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1. 发明申请

US20060224201A1 System and method for using atrial pacing to enhance function of stunned atrial myocardium following conversion to normal sinus rhythm 有权
标题翻译：使用心房起搏来改善正常窦性心律后震颤心房心肌功能的系统和方法
公开(公告)号：US20060224201A1
公开(公告)日：2006-10-05
申请号：US11095846
申请日：2005-03-31
申请人： Douglas Hettrick , David Euler
发明人： Douglas Hettrick , David Euler
IPC分类号： A61N1/365
CPC分类号： A61N1/3622 , A61B5/046 , A61N1/3627 , A61N1/36514 , A61N1/36557 , A61N1/36564 , A61N1/3962
摘要： An implantable medical device (IMD) includes a therapy circuit for delivering atrial pacing and a control circuit for detecting a return to sinus rhythm, determining the duration of atrial arrhythmia preceding the return to sinus rhythm, and controlling the therapy circuit to deliver transient atrial pacing based on the duration.
摘要翻译：可植入医疗装置（IMD）包括用于递送心房起搏的治疗电路和用于检测窦性心律恢复的控制电路，确定在返回到窦性心律之前心房心律失常的持续时间，以及控制治疗电路以递送瞬时心房起搏基于持续时间。

2. 发明申请

US20060224203A1 Method and apparatus for evaluating ventricular performance during isovolumic contraction 有权
标题翻译：在等容收缩期间评估心室性能的方法和装置
公开(公告)号：US20060224203A1
公开(公告)日：2006-10-05
申请号：US11097706
申请日：2005-03-31
申请人： Douglas Hettrick , David Euler
发明人： Douglas Hettrick , David Euler
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B8/0858 , A61N1/36528 , A61N1/3684
摘要： A method of evaluating ventricular performance of a heart employing sensors to measure a ventricular dimension signal and deriving indices of ventricular performance therefrom. Premature Shortening (PS) and Isovolumic Lengthening (IL) comprise two indices of ventricular performance determined from analysis of the left ventricular dimension signal during the transition from ventricular filling to ventricular ejection. Measured values of PS and IL are compared to other measured values or reference values to determine if ventricular performance has improved (or worsened). In some embodiments, the dimension sensors may comprise piezoelectric sonomicrometer crystals that operate as ultrasound transmitters and receivers. The sensors may be mounted in relation to a ventricle of the heart either temporarily or permanently, and may be configured either separately from or integrally with cardiac pacing leads.
摘要翻译：评估使用传感器测量心室尺寸信号并从其导出心室性能指数的心脏心室性能的方法。过早缩短（PS）和等压延长（IL）包括从心室充填到心室射血的过渡期间从左心室尺寸信号的分析确定的两个心室指数指数。将PS和IL的测量值与其他测量值或参考值进行比较，以确定心室性能是否改善（或恶化）。在一些实施例中，尺寸传感器可以包括作为超声波发射器和接收器操作的压电经济测量晶体。传感器可以相对于心脏的心室临时或永久地安装，并且可以与心脏起搏引线分开地或与心脏起搏引线一体地配置。

3. 发明申请

US20050159783A1 Control of atrial defibrillation therapy based on hemodynamic sensor feedback 有权
标题翻译：基于血流动力学传感器反馈控制心房除颤治疗
公开(公告)号：US20050159783A1
公开(公告)日：2005-07-21
申请号：US10760155
申请日：2004-01-16
申请人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
发明人： Douglas Hettrick , David Euler , Eduardo Warman , Michael Ujhelyi , Rahul Mehra , Paul Ziegler , Shailesh Kumar Musley , Charles Distad , David Ritscher
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDS) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMDS）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

