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1. 发明授权

US07551293B2 Method and apparatus for three-dimensional spectrally encoded imaging 有权
标题翻译：用于三维光谱编码成像的方法和装置
公开(公告)号：US07551293B2
公开(公告)日：2009-06-23
申请号：US10997789
申请日：2004-11-24
申请人： Dvir Yelin , Brett E. Bouma , Nicusor Iftimia , Guillermo J. Tearney
发明人： Dvir Yelin , Brett E. Bouma , Nicusor Iftimia , Guillermo J. Tearney
IPC分类号： G01J3/45 , G01B9/02 , G01B11/02
CPC分类号： G01B11/2441 , A61B1/042 , A61B5/1077 , G01B9/02027 , G01B9/02044 , G01B11/2509
摘要： A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.
摘要翻译：可以提供用于提供与样本的至少一部分相关联的信息的方法和装置。例如，可以对提供在样品上的至少一个电磁辐射波长进行编码，以确定该部分的至少一个横向位置。可以获得从样品返回的至少一个第一电磁辐射电磁辐射与从参考物返回的至少一个第二电磁辐射之间的相对相位，以确定该部分的至少一个相对深度位置。此外，可以基于横向位置和相对深度位置来提供该部分的信息。例如，信息可以是与样本部分相关联的深度信息和/或三维信息。

2. 发明授权

US08559012B2 Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
标题翻译：光学相干断层扫描中的斑点减少通过路径长度编码角复合
公开(公告)号：US08559012B2
公开(公告)日：2013-10-15
申请号：US13465517
申请日：2012-05-07
申请人： Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
发明人： Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。具体地，干涉仪可以转发电磁辐射。此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

3. 发明授权

US08174702B2 Speckle reduction in optical coherence tomography by path length encoded angular compounding 有权
标题翻译：光学相干断层扫描中的斑点减少通过路径长度编码角复合
公开(公告)号：US08174702B2
公开(公告)日：2012-05-08
申请号：US12510047
申请日：2009-07-27
申请人： Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
发明人： Guillermo J. Tearney , Nicusor Iftimia , Brett E. Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/6852 , G01B9/02028 , G01B9/02082 , G01B9/02087 , G01B9/02091 , G01J9/0215 , G01N21/4795 , G02B26/105 , G02B27/48
摘要： Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. Exemplary embodiments of the present invention can facilitate an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, exemplary embodiments of an apparatus probe catheter and method can be provided for irradiating a structure. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the structure. Such exemplary arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.
摘要翻译：斑点，减少光学相干断层扫描（“OCT”）中的图像质量的因素可能会限制识别对各种疾病的诊断重要的细胞结构的能力。本发明的示例性实施例可以有助于通过路径长度编码（“ACPE”）实现角复合角度复合，以减少OCT图像中的斑点。通过平均以不同入射角度获取的图像，每个图像由路径长度编码，ACPE保持高速图像采集，并对OCT探针光学元件进行最小修改。从体内组织模型和人体皮肤获得的ACPE图像显示出比传统OCT和增加的信噪比（“SNR”）的定性改善。因此，可以提供用于照射结构的装置探针导管和方法的示例性实施例。具体地，干涉仪可以转发电磁辐射。此外，样品臂可以接收电磁辐射，并且可以包括便于从电磁辐射产生至少两个辐射以便照射结构的装置。这种示例性布置可以被配置为相对于至少两个辐射的第二辐射来延迟所述至少两个辐射的第一辐射。

4. 发明授权

US08384907B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US08384907B2
公开(公告)日：2013-02-26
申请号：US12946635
申请日：2010-11-15
申请人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Brett E. Bouma
IPC分类号： G01B9/02 , G01J3/45
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method, apparatus and arrangement according an exemplary embodiment of the present invention can be provided for generating an image of at least one portion of an anatomical structure. For example, the portion can have an area greater than about 1 mm2, and the image can have a resolution a transverse resolution that is below about 10 μm. For example, light can be scanned over such portion so as to generate first information which is related to the portion, where the light may be provided through a diffraction arrangement to generate a spectrally dispersed line. Method, apparatus and arrangement according to a further exemplary embodiment of the present invention can be provided for positioning a radiation or optical beam within an anatomical structure based on signals generated by scanning a portion of the structure using the same or a different beam.
摘要翻译：可以提供根据本发明的示例性实施例的方法，装置和装置，用于生成解剖结构的至少一部分的图像。例如，该部分可以具有大于约1mm 2的面积，并且图像可以具有低于约10μm的横向分辨率的分辨率。例如，可以在这样的部分上扫描光，以便产生与该部分相关的第一信息，其中可以通过衍射装置提供光以产生光谱分散的线。可以提供根据本发明的另一示例性实施例的方法，装置和装置，用于基于通过使用相同或不同的束扫描结构的一部分而产生的信号来将辐射或光束定位在解剖结构内。

