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1. 发明申请

US20110228993A1 AUTOMATIC EXPOSURE TIME SELECTION FOR IMAGING TISSUE 有权
标题翻译：自动曝光时间选择用于成像组织
公开(公告)号：US20110228993A1
公开(公告)日：2011-09-22
申请号：US13117789
申请日：2011-05-27
申请人： Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson , Jason Christiansen
发明人： Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson , Jason Christiansen
IPC分类号： G06K9/00
CPC分类号： H04N5/2353
摘要： The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.
摘要翻译：本发明涉及一种用于自动调节曝光时间以改善或以其它方式优化数字图像的动态范围的系统。该系统包括被配置为在第一曝光时间内在视野内拍摄被摄体的图像的照相机。拍摄的图像由多个像素组成，每个像素具有相应的强度值。该系统还包括配置为控制相机的曝光时间的快门或适当的控制。一种控制器，被配置为执行以下步骤，包括：（a）查询像素强度值的频率分布; （b）确定这种分布或直方图的有效“质心”以确定经调整的曝光时间; 和（c）在经调整的曝光时间捕获被摄体的第二图像，从而获得具有改善或最佳动态范围的图像。

2. 发明授权

US07978258B2 Automatic exposure time selection for imaging tissue 有权
标题翻译：成像组织的自动曝光时间选择
公开(公告)号：US07978258B2
公开(公告)日：2011-07-12
申请号：US12201753
申请日：2008-08-29
申请人： Jason Christiansen , Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson
发明人： Jason Christiansen , Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson
IPC分类号： H04N5/238
CPC分类号： H04N5/2353
摘要： The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.
摘要翻译：本发明涉及一种用于自动调节曝光时间以改善或以其它方式优化数字图像的动态范围的系统。该系统包括被配置为在第一曝光时间内在视野内拍摄被摄体的图像的照相机。拍摄的图像由多个像素组成，每个像素具有相应的强度值。该系统还包括配置为控制相机的曝光时间的快门或适当的控制。一种控制器，被配置为执行以下步骤，包括：（a）查询像素强度值的频率分布; （b）确定这种分布或直方图的有效“质心”以确定经调整的曝光时间; 和（c）在经调整的曝光时间捕获被摄体的第二图像，从而获得具有改善或最佳动态范围的图像。

3. 发明授权

US08878983B2 Automatic exposure time selection for imaging tissue 有权
标题翻译：成像组织的自动曝光时间选择
公开(公告)号：US08878983B2
公开(公告)日：2014-11-04
申请号：US13117789
申请日：2011-05-27
申请人： Jason Christiansen , Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson
发明人： Jason Christiansen , Dylan M. Reilly , Brian Bourke-Martin , Mark Gustavson
IPC分类号： H04N5/238 , H04N5/235
CPC分类号： H04N5/2353
摘要： The invention relates to a system for automatically adjusting an exposure time to improve or otherwise optimize a dynamic range of a digital image. The system includes a camera configured to capture an image of a subject within the field of view at a first exposure time. The captured image is composed of multiple pixels, with each pixel having a respective intensity value. The system further includes a shutter or suitable control configured to control an exposure time of the camera. A controller configured to carryout the following steps including: (a) querying a frequency distribution of pixel intensity values; (b) determining an effective “center of mass” of such a distribution, or histogram, to determine an adjusted exposure time; and (c) capturing a second image of the subject at the adjusted exposure time thereby obtaining an image with an improved or optimal dynamic range.
摘要翻译：本发明涉及一种用于自动调节曝光时间以改善或以其它方式优化数字图像的动态范围的系统。该系统包括被配置为在第一曝光时间内在视野内拍摄被摄体的图像的照相机。拍摄的图像由多个像素组成，每个像素具有相应的强度值。该系统还包括配置为控制相机的曝光时间的快门或适当的控制。一种控制器，被配置为执行以下步骤，包括：（a）查询像素强度值的频率分布; （b）确定这种分布或直方图的有效“质心”以确定经调整的曝光时间; 和（c）在经调整的曝光时间捕获被摄体的第二图像，从而获得具有改善或最佳动态范围的图像。

