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1. 发明授权

US08868196B2 Neurostimulation system and method for rostro-caudally steering current using longitudinal ideal multipole configurations 有权
标题翻译：使用纵向理想多极配置的神经刺激系统和鲁棒转向电流的方法
公开(公告)号：US08868196B2
公开(公告)日：2014-10-21
申请号：US13420140
申请日：2012-03-14
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/372 , A61N1/36
CPC分类号： A61N1/36185 , A61N1/36071 , A61N1/37247 , A61N1/37264
摘要： A system for an electrical neurostimulator coupled to a plurality of electrodes. The system comprises a user-controlled input device configured for generating directional control signals. The system further comprises control circuitry configured for sequentially defining a plurality of different ideal bipole/tripole configurations relative to the plurality of electrodes in response to the directional control signals, generating a plurality of stimulation parameter sets respectively corresponding to the plurality of ideal bipole/tripole configurations, each stimulation parameter set defining relative amplitude values for the plurality of electrodes that emulate the respective ideal bipole/tripole configuration, and instructing the electrical neurostimulator to convey electrical energy to the plurality of electrodes in accordance with the plurality of stimulation parameter sets.
摘要翻译：一种耦合到多个电极的电神经刺激器的系统。该系统包括被配置用于产生方向控制信号的用户控制输入装置。该系统还包括控制电路，其被配置为响应于方向控制信号相对于多个电极依次定义多个不同的理想的双极/三极配置，产生分别对应于多个理想的双极/三极的多个刺激参数集配置，每个刺激参数集定义了模拟相应的理想双极/三极配置的多个电极的相对振幅值，以及指示电神经刺激器根据多个刺激参数集向多个电极传送电能。

2. 发明申请

US20120239110A1 NEUROSTIMULATION SYSTEM AND METHOD FOR ROSTRO-CAUDALLY STEERING CURRENT USING LONGITUDINAL IDEAL MULTIPOLE CONFIGURATIONS 有权
标题翻译：神经系统和方法使用纵向理想的多重配置进行转向导向电流
公开(公告)号：US20120239110A1
公开(公告)日：2012-09-20
申请号：US13420140
申请日：2012-03-14
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/372
CPC分类号： A61N1/36185 , A61N1/36071 , A61N1/37247 , A61N1/37264
摘要： A system for an electrical neurostimulator coupled to a plurality of electrodes. The system comprises a user-controlled input device configured for generating directional control signals. The system further comprises control circuitry configured for sequentially defining a plurality of different ideal bipole/tripole configurations relative to the plurality of electrodes in response to the directional control signals, generating a plurality of stimulation parameter sets respectively corresponding to the plurality of ideal bipole/tripole configurations, each stimulation parameter set defining relative amplitude values for the plurality of electrodes that emulate the respective ideal bipole/tripole configuration, and instructing the electrical neurostimulator to convey electrical energy to the plurality of electrodes in accordance with the plurality of stimulation parameter sets.
摘要翻译：一种耦合到多个电极的电神经刺激器的系统。该系统包括被配置用于产生方向控制信号的用户控制输入装置。该系统还包括控制电路，其被配置为响应于方向控制信号相对于多个电极依次定义多个不同的理想的双极/三极配置，产生分别对应于多个理想的双极/三极的多个刺激参数集配置，每个刺激参数集定义了模拟相应的理想双极/三极配置的多个电极的相对振幅值，以及指示电神经刺激器根据多个刺激参数集向多个电极传送电能。

3. 发明授权

US08706250B2 Neurostimulation system for implementing model-based estimate of neurostimulation effects 有权
标题翻译：用于实施基于模型的神经刺激作用估计的神经刺激系统
公开(公告)号：US08706250B2
公开(公告)日：2014-04-22
申请号：US13244388
申请日：2011-09-24
申请人： Changfang Zhu , Dongchul Lee
发明人： Changfang Zhu , Dongchul Lee
IPC分类号： A61N1/372
CPC分类号： A61N1/36128 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63 , G16H50/50
摘要： A neurostimulation system for use in providing therapy to a patient comprises a user input device configured for receiving input from a user, and processing circuitry configured for selecting an electrode configuration in response to receiving the input from the user, providing an electrical model of a neuronal element of the patient, providing a discrete approximation of a differential equation of a neural response parameter (e.g., a transmembrane voltage potential) of the electrical model as a function of discrete space (e.g., nodes along the electrical model) and as a function of a finite time difference, computing the neural response parameter in the differential equation approximation at a specified time for each of a plurality of points on a membrane of the neuronal element, and performing a human-discernible function based on the computed neural response parameters.
摘要翻译：用于向患者提供治疗的神经刺激系统包括被配置为从用户接收输入的用户输入设备，以及响应于接收来自用户的输入而选择电极配置的处理电路，提供神经元的电模型提供患者的元件，提供作为离散空间的函数的电模型的神经反应参数（例如，跨膜电压电位）的微分方程的离散近似（例如，沿着电模型的节点），并且作为有限时间差，在神经元元件的膜上的多个点中的每一个点的规定时间计算微分方程近似中的神经反应参数，以及基于所计算的神经反应参数执行人类可辨别的函数。

