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1. 发明申请

US20140120162A1 Bioadhesive Drug Delivery Compositions 审中-公开
标题翻译：生物粘附药物输送组合物
公开(公告)号：US20140120162A1
公开(公告)日：2014-05-01
申请号：US14124040
申请日：2012-06-06
申请人： Edith Mathiowitz , Solomon S. Steiner , Bryan E. Laulicht , Sasha Bakhru
发明人： Edith Mathiowitz , Solomon S. Steiner , Bryan E. Laulicht , Sasha Bakhru
IPC分类号： A61K47/34 , A61K47/32
CPC分类号： A61K47/34 , A61K9/4858 , A61K47/32
摘要： Compositions containing one or more active agents, one or more bioadhesives elements, and one or more charge masking agents are described herein. In some embodiments, the one or more active agents are biomolecules or macromolecules, such as polysaccharides, proteins, peptides, or nucleic acids, which are charged at physiological pH. The one or more charge masking agents are selected based on the nature of the charge on the active agent. The compositions may also contain one or more controlled release materials, such as extended or sustained release materials or delayed release materials, in order to modify release of the active agent.
摘要翻译：本文描述了包含一种或多种活性剂，一种或多种生物粘合剂元件和一种或多种电荷掩蔽剂的组合物。在一些实施方案中，一种或多种活性剂是在生理pH下加入的生物分子或大分子，例如多糖，蛋白质，肽或核酸。基于活性剂上的电荷的性质来选择一种或多种电荷掩蔽剂。为了改变活性剂的释放，组合物还可以含有一种或多种受控释放材料，例如延长或持续释放材料或延迟释放材料。

2. 发明申请

US20140178479A1 Concentrated Felbamate Formulations for Parenteral Administration 审中-公开
标题翻译：用于肠胃外给药的浓缩费尔布糖苷制剂
公开(公告)号：US20140178479A1
公开(公告)日：2014-06-26
申请号：US14238138
申请日：2012-04-09
申请人： Sasha H. Bakhru , Bryan E. Laulicht , Edith Mathiowitz , Solomon S. Steiner
发明人： Sasha H. Bakhru , Bryan E. Laulicht , Edith Mathiowitz , Solomon S. Steiner
IPC分类号： A61K9/00 , A61K31/27 , A61K31/55
CPC分类号： A61K31/27 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/145 , A61K31/55 , A61K47/10 , A61K47/20
摘要： Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved at high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size from about 100 nm to about 5 microns, preferably from about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological diseases/disorders and/or neurological injury or trauma.
摘要翻译：本文描述了用于肠胃外给药的神经保护剂的制剂。制剂是浓缩（过饱和）溶液或微粒浓缩悬浮液的形式。悬浮介质或溶剂溶剂载体也可以含有溶解的神经保护剂。对于过饱和溶液，在适于肠胃外给药的溶剂中，该试剂以至少约1重量％，5重量％，10重量％，15重量％或20重量％的高浓度溶解。对于浓缩悬浮液，微粒具有约100nm至约5微米，优选约50nm至约3微米，更优选约10nm至约2微米的有效粒度。本文描述的制剂可用于治疗各种神经疾病/障碍和/或神经损伤或创伤。

3. 发明申请

US20140207105A1 Methods for Effectively and Rapidly Desensitizing Allergic Patients 审中-公开
标题翻译：有效和快速脱敏过敏患者的方法
公开(公告)号：US20140207105A1
公开(公告)日：2014-07-24
申请号：US14240706
申请日：2012-08-30
申请人： Bryan E. Laulicht , Sasha H. Bakhru , Solomon S. Steiner , Edith Mathiowitz
发明人： Bryan E. Laulicht , Sasha H. Bakhru , Solomon S. Steiner , Edith Mathiowitz
IPC分类号： A61K39/35 , A61M37/00
CPC分类号： A61K39/35 , A61K31/43 , A61K31/60 , A61K39/36 , A61K2039/54 , A61K2039/55511 , A61K2039/55555 , A61K2039/55583 , A61K2039/577 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0061
摘要： Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or microparticles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines.
摘要翻译：已经开发了用于将患者未来接触抗原脱敏的剂量将抗原递送至淋巴系统的方法和组合物。通过将少量抗原引入淋巴系统来实现快速脱敏。在优选的实施方案中，施用组合物以通过皮内给药，使用例如微针或微粒，口服给药，使用例如肠溶衣胶囊或淋巴细胞，以产生治疗有效水平的淋巴内的抗原，其中巨噬细胞以最大浓度存在片剂或自体输血。在一些实施方案中，用于递送抗原的方法和组合物通过小肠的派尔氏贴片摄取。

