37/02 , B01J23/00 , B01J31/00 , C07B31/00 , C07B41/02 , C07B41/12 , C07B61/00 , C07C27/00 , C07C37/00 , C07C37/01 , C07C37/055 , C07C39/00 , C07C39/06 , C07C67/00 , C07C69/017 , C07F5/00 , C07C39/10 , C07C69/76
CPC分类号： C07F5/00 , C07C37/01 , C07C37/0555 , C07C67/00
摘要： A process for replacing an aromatic carbon-thallium bond with a carbon-oxygen bond. The process is particularly suitable for producing specific aromatic isomers by thallating an aromatic compound and replacing the thallium with a carboxylate group which can be further hydrolyzed if desired to form an aromatic hydroxyl compound.
摘要翻译：用碳 - 氧键代替芳族碳 - 铊键的方法。该方法特别适用于通过使芳族化合物松弛并用羧酸酯基团代替铊来生产特定的芳族异构体，如果需要，可以进一步水解形成芳族羟基化合物。

2. 发明申请

US20140171332A1 SYSTEM FOR THE EFFICIENT DISCOVERY OF NEW THERAPEUTIC DRUGS 审中-公开
标题翻译：新治疗药物有效发现的系统
公开(公告)号：US20140171332A1
公开(公告)日：2014-06-19
申请号：US14098404
申请日：2013-12-05
申请人： Alan H. Katz , Philip J. Farrelly
发明人： Alan H. Katz , Philip J. Farrelly
IPC分类号： G06F19/00
CPC分类号： G16C20/60 , G16B35/00 , G16C20/50 , Y02A90/26
摘要： The invention provides for carrying out 3-dimensional similarity searching by comparing a probe molecule to each member of a 3-dimensional database. The probe molecule is overlapped with each member of a database of molecules and then the database molecule is rotated and translates until its similarity with the probe molecule is maximized. The system can contain ten different scoring functions to rate the similarity between the two molecules. Each function employs different molecular features when scoring a particular comparison. Some methods are based on the relative shape of the two molecules, and some are based on the overlap of key atoms such as oxygen, nitrogen, sulfur, and/or halogens.
摘要翻译：本发明提供了通过将探针分子与三维数据库的每个成员进行比较来进行三维相似性搜索。探针分子与分子数据库的每个成员重叠，然后数据库分子被旋转和平移，直到其与探针分子的相似性最大化。该系统可以包含十个不同的评分函数来评估两个分子之间的相似性。每个功能在划分特定比较时采用不同的分子特征。一些方法基于两个分子的相对形状，一些方法基于诸如氧，氮，硫和/或卤素的关键原子的重叠。

3. 发明授权

US06451827B2 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译：用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯
公开(公告)号：US06451827B2
公开(公告)日：2002-09-17
申请号：US09771469
申请日：2001-01-26
申请人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号： A61K3144
CPC分类号： C07D213/40 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C309/77 , C07D209/08 , C07D233/54 , C07D263/58 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07F9/4006 , C07C22/04
摘要： This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译：本发明提供具有结构的式I化合物，其中B，C，D和R 1如本说明书中所定义，或其药学上可接受的盐，其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。

4. 发明授权

US4886886A Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids 失效
标题翻译：取代的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸
公开(公告)号：US4886886A
公开(公告)日：1989-12-12
申请号：US223481
申请日：1988-07-25
申请人： Brian A. McKittrick , Alan H. Katz
发明人： Brian A. McKittrick , Alan H. Katz
IPC分类号： C07D491/04 , C07D491/052
CPC分类号： C07D491/04
摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
摘要翻译：其特征在于具有位置1-，4-，5-，6-，7-和8位上具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核 - 被披露。所述衍生物是有用的抗炎和止痛剂，并且还公开了它们的制备和使用方法。

5. 发明授权

US4855445A Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids 失效
标题翻译：取代的-8-烯基-1,3,4,9-四氢吡喃（3,4-b）吲哚-1-乙酸
公开(公告)号：US4855445A
公开(公告)日：1989-08-08
申请号：US294705
申请日：1989-01-09
申请人： Alan H. Katz , Christopher A. Demerson
发明人： Alan H. Katz , Christopher A. Demerson
IPC分类号： C07D491/04 , C07D491/052
CPC分类号： C07D491/04
摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.
摘要翻译：公开了具有在位置1-，5-，6-，7-和8-位置具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核的吲哚衍生物。所述衍生物是有用的抗炎和/或止痛剂。还公开了其制备和使用方法。

