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1. 发明申请

US20150015879A1 METHODS AND APPARATUS FOR IMAGING WITH MULTIMODE OPTICAL FIBERS 有权
标题翻译：用于多模光纤成像的方法和装置
公开(公告)号：US20150015879A1
公开(公告)日：2015-01-15
申请号：US14389275
申请日：2013-03-28
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Ioannis Papadopoulos , Salma Farahi , Christophe Moser , Demetri Psaltis
IPC分类号： H04N1/40 , G02B6/028 , G02F1/313 , G02F1/01 , G01J3/44 , G01J3/02
CPC分类号： H04N1/40 , G01J3/0218 , G01J3/44 , G02B6/0288 , G02B23/26 , G02B26/06 , G02B27/58 , G02F1/011 , G02F1/0136 , G02F1/313 , G03H1/0005 , G03H1/2286 , G03H1/2294 , G03H2001/0434 , G03H2001/0447 , H04B10/2581
摘要： A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode waveguide and a second step consists in projecting a specific pattern on the waveguide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by changing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectroscopy or imaging, 3D linear scattering imaging or two-photon imaging. Super-resolution, i.e., resolution below the diffraction limit, is achieved for example but not limited to, using the STimulated Emission Depletion microscopy (STED) technique or the Structured Illumination Microscopy (SIM) technique or a stochastic illumination based method (PALM, STORM) in combination with the multimode waveguide imaging method.
摘要翻译：多模波导照明器和成像器依赖于波前整形系统，其用于补偿多模波导的模式加扰和光色散。第一步包括校准多模波导，第二步包括将特定图案投影在波导近端上，以便在其远端产生期望的光图案。可以通过改变在波导的近端处投影的相位图案来动态地扫描或改变照明图案。第三和最后一步是通过相同的波导收集由样品产生的光学信息，以形成图像。已知的自由空间显微技术可以适用于多模波导的内窥镜检查，例如但不限于荧光成像或拉曼光谱学或成像，3D线性散射成像或双光子成像。超分辨率，即低于衍射极限的分辨率，例如但不限于使用受激发射耗尽显微镜（STED）技术或结构照明显微镜（SIM）技术或基于随机照明的方法（PALM，STORM ）结合多模波导成像方法。

2. 发明授权

US11993017B2 Methods and apparatus for tomographic additive manufacturing with a spatially coherent light source 有权
公开(公告)号：US11993017B2
公开(公告)日：2024-05-28
申请号：US17291115
申请日：2019-11-05
申请人： Ecole Polytechnique Federale de Lausanne (EPFL)
发明人： Paul Delrot , Damien Loterie , Christophe Moser
IPC分类号： B29C64/268 , B29C64/135 , B29C64/282 , B33Y10/00 , B33Y30/00
CPC分类号： B29C64/268 , B29C64/135 , B29C64/282 , B33Y10/00 , B33Y30/00
摘要： A method of fabricating a three-dimensional article comprises providing a spatially coherent light source (101, 201), generating from the light source (101, 201), patterns of light based on computed tomographic projections of the three-dimensional article, and projecting the patterns of light into a photoresponsive medium. The projecting is configured to define a three-dimensional dose distribution, thereby locally altering the phase of the photoresponsive medium and creating the article.

3. 发明授权

US11446861B2 Methods and apparatus for three-dimensional fabrication by tomographic back projections 有权
公开(公告)号：US11446861B2
公开(公告)日：2022-09-20
申请号：US16641680
申请日：2018-08-23
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Damien Loterie , Paul Delrot , Christophe Moser
IPC分类号： B29C64/124 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B29C64/393 , B29C64/241 , H04N1/00
摘要： A method for producing a three-dimensional object comprising computing a sequence of back-projections describing the three-dimensional object to be formed from different orientation angles of the object, defining a sequence of patterns of light using the back-projections, and irradiating with each of the patterns of light at the respective corresponding orientation angle. According to the defined sequence, a photoresponsive material is capable of altering its material phase, upon irradiation by light, thereby creating a three-dimensional distribution of alterations within the photoresponsive medium which physically reproduces the three-dimensional object, thereby creating the three-dimensional object.