4. 发明申请

US20120296392A1 Display of region of activation in neurostimulation programming screen 有权
标题翻译：在神经刺激编程屏幕中显示激活区域
公开(公告)号：US20120296392A1
公开(公告)日：2012-11-22
申请号：US13506832
申请日：2012-05-17
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/36146
摘要： A system for use with a neurostimulator coupled to one or more electrodes implanted adjacent neural tissue of a patient. The system comprises a user input device configured for allowing a user to select different nerve fiber diameters and to select a set of stimulation parameters. The system further comprises processing circuitry configured estimating regions of activation within the neural tissue of the patient based on the selected nerve fiber diameters and the selected stimulation parameter set. The system further comprises a display device configured for displaying the estimated regions of tissue activation. The user input device may further be configured for allowing the user to select different tissue regions of therapy, in which case, the display device may display the different tissue region on a human body map, and different indicia associating the displayed tissue regions for therapy to displayed estimated regions of tissue activation.
摘要翻译：一种与神经刺激器一起使用的系统，该神经刺激器耦合到植入患者的神经组织的一个或多个电极。该系统包括用户输入装置，其被配置为允许用户选择不同的神经纤维直径并选择一组刺激参数。该系统还包括处理电路，其配置为基于所选择的神经纤维直径和所选择的刺激参数集来估计患者的神经组织内的激活区域。该系统还包括被配置为显示组织激活的估计区域的显示装置。用户输入设备还可以被配置为允许用户选择不同的治疗组织区域，在这种情况下，显示设备可以在人体图上显示不同的组织区域，并且将显示的组织区域与治疗相关联的不同标记与显示组织激活的估计区域。

5. 发明申请

US20120239116A1 NEUROSTIMULATION SYSTEM FOR MATCHING IDEAL POLE SPACING WITH EFFECTIVE ELECTRODE SEPARATION 有权
标题翻译：用于匹配有效电极分离的理想点距离的神经网络系统
公开(公告)号：US20120239116A1
公开(公告)日：2012-09-20
申请号：US13420312
申请日：2012-03-14
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/372
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/37247 , G06F19/3481 , G16H40/63
摘要： A system for a neurostimulator coupled to electrodes. The system comprises a input device configured for generating control signals, and control circuitry configured for defining at least one ideal multipole configuration relative to the electrodes in response to the control signals, the control circuitry, for each of the ideal multipole configuration(s), being further configured for, designating at least one of the electrodes as a reference electrode, estimating an effective electrode separation at each of the reference electrode(s), defining a spacing between the poles based on the estimated effective electrode separation at each of the reference electrode(s), generating at least one stimulation parameter set respectively corresponding to the ideal multipole configuration(s), each of the stimulation parameter set(s) defining relative amplitude values for the electrodes that emulate the respective ideal multipole configuration, and instructing the electrical neurostimulator to convey electrical energy to the electrodes in accordance with the stimulation parameter set(s).
摘要翻译：耦合到电极的神经刺激器的系统。该系统包括被配置用于产生控制信号的输入装置和被配置为响应于控制信号而定义至少一个理想的多极配置的控制电路，控制电路针对每个理想的多极配置，进一步配置为：将至少一个电极指定为参考电极，估计每个参考电极处的有效电极分离，基于每个参考电极处的估计的有效电极间隔来限定极点之间的间隔产生分别对应于理想多极配置的至少一个刺激参数集，所述刺激参数组中的每个刺激参数组限定用于模拟相应的理想多极配置的电极的相对振幅值，并且指示电神经刺激器根据电传送电能到电极刺激参数集（s）。