4. 发明申请

US20070203522A1 Method and apparatus for treating diastolic heart failure 有权
标题翻译：用于治疗舒张性心力衰竭的方法和装置
公开(公告)号：US20070203522A1
公开(公告)日：2007-08-30
申请号：US11363729
申请日：2006-02-28
申请人： Douglas Hettrick , Lawrence Mulligan , David Euler
发明人： Douglas Hettrick , Lawrence Mulligan , David Euler
IPC分类号： A61N1/00
CPC分类号： A61N1/3627
摘要： Methods and systems for treating patients with diastolic heart failure (DHF) are disclosed which include slowing a patient's heart rate below its intrinsic rate, and controlling the rate using cardiac pacing therapy to improve LV filling and cardiac output. In certain embodiments, a pacing treatment rate may be determined by adjusting an adaptive rate by an amount determined by evaluating one or more patient parameters.
摘要翻译：公开了用于治疗舒张性心力衰竭（DHF）患者的方法和系统，其包括将患者的心率降低到其内在速率以下，并且使用心脏起搏治疗来控制速率以改善LV灌注和心输出量。在某些实施例中，起搏治疗率可以通过将自适应速率调整到通过评估一个或多个患者参数确定的量来确定。

5. 发明申请

US20050288725A1 Combination of electrogram and intra-cardiac pressure to discriminate between fibrillation and tachycardia 有权
标题翻译：电图和心脏内压力的组合来区分原纤维性颤动和心动过速
公开(公告)号：US20050288725A1
公开(公告)日：2005-12-29
申请号：US10881541
申请日：2004-06-29
申请人： Douglas Hettrick , David Euler , Mark Brown
发明人： Douglas Hettrick , David Euler , Mark Brown
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/04 , A61B5/042 , A61B5/046 , A61B5/0464 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61B5/0464 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36564 , A61N1/3956
摘要： A system and method for detecting and classifying cardiac arrhythmias based on cardiac pressure signals or the combination of cardiac electrical and cardiac pressure signals. A cardiac electrogram signal is sensed to derive a cardiac rate from which an arrhythmia detection is made when the cardiac rate meets arrhythmia detection criteria. An intracardiac pressure signal is sensed to derive an indicator of tachycardia based on an analysis of the pressure signal in either the time domain or frequency domain. The detected arrhythmia is classified as tachycardia or fibrillation based on the tachycardia indicator wherein the tachycardia indicator is compared to tachycardia detection criteria and the arrhythmia is classified as tachycardia if tachycardia detection criteria are met and the arrhythmia is classified as fibrillation if the tachycardia detection criteria are not met.
摘要翻译：一种基于心脏压力信号或心脏电压和心脏压力信号的组合来检测和分类心律失常的系统和方法。感测到心电图信号以导出当心率达到心律失常检测标准时进行心律失常检测的心率。基于对时域或频域中的压力信号的分析，感测心内压力信号以导出心动过速的指标。检测到的心律失常根据心动过速指标分类为心动过速指标，其中心动过速指标与心动过速检测标准进行比较，如果心动过速检测标准得到满足，则将心律不齐分类为心动过速，如果心动过速检测标准为没见过。

6. 发明申请

US20070255326A1 METHOD AND SYSTEM FOR DETECTING CARDIAC ARRHYTHMIAS DURING OVERDRIVE PACING 有权
标题翻译：用于检测过氧化物酶的心脏病的方法和系统
公开(公告)号：US20070255326A1
公开(公告)日：2007-11-01
申请号：US11380328
申请日：2006-04-26
申请人： Douglas Hettrick , Kristin Myers , Katherine Anderson
发明人： Douglas Hettrick , Kristin Myers , Katherine Anderson
IPC分类号： A61N1/00
CPC分类号： A61N1/3622
摘要： A method and apparatus are provided for detecting cardiac arrhythmias during overdrive pacing. A maximum paced rate and a reduced paced rate for a heart are determined, the maximum paced rate being higher than the reduced paced rate. The heart is paced at the maximum paced rate. After the heart is paced at the maximum paced rate for a predetermined amount of time, the heart is paced at the reduced paced rate.
摘要翻译：提供了一种用于在超速起搏过程中检测心律不齐的方法和装置。确定心脏的最大起搏速度和降低的起搏速率，最大起搏速度高于降低的起搏速度。心脏以最高的起搏速度起搏。心脏以最大的起搏速度起搏一段预定的时间后，心脏以降低的起搏速度起搏。