4. 发明授权

US09871948B2 Methods and apparatus for imaging with multimode optical fibers 有权
公开(公告)号：US09871948B2
公开(公告)日：2018-01-16
申请号：US14389275
申请日：2013-03-28
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Ioannis Papadopoulos , Salma Farahi , Christophe Moser , Demetri Psaltis
IPC分类号： H04N1/40 , G02B6/028 , G02F1/313 , G02F1/01 , G01J3/44 , G01J3/02 , G02B23/26 , G02B26/06 , G03H1/00 , G02B27/58 , H04B10/2581 , G03H1/22 , G03H1/04
CPC分类号： H04N1/40 , G01J3/0218 , G01J3/44 , G02B6/0288 , G02B23/26 , G02B26/06 , G02B27/58 , G02F1/011 , G02F1/0136 , G02F1/313 , G03H1/0005 , G03H1/2286 , G03H1/2294 , G03H2001/0434 , G03H2001/0447 , H04B10/2581
摘要： A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode waveguide and a second step consists in projecting a specific pattern on the wave guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by changing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros copy or imaging, 3D linear scattering imaging or two-photon imaging. Super-resolution, i.e., resolution below the diffraction limit, is achieved for example but not limited to, using the STimulated Emission Depletion microscopy (STED) technique or the Structured Illumination Microscopy (SIM) technique or a stochastic illumination based method (PALM, STORM) in combination with the multimode waveguide imaging method.

5. 发明申请

US20170274218A1 Device for Photoactivation and Reaction Monitoring 审中-公开
公开(公告)号：US20170274218A1
公开(公告)日：2017-09-28
申请号：US15509205
申请日：2015-09-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Andreas Schmocker , Christophe Moser , Dominique Pioletti , Pierre-Etienne Bourban
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B17/0057 , A61B17/12031 , A61B17/12113 , A61B17/12186 , A61B17/12195 , A61B2017/00411 , A61B2017/005 , A61B2017/00632 , A61B2017/1205 , A61C19/003 , A61F2/0059 , A61F2/12 , A61N2005/0628 , A61N2005/0651 , A61N2005/067
摘要： The present invention relates to a device to photocure and/or photoactivate a photosensitive material. The device comprises several subsystems to transmit light towards an area of interest where a photosensitive material is applied as well as to collect light reflected by the applied photosensitive material. Reflected light is analyzed by an optical detector to monitor the photocuring and/or photoactivation process. Further means to inject or otherwise apply a photosensitive material can be combined in the same device. Methods for applying a fluent polymerizable material to a target site and for effecting polymerization of the fluent light-sensitive material in situ are also disclosed.

6. 发明申请

US20170031144A1 Compact Side and Multi Angle Illumination Lensless Imager and Method of Operating the Same 审中-公开
标题翻译：紧凑型侧面和多角度照明无镜片成像仪及其操作方法
公开(公告)号：US20170031144A1
公开(公告)日：2017-02-02
申请号：US15219315
申请日：2016-07-26
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Manon Rostykus , Christophe Moser
IPC分类号： G02B21/00 , G02B27/58 , G02B21/36 , G02B5/32 , F21V8/00 , G02B21/06 , G02B27/42
CPC分类号： G02B21/0056 , G02B5/32 , G02B21/06 , G02B21/365 , G02B27/4205 , G02B27/58 , G03H1/0248 , G03H1/0443 , G03H1/0465 , G03H2001/0434 , G03H2001/0439 , G03H2001/0447 , G03H2222/34 , G03H2223/18 , G03H2223/23 , G03H2240/56
摘要： A system for subpixel resolution imaging of an amplitude and quantitative phase image, the system including a waveguide having a top plane, a bottom plane, and two sides, an array of light sources emitting first befit beams from one side of the two sides of a waveguide, a holographic photopolymer film positioned on the top plane or the bottom plane of the waveguide and arranged to be illuminated by the first light beams from the array of light sources via the waveguide and to produce second light beams by diffraction, and an imaging device for capturing interference pattern light beams that passed through a sample, the sample arranged to be illuminated by the second light beams.
摘要翻译：一种用于振幅和定量相位图像的子像素分辨率成像的系统，所述系统包括具有顶平面，底平面和两侧的波导，从一侧的一侧的一侧发射第一光束的光源阵列波导，全息光聚合物膜，其位于波导的顶平面或底平面上，并布置成经由波导从来自光源阵列的第一光束照射，并通过衍射产生第二光束，并且成像装置用于捕获通过样品的干涉图案光束，该样品布置成由第二光束照射。

