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1. 发明授权

US07581902B2 In situ immobilization of metals in contaminated sites using stabilized iron phosphate nanoparticles 失效
标题翻译：使用稳定的磷酸铁纳米粒子原位固定金属在受污染的场所
公开(公告)号：US07581902B2
公开(公告)日：2009-09-01
申请号：US11680266
申请日：2007-02-28
申请人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie F. Harper , Feng He
发明人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie F. Harper , Feng He
IPC分类号： B09C1/00
CPC分类号： C01G13/00 , B09C1/002 , B09C1/08 , B09C1/10 , B82Y30/00 , C01G49/12 , C02F1/281 , C02F1/5263 , C02F2101/20 , C02F2103/007 , C02F2103/06 , C02F2305/08 , C22B3/0097 , C22B13/00 , C22B43/00 , Y02P10/234
摘要： A method for preparing a class of highly stabilized and soil-dispersible nanoparticles and using the nanoparticles as a remediation technology for immobilizing toxic metals at toxic metal contaminated sites. The method employs a composition containing select polysaccharides (starch or cellulose) as a stabilizer for the nanoparticles in a liquid carrier, and results in suspensions of nanoparticles of desired size and mobility in water, soils or sediments. The stabilizer can facilitate controlling the dispersibility of the nanoparticles in the liquid carrier. An effective amount of the composition is delivered to a contaminated site so that the nanoparticles can immobilize one or more toxic metals of the contaminated site.
摘要翻译：一种制备一类高度稳定和可分散土壤的纳米颗粒的方法，并使用纳米颗粒作为固定有毒金属在有毒金属污染场所的修复技术。该方法使用含有选择性多糖（淀粉或纤维素）作为液体载体中的纳米颗粒的稳定剂的组合物，并且导致在水，污垢或沉积物中具有所需尺寸和迁移率的纳米颗粒的悬浮液。稳定剂可以有助于控制纳米颗粒在液体载体中的分散性。将有效量的组合物输送到污染部位，使得纳米颗粒可以固定受污染部位的一种或多种有毒金属。

2. 发明授权

US07887880B2 Preparation and application of stabilized iron nanoparticles for dechlorination of chlorinated hydrocarbons in soils, sediments, and ground water 有权
标题翻译：稳定的铁纳米颗粒在土壤，沉积物和地下水中氯化烃脱氯的制备和应用
公开(公告)号：US07887880B2
公开(公告)日：2011-02-15
申请号：US11571390
申请日：2005-06-30
申请人： Dongye Zhao , Feng He
发明人： Dongye Zhao , Feng He
IPC分类号： B05D7/00 , A62D3/34
CPC分类号： C02F1/705 , B09C1/002 , B09C1/08 , C02F2101/36 , C02F2103/06 , Y10T428/12028
摘要： A stabilized, chemically reactive, metallic nano-material effective for degradation of chlorinated organic compounds in soils, sediments and groundwater. The nano-material is composed of a magnetic metal nanoparticle and a carbohydrate stabilizer bound to the nanoparticle. The preferred metal nanoparticle is iron and the preferred carbohydrate stabilizer is either a starch or a water soluble cellulose such as sodium carboxymethyl cellulose. The nanoparticle may be either mono-metallic, bi-metallic or multi-metallic in nature, but is preferably bi-metallic wherein it is coated with a secondary catalytic metal coating, preferably palladium. A method of making the metallic nano-material is further disclosed wherein a solution of the metal nanoparticle and carbohydrate stabilizer is prepared, and the nanoparticle is then reduced under inert conditions. A process for reductive dechlorination of chlorinated organic compounds is also disclosed wherein the reduced magnetic metal nanoparticle is prepared, and then contacted with a chlorinated organic compound to dechlorinate the compound. Preferably, the nano-material is injected into a site such as soil subsurface or groundwater contaminated with a chlorinated organic compound to provide in-situ dechlorination.
摘要翻译：稳定的化学反应性金属纳米材料有效降解土壤，沉积物和地下水中的氯化有机化合物。纳米材料由磁性金属纳米颗粒和与纳米颗粒结合的碳水化合物稳定剂组成。优选的金属纳米颗粒是铁，优选的碳水化合物稳定剂是淀粉或水溶性纤维素如羧甲基纤维素钠。纳米颗粒本质上可以是单金属的，双金属的或多金属的，但优选是双金属的，其中涂覆有次级催化金属涂层，优选钯。进一步公开了制备金属纳米材料的方法，其中制备金属纳米颗粒和碳水化合物稳定剂的溶液，然后在惰性条件下还原纳米颗粒。还公开了氯化有机化合物的还原脱氯方法，其中制备还原的磁性金属纳米颗粒，然后与氯化有机化合物接触以使化合物脱氯。优选地，将纳米材料注入诸如被氯化有机化合物污染的地下水或地下水等地点，以提供原位脱氯。