5. 发明授权

US08289522B2 Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures 有权
标题翻译：用于提供一个或多个生物结构的多模态显微镜成像的布置和方法
公开(公告)号：US08289522B2
公开(公告)日：2012-10-16
申请号：US12943762
申请日：2010-11-10
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett E. Bouma
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Wang-Yuhl Oh , Brett E. Bouma
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Method and apparatus according to an exemplary embodiment of the present invention can be provided. For example, first data associated with a first signal received from at least one region of at least one sample can be provided based on a first modality, and second data associated with a second signal received from the at least one sample can be provided based on a second modality which is different from the first modality. Third data associated with a reference can be received. Further data can be generated based on the first, second and third data. In addition, third data associated with a second signal received from the at least one sample can be obtained. Each of the third data can be based on a further modality which is different from the first modality and the second modality, and the further data can be further determined based on the third data. Further, the first modality can be a spectral-encoded modality, and the second modality can be a non-spectral-encoding modality.
摘要翻译：可以提供根据本发明的示例性实施例的方法和装置。例如，可以基于第一模态来提供与从至少一个样本的至少一个区域接收的第一信号相关联的第一数据，并且可以基于从至少一个样本接收的与第二信号相关联的第二数据基于第二种模式与第一种模式不同。可以接收与参考相关联的第三数据。可以基于第一，第二和第三数据生成进一步的数据。此外，可以获得与从至少一个样本接收的第二信号相关联的第三数据。第三数据中的每一个可以基于与第一模态和第二模态不同的另一模态，并且可以基于第三数据进一步确定另外的数据。此外，第一模式可以是频谱编码模式，并且第二模态可以是非频谱编码模式。

6. 发明授权

US07809226B2 Imaging system and related techniques 有权
公开(公告)号：US07809226B2
公开(公告)日：2010-10-05
申请号：US12205787
申请日：2008-09-05
申请人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
发明人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
IPC分类号： G02B6/02 , G02B6/06
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.

7. 发明授权

US07809225B2 Imaging system and related techniques 有权
标题翻译：成像系统及相关技术
公开(公告)号：US07809225B2
公开(公告)日：2010-10-05
申请号：US12205775
申请日：2008-09-05
申请人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
发明人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
IPC分类号： G02B6/02 , G02B6/06
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.
摘要翻译：描述了使用双包层光纤进行成像的方法和装置。

8. 发明授权

US08369669B2 Imaging system and related techniques 有权
标题翻译：成像系统及相关技术
公开(公告)号：US08369669B2
公开(公告)日：2013-02-05
申请号：US13084344
申请日：2011-04-11
申请人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
发明人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
IPC分类号： G02B6/26 , G02B6/42 , G02B6/34 , G02B6/06
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.
摘要翻译：描述了使用双包层光纤进行成像的方法和装置。

9. 发明授权

US08149418B2 Method and apparatus for optical imaging via spectral encoding 有权
标题翻译：通过频谱编码进行光学成像的方法和装置
公开(公告)号：US08149418B2
公开(公告)日：2012-04-03
申请号：US12910533
申请日：2010-10-22
申请人： Guillermo J. Tearney , Brett E. Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett E. Bouma , Dvir Yelin
IPC分类号： G01B9/02
CPC分类号： G01N33/4833 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/6852 , G01B9/02 , G01B9/02027 , G01B9/02049 , G01B9/02064 , G01B9/02087 , G01B9/02091 , G01B9/04 , G01N21/25 , G01N21/27 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N23/046 , G01N2021/1765 , G01N2223/419 , G02B21/0028 , G02B23/2423 , G02B23/243 , G02B23/2461 , G02B23/2476
摘要： Exemplary method, apparatus and arrangement can be provided for obtaining information associated with a sample such as a portion of an anatomical structure. The information can be generated using first data, which can be based on a signal obtained from a location on the sample, and second data, where the second data can be obtained by combining a second signal received from the sample with a third reference signal. An image of a portion of the sample can also be generated based on the information. For example, the first data can be associated with spectral encoding microscopy data, and the second data can be associated with optical coherence tomography data.
摘要翻译：可以提供示例性方法，装置和布置来获得与诸如解剖结构的一部分的样本相关联的信息。可以使用可以基于从样本上的位置获得的信号的第一数据和第二数据来生成信息，其中可以通过将从样本接收的第二信号与第三参考信号组合来获得第二数据。也可以基于该信息生成样本的一部分的图像。例如，第一数据可以与光谱编码显微镜数据相关联，并且第二数据可以与光学相干断层扫描数据相关联。

10. 发明申请

US20090022463A1 IMAGING SYSTEM AND RELATED TECHNIQUES 有权
标题翻译：成像系统及相关技术
公开(公告)号：US20090022463A1
公开(公告)日：2009-01-22
申请号：US12205775
申请日：2008-09-05
申请人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
发明人： Brett E. Bouma , Guillermo J. Tearney , Dvir Yelin
IPC分类号： G02B6/02
CPC分类号： G01N21/474 , G01N21/47 , G02B6/02 , G02B6/02042 , G02B6/036 , G02B6/03605 , G02B6/03622 , G02B6/03638 , G02B6/4298 , G02B23/2469 , G02B23/26 , G02B26/10 , G02B27/48
摘要： A method and apparatus for imaging using a double-clad fiber is described.
摘要翻译：描述了使用双包层光纤进行成像的方法和装置。

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