4. 发明申请

US20100136549A1 REPRODUCIBLE QUANTIFICATION OF BIOMARKER EXPRESSION 有权
标题翻译：生物标记表达的可重复定量
公开(公告)号：US20100136549A1
公开(公告)日：2010-06-03
申请号：US12560129
申请日：2009-09-15
申请人： Jason Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Gregory R. Tedeschi , Dylan M. Reilly , Maciej P. Zerkowski , Christine (Jones) Williams , Dongxiao Wang
发明人： Jason Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Gregory R. Tedeschi , Dylan M. Reilly , Maciej P. Zerkowski , Christine (Jones) Williams , Dongxiao Wang
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G06T7/0012 , G06F19/12 , G06F19/24 , G06F19/26 , G06K9/00147 , G06T7/44 , G06T2207/30024
摘要： A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.
摘要翻译：描述了用于可重复定量生物标志物表达的方法，包括组织样品中的生物标志物表达。描述方法和系统，其独立于仪器，其位置或操作者获得生物标志物表达的可再现分数。

5. 发明授权

US09240043B2 Reproducible quantification of biomarker expression 有权
标题翻译：可重现的生物标志物表达定量
公开(公告)号：US09240043B2
公开(公告)日：2016-01-19
申请号：US12560129
申请日：2009-09-15
申请人： Jason Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Gregory R. Tedeschi , Dylan M. Reilly , Maciej P. Zerkowski , Christine Williams , Dongxiao Wang
发明人： Jason Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Gregory R. Tedeschi , Dylan M. Reilly , Maciej P. Zerkowski , Christine Williams , Dongxiao Wang
IPC分类号： G01N33/48 , G01N33/50 , G01N31/00 , G06T7/00 , G06F19/12 , G06F19/24 , G06F19/26 , G06T7/40
CPC分类号： G06T7/0012 , G06F19/12 , G06F19/24 , G06F19/26 , G06K9/00147 , G06T7/44 , G06T2207/30024
摘要： A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.
摘要翻译：描述了用于可重复定量生物标志物表达的方法，包括组织样品中的生物标志物表达。描述方法和系统，其独立于仪器，其位置或操作者获得生物标志物表达的可再现分数。

6. 发明授权

US08335360B2 Compartment segregation by pixel characterization using image data clustering 有权
标题翻译：通过使用图像数据聚类的像素表征进行隔室隔离
公开(公告)号：US08335360B2
公开(公告)日：2012-12-18
申请号：US12153171
申请日：2008-05-14
申请人： Jason H. Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Dylan M. Reilly , Gregory R. Tedeschi
发明人： Jason H. Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Dylan M. Reilly , Gregory R. Tedeschi
IPC分类号： G06K9/00
CPC分类号： G06K9/6201 , G01N33/5082 , G01N33/57423 , G06K9/00127
摘要： The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.
摘要翻译：本发明一般涉及限定区域或室的改进方法，其中生物标志物表达被检测和量化。特别地，本发明涉及以最小的操作者干预或决策来客观地描绘标记物定义的隔室的自动化方法。该方法提供组织，细胞或亚细胞区室的精确定义，特别是在定量分析蛋白质表达的组织学组织切片中。

7. 发明申请

US20090034823A1 Compartment segregation by pixel characterization using image data clustering 有权
标题翻译：通过使用图像数据聚类的像素表征进行隔室隔离
公开(公告)号：US20090034823A1
公开(公告)日：2009-02-05
申请号：US12153171
申请日：2008-05-14
申请人： Jason H. Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Dylan M. Reilly
发明人： Jason H. Christiansen , Robert Pinard , Mark Gustavson , Brian Bourke , Dylan M. Reilly
IPC分类号： G06K9/00
CPC分类号： G06K9/6201 , G01N33/5082 , G01N33/57423 , G06K9/00127
摘要： The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.
摘要翻译：本发明一般涉及限定区域或室的改进方法，其中生物标志物表达被检测和量化。特别地，本发明涉及以最小的操作者干预或决策来客观地描绘标记物定义的隔室的自动化方法。该方法提供组织，细胞或亚细胞区室的精确定义，特别是在定量分析蛋白质表达的组织学组织切片中。