3. 发明申请

US20080190865A1 Preparation and Applications of Stabilized Metal Nanoparticles for Dechlorination of Chlorinated Hydrocarbons in Soils, Sediments, and Ground Water 有权
标题翻译：稳定金属纳米粒子在土壤，沉积物和地下水中氯化烃脱氯的制备与应用
公开(公告)号：US20080190865A1
公开(公告)日：2008-08-14
申请号：US11571390
申请日：2005-06-30
申请人： Dongye Zhao , Feng He
发明人： Dongye Zhao , Feng He
IPC分类号： C02F1/70 , A62D3/34 , C22C38/00 , C22C19/03 , C22C19/07 , C22C18/00 , C22C22/00 , C22C5/04
CPC分类号： C02F1/705 , B09C1/002 , B09C1/08 , C02F2101/36 , C02F2103/06 , Y10T428/12028
摘要： A stabilized, chemically reactive, metallic nano-material effective for degradation of chlorinated organic compounds in soils, sediments and groundwater. The nano-material is composed of a magnetic metal nanoparticle and a carbohydrate stabilizer bound to the nanoparticle. The preferred metal nanoparticle is iron and the preferred carbohydrate stabilizer is either a starch or a water soluble cellulose such as sodium carboxymethyl cellulose. The nanoparticle may be either mono-metallic, bi-metallic or multi-metallic in nature, but is preferably bi-metallic wherein it is coated with a secondary catalytic metal coating, preferably palladium. A method of making the metallic nano-material is further disclosed wherein a solution of the metal nanoparticle and carbohydrate stabilizer is prepared, and the nanoparticle is then reduced under inert conditions. A process for reductive dechlorination of chlorinated organic compounds is also disclosed wherein the reduced magnetic metal nanoparticle is prepared, and then contacted with a chlorinated organic compound to dechlorinate the compound. Preferably, the nano-material is injected into a site such as soil subsurface or groundwater contaminated with a chlorinated organic compound to provide in-situ dechlorination.
摘要翻译：稳定的化学反应性金属纳米材料有效降解土壤，沉积物和地下水中的氯化有机化合物。纳米材料由磁性金属纳米颗粒和与纳米颗粒结合的碳水化合物稳定剂组成。优选的金属纳米颗粒是铁，优选的碳水化合物稳定剂是淀粉或水溶性纤维素如羧甲基纤维素钠。纳米颗粒本质上可以是单金属的，双金属的或多金属的，但优选是双金属的，其中涂覆有次级催化金属涂层，优选钯。进一步公开了制备金属纳米材料的方法，其中制备金属纳米颗粒和碳水化合物稳定剂的溶液，然后在惰性条件下还原纳米颗粒。还公开了氯化有机化合物的还原脱氯方法，其中制备还原的磁性金属纳米颗粒，然后与氯化有机化合物接触以使化合物脱氯。优选地，将纳米材料注入诸如被氯化有机化合物污染的地下水或地下水等地点，以提供原位脱氯。