7. 发明申请

US20070038258A1 ADDRESSING RECURRENT ATRIAL FIBRILLATION 失效
标题翻译：解决复发性复发
公开(公告)号：US20070038258A1
公开(公告)日：2007-02-15
申请号：US11532741
申请日：2006-09-18
申请人： Eduardo Warman , Stefan Holzer , Helmut Puererfellner , Douglas Hettrick , Paul Ziegler
发明人： Eduardo Warman , Stefan Holzer , Helmut Puererfellner , Douglas Hettrick , Paul Ziegler
IPC分类号： A61N1/362
CPC分类号： A61N1/3962 , A61N1/395
摘要： The invention is directed to techniques for applying overdrive pacing to one or both atria following termination of an AF episode, to prevent a recurrent AF episode. An implantable medical device such as a pacemaker applies overdrive pacing according to overdrive pacing parameters, and sets the parameters as a function of the response of the patient to overdrive pacing. The parameters may be adjusted upward or downward, so that overdrive pacing may be applied effectively but not over-applied.
摘要翻译：本发明涉及用于在AF发作终止之后向一个或两个心房施加超速起搏的技术，以防止复发性AF发作。诸如起搏器的可植入医疗装置根据超速起搏参数应用过速起搏，并且将参数设置为患者对超速起搏的响应的函数。可以向上或向下调节参数，从而可以有效地施加过度起搏，但不会过度施加。

8. 发明申请

US20070021671A1 System and method of determining cardiac pressure 有权
标题翻译：确定心脏压力的系统和方法
公开(公告)号：US20070021671A1
公开(公告)日：2007-01-25
申请号：US11184638
申请日：2005-07-19
申请人： Douglas Hettrick , Todd Zielinski
发明人： Douglas Hettrick , Todd Zielinski
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61B5/0215 , A61B5/6882 , A61N1/3627 , A61N1/36564
摘要： A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.
摘要翻译：压力传感器部署在右心房，并与卵圆窝的组织接触。卵圆窝作为膜，压力传感器确定左心房内的相对和/或绝对压力，同时保留在右心房内。提供了各种实施例以将传感器部署和锚定到适当的位置。

9. 发明申请

US20070021666A1 System and method of determining cardiac pressure 有权
公开(公告)号：US20070021666A1
公开(公告)日：2007-01-25
申请号：US11184639
申请日：2005-07-19
申请人： Douglas Hettrick , Todd Zielinski
发明人： Douglas Hettrick , Todd Zielinski
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/6882 , A61N1/36564
摘要： A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.

10. 发明申请

US20060224204A1 System and method for controlling implantable medical device parameters in response to atrial pressure attributes 有权
标题翻译：用于根据心房压力属性控制植入式医疗装置参数的系统和方法
公开(公告)号：US20060224204A1
公开(公告)日：2006-10-05
申请号：US11097408
申请日：2005-03-31
申请人： Douglas Hettrick , Todd Zielinski , Amber Jaeger , Nicole Campbell
发明人： Douglas Hettrick , Todd Zielinski , Amber Jaeger , Nicole Campbell
IPC分类号： A61N1/365
CPC分类号： A61N1/36564
摘要： In an implantable medical device disclosed herein, a real-time left atrial pressure (“LAP”) signal obtained from a patient's heart is used as a feedback control mechanism to adjust one or more device parameters. In accordance with one example embodiment of the invention, the device identifies specific characteristics and attributes of the LAP signal that correlate to hemodynamic performance, and adjusts the device parameters to optimize the LAP characteristics and attributes. The example device is a dual-chamber pacing system, the controlled operating parameter may include the atrioventricular pacing delay, and one LAP attribute suitable for controlling the atrioventricular pacing delay relates to time intervals of v-wave, a-wave, and/or c-wave characteristics of the LAP signal.
摘要翻译：在本文公开的可植入医疗装置中，使用从患者心脏获得的实时左心房压力（“LAP”）信号作为反馈控制机构来调节一个或多个装置参数。根据本发明的一个示例实施例，该装置识别与血液动力学性能相关的LAP信号的特定特征和属性，并且调整装置参数以优化LAP特征和属性。示例性装置是双室起搏系统，受控的操作参数可以包括房室起搏延迟，并且适合于控制房室起搏延迟的一个LAP属性涉及v波，a波和/或c的时间间隔波特性的LAP信号。

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