6. 发明申请

US20120165901A1 NEUROSTIMULATION SYSTEM FOR ESTIMATING DESIRED STIMULATION AMPLITUDE FOR ELECTRODE CONFIGURATION 有权
标题翻译：用于估计用于电极配置的所需刺激振幅的神经网络系统
公开(公告)号：US20120165901A1
公开(公告)日：2012-06-28
申请号：US13335924
申请日：2011-12-22
申请人： Changfang Zhu , Dongchul Lee
发明人： Changfang Zhu , Dongchul Lee
IPC分类号： A61N1/372
CPC分类号： A61N1/36192 , A61B5/04001 , A61B5/407 , A61N1/36071 , A61N1/36128 , A61N1/36153 , A61N1/36157 , A61N1/36185 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： A neurostimulation system comprises a user input device configured for receiving input from a user, and processing circuitry configured for (a) selecting a first electrode configuration in response to receiving the user input, (b) predicting a neural response induced by electrical energy theoretically conveyed by the first electrode configuration at a specified amplitude, (c) deriving a metric value from the predicted neural response, (d) comparing the metric value to a reference threshold value, (e) adjusting the specified amplitude of the electrical energy if the metric value is not in a specified range relative to the reference threshold value, (f) repeating steps (b)-(e) using the adjusted amplitude as the specified amplitude until the metric value is in the specific range relative to the reference threshold value, and (g) instructing a neurostimulation device to deliver the electrical energy at the adjusted amplitude via the first electrode configuration to stimulate the patient.
摘要翻译：神经刺激系统包括被配置用于接收来自用户的输入的用户输入设备和配置用于（a）响应于接收到用户输入选择第一电极配置的处理电路，（b）预测由理论上传达的电能引起的神经响应通过所述第一电极配置以指定的幅度，（c）从所述预测的神经反应导出度量值，（d）将所述度量值与参考阈值进行比较，（e）如果所述度量值的度量值不在相对于参考阈值的指定范围内，（f）使用调整幅度作为指定幅度重复步骤（b） - （e），直到度量值相对于参考阈值处于特定范围内，和（g）指示神经刺激装置通过第一电极配置传递经调整的振幅的电能以刺激患者。

7. 发明授权

US09764140B2 Display of region of activation in neurostimulation programming screen 有权
公开(公告)号：US09764140B2
公开(公告)日：2017-09-19
申请号：US13506832
申请日：2012-05-17
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/36
CPC分类号： A61N1/36146
摘要： A system for use with a neurostimulator coupled to one or more electrodes implanted adjacent neural tissue of a patient. The system comprises a user input device configured for allowing a user to select different nerve fiber diameters and to select a set of stimulation parameters. The system further comprises processing circuitry configured estimating regions of activation within the neural tissue of the patient based on the selected nerve fiber diameters and the selected stimulation parameter set. The system further comprises a display device configured for displaying the estimated regions of tissue activation. The user input device may further be configured for allowing the user to select different tissue regions of therapy, in which case, the display device may display the different tissue region on a human body map, and different indicia associating the displayed tissue regions for therapy to displayed estimated regions of tissue activation.

8. 发明授权

US09014820B2 Neurostimulation system for matching ideal pole spacing with effective electrode separation 有权
标题翻译：神经刺激系统，用于匹配理想极间距和有效电极分离
公开(公告)号：US09014820B2
公开(公告)日：2015-04-21
申请号：US13420312
申请日：2012-03-14
申请人： Dongchul Lee , Changfang Zhu
发明人： Dongchul Lee , Changfang Zhu
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05 , G06F19/00
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/37247 , G06F19/3481 , G16H40/63
摘要： A system for a neurostimulator coupled to electrodes. The system comprises a input device configured for generating control signals, and control circuitry configured for defining at least one ideal multipole configuration relative to the electrodes in response to the control signals, the control circuitry, for each of the ideal multipole configuration(s), being further configured for, designating at least one of the electrodes as a reference electrode, estimating an effective electrode separation at each of the reference electrode(s), defining a spacing between the poles based on the estimated effective electrode separation at each of the reference electrode(s), generating at least one stimulation parameter set respectively corresponding to the ideal multipole configuration(s), each of the stimulation parameter set(s) defining relative amplitude values for the electrodes that emulate the respective ideal multipole configuration, and instructing the electrical neurostimulator to convey electrical energy to the electrodes in accordance with the stimulation parameter set(s).
摘要翻译：耦合到电极的神经刺激器的系统。该系统包括被配置用于产生控制信号的输入装置和被配置为响应于控制信号而定义至少一个理想的多极配置的控制电路，控制电路针对每个理想的多极配置，进一步配置为：将至少一个电极指定为参考电极，估计每个参考电极处的有效电极分离，基于每个参考电极处的估计的有效电极间隔来限定极点之间的间隔产生分别对应于理想多极配置的至少一个刺激参数集，所述刺激参数组中的每个刺激参数组限定用于模拟相应的理想多极配置的电极的相对振幅值，并且指示电神经刺激器根据电传送电能到电极刺激参数集（s）。