4. 发明申请

US20070203388A1 In Situ Immobilization of Metals in Contaminated Sites Using Stabilized Nanoparticles 失效
标题翻译：使用稳定纳米颗粒原位固定在污染场所的金属
公开(公告)号：US20070203388A1
公开(公告)日：2007-08-30
申请号：US11680266
申请日：2007-02-28
申请人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie Harper , Feng He
发明人： Dongye Zhao , Zhong Xiong , Mark Barnett , Ruiqiang Liu , Willie Harper , Feng He
IPC分类号： B09B3/00
CPC分类号： C01G13/00 , B09C1/002 , B09C1/08 , B09C1/10 , B82Y30/00 , C01G49/12 , C02F1/281 , C02F1/5263 , C02F2101/20 , C02F2103/007 , C02F2103/06 , C02F2305/08 , C22B3/0097 , C22B13/00 , C22B43/00 , Y02P10/234
摘要： A method for preparing a class of highly stabilized and soil-dispersible nanoparticles and using the nanoparticles as a remediation technology for immobilizing toxic metals at toxic metal contaminated sites. The method employs a composition containing select polysaccharides (starch or cellulose) as a stabilizer for the nanoparticles in a liquid carrier, and results in suspensions of nanoparticles of desired size and mobility in water, soils or sediments. The stabilizer can facilitate controlling the dispersibility of the nanoparticles in the liquid carrier. An effective amount of the composition is delivered to a contaminated site so that the nanoparticles can immobilize one or more toxic metals of the contaminated site.
摘要翻译：一种制备一类高度稳定和可分散土壤的纳米颗粒的方法，并使用纳米颗粒作为固定有毒金属在有毒金属污染场所的修复技术。该方法使用含有选择性多糖（淀粉或纤维素）作为液体载体中纳米颗粒的稳定剂的组合物，并且导致在水，污垢或沉积物中具有所需尺寸和迁移率的纳米颗粒的悬浮液。稳定剂可以有助于控制纳米颗粒在液体载体中的分散性。将有效量的组合物输送到污染部位，使得纳米颗粒可以固定受污染部位的一种或多种有毒金属。

5. 发明授权

US09474762B2 Triazolopyridine compounds 有权
标题翻译：三唑并吡啶化合物
公开(公告)号：US09474762B2
公开(公告)日：2016-10-25
申请号：US14716159
申请日：2015-05-19
申请人： Chao Chen , Haibing Deng , Haibing Guo , Feng He , Lei Jiang , Fang Liang , Yuan Mi , Huixin Wan , Yao-Chang Xu , Hongping Yu , Ji Yue Zhang
发明人： Chao Chen , Haibing Deng , Haibing Guo , Feng He , Lei Jiang , Fang Liang , Yuan Mi , Huixin Wan , Yao-Chang Xu , Hongping Yu , Ji Yue Zhang
IPC分类号： A61K31/00 , A61K31/551 , C07D471/04 , C07D519/00 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D491/107 , A61K31/4709
CPC分类号： A61K31/551 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/5513 , A61K45/06 , C07D471/04 , C07D491/107 , C07D519/00
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

6. 发明申请

US20140004101A1 SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS 审中-公开
标题翻译： SMAC PEPTIDOMETICS有用作为IAP抑制剂
公开(公告)号：US20140004101A1
公开(公告)日：2014-01-02
申请号：US14013666
申请日：2013-08-29
申请人： Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
发明人： Zhuoliang Chen , Christine Hiu-Tung Chen , Mark G. Charest , Miao Dai , Feng He , Lei Huangshu , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC分类号： C07D417/04 , A61K31/427 , A61K45/06
CPC分类号： C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要： The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。

