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1. 发明授权

US4687765A Method and composition for thrombolytic treatment 失效
标题翻译：溶栓治疗的方法和组成
公开(公告)号：US4687765A
公开(公告)日：1987-08-18
申请号：US760483
申请日：1985-07-30
申请人： Edmond G. Vairel , Huguette Brouty-Boye , Francis Toulemonde , Christian Doutremepuich
发明人： Edmond G. Vairel , Huguette Brouty-Boye , Francis Toulemonde , Christian Doutremepuich
IPC分类号： A61K31/725
CPC分类号： A61K31/715 , Y10S514/822
摘要： The invention relates to a method and composition for thrombolytic treatment. It comprises administering to thrombosis-afflicted patients a low molecular weight heparin in an amount effective to cause lysis of thrombi in vivo.
摘要翻译：本发明涉及溶栓治疗的方法和组合物。其包括给血栓形成患者施用有效引起体内血栓溶解的量的低分子量肝素。

2. 发明授权

US4029767A Pharmaceutical compositions of stable urokinase-heparin complexes and methods for use thereof 失效
标题翻译：稳定的尿激酶 - 肝素复合物的药物组合物及其使用方法
公开(公告)号：US4029767A
公开(公告)日：1977-06-14
申请号：US629076
申请日：1975-11-05
申请人： Edmond G. Vairel , Jean Goulay , Jean Choay
发明人： Edmond G. Vairel , Jean Goulay , Jean Choay
IPC分类号： A61K38/00 , C12N9/72 , A61K37/48 , A61K31/725
CPC分类号： C12N9/6462 , C12Y304/21073 , A61K38/00
摘要： The present invention relates to pharmaceutical compositions of stable urokinase-heparin complexes, wherein the urokinase is purified, and methods for use thereof.
摘要翻译：本发明涉及稳定尿激酶 - 肝素复合物的药物组合物，其中尿激酶被纯化，及其使用方法。

3. 发明授权

US4106992A Purification of urokinase 失效
标题翻译：尿激酶的纯化
公开(公告)号：US4106992A
公开(公告)日：1978-08-15
申请号：US628968
申请日：1975-11-05
申请人： Edmond G. Vairel , Jean Goulay , Jean Choay
发明人： Edmond G. Vairel , Jean Goulay , Jean Choay
IPC分类号： A61K38/00 , C12N9/72 , C07G7/02
CPC分类号： C12N9/6462 , C12Y304/21073 , A61K38/00 , Y10S435/815
摘要： An initial solution of crude urokinase especially of human origin, is subjected to exclusion chromatography by contact with a DEAE cellulose resin, following adjustment of the pH of the solution to a value of from 4 to 6, and of its conductivity to a value of from 15,000 to 25,000 micromhos. An effluent enriched in urokinase is collected. A urokinase, mixed with foreign proteins, especially pyrogens, is purified by a partial saturation of an aqueous solution of this mixture by ammonium sulphate to a value for which the precipitate formed would not entrain more than 5% of the total activity of urokinase of the initial solution. A supernatant liquid enriched in urokinase is collected . A complex of urokinase and heparin, urokinase heparinate, is made by reacting an enriched solution of urokinase with a solution of heparin. It has relative activities of 30,000 to 100,000 CTA units of urokinase for 100 Iu of heparin. In an isotonic perfusion solution in glucose serum, its dilution is from 300,000 to 900,000 CTA units of urokinase/250 ml.
摘要翻译：通过与DEAE纤维素树脂的接触，将溶液的pH值调整至4至6，并将其电导率调节至从 15,000至25,000微镜。收集富含尿激酶的流出液。与外来蛋白质，特别是热原混合的尿激酶通过硫酸铵将该混合物的水溶液部分饱和至达到其形成的沉淀物不会夹带大于5％的尿激酶活性的值的纯化初始解决方案收集富含尿激酶的上清液。通过使尿激酶的富集溶液与肝素溶液反应制成尿激酶和肝素复合物，尿激酶尿激酶。对于100 Iu肝素，它具有30,000至100,000 CTA尿激酶单位的相对活性。在葡萄糖血清中的等渗灌注溶液中，其稀释度为30,000至900,000 CTA单位的尿激酶/ 250ml。

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