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1. 发明授权

US5311132A Method of enhancing the focus of magnetic resonance images 失效
标题翻译：增强磁共振图像焦点的方法
公开(公告)号：US5311132A
公开(公告)日：1994-05-10
申请号：US920959
申请日：1992-07-28
申请人： Douglas C. Noll , John M. Pauly , Albert Macovski
发明人： Douglas C. Noll , John M. Pauly , Albert Macovski
IPC分类号： G01R33/565 , G01R33/20
CPC分类号： G01R33/56563 , G01R33/56527
摘要： Disclosed is a method for automatically removing blur in magnetic resonance image signals introduced due to inhomogeneity in the magnetic field and variations in magnetic susceptibility of an object being imaged. Detected signals are demodulated at several different frequencies and reconstructed to create a series of base images. The amount of blur is determined by establishing a focusing measure for each point or part in each base image, and a composite image is then constructed using only the unblurred regions from each base image. Focusing criterion can include minimization of the imaginary part of the complex MRI after removal of constant and low frequency phase information.
摘要翻译：公开了一种用于自动消除由于磁场不均匀性引起的磁共振图像信号中的模糊和被成像对象的磁化率的变化的方法。检测到的信号在几个不同的频率下进行解调，并重构以产生一系列基本图像。通过为每个基本图像中的每个点或部分建立聚焦测量来确定模糊的量，然后仅使用来自每个基本图像的未加密的区域来构造合成图像。聚焦准则可以包括去除恒定和低频相位信息后复杂MRI的虚部的最小化。

2. 发明授权

US5257626A Method of noninvasive myocardial motion analysis using bidirectional motion intergration in phase contrast MRI maps of myocardial velocity 失效
标题翻译：无创心肌运动分析方法采用双向运动整合相位对比MRI图，心肌速度
公开(公告)号：US5257626A
公开(公告)日：1993-11-02
申请号：US921804
申请日：1992-07-28
申请人： Norbert J. Pelc , Douglas C. Noll , John M. Pauly
发明人： Norbert J. Pelc , Douglas C. Noll , John M. Pauly
IPC分类号： G01R33/561 , G01R33/563 , G01R33/567 , A61B5/055 , A61B8/00
CPC分类号： G01R33/563 , G01R33/5617 , G01R33/56316 , G01R33/5676
摘要： Measures of a velocity component during a plurality of time frames of cyclical motion of a region of interest are obtained using contrast cine MRI techniques. Trajectories of the region of interest are calculated in a backward direction and in a forward direction. The trajectories are then combined to define a motion trajectory. The forward and backward trajectories are weighted prior to combining with the forward trajectory being more heavily weighted for early frames and the backward trajectory being more heavily weighted for late frames.
摘要翻译：使用对比电影MRI技术获得感兴趣区域的循环运动的多个时间帧期间的速度分量的测量。在向后方向和向前方向上计算感兴趣区域的轨迹。然后组合轨迹以定义运动轨迹。前向和后向轨迹在组合之前被加权，前向轨迹对于早期帧是更加重的，并且后向轨迹对于后期帧更加重。

3. 发明授权

US5402067A Apparatus and method for rare echo imaging using k-space spiral coverage 失效
标题翻译：使用k空间螺旋覆盖的稀有回波成像的装置和方法
公开(公告)号：US5402067A
公开(公告)日：1995-03-28
申请号：US101865
申请日：1993-08-04
申请人： John M. Pauly , Daniel M. Spielman , Craig H. Meyer , Albert Macovski , Norbert J. Pelc
发明人： John M. Pauly , Daniel M. Spielman , Craig H. Meyer , Albert Macovski , Norbert J. Pelc
IPC分类号： G01R33/20 , A61B5/055 , G01R33/48 , G01R33/561 , G01V3/00
CPC分类号： G01R33/5615 , G01R33/446 , G01R33/5617
摘要： A long train of spin echoes is produced using a RARE excitation pulse sequence, and during each spin echo an annular segment of a long k-space spiral as determined by read-out magnetic gradients is detected. At the end of the echo train the entire k-space spiral will have been covered. Each of the segments can be a unique annular portion of the k-space spiral. Alternatively, fewer annular segments of the spiral can be provided, with the fewer annular segments rotated in k-space and replayed to cover interleaved paths in k-space. The imaging gradients are refocused at the time of each spin-echo pulse in order to permit the long echo pulse trains of RARE imaging. Each spiral segment is surrounded by gradient lobes that move out from the k-space origin to the beginning of the segment, and move back to the origin from the end of the segment. Advantageously, the magnetic gradient lobes can be produced concurrently with parasitic echo crusher gradients at the beginning and end of each spin-echo pulse. Further, off-resonance effects can be placed in sidelobes of the spin-echo signal to facilitate suppression in the detected signals.
摘要翻译：使用RARE激励脉冲序列产生长串自旋回波，并且在每个自旋回波期间，检测由读出磁梯度确定的长k空间螺旋的环形段。在回波列车的末端，整个k空间螺旋将被覆盖。每个段可以是k空间螺旋的独特的环形部分。或者，可以提供更少的螺旋环形段，其中较少的环形段在k空间中旋转并且重播以覆盖k空间中的交错路径。在每个自旋回波脉冲时，成像梯度被重新聚焦，以便允许RARE成像的长回波脉冲序列。每个螺旋段由从k空间原点移出到段的开头的梯度波瓣包围，并从段的末尾返回到原点。有利地，可以在每个自回波脉冲的开始和结束处与寄生回波破碎机梯度同时产生磁梯度波瓣。此外，离共振效应可以置于自旋回波信号的旁瓣中，以便于检测信号中的抑制。

