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1. 发明授权

US06936633B2 Pyrrolidinone derivatives 失效
公开(公告)号：US06936633B2
公开(公告)日：2005-08-30
申请号：US10750247
申请日：2003-12-31
申请人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
发明人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/422 , A61K31/4439 , A61P1/04 , A61P1/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/02 , C07D207/24 , C07D207/26 , C07D207/273 , C07D207/36 , C07D207/38 , C07D401/04 , C07D405/04 , C07D405/08 , C07D409/04 , C07D409/06 , C07D413/06 , C07D207/04
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.

2. 发明申请

US20050004180A1 Pyrrolidinone derivatives 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：US20050004180A1
公开(公告)日：2005-01-06
申请号：US10489661
申请日：2002-09-26
申请人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Laurent Knerr , Rama Kondru , Eric Schwartz , Hai-Xiao Zhai
发明人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Laurent Knerr , Rama Kondru , Eric Schwartz , Hai-Xiao Zhai
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/422 , A61K31/4439 , A61P1/04 , A61P1/16 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/02 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/08 , A61P39/02 , C07D207/24 , C07D207/26 , C07D207/273 , C07D207/36 , C07D207/38 , C07D401/04 , C07D405/04 , C07D405/08 , C07D409/04 , C07D409/06 , C07D413/06
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.
摘要翻译：本发明提供了用于治疗由CCR2，MCP-1介导的病症或其相互作用的药物组合物和新化合物。本发明的化合物是吡咯烷酮和吡咯烷 - 硫堇。

3. 发明授权

US06727275B2 Pyrrolidinone derivatives 失效
公开(公告)号：US06727275B2
公开(公告)日：2004-04-27
申请号：US10255494
申请日：2002-09-26
申请人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
发明人： Dong Zou , Olivier Dasse , Janelle Evans , Paul Higgins , Jeremy Kintigh , Rama Kondru , Eric Schwartz , Laurent Knerr , Hai-Xiao Zhai
IPC分类号： C07D20726
CPC分类号： C07D207/273 , A61K31/4015 , A61K31/4439 , C07D207/24 , C07D207/36 , C07D401/04 , C07D405/04 , C07D409/04 , C07D409/06 , C07D413/06
摘要： The present invention provides pharmaceutical compositions and novel compounds useful in the treatment of conditions mediated by CCR2, MCP-1 or the interaction thereof. The compounds of the present invention are pyrrolidinones and pyrrolidine-thiones.

4. 发明申请

US20070032533A1 Nitric oxide enhancing angiotensin II antagonist compounds, compositions and methods of use 审中-公开
标题翻译：一氧化氮增强型血管紧张素II拮抗剂化合物，组合物和使用方法
公开(公告)号：US20070032533A1
公开(公告)日：2007-02-08
申请号：US11499770
申请日：2006-08-07
申请人： David Garvey , Xiong Cai , Xinqin Fang , Ramani Ranatunge , Shiow-Jyi Wey , Hai-Xiao Zhai
发明人： David Garvey , Xiong Cai , Xinqin Fang , Ramani Ranatunge , Shiow-Jyi Wey , Hai-Xiao Zhai
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/42
CPC分类号： C07D257/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D471/04
摘要： The invention describes compositions and kits comprising at least one nitric oxide enhancing angiotensin II antagonist compound, or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitric oxide enhancing angiotensin II antagonist compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension (o) treating central nervous system disorders; (p) treating metabolic syndrome; and (q) treating hyperlipidemia. The nitric oxide enhancing angiotensin II antagonist compounds comprise at least one nitric oxide enhancing group linked to the angiotensin II antagonist compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.
摘要翻译：本发明描述了包含至少一种一氧化氮增强型血管紧张素II拮抗剂化合物或其药学上可接受的盐的组合物和试剂盒，以及包含至少一种一氧化氮增强型血管紧张素II拮抗剂化合物和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; （k）治疗肾病; （l）治疗外周血管疾病; （m）治疗门静脉高压（o）治疗中枢神经系统疾病; （p）治疗代谢综合征; 和（q）治疗高脂血症。一氧化氮增强型血管紧张素II拮抗剂化合物包含通过一个或多个位点如碳，氧和/或氮通过不能水解的键或部分与血管紧张素II拮抗剂化合物连接的至少一个一氧化氮增强基团。

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