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1. 发明申请

US20220380930A1 NANOPORE FORMING METHOD AND USES THEREOF 有权
公开(公告)号：US20220380930A1
公开(公告)日：2022-12-01
申请号：US17876161
申请日：2022-07-28
申请人： Ecole Polytechnique Federale De Lausanne (EPFL) , Roche Sequencing Solutions, Inc.
发明人： Jiandong FENG , Ke LIU , Aleksandra RADENOVIC , Yann ASTIER
IPC分类号： C25F3/12 , B23H9/14 , B23H7/20 , G01N33/487 , G01N27/414 , C12Q1/6869 , C25F7/00 , G01N27/447
摘要： The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

2. 发明申请

US20210189585A1 NANOPORE FORMING METHOD AND USES THEREOF 有权
公开(公告)号：US20210189585A1
公开(公告)日：2021-06-24
申请号：US17174230
申请日：2021-02-11
申请人： Ecole Polytechnique Federale De Lausanne (EPFL) , Roche Sequencing Solutions, Inc.
发明人： Jiandong FENG , Ke LIU , Aleksandra RADENOVIC , Yann ASTIER
IPC分类号： C25F3/12 , B23H7/20 , B23H9/14 , C12Q1/6869 , G01N27/414 , G01N27/447 , G01N33/487 , C25F7/00
摘要： The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

3. 发明申请

US20190323143A1 NANOPORE FORMING METHOD AND USES THEREOF 审中-公开
公开(公告)号：US20190323143A1
公开(公告)日：2019-10-24
申请号：US16432163
申请日：2019-06-05
申请人： Ecole Polytechnique Federale De Lausanne (EPFL) , Roche Sequencing Solutions, Inc.
发明人： Jiandong FENG , Ke LIU , Aleksandra RADENOVIC , Yann ASTIER
IPC分类号： C25F3/12 , C12Q1/6869 , G01N33/487 , C25F7/00 , B23H7/20 , G01N27/414 , G01N27/447 , B23H9/14
摘要： The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

4. 发明申请

US20160016840A1 MANUFACTURING OF ORIFICES IN GLASS LIKE MATERIALS, E.G. NANOCAPILLARIES, AND OBJECTS OBTAINED ACCORDING TO THIS PROCESS 审中-公开
标题翻译：在玻璃样材料中制造成分，E.G. NANOCAPILLARIES以及根据本程序获得的物品
公开(公告)号：US20160016840A1
公开(公告)日：2016-01-21
申请号：US14777220
申请日：2014-03-14
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Lorenz Jan STEINBOCK , Aleksandra RADENOVIC
IPC分类号： C03B23/08 , C03C23/00 , C03B23/09 , C03C11/00
CPC分类号： C03B23/08 , B23K26/384 , C03B23/043 , C03B23/057 , C03B23/099 , C03C11/00 , C03C23/004 , G01N33/48728
摘要： The ability to reshape nanopores and observe their shrinkage under an electron microscope is a powerful and novel technique14,17. It increases the sensitivity of the resistive pulse sensing and enables to detect very short and small molecules12,31. However, this has not yet been shown for glass having a tubular shape, for instance nanocapillaries. In contrast to their solid-state nanopore counterparts25, nanocapillaries are cheap, easily fabricated and in the production do not necessitate clean room facilities. Nanocapillaries made out of glass-like materials such as quartz or borosilicate glass can be shrunken under a scanning electron microscope beam. Since the shrinking is caused by the thermal heating of the electrons, increasing the beam current increases the shrink rate. Higher acceleration voltage on the contrary increases the electron penetration depth and reduces the electron density causing slower shrink rates. This allows to fine control the shrink rate and to stop the shrinking process at any desired diameter. A shrunken nanocapillary may detect DNA translocation with six times higher signal amplitudes than an unmodified nanocapillary. The invention opens a new path to detect small and short molecules such as proteins or RNA with nanocapillaries and also increase the sensitivity of other techniques such as SNOM or SCIM, which also rely on conical glass capillaries.
摘要翻译：在电子显微镜下重塑纳米孔并观察其收缩的能力是一种强大而新颖的技术14,17。它增加了电阻脉冲感测的灵敏度，并且能够检测非常短和小的分子12,31。然而，对于具有管状形状的玻璃，例如纳米毛细管，尚未显示出这一点。与其固态纳米孔对应物25相反，纳米毛细管便宜，易于制造，并且在生产中不需要洁净室设施。由诸如石英或硼硅酸盐玻璃的玻璃状材料制成的纳米玻璃可以在扫描电子显微镜光束下收缩。由于收缩是由电子的热加热引起的，所以增加束电流增加了收缩率。相反，较高的加速电压会增加电子穿透深度并降低电子密度，从而导致较慢的收缩率。这允许精细控制收缩率并且在任何期望的直径处停止收缩过程。缩小的纳米毛细血管可以检测到DNA移位比未修饰的纳米毛细管高6倍的信号幅度。本发明开辟了新的途径，用于检测小分子和短分子，例如具有纳米囊的蛋白质或RNA，并且还增加其它技术如SNOM或SCIM的灵敏度，其也依赖于锥形玻璃毛细管。

5. 发明申请

US20180073161A1 NANOPORE FORMING METHOD AND USES THEREOF 审中-公开
公开(公告)号：US20180073161A1
公开(公告)日：2018-03-15
申请号：US15688264
申请日：2017-08-28
申请人： Ecole Polytechnique Federale De Lausanne (EPFL) , Roche Diagnostics GmbH , F. Hoffmann-LaRoche AG , Roche Molecular Systems, Inc.
发明人： Jiandong FENG , Ke LIU , Aleksandra RADENOVIC , Yann ASTIER
IPC分类号： C25F3/12 , G01N33/487 , G01N27/447 , C25F7/00 , C12Q1/68
CPC分类号： C25F3/12 , B23H7/20 , B23H9/14 , C12Q1/6869 , C25F7/00 , G01N27/4145 , G01N27/44791 , G01N33/48721 , G01R19/0092
摘要： The invention relates to a method for making nanopores in thin layers or monolayers of transition metal dichalcogenides that enables accurate and controllable formation of pore within those thin layer(s) with sub-nanometer precision.

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