4. 发明授权

US08638096B2 Method of autocalibrating parallel imaging interpolation from arbitrary K-space sampling with noise correlations weighted to reduce noise of reconstructed images 有权
标题翻译：从任意K空间采样中自动校准平行成像插值的方法，加权噪声相关，以减少重构图像的噪声
公开(公告)号：US08638096B2
公开(公告)日：2014-01-28
申请号：US12907764
申请日：2010-10-19
申请人： Tao Zhang , Michael Lustig , John M. Pauly , Shreyas S. Vasanawala
发明人： Tao Zhang , Michael Lustig , John M. Pauly , Shreyas S. Vasanawala
IPC分类号： G01R33/56
CPC分类号： G01R33/5611 , G01R33/4824
摘要： A computer implemented method for magnetic resonance imaging is provided. A 3D Fourier Transform acquisition is performed with two phase encode directions, wherein phase code locations are chosen so that a total number of phase encodes is less than a Nyquist rate, and closest distances between phase encode locations takes on a multiplicity of values. Readout signals are received through a multi-channel array of a plurality of receivers. An autocalibrating parallel imaging interpolation is performed and a noise correlation is generated. The noise correlation is used to weight a data consistency term of a compressed sensing iterative reconstruction. An image is created from the autocalibration parallel imaging using the weighted data consistency term. The image is displayed.
摘要翻译：提供了一种用于磁共振成像的计算机实现方法。使用两个相位编码方向执行3D傅立叶变换采集，其中选择相位位置使得相位编码的总数小于奈奎斯特速率，并且相位编码位置之间的最近距离具有多个值。通过多个接收器的多通道阵列接收读出信号。执行自动校准并行成像内插，并产生噪声相关。噪声相关用于加权压缩感测迭代重建的数据一致性项。使用加权数据一致性项从自动校准并行成像创建图像。显示图像。

5. 发明授权

US07928729B2 Distortion-free magnetic resonance imaging near metallic implants 有权
标题翻译：在金属植入物附近的无畸变磁共振成像
公开(公告)号：US07928729B2
公开(公告)日：2011-04-19
申请号：US12188031
申请日：2008-08-07
申请人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
发明人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
IPC分类号： G01V3/00
CPC分类号： G01R33/4833 , G01R33/5611 , G01R33/5618 , G01R33/56536 , G01R33/56563
摘要： A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
摘要翻译：提供了一种具有切片方向失真校正的3D磁共振成像（MRI）方法。使用具有带宽的RF脉冲激发具有沿着第一轴的厚度的一个或多个选择性横截面，其中选择性截面是选择性切片或选择性板。应用重聚焦脉冲以形成自旋回波。一个或多个2D编码图像信号是沿第二轴读出并沿第三轴进行相位编码的。通过解析频率偏移来解决位置来校正切片方向失真。

6. 发明申请

US20100033179A1 DISTORTION-FREE MAGNETIC RESONANCE IMAGING NEAR METALLIC IMPLANTS 有权
标题翻译：无损磁性共振成像近金属植入物
公开(公告)号：US20100033179A1
公开(公告)日：2010-02-11
申请号：US12188031
申请日：2008-08-07
申请人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
发明人： Brian A. Hargreaves , Wenmiao Lu , John M. Pauly , Garry E. Gold , Kim B. Pauly
IPC分类号： G01R33/56
CPC分类号： G01R33/4833 , G01R33/5611 , G01R33/5618 , G01R33/56536 , G01R33/56563
摘要： A method for 3D magnetic resonance imaging (MRI) with slice-direction distortion correction is provided. One or more selective cross-sections with a thickness along a first axis is excited using a RF pulse with a bandwidth, wherein a selective cross-section is either a selective slice or selective slab. A refocusing pulse is applied to form a spin echo. One or more 2D encoded image signals are acquired with readout along a second axis and phase encoding along a third axis. Slice-direction distortion is corrected by resolving the position by resolving the frequency offset.
摘要翻译：提供了一种具有切片方向失真校正的3D磁共振成像（MRI）方法。使用具有带宽的RF脉冲激发具有沿着第一轴的厚度的一个或多个选择性横截面，其中选择性截面是选择性切片或选择性板。应用重聚焦脉冲以形成自旋回波。一个或多个2D编码图像信号是沿第二轴读出并沿第三轴进行相位编码的。通过解析频率偏移来解决位置来校正切片方向失真。

