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1. 发明申请

US20070179545A1 Method and system for controlling pulmonary capillary pressure 有权
标题翻译：控制肺毛细血管压力的方法和系统
公开(公告)号：US20070179545A1
公开(公告)日：2007-08-02
申请号：US11343175
申请日：2006-01-30
申请人： Dwight Warkentin , David Euler
发明人： Dwight Warkentin , David Euler
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36564
摘要： A method of controlling pulmonary capillary pressure is disclosed which includes increasing the output of a first ventricle (V1) (e.g., a left ventricle) relative to second ventricle (e.g., right ventricle) by increasing the magnitude of a post extrasystolic potentiation (PESP) therapy effect in the first ventricle relative to the magnitude of a PESP therapy effect produced in the second ventricle. In certain embodiments of the invention, this may be accomplished by adjusting the extra-stimulus interval (ESI) in either or both of the left ventricle and the right ventricle, for example.
摘要翻译：公开了一种控制肺毛细血管压力的方法，其包括通过增加收缩后增强功能（PESP）的幅度来增加相对于第二脑室（例如，右心室）的第一脑室（V1）（例如，左心室）的输出，相对于在第二脑室产生的PESP治疗效果的大小，第一脑室的治疗效果。在本发明的某些实施方案中，例如可以通过调整左心室和右心室中的任一者或两者的额外刺激间隔（ESI）来实现。

2. 发明申请

US20050027322A1 Mechanically-based interval optimization for a biventricular pacing engine 失效
标题翻译：用于双心室起搏引擎的基于机械的间隔优化
公开(公告)号：US20050027322A1
公开(公告)日：2005-02-03
申请号：US10629075
申请日：2003-07-29
申请人： Dwight Warkentin
发明人： Dwight Warkentin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36564 , A61N1/3682 , A61N1/3684
摘要： According to the present invention, discrete measurements of fluid pressure development (and derivatives thereof) are used in optimizing hemodynamics for cardiac resynchronization therapy (CRT) delivery and multiple chamber cardiac pacing, and in enhancing hemodynamics in the event of a sub-optimal left-side lead placement. For example, such diverse pressure measurements include: maximum positive or negative dP/dt values, ePAD, RV systolic, RV diastolic, pulse pressure, and the like. According to the present invention, on a periodic basis or upon demand one or more cardiac pacing intervals are iteratively cycled through a predetermined range and the resulting pressure measurements stored for comparison. The cardiac pacing intervals are then adjusted based at least in part upon the most appropriate, or desirable, measured hemodynamics of the patient. The present invention may be implemented as computer readable instructions executed by a microprocessor-based implantable medical device.
摘要翻译：根据本发明，流体压力发展（及其衍生物）的离散测量用于优化用于心脏再同步治疗（CRT）递送和多室心脏起搏的血液动力学，并且在用于增强血液动力学的情况下，侧排位置。例如，这种不同的压力测量包括：最大正或负dP / dt值，ePAD，RV收缩压，RV舒张压，脉压等。根据本发明，周期性地或根据需要，一个或多个心脏起搏间隔在预定范围内迭代循环，并且将所得到的压力测量值存储用于比较。然后至少部分地基于最合适的或期望的测量的患者的血液动力学来调整心脏起搏间隔。本发明可以被实现为由基于微处理器的可植入医疗装置执行的计算机可读指令。

3. 发明申请

US20070250122A1 Method of Delivering PESP/ICC as Well as Adjusting the Refractory Period of the Heart 有权
$Method of Delivering PESP/ICC as Well as Adjusting the Refractory Period of the Heart$
标题翻译：提供PESP / ICC的方法以及调整心脏的耐火期
公开(公告)号：US20070250122A1
公开(公告)日：2007-10-25
申请号：US11379892
申请日：2006-04-24
申请人： Dwight Warkentin , D. Deno
发明人： Dwight Warkentin , D. Deno
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/36014 , A61N1/36114 , A61N1/36514 , A61N1/36585 , A61N1/368
摘要： Medical devices and methods are used to treat cardiac dysfunction conditions which involve delivery of stimulation pulses in cardiac refractory periods in order to modulate an effective refractory period (ERP). Such devices and methods may be used in conjunction with or in place of other therapies, including increased cardiac contractility (ICC) therapy, post extrasystolic potentiation (PESP) therapy, and other therapies to achieve increased heart contractility, provide a safer and more effective regimen for the corresponding stimulation therapies, and reduce the risk of inducing an arrhythmia.
摘要翻译：医疗器械和方法被用于治疗心脏功能障碍状况，其涉及在心脏不应期内输送刺激脉冲以调节有效的不应期（ERP）。这些装置和方法可以与其他疗法结合使用或替代其它疗法，包括增加心肌收缩力（ICC）治疗，收缩后增强疗法（PESP）疗法和其他疗法以达到增加的心脏收缩力，提供更安全和更有效的方案用于相应的刺激疗法，并降低引起心律失常的风险。

4. 发明申请

US20050075673A1 Method and apparatus for controlling extra-systolic stimulation (ESS) therapy using ischemia detection 审中-公开
标题翻译：使用缺血检测来控制收缩期刺激（ESS）治疗的方法和装置
公开(公告)号：US20050075673A1
公开(公告)日：2005-04-07
申请号：US10680462
申请日：2003-10-07
申请人： Dwight Warkentin , Robert Stadler , Glenn Zillmer , D. Deno
发明人： Dwight Warkentin , Robert Stadler , Glenn Zillmer , D. Deno
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： An implantable cardiac stimulation device capable of delivering ESS, monitoring for myocardial ischemia and responding to the detection of myocardial ischemia by modifying the delivery of ESS. Modification of ESS delivery may include disabling ESS, initiating ESS, and/or modifying ESS control parameters.
摘要翻译：一种植入式心脏刺激装置，能够传递ESS，监测心肌缺血，并通过修改ESS的传递来应对心肌缺血的检测。 ESS传送的修改可能包括禁用ESS，启动ESS和/或修改ESS控制参数。

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