8. 发明申请

US20130344510A1 IDENTIFICATION OF CANCER PATIENTS LIKELY TO BENEFIT FROM RADIATION THERAPY 审中-公开
标题翻译：癌症患者的鉴定有利于从辐射治疗中获益
公开(公告)号：US20130344510A1
公开(公告)日：2013-12-26
申请号：US13990727
申请日：2011-12-02
申请人： Mark Gustavson , Jason Christiansen , Anthony Martin Magliocco
发明人： Mark Gustavson , Jason Christiansen , Anthony Martin Magliocco
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57415 , G01N2333/723 , G01N2800/52
摘要： Disclosed herein are methods of identifying suitable patients for postoperative radiotherapy based on the discovery that the quantification of ER, beyond simple positive/negative characterization, can provide valuable predictive information for the treatment of cancer, specifically breast cancer, and more particularly may predict a group more likely to respond to RT and spare patients from a potentially harmful treatment. Furthermore, the true quantification of ER expression provides a continuous recurrence risk assessment for patients being treated with tamoxifen, and therefore the standardization of the data across sites and imaging platforms significantly reduces the misclassification of patients when compared to the current standard by which ER expression is determined.
摘要翻译：本文公开了基于以下发现来鉴定合适的患者的方法：基于以下发现：除了简单的阳性/阴性表征之外，ER的定量可以提供用于治疗癌症，特别是乳腺癌的有价值的预测信息，更具体地，可以预测组更有可能对RT和备用患者进行有潜在的有害治疗。此外，ER表达的真实定量为接受他莫昔芬治疗的患者提供了连续的复发风险评估，因此与现有标准相比，跨站点和成像平台的数据标准化显着降低了患者的错误分类，决心。

9. 发明授权

US08367351B2 Methods for determining signal transduction activity in tumors 有权
标题翻译：确定肿瘤信号转导活性的方法
公开(公告)号：US08367351B2
公开(公告)日：2013-02-05
申请号：US12299699
申请日：2007-05-07
申请人： Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
发明人： Mark Gustavson , Jennifer Giltnane , Marisa P. Dolled-Filhart , Robert L. Camp , David L. Rimm
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/6893 , G01N33/5035 , G01N33/5041 , G01N33/5082 , G01N33/566 , G01N33/574 , Y10T436/10
摘要： The method of the invention pertains to determining the signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
摘要翻译：本发明的方法涉及通过免疫组织化学技术测定组织切片中的信号转导活性。确定感兴趣受体的表达水平以及受体信号转导途径的一个或多个效应分子的表达水平。此外，发现亚细胞区室中效应分子与受体表达的表达水平的组合比具有预后意义。

10. 发明申请

US20090074266A1 METHOD AND SYSTEM FOR DETERMINING AN OPTIMAL DILUTION OF A REAGENT 有权
标题翻译：用于确定试剂的最佳稀释度的方法和系统
公开(公告)号：US20090074266A1
公开(公告)日：2009-03-19
申请号：US12188133
申请日：2008-08-07
申请人： Robert Pinard , Gregory R. Tedeschi , Mark Gustavson
发明人： Robert Pinard , Gregory R. Tedeschi , Mark Gustavson
IPC分类号： G06K9/00
CPC分类号： G01N33/53
摘要： A system and method for automatically and quantitatively determining the optimal dilution of a reagent is provided. In one embodiment of the claimed method, a plurality of dilution sets are received, where each of the dilution sets consist of a different respective dilution value and a respective plurality of immunoassay staining intensity values. A respective dynamic range metric is determining for each of the plurality of dilution sets relative to the respective plurality immunoassay staining intensity values. Having found the respective dynamic range metric, a dilution set having the numerically optimal dynamic range metric is selected and the dilution value of that dilution set is selected as being representative of an optimal dilution level of the reagent for use in a quantitative immunoassay. In one embodiment, a system is provided with a microscope, an image sensor, and processor module configured determine an optimal dilution of a reagent for use in an quantitative immunoassay.
摘要翻译：提供了用于自动和定量地确定试剂的最佳稀释度的系统和方法。在所要求保护的方法的一个实施方案中，接收多个稀释组，其中每个稀释组由不同的相应稀释值和相应的多个免疫测定染色强度值组成。相应的动态范围度量是相对于相应的多个免疫测定染色强度值确定多个稀释组中的每一个。已经找到相应的动态范围度量，选择具有数值最优动态范围度量的稀释组，并且选择该稀释组的稀释值代表用于定量免疫测定的试剂的最佳稀释水平。在一个实施例中，提供了具有显微镜，图像传感器和配置的处理器模块的系统，以确定用于定量免疫测定中的试剂的最佳稀释度。

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