7. 发明授权

US11872746B2 Photoresponsive materials for volumetric additive manufacturing 有权
公开(公告)号：US11872746B2
公开(公告)日：2024-01-16
申请号：US17291114
申请日：2019-11-05
申请人： Ecole Polytechnique Federale de Lausanne (EPFL)
发明人： Paul Delrot , Damien Loterie , Christophe Moser
IPC分类号： B29C64/135 , B33Y10/00 , B33Y50/02 , B33Y70/00 , B29C64/393 , C09D183/04 , B29C64/241 , B29K33/00 , B29K77/00 , B29K83/00
CPC分类号： B29C64/135 , B29C64/393 , B33Y10/00 , B33Y50/02 , B33Y70/00 , C09D183/04 , B29C64/241 , B29K2033/08 , B29K2077/00 , B29K2083/00
摘要： Photoresponsive materials for use with a volumetric additive manufacturing system are described herein. Some embodiments of photoresponsive materials described herein include at least one constituent selected from the group consisting of (i) a thiol-containing siloxane prepolymer, (ii) a vinyl-containing siloxane prepolymer, (iii) a reinforcing filler, (iv) a photoinitiator (v) a polymerization inhibitor. Various methods of using the same photoresponsive materials in additive manufacturing processes, such as volumetric additive manufacturing, are also described.

8. 发明授权

US11179033B2 System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination 有权
公开(公告)号：US11179033B2
公开(公告)日：2021-11-23
申请号：US16300937
申请日：2017-05-12
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Timothé Laforest , Dino Carpentras , Christophe Moser , Mathieu Künzi , Francine Behar-Cohen
IPC分类号： A61B3/12 , A61B3/00 , A61B3/14
摘要： A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable and arranged to direct light towards at least one of a retina and an iris of the eye, causing an output beam from light backscattered from the at least one of the retina and the iris by the oblique illumination, capturing the output beam with an imaging system to provide a sequence of images of a fundus of the eye, and retrieving a phase and absorption contrast image from the sequence of images of the fundus, wherein the sequence of images of the fundus of the step of capturing is obtained by sequentially turning on one or more of the plurality of light emitting areas at a time in the step of providing the oblique illumination.

9. 发明授权

US09206998B2 Self-tracking solar concentrator 有权
标题翻译：自动跟踪太阳能集中器
公开(公告)号：US09206998B2
公开(公告)日：2015-12-08
申请号：US14390179
申请日：2013-04-03
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Eric Tremblay , Christophe Moser
IPC分类号： G02B6/32 , F24J2/38 , F21V8/00 , H01L31/054 , G01S17/66 , G02B6/42
CPC分类号： F24S50/20 , G01S17/66 , G02B6/0013 , G02B6/32 , G02B6/4295 , H01L31/0543 , H01L31/0547 , H01L31/0549 , Y02E10/52
摘要： A system for capturing solar light of the sun, whereby the solar light comprises a short wavelength light component and a long wavelength light component. The system comprises at least a lens (101), a light-guide (102), and a self-adaptive coupling feature (103). The at least one lens is arranged adjacent to the light-guide in order to focus the long wavelength component onto the self-adaptive coupling feature, and the self-adaptive coupling feature is configured to couple the short wavelength light component into the light-guide.
摘要翻译：一种用于捕获太阳太阳光的系统，由此太阳光包括短波长光分量和长波长光分量。该系统至少包括透镜（101），光导（102）和自适应耦合特征（103）。所述至少一个透镜被布置为与所述导光体相邻，以便将所述长波长分量聚焦到所述自适应耦合特征上，并且所述自适应耦合特征被配置为将所述短波长光分量耦合到所述光导。

10. 发明授权

US11155774B2 Method and apparatus for generating three-dimensional patterned soft structures and uses thereof 有权
公开(公告)号：US11155774B2
公开(公告)日：2021-10-26
申请号：US16018226
申请日：2018-06-26
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Paul Delrot , Sylvain Paul Hauser , Jan Krizek , Christophe Moser
IPC分类号： B33Y10/00 , C12M3/00 , B33Y70/00 , C12N5/00 , B33Y30/00 , B29C64/112 , B33Y80/00 , B29L31/00 , C12M1/26
摘要： A method for generating a three-dimensional patterned soft structure, including the steps of providing a soft supporting substrate, providing a drop-on-demand system with a device for varying the velocity of the jetted droplets, providing a liquid ink, jetting the liquid ink towards the soft supporting substrate with the drop-on-demand system, controlling an injection depth of the liquid ink into the soft supporting substrate by varying a jetting velocity of the liquid ink; and depositing droplets of the liquid ink over a volume of the soft supporting substrate, thereby generating the three-dimensional patterned soft structure.

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