7. 发明授权

US08577386B2 Resource measurement and reporting method in long term evolution system 有权
标题翻译：长期演化体系中的资源测量与报告方法
公开(公告)号：US08577386B2
公开(公告)日：2013-11-05
申请号：US13133794
申请日：2008-12-30
申请人： Yin Gao , Feng He
发明人： Yin Gao , Feng He
IPC分类号： H04W72/00
CPC分类号： H04W24/10
摘要： A method for measuring and reporting resource in a long term evolution system comprises: a source base station encapsulating a resource status request message and sending the message to a target base station; after receiving the resource status request message, the target base station processing the message, and sending a resource status success response to the source base station if the processing is successful, or else sending a resource status failure response if the processing is failed; the source base station encapsulating at least a message type (2), a measurement request type (3), a source base station global identifier (4) and measurement configuration information (5) in the resource status request message, wherein, the measurement request type (3) is one or more of start, modify and end (7); the measurement configuration information (5) is measurement configuration information (5) in current measurement request type (3). The method makes it convenient to start, modify or end the current measurement by the target base station during network operation after a plurality of resource status measuring and reporting are launched between base stations, and thus reducing the number of information exchange between base stations.
摘要翻译：一种用于在长期演进系统中测量和报告资源的方法包括：源基站封装资源状态请求消息并将消息发送到目标基站; 在接收到资源状态请求消息之后，目标基站处理该消息，并且如果处理成功则向源基站发送资源状态成功响应，或者如果处理失败则发送资源状态失败响应; 所述源基站在资源状态请求消息中至少封装消息类型（2），测量请求类型（3），源基站全局标识符（4）和测量配置信息（5），其中，所述测量请求类型（3）是开始，修改和结束（7）中的一个或多个; 测量配置信息（5）是当前测量请求类型（3）中的测量配置信息（5）。该方法使得在基站之间启动多个资源状态测量和报告之后，网络操作期间目标基站的启动，修改或结束方便，从而减少基站之间的信息交换次数。

8. 发明授权

US08507676B2 Heterocyclic oxime compounds 有权
标题翻译：杂环肟化合物
公开(公告)号：US08507676B2
公开(公告)日：2013-08-13
申请号：US13567386
申请日：2012-08-06
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-Chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , C07D403/12 , A61K31/4985 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).
摘要翻译：本发明涉及式（I）的化合物及其盐：其中取代基如说明书中所定义; 用于治疗人或动物体的式（I）化合物，特别是关于c-Met酪氨酸激酶介导的疾病或病症; 使用式（I）化合物制备用于治疗这些疾病的药物; 包含式（I）化合物，任选在组合配偶体存在下的药物组合物，以及制备式（I）化合物的方法。

9. 发明授权

US08410264B2 Heterocyclic oxime compounds 有权
公开(公告)号：US08410264B2
公开(公告)日：2013-04-02
申请号：US12859653
申请日：2010-08-19
申请人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
发明人： Miao Dai , Xingnian Fu , Feng He , Lei Jiang , Yue Li , Fang Liang , Lei Liu , Yuan Mi , Yao-chang Xu , Guoliang Xun , Xiaoxia Yan , Zhengtian Yu , Ji Yue Zhang
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I).

10. 发明申请

US20110015232A1 Pyrrolydine Derivatives as IAP Inhibitors 失效
标题翻译：吡咯列酮衍生物作为IAP抑制剂
公开(公告)号：US20110015232A1
公开(公告)日：2011-01-20
申请号：US12445435
申请日：2007-10-10
申请人： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
发明人： Mark G. Charest , Christine Hiu-Tung CHEN , Ming Chen , Zhuoliang Chen , Miao Dai , Feng He , Huangshu Lei , Christopher Straub , Run-Ming David Wang , Leigh Zawel
IPC分类号： A61K31/4439 , C07D405/14 , C07D401/14 , C12N5/07
CPC分类号： C07K5/06191
摘要： The present invention relates to novel IAP inhibitor compounds of: Formula (I).
摘要翻译：本发明涉及式（I）的新型IAP抑制剂化合物。

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