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1. 发明授权

US5782886A Pacemaker with improved hysteresis 失效
标题翻译：起搏器具有改善的滞后
公开(公告)号：US5782886A
公开(公告)日：1998-07-21
申请号：US808314
申请日：1997-02-28
申请人： Edoardo C. Kuiper , Hendrik Reineman , Johannes S. van der Veen
发明人： Edoardo C. Kuiper , Hendrik Reineman , Johannes S. van der Veen
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/368
摘要： An implantable pacemaker system is provided with a conditional hysteresis feature, whereby a hysteresis value is added to the pacing escape interval only when the prior spontaneous rate corresponded to a rate below the top of a predetermined hysteresis band. This feature limits the lengthening of the escape interval when there are sudden drops in the natural rate thereby avoiding excessive changes in rate. In a preferred embodiment, the pacemaker defines a hysteresis band around a given pacing rate, e.g., lower rate limit, the band having an upper hysteresis limit and a lower hysteresis limit. No hysteresis lengthening of the escape interval is utilized for spontaneous heartbeats having rates above the upper hysteresis limit; for spontaneous heartbeats having rates between the lower rate limit and the upper hysteresis limit, an escape interval is set to have a value corresponding to a rate between the pacing limit and the lower rate limit of the hysteresis band which is, e.g., 0-30 bpm below the lower rate limit; and for a sensed spontaneous rate below the lower rate limit, a hysteresis escape interval corresponding to the lower hysteresis limit is established. In the preferred embodiment, sensed heartbeats having a prior rate between the lower rate limit and the upper hysteresis limit cause an escape interval which is lengthened beyond the LRL escape interval by an amount which varies linearly with the differential between the upper hysteresis rate limit and the spontaneous rate.
摘要翻译：可植入起搏器系统具有条件滞后特征，由此仅在先前的自发速率对应于低于预定滞后带的顶部的速率时才将滞后值加到起搏逃逸间隔上。该特征限制了自然速率突然下降时逃逸间隔的延长，从而避免了速率的过度变化。在优选实施例中，起搏器定义围绕给定起搏速率的滞后带，例如较低速率极限，具有较高滞后极限和较低磁滞极限的频带。对于速率高于上限滞后极限的自发性心跳，不利于逃逸间隔的滞后延长; 对于具有较低速率限制和较高滞后限制之间的速率的自发心跳，逃避间隔被设置为具有对应于起搏极限与滞后带的较低速率极限之间的速率的值，例如0-30 bpm低于下限; 并且对于低于较低速率限制的感测自发速率，建立对应于较低滞后极限的滞后逃逸间隔。在优选实施例中，具有较低速率限制和较高滞后限制之间的先前速率的感测心跳导致延长超过LRL逃逸间隔的逃逸间隔，其量随着上滞后速率限制和自发率

2. 发明授权

US6148235A Implantable stimulator with battery status measurement 失效
标题翻译：具有电池状态测量的可植入刺激器
公开(公告)号：US6148235A
公开(公告)日：2000-11-14
申请号：US118706
申请日：1998-07-17
申请人： Edoardo C. Kuiper
发明人： Edoardo C. Kuiper
IPC分类号： A61N1/37 , A61N1/378
CPC分类号： A61N1/3708
摘要： There is provided an implantable device system such as a battery-powered pacemaker system, with an improved capability of measuring battery internal impedance, thereby providing the means to determine anticipated device End of Life. Within one pacemaker cycle following a sensed beat or a delivered stimulus, and before delivery of a next stimulus, three battery measurements are taken at equally spaced time intervals. Due to the RC nature of the battery internal impedance, the first two battery voltage measurements can be used to calculate what the voltage would be at the third time, assuming no change in current load. At the third time, a predetermined incremental current load is added, and the battery voltage at the time of the added current load is measured. The voltage differential between the calculated battery voltage and the measured battery voltage at the third time, together with the predetermined incremental current load, is used to calculate the battery impedance.
摘要翻译：提供了诸如电池供电的起搏器系统的可植入装置系统，其具有改进的测量电池内部阻抗的能力，从而提供了确定预期装置寿命终止的手段。在感觉到的搏动或传递的刺激之后的一个起搏器循环中，并且在递送下一个刺激之前，以相等间隔的时间间隔进行三次电池测量。由于电池内部阻抗的RC性质，假设电流负载没有变化，前两次电池电压测量可用于计算第三次的电压。在第三时间，增加预定的增加的电流负载，并且测量在添加的电流负载时的电池电压。使用计算出的电池电压和第三次测量的电池电压之间的电压差以及预定的增加的电流负载来计算电池阻抗。

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