6. 发明授权

US4775690A Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids 失效
公开(公告)号：US4775690A
公开(公告)日：1988-10-04
申请号：US2825
申请日：1987-01-13
申请人： Alan H. Katz , Christopher A. Demerson , Leslie G. Humber
发明人： Alan H. Katz , Christopher A. Demerson , Leslie G. Humber
IPC分类号： C07D491/04 , C07D491/052 , A61K31/40
CPC分类号： C07D491/04
摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

7. 发明授权

US06765021B2 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译：用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯
公开(公告)号：US06765021B2
公开(公告)日：2004-07-20
申请号：US10215438
申请日：2002-08-09
申请人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号： A61K3117
CPC分类号： C07F9/4006 , C07B2200/07 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C225/20 , C07C233/43 , C07C235/46 , C07C235/48 , C07C235/52 , C07C237/30 , C07C255/54 , C07C271/12 , C07C271/16 , C07C271/28 , C07C271/30 , C07C309/77 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D213/40 , C07D233/54 , C07D263/58 , C07D295/088 , C07D295/13 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07C22/04
摘要： This invention provides compounds of formula I having the structure wherein: B, D, C, and R1 as defined herein.
摘要翻译：本发明提供具有本文定义的B，D，C和R 1结构的式I化合物。

8. 发明授权

US06214877B1 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia 失效
标题翻译：用于治疗胰岛素抵抗和高血糖症的2,3,5-取代联苯
公开(公告)号：US06214877B1
公开(公告)日：2001-04-10
申请号：US09307850
申请日：1999-05-10
申请人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
发明人： John A. Butera , Craig E. Caufield , Russell F. Graceffa , Alexander Greenfield , Eric G. Gundersen , Lisa Marie Havran , Alan H. Katz , Joseph R. Lennox , Scott C. Mayer , Robert E. McDevitt
IPC分类号： A61K31166
CPC分类号： C07F9/4006 , C07B2200/07 , C07C17/16 , C07C45/68 , C07C45/71 , C07C47/575 , C07C205/35 , C07C205/37 , C07C225/20 , C07C233/43 , C07C235/46 , C07C235/48 , C07C235/52 , C07C237/30 , C07C255/54 , C07C271/12 , C07C271/16 , C07C271/28 , C07C271/30 , C07C309/77 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D213/40 , C07D233/54 , C07D263/58 , C07D295/088 , C07D295/13 , C07D307/58 , C07D307/80 , C07D307/81 , C07D317/54 , C07D333/74 , C07D413/12 , C07C22/04
摘要： This invention provides compounds of Formula I having the structure wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
摘要翻译：本发明提供具有结构的式I化合物，其中B，C，D和R 1如本说明书中所定义，或其药学上可接受的盐，其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。

9. 发明授权

US4971960A Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids 失效
标题翻译：取代的1,3,4,9-四氢吡喃（3,4-b）吲哚-1-乙酸
公开(公告)号：US4971960A
公开(公告)日：1990-11-20
申请号：US299169
申请日：1989-02-14
申请人： Alan H. Katz , Christopher A. Demerson , Leslie G. Humber
发明人： Alan H. Katz , Christopher A. Demerson , Leslie G. Humber
IPC分类号： C07D491/04
CPC分类号： C07D491/04
摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
摘要翻译：其特征在于具有在位置1和4具有取代基的1,3,4,9-四氢吡喃并[3,4-b]吲哚-1-乙酸核。所述核可以任选地在5,6位，衍生物是有用的抗炎和止痛剂，并且还公开了它们的制备和使用方法。

10. 发明授权

US4904799A Preparation of tryptophols 失效
标题翻译： tryptophols的制备
公开(公告)号：US4904799A
公开(公告)日：1990-02-27
申请号：US390801
申请日：1989-08-08
申请人： Brian A. McKittrick , Alan H. Katz
发明人： Brian A. McKittrick , Alan H. Katz
IPC分类号： A61K31/40 , A61P25/04 , A61P29/00 , C07D491/04 , C07D491/052
CPC分类号： C07D491/04
摘要： Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

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