7. 发明申请

US20080150528A1 RF FIELD MAPPING FOR MAGNETIC RESONANCE IMAGING 有权
标题翻译：用于磁共振成像的射频场映射
公开(公告)号：US20080150528A1
公开(公告)日：2008-06-26
申请号：US11614798
申请日：2006-12-21
申请人： Charles H. Cunningham , Krishna S. Nayak , John M. Pauly
发明人： Charles H. Cunningham , Krishna S. Nayak , John M. Pauly
IPC分类号： G01V3/14
CPC分类号： G01R33/583 , G01R33/246 , G01R33/446 , G01R33/4824 , G01R33/4835 , G01R33/5607 , G01R33/561
摘要： For in vivo magnetic resonance imaging at high field (≧3 T) it is essential to consider the homogeneity of the active B1 field (B1+), particularly if surface coils are used for RF transmission. A new method is presented for highly rapid B1+ magnitude mapping. It combines the double angle method with a B1-insensitive magnetization-reset sequence such that the choice of repetition time (TR) is independent of T1 and with a multi-slice segmented (spiral) acquisition to achieve volumetric coverage with adequate spatial resolution in a few seconds.
摘要翻译：对于在高场（> = 3T）下的体内磁共振成像，必须考虑活性B 1区域（B 1 + 1）的均匀性，特别是如果表面线圈用于RF传输。提出了一种用于高度快速的B＆lt; 1＆gt; +幅度映射的新方法。它将双重角度方法与B 1敏感磁化复位序列相结合，使得重复时间（TR）的选择与T 1> 1不相关，切片分段（螺旋）采集，在几秒钟内实现足够的空间分辨率的体积覆盖。

8. 发明授权

US07276904B2 Method for generating T1-weighted magnetic resonance images and quantitative T1 maps 有权
标题翻译：用于产生T1加权磁共振图像和定量T1图的方法
公开(公告)号：US07276904B2
公开(公告)日：2007-10-02
申请号：US11136194
申请日：2005-05-24
申请人： Reed F. Busse , John M. Pauly , Greg Zaharchuk
发明人： Reed F. Busse , John M. Pauly , Greg Zaharchuk
IPC分类号： G01V3/00
CPC分类号： G01R33/50 , G01R33/5615 , G01R33/5617
摘要： Methods and systems for generating T1-weighted images are provided. The method includes acquiring a pair of single-shot fast-spin-echo (SSFSE) images S1 and S2. The method further includes generating a T1-weighted image ST1w based on S1 and S2.
摘要翻译：提供了生成T1加权图像的方法和系统。该方法包括获取一对单次快速自旋回波（SSFSE）图像S 1和S 2 2。该方法还包括基于S 1和S 2 2生成T1加权图像S T1W1。

9. 发明授权

US07096056B2 Functional magnetic resonance imaging using steady state free precession 有权
标题翻译：功能磁共振成像使用稳态自由进动
公开(公告)号：US07096056B2
公开(公告)日：2006-08-22
申请号：US10463008
申请日：2003-06-16
申请人： Karla L. Miller , John M. Pauly
发明人： Karla L. Miller , John M. Pauly
IPC分类号： A61B5/05 , G01V3/00
CPC分类号： G01R33/4806 , A61B5/055 , A61B5/145 , G01R33/5613
摘要： A method for functional magnetic resonance imaging (fMRI) uses steady-state free precession (SSFP) to image changes in blood oxygenation between two time periods. A center frequency of the SSFP sequence is placed between the different resonant frequencies for oxyhemoglobin and deoxyhemoglobin whereby the signals have a phase difference of 180° and tend to cancel. By repeating the SSFP imaging sequence at different times, the difference in the measured signals provides a measure of change in oxyhemoglobin. RF flip angle of the SSFP sequence is chosen to maximize signal level in the frequency range from that of water in the presence of oxyhemoglobin and that of water in the presence of deoxyhemoglobin.
摘要翻译：功能磁共振成像（fMRI）的方法使用稳态自由进动（SSFP）来在两个时间段之间成像血氧饱和度变化。 SSFP序列的中心频率位于氧合血红蛋白和脱氧血红蛋白的不同谐振频率之间，由此信号具有180°的相位差并趋于抵消。通过在不同时间重复SSFP成像序列，测量信号的差异提供氧合血红蛋白变化的量度。选择SSFP序列的RF翻转角来使得在存在氧合血红蛋白的情况下在水的频率范围内的信号水平和在脱氧血红蛋白存在下的水的信号水平最大化。

10. 发明授权

US06806708B1 Multi-coil reconstruction of MRI signals using linear phase multiplied data with separate demodulators for each coil 有权
标题翻译：使用线性相位相乘数据对MRI信号进行多线圈重建，每个线圈采用单独的解调器
公开(公告)号：US06806708B1
公开(公告)日：2004-10-19
申请号：US10464296
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5611
摘要： Imaging time using PILS is reduced by using multiple coils with localized sensitivities with each coil having a separate demodulation channel thereby permitting parallel signal processing and image reconstruction. Images from the multiple coils are then combined to form an image with a larger field of view (FOV).
摘要翻译：使用PILS的成像时间通过使用具有局部灵敏度的多个线圈来减少，每个线圈具有单独的解调信道，从而允许并行信号处理和图像重建。然后将来自多个线圈的图像组合以形成具有较大视场（FOV）的图像。

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