9. 发明授权

US08644947B2 Neurostimulation system for estimating desired stimulation amplitude for electrode configuration 有权
标题翻译：用于估计电极配置的所需刺激振幅的神经刺激系统
公开(公告)号：US08644947B2
公开(公告)日：2014-02-04
申请号：US13335924
申请日：2011-12-22
申请人： Changfang Zhu , Dongchul Lee
发明人： Changfang Zhu , Dongchul Lee
IPC分类号： A61N1/00
CPC分类号： A61N1/36192 , A61B5/04001 , A61B5/407 , A61N1/36071 , A61N1/36128 , A61N1/36153 , A61N1/36157 , A61N1/36185 , A61N1/37247 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： A neurostimulation system comprises a user input device configured for receiving input from a user, and processing circuitry configured for (a) selecting a first electrode configuration in response to receiving the user input, (b) predicting a neural response induced by electrical energy theoretically conveyed by the first electrode configuration at a specified amplitude, (c) deriving a metric value from the predicted neural response, (d) comparing the metric value to a reference threshold value, (e) adjusting the specified amplitude of the electrical energy if the metric value is not in a specified range relative to the reference threshold value, (f) repeating steps (b)-(e) using the adjusted amplitude as the specified amplitude until the metric value is in the specific range relative to the reference threshold value, and (g) instructing a neurostimulation device to deliver the electrical energy at the adjusted amplitude via the first electrode configuration to stimulate the patient.
摘要翻译：神经刺激系统包括被配置用于接收来自用户的输入的用户输入设备和配置用于（a）响应于接收到用户输入选择第一电极配置的处理电路，（b）预测由理论上传达的电能引起的神经响应通过所述第一电极配置以指定的幅度，（c）从所述预测的神经反应导出度量值，（d）将所述度量值与参考阈值进行比较，（e）如果所述度量值的度量值不在相对于参考阈值的指定范围内，（f）使用调整幅度作为指定幅度重复步骤（b） - （e），直到度量值相对于参考阈值处于特定范围内，和（g）指示神经刺激装置通过第一电极配置传递经调整的振幅的电能以刺激患者。

10. 发明申请

US20120165900A1 NEUROSTIMULATION SYSTEM FOR IMPLEMENTING MODEL-BASED ESTIMATE OF NEUROSTIMULATION EFFECTS 有权
标题翻译：用于实施基于模型的神经病变效应估计的神经网络系统
公开(公告)号：US20120165900A1
公开(公告)日：2012-06-28
申请号：US13244388
申请日：2011-09-24
申请人： Changfang Zhu , Dongchul Lee
发明人： Changfang Zhu , Dongchul Lee
IPC分类号： A61N1/372
CPC分类号： A61N1/36128 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63 , G16H50/50
摘要： A neurostimulation system for use in providing therapy to a patient comprises a user input device configured for receiving input from a user, and processing circuitry configured for selecting an electrode configuration in response to receiving the input from the user, providing an electrical model of a neuronal element of the patient, providing a discrete approximation of a differential equation of a neural response parameter (e.g., a transmembrane voltage potential) of the electrical model as a function of discrete space (e.g., nodes along the electrical model) and as a function of a finite time difference, computing the neural response parameter in the differential equation approximation at a specified time for each of a plurality of points on a membrane of the neuronal element, and performing a human-discernible function based on the computed neural response parameters.
摘要翻译：用于向患者提供治疗的神经刺激系统包括被配置为从用户接收输入的用户输入设备，以及响应于接收来自用户的输入而选择电极配置的处理电路，提供神经元的电模型提供患者的元件，提供作为离散空间的函数的电模型的神经反应参数（例如，跨膜电压电位）的微分方程的离散近似（例如，沿着电模型的节点），并且作为有限时间差，在神经元元件的膜上的多个点中的每一个点的规定时间计算微分方程近似中的神经反应参数，以及基于所计算的神经反应参数执行人类可辨别的函数。

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