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1. 发明申请

US20130217059A1 FLUORESCENT DYES 有权
标题翻译：荧光染色
公开(公告)号：US20130217059A1
公开(公告)日：2013-08-22
申请号：US13733324
申请日：2013-01-03
申请人： ENZO LIFE SCIENCES, INC.
发明人： PRAVEEN PANDE , ZAIGUO LI , MACIEJ SZCZEPANIK , WAYNE FORREST PATTON
IPC分类号： C09B23/16 , G01N33/58
CPC分类号： C09B23/164 , C09B23/0066 , C09B23/0075 , C09B23/0091 , C09B23/04 , C09B23/06 , C09B23/083 , C09B23/105 , C09B23/145 , C09B23/146 , C12Q1/68 , G01N33/583
摘要： The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins, nucleic acids and cellular organelles. Dyes are provided that may be used free in solution where the binding of the dye to the target molecule provides signal generation. Dyes are also provided that comprise reactive groups that may be used to attach the dyes to probes that will bind to desirable target molecules. The novel dyes of the present invention have been modified to provide beneficial properties.
摘要翻译：本发明提供可用于检测或定量所需靶分子（例如蛋白质，核酸和细胞器器）的染料，活性染料和标记试剂。提供可以在染料与靶分子的结合提供信号产生的溶液中游离的染料。还提供了包含可用于将染料连接到将与所需靶分子结合的探针的反应性基团的染料。已经对本发明的新型染料进行了改进以提供有益的性质。

2. 发明申请

US20170137863A1 Self-Immolative Probes for Enzyme Activity Detection 审中-公开
公开(公告)号：US20170137863A1
公开(公告)日：2017-05-18
申请号：US15416119
申请日：2017-01-26
申请人： ENZO LIFE SCIENCES, INC., C/O ENZO BIOCHEM, INC.
发明人： IRINA LEBEDEVA , WAYNE FORREST PATTON , MACIEJ SZCZEPANIK , YUEJUN XIANG , PRAVEEN PANDE
IPC分类号： C12Q1/26 , C09K11/06 , C07D491/052 , C07D491/20 , C07D493/10 , C07D311/08
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound having the structure: (SIG)-(SI-MOD)m where SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. When MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided are methods of determining whether a sample, such as a cell, comprises an activator, such as a nitroreducase, using the compound. Further provided are methods of determining whether a mammalian cell is hypoxic using the compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase using the compound where nitroreductase is the activator is also provided.

3. 发明申请

US20150191768A1 SELF-IMMOLATIVE PROBES FOR ENZYME ACTIVITY DETECTION 有权
标题翻译：用于酶活性检测的自我检测
公开(公告)号：US20150191768A1
公开(公告)日：2015-07-09
申请号：US14447817
申请日：2014-07-31
申请人： Enzo Life Sciences, Inc. c/o Enzo Biochem, Inc.
发明人： MACIEJ SZCZEPANIK , IRINA V. LEBEDEVA , YUEJUN XIANG , PRAVEEN PANDE , WAYNE FORREST PATTON
IPC分类号： C12Q1/48 , C12Q1/44 , C12Q1/37
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound comprising the structure: (SIG)-(SI-MOD)m. In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.
摘要翻译：提供了包含以下结构的化合物：（SIG） - （SI-MOD）m。在该化合物中，SIG是信号分子，SI是与SIG结合的自消除结构，使得SIG相对于没有SI的SIG的信号具有降低的信号，MOD是与SI结合的部分，其经受活化剂，m为1至约10的整数。用该化合物，当MOD被活化剂修饰时，SI是不稳定的并且从SIG自我裂解，使得SIG产生增加的信号。还提供了使用上述化合物来确定样品是否包含活化剂的方法。另外提供了使用上述硝基还原酶是活化剂的化合物来确定细胞是否包含硝基还原酶的方法。还提供了使用上述硝基还原酶是活化剂的化合物来确定哺乳动物细胞是否缺氧的方法。还提供了使用上述硝基还原酶为活化剂的化合物检测包含硝基还原酶的微生物的方法。还提供了使用上述硝基还原酶是活化剂的化合物来鉴定样品中的硝基还原酶的方法。

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