4. 发明申请

US20110221083A1 POLYMER-BASED MICROSTRUCTURES 审中-公开
标题翻译：聚合物微结构
公开(公告)号：US20110221083A1
公开(公告)日：2011-09-15
申请号：US13047426
申请日：2011-03-14
申请人： Bryan E. Laulicht , Sasha Bakhru
发明人： Bryan E. Laulicht , Sasha Bakhru
IPC分类号： B29B9/12 , B05B1/14
CPC分类号： B01J13/14 , B01J13/08
摘要： The present invention relates to the fields of controlled release of drugs, proteins, nucleic acids, and other pharmaceuticals. It also relates to delivery systems for these agents and other compounds. The invention also relates to stable encapsulation of cells and molecules. The invention provides a population of microstructures comprising a permeable polymer shell, wherein the standard variance in the volume of the microstructures is usually less than or equal to 20%, preferably 10%, of the mean, and wherein the diffusion characteristics of the polymer shell vary within the population of microstructures. It also provides for an apparatus and a method of forming a population of microstructures, which method for making microstructures by introducing drops of a polymer solution into a receiving solution under conditions that permit cross-linking of the polymer in the receiving solution. Microstructures of calcium-cross-linked alginate with a chitosin capsule are disclosed.
摘要翻译：本发明涉及药物，蛋白质，核酸和其他药物的控制释放领域。它还涉及这些试剂和其它化合物的递送系统。本发明还涉及细胞和分子的稳定包封。本发明提供了包含可渗透聚合物壳的微观组织群，其中微结构体积的标准差异通常小于或等于平均值的20％，优选10％，并且其中聚合物壳的扩散特性在微观结构的群体内变化。它还提供了一种形成微观结构群体的装置和方法，该方法通过在允许聚合物在接收溶液中交联的条件下将聚合物溶液的液滴引入接收溶液来制备微结构。公开了钙交联藻酸盐与壳聚糖胶囊的微结构。

5. 发明申请

US20080175918A1 CHEMICALLY CROSS-LINKED ELASTOMERIC MICROCAPSULES 审中-公开
标题翻译：化学交联的弹性微球
公开(公告)号：US20080175918A1
公开(公告)日：2008-07-24
申请号：US11971507
申请日：2008-01-09
申请人： Bryan E. Laulicht
发明人： Bryan E. Laulicht
IPC分类号： A61K9/50 , A61P31/00 , A61P35/00
CPC分类号： A61K9/5031
摘要： The present invention relates to the fields of stably encapsulating oral care, skin care, scented, flavoring agents for cued release, and therapeutic agents for extended and sustained release. The invention relates to the stable microencapsulation of these agents for incorporation into dentifrices, topical ointments, microwavable food products, dryer sheets and chewing gums to be released during brushing, applying, heating, tumbling, and masticating respectively. Additionally, the invention encompasses extended and sustained release formulations that achieve reservoir-type delivery of therapeutic agents. The invention discloses methods for manufacturing and post-processing populations of chemically cross-linked elastomeric microcapsules allowing for the incorporation of encapsulated agents into a wide range of formulations without significantly altering their physio-chemical properties while providing for the cued delivery of the encapsulated agent upon the reception of a single or multiple mechanical or thermo-mechanical cues, or extended delivery via diffusion.
摘要翻译：本发明涉及稳定包封口腔护理，皮肤护理，香味，调理释放的调味剂以及用于延长和持续释放的治疗剂的领域。本发明涉及这些试剂稳定的微胶囊化，用于掺入洁牙剂，局部软膏，微波加工食品，干燥片和口香糖中，分别在刷牙，涂抹，加热，翻滚和咀嚼过程中释放。另外，本发明包括实现治疗剂的储库型递送的延长和持续释放制剂。本发明公开了用于制造和后处理化学交联的弹性体微胶囊的种群的方法，其允许将包封的试剂掺入到宽范围的制剂中，而不显着改变其生理化学性质，同时提供包封的药剂的提供递送接收单个或多个机械或热机械线索，或通过扩散延长传送。

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